JP2020054353A - 希ガスが豊富な液体ならびにその調製及び使用の方法 - Google Patents
希ガスが豊富な液体ならびにその調製及び使用の方法 Download PDFInfo
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- JP2020054353A JP2020054353A JP2019214954A JP2019214954A JP2020054353A JP 2020054353 A JP2020054353 A JP 2020054353A JP 2019214954 A JP2019214954 A JP 2019214954A JP 2019214954 A JP2019214954 A JP 2019214954A JP 2020054353 A JP2020054353 A JP 2020054353A
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Landscapes
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Abstract
Description
I.薬剤及び栄養補助食品製剤
経口製剤
薬剤及び栄養補助食品製剤のための追加成分
電解質
ビタミン及びミネラル
アミノ酸
炭水化物
香味剤
フラバノール
感覚惹起剤
刺激剤
着色剤
防腐剤
酸味剤
酸化防止剤
水
アルコール
海のミネラル
脂質成分
II.希ガス製剤の服用
HED(mg/kg)=動物用量(mg/kg)×(動物Km/ヒトKm)
III.希ガスの封入
油成分
水溶性分子
以下の実施例は、本発明の好ましい実施形態を示すために挙げられる。発明者によって発見された技術を示す実施例に開示された技術は、本発明の実施においてうまく機能し、したがって、その実施の好ましい方法とすることができると当業者には理解される。しかし、当業者は、本公開に照らして、開示されている特定の実施形態に多くの変更を実施することができ、本発明の趣旨及び範囲から逸脱することなく同様またはほぼ同じ結果がなお得られることを理解しなければならない。
実施例1−実施例2の試験のための方法
縫合糸を除去した後すぐに、外頸動脈を結紮し、総頸動脈を通じてMCAへ血液を再潅流させた。いずれの実験でも、加熱ランプ及び加熱パッドを備えたフィードフォワード温度コントローラー(Harvard Apparatus, Holliston, MA, USA)を使用して、体温をモニターし、虚血の間及び再潅流の最初の1時間、37℃で維持した。血圧を記録するため右大腿動脈にポリエチレンカテーテルを導入した。スタンダードレーザードップラーモニター(PF5010 LDPMユニット及びPF5001 メインユニット、Perimed、Jarfalla、Stockholm、Sweden)に接続したPR407−1ストレートニードルレーザードップラー流量計プローブ(Perimed、Jarfalla、Stockholm、Sweden)を使用して大脳血流をモニターした。虚血性ペナンブラの領域(ブレグマの側方2mm及び後方2mm)に血流遮断を記録した。
実施例2−Xe投与試験
かご状分子に封入したキセノンの調製
純粋キセノン過飽和水の調製
Xeが豊富な水の調製
キセノンが豊富な水に溶解したXeの測定
動物
心エコー測定及び心エコー画像(生体内で)
血圧測定
タンパク質定量
β−アミロイド測定
ウェスタンブロット分析 心臓組織に心筋型トロポニン発現
統計的分析
実施例4−Xeが高められた水によるさらなる試験の結果
Xeが豊富な水に溶解されるキセノン
キセノンが豊富な水が虚血性ストレスに対する心臓の耐性を増大させる。
キセノンが豊富な水が血圧を安定させる
* * *
リファレンス
以下のリファレンスは、本明細書に記載されたものを補足する例示的な手順のまたは他の詳細を提供する範囲内で、特に参照により本明細書に組み込まれる。
米国特許第4,981,687号
米国特許第5,089,477号
米国特許第5,147,650号
米国特許第5,236,712号
米国特許第5,238,684号
米国特許第7,976,743号
米国特許公開第20030177784号
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Meir et al., “Atherosclerosis in the Apolipoprotein E−Deficient Mouse − A Decade of Progress,” Arterioscler.Thromb.Vasc.Biol., 24:1006−1014、 2004.
Okada et al., Arteriosclerosis, Thrombosis, and Vascular Biol., 32:1902−1909, 2012.
Pagel、 J. Cardiothorac.Vasc.Anesth., 24:143−163、 2010.
Saleh “Novel Phenomena In Encapsulating Hydrocarbon Gases,” in Novel Phenomena In Encapsulating Hydrocarbon Gases, 2007.
