JP2019518022A5 - - Google Patents
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- Publication number
- JP2019518022A5 JP2019518022A5 JP2018562567A JP2018562567A JP2019518022A5 JP 2019518022 A5 JP2019518022 A5 JP 2019518022A5 JP 2018562567 A JP2018562567 A JP 2018562567A JP 2018562567 A JP2018562567 A JP 2018562567A JP 2019518022 A5 JP2019518022 A5 JP 2019518022A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- intrahepatic cholestasis
- ceradelpar
- amount
- day
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 10
- 229940079593 drugs Drugs 0.000 claims 9
- 208000001024 Intrahepatic Cholestasis Diseases 0.000 claims 6
- 230000000875 corresponding Effects 0.000 claims 6
- SBZKOWAPPRXYGA-XRIGFGBMSA-N (2S)-2,6-diaminohexanoic acid;dihydrate Chemical compound O.O.NCCCC[C@H](N)C(O)=O SBZKOWAPPRXYGA-XRIGFGBMSA-N 0.000 claims 2
- 201000011374 Alagille syndrome Diseases 0.000 claims 2
- 208000003167 Cholangitis Diseases 0.000 claims 2
- 206010008609 Cholangitis sclerosing Diseases 0.000 claims 2
- 102000006832 Jagged-1 Protein Human genes 0.000 claims 2
- 108010047319 Jagged-1 Protein Proteins 0.000 claims 2
- 150000008545 L-lysines Chemical class 0.000 claims 2
- 201000000742 primary sclerosing cholangitis Diseases 0.000 claims 2
- 208000004624 progressive familial intrahepatic 1 Cholestasis Diseases 0.000 claims 2
- 201000002150 progressive familial intrahepatic cholestasis Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- JWHYSEDOYMYMNM-QGZVFWFLSA-N 2-[4-[(2R)-2-ethoxy-3-[4-(trifluoromethyl)phenoxy]propyl]sulfanyl-2-methylphenoxy]acetic acid Chemical compound C([C@@H](OCC)CSC=1C=C(C)C(OCC(O)=O)=CC=1)OC1=CC=C(C(F)(F)F)C=C1 JWHYSEDOYMYMNM-QGZVFWFLSA-N 0.000 claims 1
- 210000000941 Bile Anatomy 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 229950009639 seladelpar Drugs 0.000 claims 1
Claims (18)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662343688P | 2016-05-31 | 2016-05-31 | |
| US62/343,688 | 2016-05-31 | ||
| PCT/US2017/029620 WO2017209865A1 (en) | 2016-05-31 | 2017-04-26 | Treatment of intrahepatic cholestatic diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019518022A JP2019518022A (en) | 2019-06-27 |
| JP2019518022A5 true JP2019518022A5 (en) | 2020-05-21 |
| JP7079735B2 JP7079735B2 (en) | 2022-06-02 |
Family
ID=58699276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018562567A Active JP7079735B2 (en) | 2016-05-31 | 2017-04-26 | Treatment of intrahepatic cholestasis disease |
Country Status (25)
| Country | Link |
|---|---|
| US (5) | US10272058B2 (en) |
| EP (1) | EP3463328B1 (en) |
| JP (1) | JP7079735B2 (en) |
| KR (1) | KR102408288B1 (en) |
| CN (1) | CN109195594A (en) |
| AU (1) | AU2017274293B2 (en) |
| BR (1) | BR112018074147A2 (en) |
| CA (1) | CA3024155C (en) |
| DK (1) | DK3463328T3 (en) |
| ES (1) | ES2921230T3 (en) |
| HR (1) | HRP20220903T1 (en) |
| HU (1) | HUE059838T2 (en) |
| IL (1) | IL263372B2 (en) |
| LT (1) | LT3463328T (en) |
| MX (1) | MX2018014915A (en) |
| NZ (1) | NZ748721A (en) |
| PL (1) | PL3463328T3 (en) |
| PT (1) | PT3463328T (en) |
| RS (1) | RS63345B1 (en) |
| RU (1) | RU2765460C2 (en) |
| SG (1) | SG11201810123SA (en) |
