JP2018522241A - アッセイを実行するための流体システム - Google Patents
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Abstract
Description
Claims (29)
- 流体試験システムであって、
1つのみのポートを有するマイクロ流体チャネルと、
前記マイクロ流体チャネルの終端端部に配置される第1のチャンバと、
前記マイクロ流体チャネルに結合される第2のチャンバであって、前記第2のチャンバは、前記第2のチャンバへの各開口部が、動作の間、重力ベクトルと略平行に整列されるよう構成されるように整列される、第2のチャンバと、
を備える、流体試験システム。 - 前記マイクロ流体チャネルに結合される1つまたはそれを上回る液体感知面積をさらに備える、請求項1に記載の流体試験システム。
- 前記1つまたはそれを上回る液体感知面積のうちの少なくとも1つは、所定の量の液体を前記第2のチャンバの中に投与するように構成される、請求項2に記載の流体試験システム。
- 前記流体チャネルに結合され、1つまたはそれを上回る試薬を含むように構成される第3のチャンバをさらに備える、請求項1に記載の流体試験システム。
- 前記第3のチャンバは、前記1つまたはそれを上回る試薬を含有するフリーズドライ丸薬を含むように定寸される、請求項4に記載の流体試験システム。
- 前記第2のチャンバは、1つまたはそれを上回る試薬を含む可撤性要素を備える、請求項1に記載の流体試験システム。
- 前記1つまたはそれを上回る試薬は、前記可撤性要素の表面上にコーティングされる、請求項6に記載の流体試験システム。
- 前記1つまたはそれを上回る試薬は、捕捉抗体を含む、請求項7に記載の流体試験システム。
- 前記1つまたはそれを上回る試薬は、単鎖または二本鎖DNAを含む、請求項7に記載の流体試験システム。
- 前記第2のチャンバは、光学照会を可能にするための少なくとも1つの透明壁を含む、請求項1に記載の流体試験システム。
- 前記第2のチャンバは、複数のビーズを含む、請求項1に記載の流体試験システム。
- 前記マイクロ流体チャネルは、複数のマイクロ流体チャネルに分裂されるように構成され、前記複数のマイクロ流体チャネルはそれぞれ、個別の第1のチャンバおよび個別の第2のチャンバに結合される、請求項1に記載の流体試験システム。
- 前記流体チャネルに結合された第3のチャンバをさらに備え、前記第3のチャンバは、前記第3のチャンバを通して移動する流体を混合するように構成される、請求項1に記載の流体試験システム。
- 前記第2のチャンバは、50マイクロリットル未満の流体体積を有する、請求項1に記載の流体試験システム。
- 方法であって、
液体が流体チャネルに結合される第1のチャンバ内に貯蔵される1つまたはそれを上回る試薬に到達するまで、前記液体を前記流体チャネルの唯一のポートを通して流動させるステップと、
前記1つまたはそれを上回る試薬の少なくとも一部を前記液体内に再懸濁させ、標的液体を形成するステップと、
前記標的液体を前記流体チャネルを通して前記第1のチャンバから離れるように流動させるステップと、
前記標的液体が前記流体チャネルに結合される第2のチャンバを通して流動するように、前記標的液体を前記流体チャネル内で往復して流動させるステップと、
前記標的液体内の前記1つまたはそれを上回る再懸濁された試薬の少なくとも一部と前記第2のチャンバ内に配置される1つまたはそれを上回る試薬とを反応させるステップと、
前記標的液体を前記流体チャネルから前記流体チャネルの唯一のポートを介して流動させるステップと、
を含む、方法。 - 前記第2のチャンバへの各開口部は、重力ベクトルと略平行に整列される、請求項15に記載の方法。
- 前記標的液体を前記流体チャネル内で往復して流動させるステップは、前記標的液体を前記流体チャネルの2つの場所間で往復して流動させるステップを含む、請求項15に記載の方法。
- 前記流体チャネルの2つの場所のそれぞれにおいて前記液体の存在を感知するステップをさらに含む、請求項15に記載の方法。
- 前記標的液体を前記流体チャネル内で往復して流動させるステップは、前記標的液体を第3のチャンバを通して流動させ、前記標的流体が前記第3のチャンバを通して流動するにつれて、前記標的液体を混合するステップを含む、請求項15に記載の方法。
- 前記第2のチャンバからの光学信号を測定するステップであって、前記光学信号は、前記第2のチャンバ内の前記1つまたはそれを上回る再懸濁された試薬の濃度と関連付けられる、ステップをさらに含む、請求項15に記載の方法。
- 第2の液体を前記流体チャネルの唯一のポートを通して流動させるステップと、
前記第2の液体が前記第2のチャンバを通して流動するように、前記第2の液体を前記流体チャネル内で往復して流動させるステップと、
前記第2の液体を前記流体チャネルから前記流体チャネルの唯一のポートを介して流動させるステップと、
