JP2019535688A5 - - Google Patents
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- Publication number
- JP2019535688A5 JP2019535688A5 JP2019522794A JP2019522794A JP2019535688A5 JP 2019535688 A5 JP2019535688 A5 JP 2019535688A5 JP 2019522794 A JP2019522794 A JP 2019522794A JP 2019522794 A JP2019522794 A JP 2019522794A JP 2019535688 A5 JP2019535688 A5 JP 2019535688A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- alkyl
- optionally substituted
- compound
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 16
- 125000003545 alkoxy group Chemical group 0.000 claims description 5
- -1 amino, hydroxyl Chemical group 0.000 claims description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims 25
- 206010019860 Hereditary angioedema Diseases 0.000 claims 5
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- PCJFEVUKVKQSSL-UHFFFAOYSA-N 2h-1,2,4-oxadiazol-5-one Chemical group O=C1N=CNO1 PCJFEVUKVKQSSL-UHFFFAOYSA-N 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 1
- 102000001399 Kallikrein Human genes 0.000 claims 1
- 108060005987 Kallikrein Proteins 0.000 claims 1
- 239000004721 Polyphenylene oxide Chemical group 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 208000005707 acquired angioedema Diseases 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 230000023555 blood coagulation Effects 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical compound [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 229920000570 polyether Chemical group 0.000 claims 1
- 0 C*c1nc(C(NCC2CC2)=O)ccc1-c(cc(c(C=C)c1)OC)c1C(Nc(cc1)ccc1C(N*)=N*)=O Chemical compound C*c1nc(C(NCC2CC2)=O)ccc1-c(cc(c(C=C)c1)OC)c1C(Nc(cc1)ccc1C(N*)=N*)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662415202P | 2016-10-31 | 2016-10-31 | |
| US62/415,202 | 2016-10-31 | ||
| PCT/US2017/058685 WO2018081513A1 (en) | 2016-10-31 | 2017-10-27 | Prodrugs of kallikrein inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019535688A JP2019535688A (ja) | 2019-12-12 |
| JP2019535688A5 true JP2019535688A5 (https=) | 2020-12-03 |
| JP7128181B2 JP7128181B2 (ja) | 2022-08-30 |
Family
ID=62025466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019522794A Active JP7128181B2 (ja) | 2016-10-31 | 2017-10-27 | カリクレイン阻害剤のプロドラッグ |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10759759B2 (https=) |
| EP (1) | EP3532057B1 (https=) |
| JP (1) | JP7128181B2 (https=) |
| AU (1) | AU2017348305B2 (https=) |
| CA (1) | CA3041058A1 (https=) |
| DK (1) | DK3532057T3 (https=) |
| ES (1) | ES2942285T3 (https=) |
| IL (1) | IL266223B2 (https=) |
| MA (1) | MA46642A (https=) |
| WO (1) | WO2018081513A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017348305B2 (en) | 2016-10-31 | 2022-04-21 | Biocryst Pharmaceuticals, Inc. | Prodrugs of kallikrein inhibitors |
| JP7668227B2 (ja) | 2019-04-08 | 2025-04-24 | バイオクライスト ファーマシューティカルズ， インコーポレイテッド | 血漿カリクレイン阻害剤および眼障害におけるその使用方法 |
| AU2021288365B2 (en) * | 2020-06-12 | 2023-07-06 | Apical Molecular Biotech. Co., Ltd. | Novel analogs of pterostilbene amino acid bearing carbonates for treating a non-alcoholic fatty liver disease and nonalcoholic steatohepatitis |
| CN111646936A (zh) * | 2020-06-22 | 2020-09-11 | 江苏亚虹医药科技有限公司 | 芳香醚类化合物的制备方法 |
| CN114933584B (zh) * | 2021-08-09 | 2022-12-27 | 上海贵之言医药科技有限公司 | 一种二氢-2h-异吲哚酯类化合物 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
| LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
| LU86084A1 (fr) | 1985-09-20 | 1987-04-02 | Faco Sa | Apparei de massage electrique |
| US5102417A (en) | 1985-11-07 | 1992-04-07 | Expandable Grafts Partnership | Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft |
| US4800882A (en) | 1987-03-13 | 1989-01-31 | Cook Incorporated | Endovascular stent and delivery system |