| SI (1) | SI3463328T1 (en) |
| UA (1) | UA122719C2 (en) |
| WO (1) | WO2017209865A1 (en) |
| ZA (1) | ZA201808360B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3119384B1 (en) | 2014-03-20 | 2018-09-12 | CymaBay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
| US10272058B2 (en) | 2014-03-20 | 2019-04-30 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
| US10512622B2 (en) | 2017-07-14 | 2019-12-24 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
| AU2019378845A1 (en) * | 2018-11-16 | 2021-06-03 | Cymabay Therapeutics, Inc. | Combination treatment of NAFLD and NASH |
| RS65546B1 (en) * | 2021-02-01 | 2024-06-28 | Cymabay Therapeutics Inc | Treatment of cholangiopathies with seladelpar |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7101993B1 (en) | 1990-01-11 | 2006-09-05 | Isis Pharmaceuticals, Inc. | Oligonucleotides containing 2′-O-modified purines |
| US7015315B1 (en) | 1991-12-24 | 2006-03-21 | Isis Pharmaceuticals, Inc. | Gapped oligonucleotides |
| US5739135A (en) | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| US6166197A (en) | 1995-03-06 | 2000-12-26 | Isis Pharmaceuticals, Inc. | Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions |
| DE69636160D1 (en) | 1995-03-06 | 2006-06-29 | Isis Pharmaceuticals Inc | PROCESS FOR SYNTHESIS OF 2'-O-SUBSTITUTED PYRIMIDINES AND OLIGOMERS THEREOF |
| TR199801581T2 (en) | 1996-02-14 | 1998-10-21 | Isis Pharmaceuticals, Inc. | �ekerle de�i�tirilmi� bo�luklu oligon�kleotid’ler. |
| US5883109A (en) | 1996-07-24 | 1999-03-16 | Bristol-Myers Squibb Company | Method for lowering serum lipid levels employing an MTP inhibitor in combination with another cholesterol lowering drug |
| US6066653A (en) | 1997-01-17 | 2000-05-23 | Bristol-Myers Squibb Co. | Method of treating acid lipase deficiency diseases with an MTP inhibitor and cholesterol lowering drugs |
| US7407943B2 (en) | 2001-08-01 | 2008-08-05 | Isis Pharmaceuticals, Inc. | Antisense modulation of apolipoprotein B expression |
| US7511131B2 (en) | 2002-11-13 | 2009-03-31 | Genzyme Corporation | Antisense modulation of apolipoprotein B expression |
| US7981915B2 (en) | 2003-04-30 | 2011-07-19 | Beth Israel Deaconess Medical Center | Methods for modulating PPAR biological activity for the treatment of diseases caused by mutations in the CFTR gene |
| WO2005042478A2 (en) | 2003-09-19 | 2005-05-12 | Janssen Pharmaceutica, N.V. | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| US7932268B2 (en) | 2004-03-05 | 2011-04-26 | The Trustees Of The University Of Pennsylvania | Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side effects |
| JO3006B1 (en) | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | Novel Lysine Salts of 4-((Phenoxy Alkyl)Thio)-Phenoxy Acetic Acid Derivatives |
| ES2712052T3 (en) | 2008-10-17 | 2019-05-09 | Cymabay Therapeutics Inc | Methods to reduce small and dense LDL particles |
| KR101357438B1 (en) * | 2009-04-29 | 2014-02-06 | 아마린 코포레이션 피엘씨 | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
| CN102834099B (en) | 2010-03-30 | 2015-05-27 | 诺华有限公司 | Uses of DGAT1 inhibitors |
| JOP20200043A1 (en) | 2011-05-10 | 2017-06-16 | Amgen Inc | Methods of treating or preventing cholesterol related disorders |