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(i)溶解した希ガス、水溶性ポリマーとともに封入されている希ガスの一部を含む実質的に水性成分、及び/または
(ii)溶解した希ガスを含む食用油成分を含む栄養補助食品組成物。
[本発明1002]
前記希ガスがヘリウム、ネオン、アルゴン、クリプトンまたはキセノンである、本発明1001の組成物。
[本発明1003]
前記希ガスがキセノンである、本発明1001の組成物。
[本発明1004]
前記組成物が2種以上の希ガスの混合物を含む、本発明1001の組成物。
[本発明1005]
前記組成物がエマルジョンを含む、本発明1001の組成物。
[本発明1006]
水溶性ポリマーがシクロデキストリンである、本発明1001の組成物。
[本発明1007]
前記シクロデキストリンがγ−またはβ−シクロデキストリンである、本発明1006の組成物。
[本発明1008]
前記シクロデキストリンがβ−シクロデキストリンである、本発明1006の組成物。
[本発明1009]
前記組成物が約0.1〜約1.0mg/mlのシクロデキストリン分子を含む、本発明1006の組成物。
[本発明1010]
前記油が多価不飽和脂肪酸(PUFA)を含む、本発明1001の組成物。
[本発明1011]
前記油が少なくとも1%、5%、10%、20%、30%、40%、50%、60%、70%、80%または90%のPUFAを含む、本発明1001の組成物。
[本発明1012]
前記油成分がキセノンまたはアルゴンガスにより飽和している、本発明1001の組成物。
[本発明1013]
前記食用油成分が可溶性キセノンガスを含む、本発明1001の組成物。
[本発明1014]
前記食用油が実質的に酸素を含まない、本発明1001の組成物。
[本発明1015]
前記油がカノーラ油、亜麻仁油、菜種油、大豆油、クルミ油、魚油、ベニバナ油、チア種油、ヒマワリ種油、ゴマ種油、海草油、トウモロコシ油、綿種油、ピーナッツ油、パーム油、アボカド油、ココナツ油、またはオリーブ油を含む、本発明1001の組成物。
[本発明1016]
前記油がΩ−3脂肪酸を含む、本発明1001の組成物。
[本発明1017]
さらに(a)25容積%〜50容積%の油、前記油が希ガスにより飽和している、及び(b)30容積%〜75容積%の水溶液を含むエマルジョンと定義される、本発明1001の組成物。
[本発明1018]
さらに(a)15容積%〜75容積%の油、前記油が希ガスにより飽和している、及び(b)25容積%〜85容積%の水溶液を含むエマルジョンと定義される、本発明1001の組成物。
[本発明1019]
前記水溶液が水、果物ジュース、野菜ジュースまたはアルコールを含む、本発明1001の組成物。
[本発明1020]
さらにリン脂質、洗浄剤、またはタンパク質成分を含む、本発明1001の組成物。
[本発明1021]
前記洗浄剤が植物性界面活性剤、合成洗浄剤または胆汁酸である、本発明1020の組成物。
[本発明1022]
前記洗浄剤がリトコール酸、デオキシコール酸、タウロコール酸、グリココール酸、ケノデオキシコール酸、またはコール酸である、本発明1020の組成物。
[本発明1023]
前記リン脂質が鶏卵ホスホコリン(鶏卵PC)、大豆PC、DPPCまたはDOPCである、本発明1020の組成物。
[本発明1024]
前記タンパク質が乳タンパク質、乳清タンパク質、大豆タンパク質分離物、またはウシ血清アルブミンである、本発明1020の組成物。
[本発明1025]
さらに油1ml当たり約1〜50gのキセノンを含む、本発明1001の組成物。
[本発明1026]
(a)15容積%〜75容積%のオリーブ油、前記油がキセノンまたはアルゴンガスにより飽和している、(b)25容積%〜85容積%の水溶液、及び1つまたは複数のリン脂質、洗浄剤またはタンパク質を含む、本発明1001の組成物。
[本発明1027]
(a)25容積%〜50容積%のオリーブ油、前記油がキセノンまたはアルゴンガスにより飽和している、(b)50容積%〜75容積%の水溶液、(c)10〜30mg/mlのホスホコリン、(d)10〜50mg/mlのBSA、及び(e)1〜5mg/mlのリトコール酸を含む、本発明1001の組成物。
[本発明1028]
(a)15容積%〜75容積%のオリーブ油、前記油がキセノンまたはアルゴンガスにより飽和している、(b)25容積%〜85容積%の水溶液、(c)10〜30mg/mlのホスホコリン、(d)10〜50mg/mlのBSA、及び(e)1〜5mg/mlのリトコール酸を含む、本発明1001の組成物。
[本発明1029]
さらに薬用植物、ビタミンまたはエネルギー供給栄養補助食品飲料と定義される、本発明1001の組成物。
[本発明1030]
さらに防腐剤、香味剤、染料、ビタミン、酸化防止剤、または植物抽出物を含む、本発明1001の組成物。
[本発明1031]
前記組成物がガス不浸透性の容器に含まれる、本発明1001から1030のいずれかの組成物。
[本発明1032]
前記容器が約1ml〜2リットルの前記組成物を含む、本発明1031の組成物。
[本発明1033]
前記容器が約1mg〜20g、1mg〜10g、1mg〜1g、1〜100mg、1〜50mg、1〜25mgまたは1〜10mgのXeを含む、本発明1032の組成物。