| US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
| US4886062A (en) | 1987-10-19 | 1989-12-12 | Medtronic, Inc. | Intravascular radially expandable stent and method of implant |
| US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| WO1990013332A1 (en) | 1989-05-11 | 1990-11-15 | Cedars-Sinai Medical Center | Stent with sustained drug delivery |
| CA2049973C (en) | 1990-02-28 | 2002-12-24 | Rodney G. Wolff | Intralumenal drug eluting prosthesis |
| US5429634A (en) | 1993-09-09 | 1995-07-04 | Pdt Systems | Biogenic implant for drug delivery and method |
| US5419760A (en) | 1993-01-08 | 1995-05-30 | Pdt Systems, Inc. | Medicament dispensing stent for prevention of restenosis of a blood vessel |
| US6774278B1 (en) | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
| MXPA03009130A (es) * | 2000-10-20 | 2004-02-26 | Biocryst Pharm Inc | Compuestos de biarilo que funcionan como inhibidores de proteasa serina. |
| RU2003132706A (ru) | 2001-04-06 | 2005-04-20 | Байокрист Фармасьютикалз, Инк. (Us) | Диариловые соединения в качестве ингибиторов сериновых протеаз |
| WO2004002985A1 (en) | 2002-06-27 | 2004-01-08 | Lg Life Sciences Ltd. | Peptidic thrombin inhibitor compound |
| US6770729B2 (en) | 2002-09-30 | 2004-08-03 | Medtronic Minimed, Inc. | Polymer compositions containing bioactive agents and methods for their use |
| GB0301938D0 (en) | 2003-01-28 | 2003-02-26 | Biochemie Gmbh | Organic compounds |
| DK2070536T3 (da) | 2006-10-06 | 2012-04-10 | Toyama Chemical Co Ltd | Farmaceutisk sammensætning med et phenylamidin-derivat og fremgangsmåde til anvendelse af den farmaceutiske sammensætning i kombination med et antifungalt middel |
| KR20100026641A (ko) | 2008-09-01 | 2010-03-10 | 동아제약주식회사 | 신규한 벤즈아미드 유도체 화합물 및 그의 제조방법 |
| WO2012137225A1 (en) | 2011-04-08 | 2012-10-11 | Sphaera Pharma Pvt. Ltd | Substituted methylformyl reagents and method of using same to modify physicochemical and/or pharmacokinetic properties of compounds |
| ES2883259T3 (es) | 2011-07-28 | 2021-12-07 | Kempharm Inc | Profármacos de metilfenidato, procesos para la obtención y uso de los mismos |
| TWI601725B (zh) | 2012-08-27 | 2017-10-11 | 加拓科學公司 | 取代的氮雜吲哚化合物及其鹽、組合物和用途 |
| US9868690B2 (en) | 2012-12-21 | 2018-01-16 | Ratiopharm Gmbh | Prodrugs of monomethyl fumarate (MMF) |
| EP3046924A1 (en) | 2013-09-20 | 2016-07-27 | IDENIX Pharmaceuticals, Inc. | Hepatitis c virus inhibitors |
| RU2733405C2 (ru) | 2014-02-07 | 2020-10-01 | Экзитера Фармасьютикалз Инк. | Терапевтические соединения и композиции |
| US10905683B2 (en) | 2014-08-22 | 2021-02-02 | Biocryst Pharmaceuticals, Inc. | Compositions and uses of amidine derivatives |
| WO2016029216A2 (en) * | 2014-08-22 | 2016-02-25 | Biocryst Pharmaceuticals, Inc. | Method for producing amidine derivatives |
| AU2017348305B2 (en) | 2016-10-31 | 2022-04-21 | Biocryst Pharmaceuticals, Inc. | Prodrugs of kallikrein inhibitors |
-
2017
- 2017-10-27 AU AU2017348305A patent/AU2017348305B2/en active Active
- 2017-10-27 ES ES17864949T patent/ES2942285T3/es active Active
- 2017-10-27 CA CA3041058A patent/CA3041058A1/en active Pending
- 2017-10-27 IL IL266223A patent/IL266223B2/en unknown
- 2017-10-27 JP JP2019522794A patent/JP7128181B2/ja active Active
- 2017-10-27 MA MA046642A patent/MA46642A/fr unknown
- 2017-10-27 US US16/345,503 patent/US10759759B2/en active Active
- 2017-10-27 WO PCT/US2017/058685 patent/WO2018081513A1/en not_active Ceased
- 2017-10-27 DK DK17864949.7T patent/DK3532057T3/da active
- 2017-10-27 EP EP17864949.7A patent/EP3532057B1/en active Active
-
2020
- 2020-08-07 US US16/987,721 patent/US11618731B2/en active Active
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