| US20150139987A1 (en) | 2013-11-20 | 2015-05-21 | Cymabay Therapeutics, Inc. | Treatment of homozygous familial hypercholesterolemia |
| US20160279085A1 (en) | 2013-11-20 | 2016-09-29 | Cymabay Therapeutics, Inc. | Treatment of Severe Hyperlipidemia |
| US10272058B2 (en) | 2014-03-20 | 2019-04-30 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
| EP3119384B1 (en) | 2014-03-20 | 2018-09-12 | CymaBay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
| PT3129018T (en) | 2014-04-11 | 2020-01-15 | Cymabay Therapeutics Inc | Treatment of nafld and nash |
| EA201790091A1 (en) | 2014-06-26 | 2017-07-31 | Саймабэй Терапьютикс, Инк. | TREATMENT OF HEAVY HYPERTRIGLICERIDEMIA |
| US10512622B2 (en) | 2017-07-14 | 2019-12-24 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
| JP7023371B2 (en) | 2017-09-26 | 2022-02-21 | サイマベイ・セラピューティクス・インコーポレイテッド | Treatment of cholestasis pruritus |
| AU2019378845A1 (en) | 2018-11-16 | 2021-06-03 | Cymabay Therapeutics, Inc. | Combination treatment of NAFLD and NASH |
| MX2021005725A (en) | 2018-11-16 | 2021-07-21 | Cymabay Therapeutics Inc | Treatment of obesity and its complications. |
-
2017
- 2017-04-25 US US15/496,875 patent/US10272058B2/en active Active
- 2017-04-26 NZ NZ748721A patent/NZ748721A/en unknown
- 2017-04-26 SG SG11201810123SA patent/SG11201810123SA/en unknown
- 2017-04-26 BR BR112018074147-7A patent/BR112018074147A2/en not_active Application Discontinuation
- 2017-04-26 RS RS20220620A patent/RS63345B1/en unknown
- 2017-04-26 DK DK17722943.2T patent/DK3463328T3/en active
- 2017-04-26 EP EP17722943.2A patent/EP3463328B1/en active Active
- 2017-04-26 KR KR1020187037704A patent/KR102408288B1/en active IP Right Grant
- 2017-04-26 CN CN201780033512.XA patent/CN109195594A/en active Pending
- 2017-04-26 ES ES17722943T patent/ES2921230T3/en active Active
- 2017-04-26 SI SI201731175T patent/SI3463328T1/en unknown
- 2017-04-26 AU AU2017274293A patent/AU2017274293B2/en active Active
- 2017-04-26 HR HRP20220903TT patent/HRP20220903T1/en unknown
- 2017-04-26 CA CA3024155A patent/CA3024155C/en active Active
- 2017-04-26 WO PCT/US2017/029620 patent/WO2017209865A1/en unknown
- 2017-04-26 RU RU2018146504A patent/RU2765460C2/en active
- 2017-04-26 UA UAA201811776A patent/UA122719C2/en unknown
- 2017-04-26 HU HUE17722943A patent/HUE059838T2/en unknown
- 2017-04-26 PL PL17722943.2T patent/PL3463328T3/en unknown
- 2017-04-26 MX MX2018014915A patent/MX2018014915A/en unknown
- 2017-04-26 JP JP2018562567A patent/JP7079735B2/en active Active
- 2017-04-26 PT PT177229432T patent/PT3463328T/en unknown
- 2017-04-26 LT LTEPPCT/US2017/029620T patent/LT3463328T/en unknown
-
2018
- 2018-11-29 IL IL263372A patent/IL263372B2/en unknown
- 2018-12-11 ZA ZA2018/08360A patent/ZA201808360B/en unknown
-
2019
- 2019-03-28 US US16/367,660 patent/US10478411B2/en active Active
- 2019-10-09 US US16/597,313 patent/US10813895B2/en active Active
-
2020
- 2020-09-18 US US17/024,971 patent/US11000494B2/en active Active
-
2021
- 2021-04-03 US US17/221,784 patent/US11596614B2/en active Active
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