JP2018106642A - Radiopharmaceutical manufacture assisting apparatus and manufacture assisting method - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a technology for enabling stable manufacture of radiopharmaceutical by effectively using the cyclotrons of external facilities.SOLUTION: A radiopharmaceutical manufacture assisting apparatus (10) comprises: a facility managing section (11) that acquires respective pieces of manufacturing information of radioactive nuclide in a plurality of manufacturing facilities having cyclotrons; a pharmaceutical preparation managing section (13) that acquires respective pieces of necessary-quantity information, indicating respective quantities of radioactive nuclide required in manufacturing lots in pharmaceutical preparation facilities, each of which receives the provision of a radioactive nuclide and manufactures a radioactive pharmaceutical; and an order-placement adjustment section (15) that, on the basis of the acquired manufacturing information and necessary amount information, selects one or more providing facilities from among a plurality of providing facilities as an order-placement facility for the radioactive nuclide for the manufacturing lot.SELECTED DRAWING: Figure 2

Description

  The present invention relates to a technique for supporting the manufacture of a radiopharmaceutical.

  Currently, there are many facilities that have cyclotrons installed, such as radiopharmaceutical manufacturers, medical institutions and research facilities. The cyclotron is a facility for producing a radionuclide (hereinafter sometimes referred to as RI (radioisotope)) that is a raw material for a radiopharmaceutical. Medical institutions that have introduced cyclotrons manufacture RI by manufacturing RI and conducting drug synthesis and quality inspection, and then PET (Positron Emission Tomography) inspection and SPECT (Single Photon Emission Computed Tomography) inspection I do. On the other hand, many medical institutions do not have a cyclotron and receive a radiopharmaceutical delivery from a radiopharmaceutical manufacturer to perform a PET inspection or a SPECT inspection. Radiopharmaceuticals have a short shelf life due to the half-life of the radionuclide used, and are difficult to stock in medical institutions, so they can be supplied stably to medical institutions that do not have radiopharmaceutical production facilities. Desired.

Patent Document 1 describes a method of effectively using a nuclide with a short half-life for screening. Specifically, hospitals excess nuclide produced ^{(18 F)} in the facility is supplied to other hospitals, the hospital the supplied nuclide by synthesizer features the synthesis of a drug material having a cyclotron And the manufactured radiopharmaceutical is subjected to positron emission CT examination. The technique described in Patent Document 1 effectively uses a nuclide with a short half-life for screening by calculating the time of such a process based on the half-life of the nuclide and creating a time schedule.

JP 2001-172204 A

Since radiopharmaceuticals are difficult to stock, facilities that use radiopharmaceuticals (hereinafter referred to as “utilization facilities”) need to reliably prepare an appropriate amount in accordance with the drug utilization schedule. However, the use timing of the medicines at each use facility varies, and the RI production timing at each use facility having the manufacturing equipment among the use facilities also varies. For this reason, it is difficult for the above-mentioned method of Patent Document 1 to stably receive a necessary amount of RI for each use facility at a necessary timing.
This invention is made | formed in view of such a situation, and provides the technique which enables the stable manufacture of a radiopharmaceutical by utilizing effectively the cyclotron which an external facility has.

  Each aspect of the present invention employs the following configurations in order to solve the above-described problems.

  A 1st side is related with the manufacturing assistance apparatus of a radiopharmaceutical. A radiopharmaceutical production support apparatus according to a first aspect is provided in a facility management unit that acquires manufacturing information of radionuclides in a plurality of providing facilities having a cyclotron, and in a preparation facility that manufactures a radiopharmaceutical that receives the radionuclide. Based on the acquired manufacturing information and necessary amount information, one or more of the provision facilities based on the preparation management unit that acquires the necessary amount information indicating the amount of the radionuclide necessary for the production lot An ordering adjustment unit that selects a facility as an ordering facility of the radionuclide for the production lot.