をさらに含む、請求項15に記載の方法。 - 前記第2の液体は、洗浄緩衝剤である、請求項21に記載の方法。
- 前記反応させるステップは、前記標的液体内の前記1つまたはそれを上回る再懸濁された試薬の少なくとも一部と前記第2のチャンバ内に配置される1つまたはそれを上回る試薬とを結合するステップを含む、請求項15に記載の方法。
- 流体試験システムであって、
1つのみのポートを有するマイクロ流体チャネルと、
複数のチャンバであって、前記複数のチャンバの各チャンバは、前記複数のチャンバのそれぞれの長さが重力ベクトルと略平行に整列されるように、直列配列で前記マイクロ流体チャネルに結合される、複数のチャンバと、
前記マイクロ流体チャネルの終端端部に配置されるチャンバと、
を備える、流体試験システム。 - 前記複数のチャンバの所与のチャンバへの各開口部は、流路に沿って前記重力ベクトルと実質的に整列される、請求項24に記載の流体試験システム。
- 前記複数のチャンバの各チャンバは、50マイクロリットル未満の流体体積を有する、請求項24に記載の流体試験システム。
- 前記マイクロ流体チャネルに沿って複数の液体感知面積をさらに備える、請求項24に記載の流体試験システム。
- 前記複数の液体感知面積は、前記複数のチャンバと所与のパターンで前記マイクロ流体チャネルに沿って配列される、請求項27に記載の流体試験システム。
- 前記所与のパターンは、前記液体感知面積の隣接するものの間に前記複数のチャンバの異なる数のチャンバを有することを含む、請求項28に記載の流体試験システム。
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CN107305210B (zh) * | 2016-04-20 | 2019-09-17 | 光宝电子(广州)有限公司 | 生物检测卡匣及其检测流体的流动方法 |
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CN108732339B (zh) * | 2017-04-19 | 2021-04-13 | 光宝电子(广州)有限公司 | 用于多重反应生物检测的流道装置及其检测方法 |
US10046322B1 (en) * | 2018-03-22 | 2018-08-14 | Talis Biomedical Corporation | Reaction well for assay device |
US10820847B1 (en) | 2019-08-15 | 2020-11-03 | Talis Biomedical Corporation | Diagnostic system |
CN111530515A (zh) * | 2020-05-08 | 2020-08-14 | 北京森美希克玛生物科技有限公司 | 一种微流控芯片 |
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US10775370B2 (en) | 2020-09-15 |
CA2992824A1 (en) | 2017-01-26 |
AU2016295622B2 (en) | 2021-09-02 |
KR102651768B1 (ko) | 2024-03-28 |
CN108136390B (zh) | 2021-07-16 |
CA2992824C (en) | 2023-12-19 |
BR112018000907A2 (pt) | 2019-05-07 |
RU2725264C2 (ru) | 2020-06-30 |
US20170014821A1 (en) | 2017-01-19 |
AU2016295622A1 (en) | 2018-02-15 |
ES2863533T3 (es) | 2021-10-11 |
RU2018102760A (ru) | 2019-08-19 |
EP3325150B1 (en) | 2021-02-17 |
JP6871905B2 (ja) | 2021-05-19 |
BR112018000907B1 (pt) | 2022-11-22 |
ZA201800836B (en) | 2019-10-30 |
US20200408752A1 (en) | 2020-12-31 |
EP3325150A1 (en) | 2018-05-30 |
WO2017013561A1 (en) | 2017-01-26 |
CN108136390A (zh) | 2018-06-08 |
JP2021120675A (ja) | 2021-08-19 |
KR20180030108A (ko) | 2018-03-21 |
HK1256696A1 (zh) | 2019-10-04 |
RU2018102760A3 (ja) | 2019-11-22 |
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