[本発明1034]
前記容器が全内容物を大気にさらさないで経口消費のための前記組成物を放出するための1回限りの物を含む、本発明1031の組成物。
[本発明1035]
前記容器が加圧されている、本発明1032の組成物。
[本発明1036]
前記容器が希ガスとともに加圧されている、本発明1035の組成物。
[本発明1037]
さらにCO 2 を含む、本発明1035の組成物。
[本発明1038]
ガス不浸透性の容器に本発明1001から1030のいずれかの組成物を含む1回分の栄養補助食品。
[本発明1039]
前記容器がびんである、本発明1038の1回分の飲料。
[本発明1040]
前記容器が1ml〜1.0mlの前記組成物を有する、本発明1039の1回分の飲料。
[本発明1041]
前記希ガスがXeを含む、本発明1038の1回分の飲料。
[本発明1042]
約1mg〜20g、1mg〜10g、1mg〜1g、1〜100mg、1〜50mg、1〜25mgまたは1〜10mgのXeを有する、本発明1041の1回分の飲料。
[本発明1043]
約25〜500mlの実質的に水性成分及び約0.1mg〜20gの溶解した希ガスを含み、水溶性を高めるために前記希ガスの一部が封入されている、1回分の栄養補助食品組成物。
[本発明1044]
溶解した希ガスを含む経口消費のために調剤された液体または半液体組成物を提供することを含む被験者の健康または健康な状態を改善する方法。
[本発明1045]
前記液体組成物が希ガスにより飽和または過飽和している、本発明1044の方法。
[本発明1046]
前記希ガスがXeを含む、本発明1045の方法。
[本発明1047]
前記液体組成物が本発明1001から1042のいずれかに従った組成物である、本発明1044の方法。
[本発明1048]
溶解した希ガスを含む有効量の組成物を経口で投与することを含む被験者に神経または心臓血管の保護を提供する方法。
[本発明1049]
前記被験者がアテローム性動脈硬化症、アルツハイマー病、血栓症脳卒中、出血性脳卒中、心不全または心臓肥大であるか、またはリスクがある、本発明1048の方法。
[本発明1050]
前記被験者がヒトである、本発明1048の方法。
[本発明1051]
前記希ガスがXeを含む、本発明1050の方法。
[本発明1052]
約0.1mg〜20g/日のXeを前記被験者に投与することを含む、本発明1051の方法。
[本発明1053]
前記被験者に1日当たり約500mg〜10g、500mg〜5g、500mg〜2g、1〜100mg、1〜50mg、1〜25mgまたは1〜10mgのXe投与することを含む、本発明1052の方法。
[本発明1054]
前記組成物が毎週、毎日、1日に2回、1日に3回、6時間ごとに、3時間ごとにまたは1時間ごとに投与される、本発明1048の方法。
[本発明1055]
前記組成物が1週間、2週間、1ヵ月または1年の期間にわたって投与される、本発明1054の方法。
[本発明1056]
さらに神経疾患または神経損傷を治療するまたは予防する方法と定義される、本発明1048の方法。
[本発明1057]
前記神経疾患がアルツハイマー病である、本発明1056の方法。
[本発明1058]
さらに前記被験者のβ−アミロイド濃度を減少させる方法と定義される、本発明1057の方法。
[本発明1059]
さらに被験者のアルツハイマー病の進行を治療するまたは予防する方法と定義される、本発明1057の方法。
[本発明1060]
前記被験者にアルツハイマー病を発症するリスクがある、本発明1057の方法。
[本発明1061]
前記被験者にアルツハイマー病の遺伝的素因がある、または前記被験者がその素因があると診断されている、本発明1057の方法。
[本発明1062]
前記神経損傷が血栓症または虚血性脳卒中である、本発明1056の方法。
[本発明1063]
有効量の希ガスが溶解した組成物を経口で投与することを含む被験者の炎症のマーカーを減少させる方法。
[本発明1064]
前記組成物が水溶性を高めるために封入されている希ガスを含む、本発明1048から1063のいずれかの方法。
[本発明1065]
前記組成物が、(i)溶解した希ガス、水溶性ポリマーとともに封入されている希ガスの一部を含む実質的に水性成分、及び/または(ii)溶解した希ガスを含む油成分を含む、本発明1048から1063のいずれかの方法。
[本発明1066]
前記希ガスがヘリウム、ネオン、アルゴン、クリプトンまたはキセノンである、本発明1065の方法。
[本発明1067]
前記希ガスがキセノンである、本発明1065の方法。
[本発明1068]
前記組成物が2種以上の希ガスの混合物を含む、本発明1065の方法。
[本発明1069]
前記組成物がエマルジョンを含む、本発明1065の方法。
[本発明1070]
水溶性ポリマーがシクロデキストリンである、本発明1065の方法。
[本発明1071]
前記シクロデキストリンがγ−またはβ−シクロデキストリンである、本発明1070の方法。
[本発明1072]
前記シクロデキストリンがβ−シクロデキストリンである、本発明1070の方法。
[本発明1073]