  A 2nd side surface is related with the manufacturing assistance method of a radiopharmaceutical. The method for supporting production of a radiopharmaceutical according to the second aspect is necessary for a production lot in a pharmaceutical facility that obtains radionuclide production information at a plurality of provision facilities having cyclotrons and produces the radiopharmaceutical upon receipt of the radionuclide. The necessary amount information indicating the amount of the radionuclide to be obtained is acquired, and based on the acquired manufacturing information and necessary amount information, one or more providing facilities are selected from the plurality of providing facilities for the production lot. Including selecting as a radionuclide ordering facility.

  According to each said aspect, the technique which enables the stable manufacture of a radiopharmaceutical using the cyclotron which an external facility has effectively can be provided.

It is a conceptual diagram which shows the surrounding environment of the manufacturing support server (support server) of the radiopharmaceutical which concerns on this embodiment. It is a figure which shows notionally the process structural example of the manufacturing assistance server (support server) of the radiopharmaceutical which concerns on this embodiment. It is a figure which shows notionally the hardware structural example of the ordering server which concerns on this embodiment. It is a figure which shows notionally the process structural example of the ordering server which concerns on this embodiment. It is a figure which shows the example of information stored in provision facility information DB. It is a flowchart which shows the manufacturing assistance method of the radiopharmaceutical which concerns on this embodiment. It is a flowchart which shows the order destination facility and the determination method of RI order quantity.

  Embodiments of the present invention will be described below. In addition, embodiment mentioned below is an illustration and this invention is not limited to the structure of the following embodiment.

First, an outline of a radiopharmaceutical manufacturing support server (hereinafter abbreviated as a support server) and a manufacturing support method according to the present embodiment will be described.
Before describing the outline, the surrounding environment related to the production of a radiopharmaceutical supported by the support server according to the present embodiment will be described with reference to FIG. FIG. 1 is a conceptual diagram showing the surrounding environment of the support server according to the present embodiment.

Providing radiopharmaceutical facilities that provide radiopharmaceuticals (use facilities), facilities that have a cyclotron and produce radiopharmaceutics on their own (hereinafter referred to as providing facilities), and radionuclides There are three types of facilities: a facility for receiving radiopharmaceuticals (hereinafter referred to as a formulation facility).
The use facility is a facility that receives and uses a radiopharmaceutical from a preparation facility. There may be a hospital facility, a university, a research institution, and the like as the use facility. In FIG. 1, FC 3-1 and FC 3-2 are exemplified as usage facilities. Hereinafter, the usage facilities are collectively referred to as usage facilities FC 3.

The providing facility is a facility that manufactures RI using its own cyclotron. The provided facility may be a facility that synthesizes RI compounds using RI that is produced in-house, or further performs radiopharmaceutical production and quality inspection using the synthesized RI compound, and provides the radiopharmaceutical by itself. It may be a facility for manufacturing. In the providing facility, RI required for manufacturing the radiopharmaceutical used in the facility is manufactured in the facility, but there are also facilities where the frequency of using the radiopharmaceutical is low and the operation rate of the cyclotron is low. Therefore, in this embodiment, the surplus RI produced at the providing facility is provided to the preparation facility.
It is desirable that the providing facility be a facility capable of manufacturing an RI with guaranteed quality that can be used for manufacturing a pharmaceutical product. In addition, the providing facility considers the amount of RI that can be provided and the RI provided, taking into account the transport of RI to the formulation facility and the attenuation of radioactivity associated with the transport of the radiopharmaceutical from the formulation facility to the user facility. It is desirable to be in a position where it can be used efficiently.
In FIG. 1, FC1-1 to FC1-6 are illustrated as providing facilities. However, the provided facility may become a use facility during maintenance of the cyclotron it owns. Hereinafter, when providing facilities are collectively referred to as providing facilities FC1.

