JP2019504087A5 - - Google Patents
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- Publication number
- JP2019504087A5 JP2019504087A5 JP2018540115A JP2018540115A JP2019504087A5 JP 2019504087 A5 JP2019504087 A5 JP 2019504087A5 JP 2018540115 A JP2018540115 A JP 2018540115A JP 2018540115 A JP2018540115 A JP 2018540115A JP 2019504087 A5 JP2019504087 A5 JP 2019504087A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- syndrome
- disease
- autoimmune
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662291453P | 2016-02-04 | 2016-02-04 | |
| US62/291,453 | 2016-02-04 | ||
| PCT/US2017/016516 WO2017136731A1 (en) | 2016-02-04 | 2017-02-03 | Rapaglutins, novel inhibitors of glut and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019504087A JP2019504087A (ja) | 2019-02-14 |
| JP2019504087A5 true JP2019504087A5 (https=) | 2020-02-13 |
| JP7104627B2 JP7104627B2 (ja) | 2022-07-21 |
Family
ID=59500972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018540115A Active JP7104627B2 (ja) | 2016-02-04 | 2017-02-03 | ラパグルチン（ｒａｐａｇｌｕｔｉｎｓ）、ｇｌｕｔの新規阻害剤及びその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11708391B2 (https=) |
| EP (1) | EP3411046B1 (https=) |
| JP (1) | JP7104627B2 (https=) |
| CN (1) | CN108697729B (https=) |
| AU (1) | AU2017213630B2 (https=) |
| CA (1) | CA3013783A1 (https=) |
| MX (1) | MX2018009408A (https=) |
| WO (1) | WO2017136731A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10774110B2 (en) * | 2016-02-04 | 2020-09-15 | The Johns Hopkins University | Rapadocins, inhibitors of equilibrative nucleoside transporter 1 and uses thereof |
| CA3013783A1 (en) | 2016-02-04 | 2017-08-10 | The Johns Hopkins University | Rapaglutins, novel inhibitors of glut and use thereof |
| US11066416B2 (en) | 2016-02-04 | 2021-07-20 | The Johns Hopkins University | Rapafucin derivative compounds and methods of use thereof |
| WO2021067405A1 (en) * | 2019-10-01 | 2021-04-08 | The Johns Hopkins University | Neuroprotective compounds and methods of use thereof |
| TW202126323A (zh) | 2019-10-01 | 2021-07-16 | 約翰斯赫普金斯大學 | 雷帕弗辛（Ｒａｐａｆｕｃｉｎ）衍生化合物及其使用方法 |
| CN112294792B (zh) * | 2020-09-22 | 2021-10-22 | 厦门市中医院 | 化合物wzb117在制备治疗和/或预防肝损伤药物中的用途 |
| CN115364224B (zh) * | 2022-08-25 | 2024-02-02 | 杭州天玑济世生物科技有限公司 | Glut1抑制剂作为线粒体自噬诱导剂的用途 |
| CN120271673A (zh) * | 2024-01-08 | 2025-07-08 | 重庆医科大学 | 一种化合物、包含其的药物组合物及其用途 |
| CN120617307B (zh) * | 2025-06-16 | 2025-12-09 | 烟台大学 | 一种wzb117纳米制剂及其制备方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5100899A (en) | 1989-06-06 | 1992-03-31 | Roy Calne | Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof |
| US5457194A (en) | 1993-03-17 | 1995-10-10 | Abbott Laboratories | Substituted aliphatic amine-containing macrocyclic immunomodulators |
| US5798355A (en) | 1995-06-07 | 1998-08-25 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity |
| US5527907A (en) | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
| US5696135A (en) | 1995-06-07 | 1997-12-09 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth |
| US7056935B2 (en) | 1995-06-07 | 2006-06-06 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
| US6984635B1 (en) | 1998-02-13 | 2006-01-10 | Board Of Trustees Of The Leland Stanford Jr. University | Dimerizing agents, their production and use |
| EP1352910A1 (en) | 2002-04-10 | 2003-10-15 | Grünenthal GmbH | New analogs of nitrobenzylthioinosine |
| CN1788006A (zh) | 2003-04-18 | 2006-06-14 | 安南塔制药公司 | 喹喔啉基大环丙型肝炎丝氨酸蛋白酶抑制剂 |
| US20060003362A1 (en) | 2004-06-04 | 2006-01-05 | Xenoport, Inc. | ENT1 transporters expressed in cancer cells |