前記組成物が約0.1〜約1.0mg/mlのシクロデキストリンを含む、本発明1070の方法。
[本発明1074]
前記油が多価不飽和脂肪酸(PUFA)を含む、本発明1065の方法。
[本発明1075]
前記油が少なくとも1%、5%、10%、20%、30%、40%、50%、60%、70%、80%または90%のPUFAを含む、本発明1065の方法。
[本発明1076]
前記油成分がキセノンまたはアルゴンガスにより飽和している、本発明1065の方法。
[本発明1077]
前記食用油成分が可溶性キセノンガスを含む、本発明1065の方法。
[本発明1078]
前記食用油が実質的に酸素を含まない、本発明1065の方法。
[本発明1079]
前記油がカノーラ油、亜麻仁油、菜種油、大豆油、クルミ油、魚油、ベニバナ油、チア種油、ヒマワリ種油、ゴマ種油、海草油、トウモロコシ油、綿種油、ピーナッツ油、パーム油、アボカド油、ココナツ油、またはオリーブ油を含む、本発明1065の方法。
[本発明1080]
前記油がΩ−3脂肪酸、Ω−6脂肪酸またはΩ−9脂肪酸を含む、本発明1065の方法。
[本発明1081]
さらに(a)25容積%〜50容積%の油、前記油が希ガスにより飽和している、及び(b)30容積%〜75容積%の水溶液を含むエマルジョンと定義される、本発明1065の方法。
[本発明1082]
さらに(a)15容積%〜75容積%の油、前記油が希ガスにより飽和している、及び(b)25容積%〜85容積%の水溶液を含むエマルジョンと定義される、本発明1065の方法。
[本発明1083]
前記水溶液が湧水、果物ジュースまたは野菜ジュースを含む、本発明1065の方法。
[本発明1084]
さらにリン脂質、洗浄剤、またはタンパク質成分を含む、本発明1065の方法。
[本発明1085]
前記洗浄剤が植物性界面活性剤、合成洗浄剤または胆汁酸である、本発明1084の方法。
[本発明1086]
前記洗浄剤がリトコール酸、デオキシコール酸、タウロコール酸、グリココール酸、ケノデオキシコール酸、またはコール酸である、本発明1084の方法。
[本発明1087]
前記リン脂質が鶏卵ホスホコリン(鶏卵PC)、大豆PC、DPPCまたはDOPCである、本発明1084の方法。
[本発明1088]
前記タンパク質が乳タンパク質、乳清タンパク質、大豆タンパク質分離物、またはウシ血清アルブミンである、本発明1084の方法。
[本発明1089]
さらに油1ml当たり約1〜50gのキセノンを含む、本発明1065の方法。
[本発明1090]
前記組成物が(a)15容積%〜75容積%のオリーブ油、前記油がキセノンまたはアルゴンガスにより飽和している、(b)25容積%〜85容積%の水溶液、及び1つまたは複数のリン脂質、洗浄剤またはタンパク質を含む、本発明1065の方法。
[本発明1091]
前記組成物が(a)25容積%〜50容積%のオリーブ油、前記油がキセノンまたはアルゴンガスにより飽和している、(b)50容積%〜75容積%の水溶液、(c)10〜30mg/mlのホスホコリン、(d)10〜50mg/mlのBSA、及び(e)1〜5mg/mlのリトコール酸を含む、本発明1065の組成物。
[本発明1092]
前記組成物が(a)15容積%〜75容積%のオリーブ油、前記油がキセノンまたはアルゴンガスにより飽和している、(b)25容積%〜85容積%の水溶液、(c)10〜30mg/mlのホスホコリン、(d)10〜50mg/mlのBSA、及び(e)1〜5mg/mlのリトコール酸を含む、本発明1065の組成物。
[本発明1093]
(a)水溶性封入ポリマーと希ガスをインキュベートすること、及び(b)前記封入希ガスを水溶液に暴露し、約2気圧〜10気圧で、約4℃〜−180℃の温度で、少なくとも4時間、前記希ガスを含む水性組成物を生成し、約2気圧〜10気圧で、約20℃〜1℃の温度で少なくとも4時間、封入希ガス溶液を生成することを含む、希ガスを含む水性組成物を生成する方法。
[本発明1094]
前記インキュベートする工程(a)が約2気圧〜8気圧、2気圧〜5気圧、2気圧〜4気圧または約3気圧で実施される、本発明1093の方法。
[本発明1095]
前記インキュベートする工程(a)が約0℃〜−150℃、−20℃〜−150℃、−20℃〜−100℃、−40℃〜−100℃または約−80℃の温度で実施される、本発明1093の方法。
[本発明1096]
前記インキュベートする工程(a)が少なくとも8時間、12時間、24時間、48時間または8時間〜3日間である、本発明1093の方法。
[本発明1097]
前記暴露する工程(b)が約2気圧〜8気圧、2気圧〜5気圧、2気圧〜4気圧または約3気圧で実施される、本発明1093の方法。
[本発明1098]
前記暴露する工程(b)が約15℃〜1℃、10℃〜1℃、8℃〜2℃、6℃〜2℃または約4℃の温度で実施される、本発明1093の方法。
[本発明1099]
前記暴露する工程(b)が少なくとも8時間、12時間、24時間、48時間または8時間〜3日間である、本発明1093の方法。
[本発明1100]
前記水溶液が溶解した希ガスを含む、本発明1093の方法。
[本発明1101]
前記水溶液が希ガスにより飽和している、本発明1099の方法。
[本発明1102]