  The preparation facility is a GMP (Good Manufacturing Practice) compliant facility that is allowed to manufacture the radiopharmaceutical using the RI provided by the providing facility FC1 as a raw material and ship it to the market. The preparation facility considers the transport time of RI with the providing facility FC1, the transport time of the radiopharmaceutical with the use facility FC3, the manufacturing time of the drug, etc., and the radiopharmaceutical according to the demand of the use facility FC3. It is desired to be installed at a position where stable supply is possible. In FIG. 1, FC5-1 and FC5-2 are illustrated as preparation facilities, and hereinafter, the preparation facilities are collectively referred to as preparation facilities FC5.

The combination of the providing facility FC1, the use facility FC3, and the preparation facility FC5 may be limited due to the relationship between the transportation time and the RI production capability. That is, the combination of the preparation facility FC5 and the provision facility FC1 in order to accept an order for a radiopharmaceutical from a certain utilization facility FC3 may be limited.
For example, the amount of RI that can be provided by the providing facility FC1-1 is 5 GBq (at the time of delivery of the providing facility), and it takes 16 hours to supply the route between the providing facility FC1-1, the preparation facility FC5-2, and the use facility FC3-2. Assume that. In this example, when RI is fluorine 18 ( ¹⁸ F), its half-life is about 2 hours. Therefore, the radiopharmaceutical produced from the RI produced at the providing facility FC1-1 is used as the utilization facility FC3. At the time of arriving at -2, the amount of radioactivity is reduced to (1/2) ⁸ and becomes about 20 MBq. Since this is inefficient, the route between the providing facility FC1-1 and the formulation facility FC5-2 cannot be adopted as the supply route to the utilization facility FC3-2.
Therefore, in the example of FIG. 1, the supply route to the utilization facility FC3-1 includes the formulation facility FC5-1, the providing facility FC1-1, FC1-2, FC1-3, FC1-4, or FC1-6. The route of is targeted. The supply route to the utilization facility FC3-2 is a route between the preparation facility FC5-2 and the providing facility FC1-3, FC1-4, FC1-5, or FC1-6.

  The support server and the manufacturing support method according to the present embodiment support the manufacturing of the radiopharmaceutical in the preparation facility FC5. Note that the numbers of the use facility FC3, the providing facility FC1, and the preparation facility FC5 targeted in the surrounding environment of the present embodiment are not limited to the example of FIG. Further, the restriction of the supply route to the use facility FC3 is not limited to the example of FIG. 1, and an efficient supply route may be determined in consideration of the transportation time. At that time, a plurality of formulation facilities FC5 may be targeted as a supply route to one use facility FC3, and one formulation facility FC5 to be provided with RI from one providing facility FC1 is always set as one. May be.

FIG. 2 is a diagram conceptually illustrating a processing configuration example of the support server 10 according to the present embodiment.
The support server 10 according to the present embodiment includes a facility management unit 11, a formulation management unit 13, and an order adjustment unit 15 as software elements. Each of these software elements is realized, for example, by executing a program stored in the memory 2 by a CPU (Central Processing Unit) 1 illustrated in FIG. The program may be installed via a communication unit 4 from a portable recording medium such as a CD (Compact Disc) or a memory card or another computer, and may be stored in the memory 2.
The support server 10 may be one or more computers, and the hardware configuration is not limited to the example of FIG.

The facility management unit 11 acquires the production information of the radionuclide (RI) in the plurality of providing facilities FC1.
Here, the “manufacturing information” is information relating to RI manufacturing at each of the plurality of providing facilities FC1. The manufacturing information may include, for example, information on a manufacturing schedule indicating manufacturing date and time and a manufacturing amount, information on manufacturing capacity of the providing facility FC1, and the like. This manufacturing information may be information predetermined for each providing facility FC1, or may include such information in part.
The method for obtaining the manufacturing information is not limited. The facility management unit 11 may acquire manufacturing information stored in the memory 2 in advance, or may acquire the manufacturing information by communication from another server (not shown). Moreover, the facility management part 11 may display the input screen and acquire the manufacturing information input via the input screen.

