JP2020012114A - 有機汚染を安定に自己洗浄するためのポリマー改質酵素を含むコーティング - Google Patents
有機汚染を安定に自己洗浄するためのポリマー改質酵素を含むコーティング Download PDFInfo
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- JP2020012114A JP2020012114A JP2019176084A JP2019176084A JP2020012114A JP 2020012114 A JP2020012114 A JP 2020012114A JP 2019176084 A JP2019176084 A JP 2019176084A JP 2019176084 A JP2019176084 A JP 2019176084A JP 2020012114 A JP2020012114 A JP 2020012114A
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Abstract
Description
ジアミノヘキサン酸、ブタン酸、シクロブチルアラニン、シクロヘキシルアラニン、シクロヘキシルグリシン、N5−アミノカルボニルオルニチン、シクロペンチルアラニン、シクロプロピルアラニン、3−スルホアラニン、2,4-ジアミノブタン酸、ジアミノプロピオン酸、2,4-ジアミノ酪酸、ジフェニルアラニン、N,N-ジメチルグリシン、ジアミノピメル酸、2,3-ジアミノプロパン酸、S−エチルチオシステイン、N−エチルアスパラギン、N−エチルグリシン、4−アザフェニルアラニン、4−フルオロフェニルアラニン、γ−グルタミン酸、γ−カルボキシグルタミン酸、ヒドロキシ酢酸、ピログルタミン酸、ホモアルギニン、ホモシステイン酸、ホモシステイン、ホモヒスチジン、2−ヒドロキシイソ吉草酸、ホモフェニルアラニン、ホモロイシン、ホモプロリン、ホモセリン、2−ヒドロキシペンタノン酸、5−ヒドロキシリシン、4−ヒドロキシプロリン、2−カルボキシオクタヒドロインドール、3−カルボキシイソキノリン、イソバリン、2−ヒドロキシプロパン酸(乳酸)、メルカプト酢酸、メルカプトブタン酸、サルコシン、4−メチル−3−ヒドロキシプロリン、メルカプトプロパン酸、ノルロイシン、ニペコチン酸、ノルチロシン、ノルバリン、ω−アミノ酸、オルニチン、ペニシラミン(3−メルカプトバリン)、2−フェニルグリシン、2−カルボキシピペリジン、サルコシン(N−メチルグリシン)、2−アミノ−3−(4−スルホフェニル)プロピオン酸、1−アミノ−1−カルボキシシクロペンタン、3−チエニルアラニン、ε−N−トリメチルリシン、3−チアゾリルアラニン、4−カルボン酸、α−アミノ-2,4-ジオキシピリミジンプロパン酸、及び2−ナフチルアラニンである。
水安定化活性コーティング材料の製造用の材料
酵素の調製
酵素のPEG化
精製した酵素(1mL、140mg/ml)(α−アミラーゼ、サーモリシン、又はリパーゼ)をスクシンイミジルエステルにより誘導化されたPEG(単官能性直鎖PEG10000、PEG12000、PEG20000、又は8アーム分枝PEG(NANOCS Inc.(New York, NY)より購入したPEG N−ヒドロキシスクシンイミドエステル)と1:5の酵素:PEGのモル比で混合する。8アーム分枝PEGはくし型の構造を有し、10,000ダルトンの分子量を有する。各分枝は〜1,200ダルトンの分子量を有する。この8アーム分枝PEGの構造は以下のような構造である。
未改質(所望により蛍光ラベルした)又はPEG改質(所望により蛍光ラベルした)α−アミラーゼ、サーモリシン、リパーゼ、又は酵素の組み合わせを、例3に記載のように溶液(600μL、140mg/ml)中で調製し、IKA RW 11 Lab-egg撹拌器により1分間激しく撹拌しながら、500μLのn−ブチルアセテート及び100μLの界面活性剤(ブチルアセテート中17%v/v)と共に2.1gのDesmodur A870に混合する。得られた白っぽいエマルジョンを0.8gのDesmophen N3600に加え、再び1分間激しく撹拌する。
例4に示すようにして形成したコートしたアルミニウムパネルを1.2cm×1.9cmのテストサイズに切り、室温においてDI水に30分撹拌しながら浸すことにより耐候試験を行う。テストパネルを取り出し、DI流水で20秒洗浄し、次いで残っている酵素活性を調べる。浸漬を2〜10回繰返し、残っている酵素活性を調べる。
有機汚染の調製、コートされた基材への適用及びコーティング調剤液の自己洗浄活性