(i)ガスが抜かれた水溶液を得ること、及び(ii)約2気圧〜10気圧の気圧で、約20℃〜1℃の温度で、少なくとも4時間ガスが抜かれた水溶液を希ガスに暴露し、希ガスにより飽和された水溶液を生成することを含む方法によって、前記水溶液が希ガスにより飽和している、本発明1100の方法。
[本発明1103]
前記希ガスがアルゴンまたはキセノンである、本発明1093の方法。
[本発明1104]
前記希ガスがキセノンである、本発明1103の方法。
[本発明1105]
前記希ガスが2種以上の希ガスの混合物を含む、本発明1093の方法。
[本発明1106]
水溶性封入ポリマーがシクロデキストリンである、本発明1093の方法。
[本発明1107]
前記シクロデキストリンがγ−またはβ−シクロデキストリンである、本発明1106の方法。
[本発明1108]
前記シクロデキストリンがβ−シクロデキストリンである、本発明1106の方法。
[本発明1109]
前記β−シクロデキストリンがヒドロキシプロピル−β−シクロデキストリンである、本発明1108の方法。
[本発明1110]
さらに薬剤または栄養補助食品組成物を生成する方法と定義される、本発明1093の方法。
[本発明1111]
前記水溶液が防腐剤、香味剤、染料、ビタミン、酸化防止剤、または植物抽出物を含む、本発明1093の方法。
[本発明1112]
さらに前記希ガスを含む前記水性組成物をガス不浸透性の容器に包装する工程(c)を含む、本発明1093の方法。
[本発明1113]
前記容器が加圧されている、本発明1112の方法。
[本発明1114]
前記容器が希ガスとともに加圧されている、本発明1113の方法。
[本発明1115]
前記容器が丸薬、カプセル、金属箔またはポリマーパケットまたはびんである、本発明1112の方法。
[本発明1116]
本発明1093から1115のいずれかに従った方法により生成された希ガスを含む水性組成物。
[本発明1117]
(a)約2気圧〜6気圧で、約0℃〜25℃の温度で、油及びガスを混合することにより、食用油に希ガスを溶解し、可溶性希ガスを含む食用油を生成することを含む、希ガスの経口投与ための組成物を生成する方法。
以下の詳細な説明から、本発明の他の目的、特徴及び利点が明らかになる。しかし、本発明の趣旨及び範囲内でさまざまな変化及び修正が、この詳細な説明から当業者に明らかになるため、詳細な説明及び特定の実施例は、本発明の好ましい実施形態を示しながら、図のみにより与えられるものである。
Claims (117)
- (i)溶解した希ガス、水溶性ポリマーとともに封入されている希ガスの一部を含む実質的に水性成分、及び/または
(ii)溶解した希ガスを含む食用油成分を含む栄養補助食品組成物。 - 前記希ガスがヘリウム、ネオン、アルゴン、クリプトンまたはキセノンである、請求項1に記載の組成物。
- 前記希ガスがキセノンである、請求項1に記載の組成物。
- 前記組成物が2種以上の希ガスの混合物を含む、請求項1に記載の組成物。
- 前記組成物がエマルジョンを含む、請求項1に記載の組成物。
- 水溶性ポリマーがシクロデキストリンである、請求項1に記載の組成物。
- 前記シクロデキストリンがγ−またはβ−シクロデキストリンである、請求項6に記載の組成物。
- 前記シクロデキストリンがβ−シクロデキストリンである、請求項6に記載の組成物。
- 前記組成物が約0.1〜約1.0mg/mlのシクロデキストリン分子を含む、請求項6に記載の組成物。
- 前記油が多価不飽和脂肪酸(PUFA)を含む、請求項1に記載の組成物。
- 前記油が少なくとも1%、5%、10%、20%、30%、40%、50%、60%、70%、80%または90%のPUFAを含む、請求項1に記載の組成物。
- 前記油成分がキセノンまたはアルゴンガスにより飽和している、請求項1に記載の組成物。
- 前記食用油成分が可溶性キセノンガスを含む、請求項1に記載の組成物。
- 前記食用油が実質的に酸素を含まない、請求項1に記載の組成物。
- 前記油がカノーラ油、亜麻仁油、菜種油、大豆油、クルミ油、魚油、ベニバナ油、チア種油、ヒマワリ種油、ゴマ種油、海草油、トウモロコシ油、綿種油、ピーナッツ油、パーム油、アボカド油、ココナツ油、またはオリーブ油を含む、請求項1に記載の組成物。
- 前記油がΩ−3脂肪酸を含む、請求項1に記載の組成物。
- さらに(a)25容積%〜50容積%の油、前記油が希ガスにより飽和している、及び
(b)30容積%〜75容積%の水溶液を含むエマルジョンと定義される、請求項1に記載の組成物。 - さらに(a)15容積%〜75容積%の油、前記油が希ガスにより飽和している、及び
(b)25容積%〜85容積%の水溶液を含むエマルジョンと定義される、請求項1に記載の組成物。 - 前記水溶液が水、果物ジュース、野菜ジュースまたはアルコールを含む、請求項1に記載の組成物。
- さらにリン脂質、洗浄剤、またはタンパク質成分を含む、請求項1に記載の組成物。
- 前記洗浄剤が植物性界面活性剤、合成洗浄剤または胆汁酸である、請求項20に記載の組成物。
- 前記洗浄剤がリトコール酸、デオキシコール酸、タウロコール酸、グリココール酸、ケノデオキシコール酸、またはコール酸である、請求項20に記載の組成物。
- 前記リン脂質が鶏卵ホスホコリン(鶏卵PC)、大豆PC、DPPCまたはDOPCである、請求項20に記載の組成物。