| GB0417852D0 (en) | 2004-08-11 | 2004-09-15 | Biotica Tech Ltd | Production of polyketides and other natural products |
| EP2368868A1 (en) | 2005-10-28 | 2011-09-28 | Praecis Pharmaceuticals Inc. | Methods for identifying compounds of interest using encoded libraries |
| US20080306098A1 (en) | 2006-11-06 | 2008-12-11 | Mutz Mitchell W | Pharmacokinetics of protease inhibitors and other drugs |
| WO2008109163A1 (en) * | 2007-03-07 | 2008-09-12 | Abraxis Bioscience, Llc. | Nanoparticle comprising rapamycin and albumin as anticancer agent |
| EP3486653A1 (en) | 2007-05-24 | 2019-05-22 | The United States Government as represented by The Department of Veterans Affairs | Treatment of skeletal muscle disorder using ent2 |
| WO2010004304A1 (en) | 2008-06-17 | 2010-01-14 | Biotica Technology Limited | Novel compounds and methods for their production |
| EP2646440A4 (en) | 2010-11-30 | 2014-06-18 | Univ Johns Hopkins | CYCLIC HYBRID LIBRARIES AND SCREENS FOR THIS |
| WO2012106702A2 (en) * | 2011-02-04 | 2012-08-09 | The General Hospital Corporation | Treatment of leukemia |
| EP2607352A1 (en) | 2011-12-22 | 2013-06-26 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Pipecolate-diketoamides for treatment of psychiatric disorders |
| KR101733736B1 (ko) | 2012-01-06 | 2017-05-10 | 삼성에스디아이 주식회사 | 리튬 이차 전지용 음극 활물질, 그 제조 방법 및 이를 포함하는 리튬 이차 전지 |
| WO2014008636A1 (en) | 2012-07-11 | 2014-01-16 | Merck Sharp & Dohme Corp. | Macrocyclic compounds as hiv integrase inhibitors |
| WO2014201405A1 (en) | 2013-06-14 | 2014-12-18 | The Board Of Regents Of The University Of Texas System | Novel allosteric inhibitors of proteasome and methods of use thereof |
| US10533016B2 (en) | 2015-01-09 | 2020-01-14 | Revolution Medicines, Inc. | Compounds that participate in cooperative binding and uses thereof |
| WO2017059207A1 (en) | 2015-10-01 | 2017-04-06 | Warp Drive Bio, Inc. | Methods and reagents for analyzing protein-protein interfaces |
| MX2018009405A (es) * | 2016-02-04 | 2018-11-09 | Univ Johns Hopkins | Sintesis y composicion de bibliotecas de rapafucina. |
| US11066416B2 (en) | 2016-02-04 | 2021-07-20 | The Johns Hopkins University | Rapafucin derivative compounds and methods of use thereof |
| CA3013783A1 (en) | 2016-02-04 | 2017-08-10 | The Johns Hopkins University | Rapaglutins, novel inhibitors of glut and use thereof |
| US10774110B2 (en) | 2016-02-04 | 2020-09-15 | The Johns Hopkins University | Rapadocins, inhibitors of equilibrative nucleoside transporter 1 and uses thereof |
| PT3445767T (pt) | 2016-04-22 | 2020-05-13 | Astrazeneca Ab | Inibidores de mcl-1 macrocíclicos para o tratamento de cancro |
| WO2018045250A1 (en) | 2016-09-02 | 2018-03-08 | The Johns Hopkins University | Mif inhibitors and methods of use thereof |
| AR112834A1 (es) | 2017-09-26 | 2019-12-18 | Novartis Ag | Derivados de rapamicina |
-
2017
- 2017-02-03 CA CA3013783A patent/CA3013783A1/en not_active Abandoned
- 2017-02-03 MX MX2018009408A patent/MX2018009408A/es unknown
- 2017-02-03 JP JP2018540115A patent/JP7104627B2/ja active Active
- 2017-02-03 CN CN201780010180.3A patent/CN108697729B/zh active Active
- 2017-02-03 WO PCT/US2017/016516 patent/WO2017136731A1/en not_active Ceased
- 2017-02-03 US US16/074,300 patent/US11708391B2/en active Active
- 2017-02-03 AU AU2017213630A patent/AU2017213630B2/en active Active
- 2017-02-03 EP EP17748278.3A patent/EP3411046B1/en active Active
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