この調製にあたって、60gの凍結乾燥したコオロギをブレンダー(Oster、600ワット)により10分間粉砕することによって粉末にする。2gのコオロギ粉末を6mLのDI水と激しく混合することにより汚染溶液を調製する。均一な間隔のテンプレートを用いてコーティング表面上に汚染を適用する。このコオロギの汚染を40℃で5分間乾燥させる。各テストパネルをガラス皿に載せ、RTにおいて300rpmで振盪させながら200mLのDI水で数回洗浄する。汚染除去の時間を記録する。誤差を小さくするため、最初と最後の時間を含めない。8つの汚染スポットの平均洗浄時間を汚染除去時間として平均する。PEG化サーモリシン含有コーティングでコートしたテストパネルは、ベース材料のみでコートしたパネルと比較して、穏やかな洗浄による改良された汚染除去を示す。
Harris, J. M. and Kozlowski, A. (2001), Improvement in protein PEGylation: peglated interferons for treatment of hepatitis C.J.Control Release 72, 217-224
[1]
ベース、
前記ベースと結合した酵素、及び
前記ベースと結合した第一のポリオキシエチレン
を含み、前記第一のポリオキシエチレンが前記酵素とは独立であり、前記ベース、前記酵素、及び前記第一のポリオキシエチレンが水安定化活性コーティング組成物を形成する、水安定化活性コーティング組成物。
[2]
前記酵素が1種以上のポリマー部分と結合して化学改質された酵素を形成する、項目1記載の組成物。
[3]
前記酵素が加水分解酵素である、項目1記載の組成物。
[4]
前記加水分解酵素が細菌中性サーモリシン様プロテアーゼ、アミラーゼ、又はリパーゼである、項目3記載の組成物。
[5]
前記ポリマー部分が第二のポリオキシエチレンの少なくとも1つの分子である、項目2記載の組成物。
[6]
前記第一のポリオキシエチレンが1,000〜15,000ダルトンの分子量を有する、項目1記載の組成物。
[7]
前記第一のポリオキシエチレン及び第二のポリオキシエチレンがオキシエチレンの同じポリマーを有する、項目5記載の組成物。
[8]
前記第二のポリオキシエチレンが介在するウレタン結合により前記酵素に共有結合している、項目5記載の組成物。
[9]
前記第二のポリオキシエチレンが分枝分子である、項目5記載の組成物。
[10]
前記分枝分子が8アームポリオキシエチレンである、項目5記載の組成物。
[11]
ベース、及び
前記ベース内に分散した化学改質された酵素
を含む水安定化活性コーティング組成物であって、前記酵素が第一のポリオキシエチレンの1以上の分子により化学的に改質されている、水安定化活性コーティング組成物。
[12]
前記酵素が、1nm〜5μmの平均粒子直径を有するタンパク粒子で前記ベースに分散している、項目11記載のコーティング組成物。
[13]
前記ベースがポリウレタンである、項目11記載のコーティング組成物。
[14]
前記第一のポリオキシエチレンが1,000〜15,000ダルトンの分子量を有する、項目1記載のコーティング組成物。
[15]
前記第一のポリオキシエチレンが分枝分子である、項目11記載のコーティング組成物。
[16]
前記第一のポリオキシエチレンが8アームポリオキシエチレンである、項目15記載のコーティング組成物。
[17]
コーティング組成物中において水風化に対する酵素の活性を安定化する方法であって、
酵素を1以上のポリマー部分と結合させて化学改質酵素を形成すること、及び
この化学改質酵素をベース中に分散させて水安定化活性コーティング材料を形成すること
を含む方法。
[18]
前記分散により、1nm〜5μmの平均粒子直径を有するタンパク粒子を与える、項目17記載の方法。
[19]
基材を前記活性コーティング材料でコートして、前記酵素が前記活性コーティング材料と接触した有機汚染の成分を酵素的に分解できるようにすることをさらに含む、項目17記載の方法。
[20]
前記酵素が加水分解酵素である、項目19記載の方法。
[21]
前記ポリマー部分がポリオキシエチレンの少なくとも1つの分子を含む、項目17記載の方法。
[22]
前記ポリオキシエチレンが1,000〜15,000ダルトンの分子量を有する、項目21記載の方法。
[23]
前記ポリマー部分が分枝ポリオキシエチレンである、項目17記載の方法。
[24]
前記ポリマー部分が8アームポリオキシエチレンである、項目17記載の方法。
[25]
前記酵素がアミラーゼであり、前記コーティングの表面活性が0.01ユニット/cm 2 以上である、項目19記載の方法。
Claims (25)
- ベース、
前記ベースと結合した酵素、及び
前記ベースと結合した第一のポリオキシエチレン
を含み、前記第一のポリオキシエチレンが前記酵素とは独立であり、前記ベース、前記酵素、及び前記第一のポリオキシエチレンが水安定化活性コーティング組成物を形成する、水安定化活性コーティング組成物。 - 前記酵素が1種以上のポリマー部分と結合して化学改質された酵素を形成する、請求項1記載の組成物。
- 前記酵素が加水分解酵素である、請求項1記載の組成物。
- 前記加水分解酵素が細菌中性サーモリシン様プロテアーゼ、アミラーゼ、リパーゼ、又はこれらの組合せである、請求項3記載の組成物。