- 前記タンパク質が乳タンパク質、乳清タンパク質、大豆タンパク質分離物、またはウシ血清アルブミンである、請求項20に記載の組成物。
- さらに油1ml当たり約1〜50gのキセノンを含む、請求項1に記載の組成物。
- (a)15容積%〜75容積%のオリーブ油、前記油がキセノンまたはアルゴンガスにより飽和している、(b)25容積%〜85容積%の水溶液、及び1つまたは複数のリン脂質、洗浄剤またはタンパク質を含む、請求項1に記載の組成物。
- (a)25容積%〜50容積%のオリーブ油、前記油がキセノンまたはアルゴンガスにより飽和している、(b)50容積%〜75容積%の水溶液、(c)10〜30mg/mlのホスホコリン、(d)10〜50mg/mlのBSA、及び(e)1〜5mg/mlのリトコール酸を含む、請求項1に記載の組成物。
- (a)15容積%〜75容積%のオリーブ油、前記油がキセノンまたはアルゴンガスにより飽和している、(b)25容積%〜85容積%の水溶液、(c)10〜30mg/mlのホスホコリン、(d)10〜50mg/mlのBSA、及び(e)1〜5mg/mlのリトコール酸を含む、請求項1に記載の組成物。
- さらに薬用植物、ビタミンまたはエネルギー供給栄養補助食品飲料と定義される、請求項1に記載の組成物。
- さらに防腐剤、香味剤、染料、ビタミン、酸化防止剤、または植物抽出物を含む、請求項1に記載の組成物。
- 前記組成物がガス不浸透性の容器に含まれる、請求項1から30のいずれか一項に記載の組成物。
- 前記容器が約1ml〜2リットルの前記組成物を含む、請求項31に記載の組成物。
- 前記容器が約1mg〜20g、1mg〜10g、1mg〜1g、1〜100mg、1〜50mg、1〜25mgまたは1〜10mgのXeを含む、請求項32に記載の組成物。
- 前記容器が全内容物を大気にさらさないで経口消費のための前記組成物を放出するための1回限りの物を含む、請求項31に記載の組成物。
- 前記容器が加圧されている、請求項32に記載の組成物。
- 前記容器が希ガスとともに加圧されている、請求項35に記載の組成物。
- さらにCO2を含む、請求項35に記載の組成物。
- ガス不浸透性の容器に請求項1から30のいずれか一項に記載の組成物を含む1回分の栄養補助食品。
- 前記容器がびんである、請求項38に記載の1回分の飲料。
- 前記容器が1ml〜1.0mlの前記組成物を有する、請求項39に記載の1回分の飲料。
- 前記希ガスがXeを含む、請求項38に記載の1回分の飲料。
- 約1mg〜20g、1mg〜10g、1mg〜1g、1〜100mg、1〜50mg、1〜25mgまたは1〜10mgのXeを有する、請求項41に記載の1回分の飲料。
- 約25〜500mlの実質的に水性成分及び約0.1mg〜20gの溶解した希ガスを含み、水溶性を高めるために前記希ガスの一部が封入されている、1回分の栄養補助食品組成物。
- 溶解した希ガスを含む経口消費のために調剤された液体または半液体組成物を提供することを含む被験者の健康または健康な状態を改善する方法。
- 前記液体組成物が希ガスにより飽和または過飽和している、請求項44に記載の方法。
- 前記希ガスがXeを含む、請求項45に記載の方法。
- 前記液体組成物が請求項1から42のいずれか一項に従った組成物である、請求項44に記載の方法。
- 溶解した希ガスを含む有効量の組成物を経口で投与することを含む被験者に神経または心臓血管の保護を提供する方法。
- 前記被験者がアテローム性動脈硬化症、アルツハイマー病、血栓症脳卒中、出血性脳卒中、心不全または心臓肥大であるか、またはリスクがある、請求項48に記載の方法。
- 前記被験者がヒトである、請求項48に記載の方法。
- 前記希ガスがXeを含む、請求項50に記載の方法。
- 約0.1mg〜20g/日のXeを前記被験者に投与することを含む、請求項51に記載の方法。
- 前記被験者に1日当たり約500mg〜10g、500mg〜5g、500mg〜2g、1〜100mg、1〜50mg、1〜25mgまたは1〜10mgのXe投与することを含む、請求項52に記載の方法。
- 前記組成物が毎週、毎日、1日に2回、1日に3回、6時間ごとに、3時間ごとにまたは1時間ごとに投与される、請求項48に記載の方法。
- 前記組成物が1週間、2週間、1ヵ月または1年の期間にわたって投与される、請求項54に記載の方法。
- さらに神経疾患または神経損傷を治療するまたは予防する方法と定義される、請求項48に記載の方法。
- 前記神経疾患がアルツハイマー病である、請求項56に記載の方法。
- さらに前記被験者のβ−アミロイド濃度を減少させる方法と定義される、請求項57に記載の方法。
- さらに被験者のアルツハイマー病の進行を治療するまたは予防する方法と定義される、請求項57に記載の方法。
- 前記被験者にアルツハイマー病を発症するリスクがある、請求項57に記載の方法。
- 前記被験者にアルツハイマー病の遺伝的素因がある、または前記被験者がその素因があると診断されている、請求項57に記載の方法。
- 前記神経損傷が血栓症または虚血性脳卒中である、請求項56に記載の方法。
- 有効量の希ガスが溶解した組成物を経口で投与することを含む被験者の炎症のマーカーを減少させる方法。
