JP2019030267A - 活性阻害剤、美白剤、飲食物および活性阻害剤の製造方法 - Google Patents
活性阻害剤、美白剤、飲食物および活性阻害剤の製造方法 Download PDFInfo
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Abstract
【解決手段】 本発明のブラックラズベリー抽出物は、メラノサイトにおけるチロシナーゼ酵素の活性阻害効果を有する。
【選択図】 なし
Description
(1) メラノサイトにおけるチロシナーゼ酵素の活性阻害効果を有するブラックラズベリー抽出物、
(2) (1)に記載のブラックラズベリー抽出物を含む美白剤、
(3) (1)に記載のブラックラズベリー抽出物を含む飲食物、
(4) (1)に記載のブラックラズベリー抽出物の製造方法であって、ブラックラズベリーの果実を冷凍する冷凍工程と、前記ブラックラズベリーの果実を解凍する解凍工程と、
前記解凍工程にて解凍した前記ブラックラズベリーの果実に溶媒を加えて撹拌する撹拌工程と、前記撹拌工程により撹拌した前記ブラックラズベリーの果実および溶媒を静置し抽出を行う抽出工程とを含むブラックラズベリー抽出物の製造方法、
(5) (1)に記載のブラックラズベリー抽出物を用いた美白方法
が提供される。
ブラックラズベリー抽出物をブラックラズベリーの果実から抽出する方法は、特に限定されないが、溶媒抽出、超臨界抽出等を用いることができる。
なお、超臨界抽出を行う場合には、超臨界状態とした二酸化炭素を用いることが好ましい。
また、溶媒抽出によって得られた抽出液は、必要に応じて濾過等の処理を行ってもよい。
なお、ブラックラズベリー抽出物としては、液体や粉末状とされた市販品または既製品を用いてもよい。
また、本発明のブラックラズベリー抽出物を配合させた食品や飲料を、錠剤、カプセル剤、シロップ等の経口投与製剤と同様の形態としてもよい。
本発明のブラックラズベリー抽出物は、肌の美白効果を得るために有用である。
(試料の準備)
試料としては、ベリー系試料3種(ブラックラズベリー(バラ科キイチゴ属)(以下、「BR」ということがある。)、ブルーベリー(ツツジ科スノキ属)(以下、「BB」ということがある。)およびラズベリー(バラ科キイチゴ属)(以下、「RB」ということがある。))の抽出物、およびブラックラズベリーの抽出物を配合した粉末製剤であるBlabina(登録商標)を用いた。
ブラックラズベリー、ブルーベリーおよびラズベリーの抽出液は、以下の手法により得た。
まず、ブラックラズベリー、ブルーベリーおよびラズベリーの果実をそれぞれ冷凍状態にて保存した。次に、それぞれの果実を解凍してカットした。ブラックラズベリー、ブルーベリーおよびラズベリーをそれぞれ秤量(約100g)し、5倍量の30v/v%(EtOH)エタノール水溶液(およそ500mL)を加え、ブレンダーを用いて8000rpm、30分の条件にて撹拌抽出を行った。さらに、室温にて24時間静置することにより、静置抽出を行い、150メッシュで濾過して上記ブラックラズベリー、ブルーベリーおよびラズベリーのエタノール抽出液をそれぞれ得た。後述するORACの測定はエタノール溶解状態で行うため、エタノール抽出液を用いて測定を行った。
なお、Blabinaについては、30v/v%(EtOH)にBlabinaを9mg/mLとなるように溶解させた。
上記抽出液の調製にて得られたブラックラズベリー、ブルーベリーおよびラズベリーそれぞれについてのエタノール抽出液、さらにBlabinaのエタノール溶液から、それぞれエバポレーターを用いてエタノール成分を蒸発させ、除去し、抽出物を得た。なお、ブラックラズベリー、ブルーベリーおよびラズベリーのエタノール抽出液は、9mg/mLの抽出物(エキス)を含んでいた。
(ORAC値による抗酸化作用の評価)
上記にて得られたベリー系検体3種(ブラックラズベリー、ブルーベリーおよびラズベリーのエタノール抽出液)のORAC値を測定した。結果を表1に示す。なお、Blabinaについては、ORAC値の測定を行わなかった。
実験に用いる細胞としては、メラノサイトを用いた。メラノサイトとしては、Normal Human Epidermal Melanocytes, juvenile foreskin(C-12400, PromoCell社より購入)を用い、専用培地(Melanocyte Growth Medium Supplement Pack; C-39410, PromoCell社より購入)を使用して37℃、5%CO2の条件にて培養した。実験の直前に0.25%Trypsin/EDTA溶液で細胞を回収し、細胞数をトリパンブルー染色処理後、Countess(Invitrogen)にて算出した。その後、24ウェルプレートまたは96ウェルプレートに播種し、24時間、前培養したのち実験に用いた。
Claims (5)
- メラノサイトにおけるチロシナーゼ酵素の活性阻害効果を有するブラックラズベリー抽出物。
- 請求項1に記載のブラックラズベリー抽出物を含む美白剤。
- 請求項1に記載のブラックラズベリー抽出物を含む飲食物。
- 請求項1に記載のブラックラズベリー抽出物の製造方法であって、
ブラックラズベリーの果実を冷凍する冷凍工程と、
前記ブラックラズベリーの果実を解凍する解凍工程と、
前記解凍工程にて解凍した前記ブラックラズベリーの果実に溶媒を加えて撹拌する撹拌工程と、
前記撹拌工程により撹拌した前記ブラックラズベリーの果実および溶媒を静置し抽出を行う抽出工程と
を含むブラックラズベリー抽出物の製造方法。 - 請求項1に記載のブラックラズベリー抽出物を用いた美白方法。
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