- 前記ポリマー部分が第二のポリオキシエチレンの少なくとも1つの分子である、請求項2記載の組成物。
- 前記第一のポリオキシエチレンが1,000〜15,000ダルトンの分子量を有する、請求項1記載の組成物。
- 前記第一のポリオキシエチレン及び第二のポリオキシエチレンがオキシエチレンの同じポリマーを有する、請求項5記載の組成物。
- 前記第二のポリオキシエチレンが介在するウレタン結合により前記酵素に共有結合している、請求項5記載の組成物。
- 前記第二のポリオキシエチレンが分枝分子である、請求項5記載の組成物。
- 前記分枝分子が8アームポリオキシエチレンである、請求項5記載の組成物。
- ベース、及び
前記ベース内に分散した化学改質された酵素
を含む水安定化活性コーティング組成物であって、前記酵素が第一のポリオキシエチレンの1以上の分子により化学的に改質されている、水安定化活性コーティング組成物。 - 前記酵素が、1nm〜5μmの平均粒子直径を有するタンパク粒子で前記ベースに分散している、請求項11記載のコーティング組成物。
- 前記ベースがポリウレタンである、請求項11記載のコーティング組成物。
- 前記第一のポリオキシエチレンが1,000〜15,000ダルトンの分子量を有する、請求項1記載のコーティング組成物。
- 前記第一のポリオキシエチレンが分枝分子である、請求項11記載のコーティング組成物。
- 前記第一のポリオキシエチレンが8アームポリオキシエチレンである、請求項15記載のコーティング組成物。
- コーティング組成物中において水風化に対する酵素の活性を安定化する方法であって、
酵素を1以上のポリマー部分と結合させて化学改質酵素を形成すること、及び
この化学改質酵素をベース中に分散させて水安定化活性コーティング材料を形成すること
を含む方法。 - 前記分散により、1nm〜5μmの平均粒子直径を有するタンパク粒子を与える、請求項17記載の方法。
- 基材を前記活性コーティング材料でコートして、前記酵素が前記活性コーティング材料と接触した有機汚染の成分を酵素的に分解できるようにすることをさらに含む、請求項17記載の方法。
- 前記酵素が加水分解酵素である、請求項19記載の方法。
- 前記ポリマー部分がポリオキシエチレンの少なくとも1つの分子を含む、請求項17記載の方法。
- 前記ポリオキシエチレンが1,000〜15,000ダルトンの分子量を有する、請求項21記載の方法。
- 前記ポリマー部分が分枝ポリオキシエチレンである、請求項17記載の方法。
- 前記ポリマー部分が8アームポリオキシエチレンである、請求項17記載の方法。
- 前記酵素がアミラーゼであり、前記コーティングの表面活性が0.01ユニット/cm2以上である、請求項19記載の方法。
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US11535773B2 (en) | 2022-12-27 |
JP7066143B2 (ja) | 2022-05-13 |
US20200109311A1 (en) | 2020-04-09 |
JP2021101028A (ja) | 2021-07-08 |
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US20190144710A1 (en) | 2019-05-16 |
US20190144709A1 (en) | 2019-05-16 |
US20230212426A1 (en) | 2023-07-06 |
US20230340296A1 (en) | 2023-10-26 |
JP2013060592A (ja) | 2013-04-04 |
US20130065291A1 (en) | 2013-03-14 |
US20160024349A1 (en) | 2016-01-28 |
US11566149B2 (en) | 2023-01-31 |
JP6867656B2 (ja) | 2021-05-12 |
JP6113977B2 (ja) | 2017-04-12 |
JP2018150559A (ja) | 2018-09-27 |
US11542410B2 (en) | 2023-01-03 |
US10563094B2 (en) | 2020-02-18 |
US20200308443A1 (en) | 2020-10-01 |
JP2017106039A (ja) | 2017-06-15 |
US20190144711A1 (en) | 2019-05-16 |
JP6353106B2 (ja) | 2018-07-04 |
JP6867656B6 (ja) | 2021-06-30 |
JP6600049B2 (ja) | 2019-10-30 |
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