- 前記組成物が水溶性を高めるために封入されている希ガスを含む、請求項48から63のいずれか一項に記載の方法。
- 前記組成物が、(i)溶解した希ガス、水溶性ポリマーとともに封入されている希ガスの一部を含む実質的に水性成分、及び/または(ii)溶解した希ガスを含む油成分を含む、請求項48から63のいずれか一項に記載の方法。
- 前記希ガスがヘリウム、ネオン、アルゴン、クリプトンまたはキセノンである、請求項65に記載の方法。
- 前記希ガスがキセノンである、請求項65に記載の方法。
- 前記組成物が2種以上の希ガスの混合物を含む、請求項65に記載の方法。
- 前記組成物がエマルジョンを含む、請求項65に記載の方法。
- 水溶性ポリマーがシクロデキストリンである、請求項65に記載の方法。
- 前記シクロデキストリンがγ−またはβ−シクロデキストリンである、請求項70に記載の方法。
- 前記シクロデキストリンがβ−シクロデキストリンである、請求項70に記載の方法。
- 前記組成物が約0.1〜約1.0mg/mlのシクロデキストリンを含む、請求項70に記載の方法。
- 前記油が多価不飽和脂肪酸(PUFA)を含む、請求項65に記載の方法。
- 前記油が少なくとも1%、5%、10%、20%、30%、40%、50%、60%、70%、80%または90%のPUFAを含む、請求項65に記載の方法。
- 前記油成分がキセノンまたはアルゴンガスにより飽和している、請求項65に記載の方法。
- 前記食用油成分が可溶性キセノンガスを含む、請求項65に記載の方法。
- 前記食用油が実質的に酸素を含まない、請求項65に記載の方法。
- 前記油がカノーラ油、亜麻仁油、菜種油、大豆油、クルミ油、魚油、ベニバナ油、チア種油、ヒマワリ種油、ゴマ種油、海草油、トウモロコシ油、綿種油、ピーナッツ油、パーム油、アボカド油、ココナツ油、またはオリーブ油を含む、請求項65に記載の方法。
- 前記油がΩ−3脂肪酸、Ω−6脂肪酸またはΩ−9脂肪酸を含む、請求項65に記載の方法。
- さらに(a)25容積%〜50容積%の油、前記油が希ガスにより飽和している、及び(b)30容積%〜75容積%の水溶液を含むエマルジョンと定義される、請求項65に記載の方法。
- さらに(a)15容積%〜75容積%の油、前記油が希ガスにより飽和している、及び(b)25容積%〜85容積%の水溶液を含むエマルジョンと定義される、請求項65に記載の方法。
- 前記水溶液が湧水、果物ジュースまたは野菜ジュースを含む、請求項65に記載の方法。
- さらにリン脂質、洗浄剤、またはタンパク質成分を含む、請求項65に記載の方法。
- 前記洗浄剤が植物性界面活性剤、合成洗浄剤または胆汁酸である、請求項84に記載の方法。
- 前記洗浄剤がリトコール酸、デオキシコール酸、タウロコール酸、グリココール酸、ケノデオキシコール酸、またはコール酸である、請求項84に記載の方法。
- 前記リン脂質が鶏卵ホスホコリン(鶏卵PC)、大豆PC、DPPCまたはDOPCである、請求項84に記載の方法。
- 前記タンパク質が乳タンパク質、乳清タンパク質、大豆タンパク質分離物、またはウシ血清アルブミンである、請求項84に記載の方法。
- さらに油1ml当たり約1〜50gのキセノンを含む、請求項65に記載の方法。
- 前記組成物が(a)15容積%〜75容積%のオリーブ油、前記油がキセノンまたはアルゴンガスにより飽和している、(b)25容積%〜85容積%の水溶液、及び1つまたは複数のリン脂質、洗浄剤またはタンパク質を含む、請求項65に記載の方法。
- 前記組成物が(a)25容積%〜50容積%のオリーブ油、前記油がキセノンまたはアルゴンガスにより飽和している、(b)50容積%〜75容積%の水溶液、(c)10〜30mg/mlのホスホコリン、(d)10〜50mg/mlのBSA、及び(e)1〜5mg/mlのリトコール酸を含む、請求項65に記載の組成物。
- 前記組成物が(a)15容積%〜75容積%のオリーブ油、前記油がキセノンまたはアルゴンガスにより飽和している、(b)25容積%〜85容積%の水溶液、(c)10〜30mg/mlのホスホコリン、(d)10〜50mg/mlのBSA、及び(e)1〜5mg/mlのリトコール酸を含む、請求項65に記載の組成物。
- (a)水溶性封入ポリマーと希ガスをインキュベートすること、及び(b)前記封入希ガスを水溶液に暴露し、約2気圧〜10気圧で、約4℃〜−180℃の温度で、少なくとも4時間、前記希ガスを含む水性組成物を生成し、約2気圧〜10気圧で、約20℃〜1℃の温度で少なくとも4時間、封入希ガス溶液を生成することを含む、希ガスを含む水性組成物を生成する方法。
- 前記インキュベートする工程(a)が約2気圧〜8気圧、2気圧〜5気圧、2気圧〜4気圧または約3気圧で実施される、請求項93に記載の方法。
- 前記インキュベートする工程(a)が約0℃〜−150℃、−20℃〜−150℃、−20℃〜−100℃、−40℃〜−100℃または約−80℃の温度で実施される、請求項93に記載の方法。
- 前記インキュベートする工程(a)が少なくとも8時間、12時間、24時間、48時間または8時間〜3日間である、請求項93に記載の方法。
- 前記暴露する工程(b)が約2気圧〜8気圧、2気圧〜5気圧、2気圧〜4気圧または約3気圧で実施される、請求項93に記載の方法。
- 前記暴露する工程(b)が約15℃〜1℃、10℃〜1℃、8℃〜2℃、6℃〜2℃または約4℃の温度で実施される、請求項93に記載の方法。
- 前記暴露する工程(b)が少なくとも8時間、12時間、24時間、48時間または8時間〜3日間である、請求項93に記載の方法。
- 前記水溶液が溶解した希ガスを含む、請求項93に記載の方法。
- 前記水溶液が希ガスにより飽和している、請求項99に記載の方法。
- (i)ガスが抜かれた水溶液を得ること、及び(ii)約2気圧〜10気圧の気圧で、約20℃〜1℃の温度で、少なくとも4時間ガスが抜かれた水溶液を希ガスに暴露し、希ガスにより飽和された水溶液を生成することを含む方法によって、前記水溶液が希ガスにより飽和している、請求項100に記載の方法。
- 前記希ガスがアルゴンまたはキセノンである、請求項93に記載の方法。
- 前記希ガスがキセノンである、請求項103に記載の方法。
- 前記希ガスが2種以上の希ガスの混合物を含む、請求項93に記載の方法。
- 水溶性封入ポリマーがシクロデキストリンである、請求項93に記載の方法。
- 前記シクロデキストリンがγ−またはβ−シクロデキストリンである、請求項106に記載の方法。
- 前記シクロデキストリンがβ−シクロデキストリンである、請求項106に記載の方法。
- 前記β−シクロデキストリンがヒドロキシプロピル−β−シクロデキストリンである、請求項108に記載の方法。
- さらに薬剤または栄養補助食品組成物を生成する方法と定義される、請求項93に記載の方法。
- 前記水溶液が防腐剤、香味剤、染料、ビタミン、酸化防止剤、または植物抽出物を含む、請求項93に記載の方法。
- さらに前記希ガスを含む前記水性組成物をガス不浸透性の容器に包装する工程(c)を含む、請求項93に記載の方法。
- 前記容器が加圧されている、請求項112に記載の方法。
- 前記容器が希ガスとともに加圧されている、請求項113に記載の方法。
- 前記容器が丸薬、カプセル、金属箔またはポリマーパケットまたはびんである、請求項112に記載の方法。
- 請求項93から115のいずれか一項に従った方法により生成された希ガスを含む水性組成物。
- (a)約2気圧〜6気圧で、約0℃〜25℃の温度で、油及びガスを混合することにより、食用油に希ガスを溶解し、可溶性希ガスを含む食用油を生成することを含む、希ガスの経口投与ための組成物を生成する方法。
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AAPS PHARMSCITECH., 2011年, vol. 12, no. 1, JPN6020050813, pages 279 - 286, ISSN: 0004420004 * |
BR. J. ANAESTH. (2011) VOL.106, NO.3, P.436P, JPN6018048772, ISSN: 0004420006 * |
CHEST (2005) VOL.128, ISSUE , P.3664-3670, JPN6018048770, ISSN: 0004420005 * |
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CN105228591A (zh) | 2016-01-06 |
CN105228591B (zh) | 2019-08-13 |
JP6625966B2 (ja) | 2019-12-25 |
US20160030470A1 (en) | 2016-02-04 |
HK1219875A1 (zh) | 2017-04-21 |
CA3132914C (en) | 2023-11-07 |
AU2019202145A1 (en) | 2019-04-18 |
AU2019202145B2 (en) | 2020-09-24 |
EP2968126A2 (en) | 2016-01-20 |
JP2016519571A (ja) | 2016-07-07 |
CA2905155A1 (en) | 2014-09-18 |
WO2014145443A3 (en) | 2014-12-11 |
US11491184B2 (en) | 2022-11-08 |
US20200215100A1 (en) | 2020-07-09 |
EP2968126B1 (en) | 2022-04-06 |
AU2014233018A1 (en) | 2015-10-01 |
EP4082552A1 (en) | 2022-11-02 |
JP6998929B2 (ja) | 2022-02-04 |
EP2968126A4 (en) | 2016-11-02 |
CN110354067A (zh) | 2019-10-22 |
WO2014145443A2 (en) | 2014-09-18 |
CA3132914A1 (en) | 2014-09-18 |
CA2905155C (en) | 2021-11-16 |
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