The preparation management unit 13 acquires necessary amount information indicating the amount of RI required for the production lot in the preparation facility FC5. In the preparation facility FC5, a production plan is drawn up by an order from the use facility FC3, and the amount of RI required for each production lot is determined in the production plan. The necessary amount information acquired by the formulation management unit 13 is information indicating the amount of RI necessary for manufacturing a radiopharmaceutical in a certain production lot.
The amount of RI indicated by the necessary amount information is set as an amount at a certain reference time point in order to correspond to the radioactive decay of RI. For example, the amount of the RI may be set as the amount at the time of drug production at the pharmaceutical facility FC5, may be set as the amount at the time of testing, or may be set as the amount at the time of RI manufacturing at the providing facility FC1. May be. This is true for all matters referred to herein as “amount of RI”.
There are no restrictions on the method of obtaining the necessary amount information. The preparation management unit 13 may acquire necessary amount information stored in the memory 2 in advance, or may acquire the necessary amount information by communication from another server (not shown). In addition, the facility management unit 11 may display the input screen and acquire necessary amount information input via the input screen.
Note that “at the time of test” (“test time”) is a reference time having radioactivity displayed on the product of the radiopharmaceutical.

  Based on the manufacturing information acquired by the facility management unit 11 and the necessary amount information acquired by the formulation management unit 13, the order adjustment unit 15 selects one or more providing facilities FC1 from the plurality of providing facilities FC1. Select as the RI ordering facility.

The support server 10 according to the present embodiment may execute the radiopharmaceutical manufacturing support method according to the present embodiment (hereinafter sometimes simply referred to as a support method) by the processing of each processing module as described above. it can.
That is, the support method according to the present embodiment acquires radionuclide (RI) production information at a plurality of providing facilities FC1, and acquires necessary amount information indicating the amount of the RI required for a production lot at the preparation facility FC5. And selecting one or more providing facilities FC1 from among the plurality of providing facilities FC1 as an ordering facility of RI for the production lot based on the acquired manufacturing information and necessary amount information.
In addition, the present embodiment may be a program for causing a computer to execute such a support method or a storage medium in which such a program is stored so as to be readable by the computer.

  The information on the ordering facility selected as described above may be used as information on the ordering party of RI that is a raw material of the radiopharmaceutical manufactured in a certain production lot in the preparation facility FC5. The ordering process may be automatically executed by a computer based on the information of the ordering facility, or the ordering process may be executed by a user (person) referring to the information.

As described in the overview, in the present embodiment, in consideration of RI manufacturing information at a plurality of providing facilities FC1, which are external facilities, an ordering party for RI in an amount necessary for manufacturing a radiopharmaceutical at the preparation facility FC5. Is selected from the plurality of providing facilities FC1.
For this reason, each providing facility FC1 can provide RI other than the amount used in the facility to the formulation facility FC5, and the facility using the radiopharmaceutical produced using the provided RI as a raw material. Can be provided to FC3. Thereby, the operation rate of the cyclotron which each providing facility FC1 has can be raised. Furthermore, since a plurality of providing facilities FC1 are targeted as candidates for ordering, the pharmaceutical agent FC5 that does not have a cyclotron can stably manufacture a radiopharmaceutical according to the demand of the use facility FC3. That is, according to the present embodiment, it is possible to stably manufacture a radiopharmaceutical by effectively utilizing the cyclotron of an external facility.

Hereinafter, the above-described support server 10 and support method will be described in more detail.
Below, the ordering server 20 is illustrated as a specific example of the above-described support server 10.
[Order server]
FIG. 3 is a diagram conceptually illustrating a hardware configuration example of the ordering server 20 according to the present embodiment.
The ordering server 20 is a so-called computer, and includes a CPU 1, a memory 2, an input / output interface (I / F) 3, a communication unit 4, and the like.

In addition to a general CPU, the CPU 1 may include an application specific integrated circuit (ASIC), a DSP (Digital Signal Processor), a GPU (Graphics Processing Unit), and the like. The memory 2 is a RAM (Random Access Memory), a ROM (Read Only Memory), or an auxiliary storage device (such as a hard disk).
The input / output I / F 3 can be connected to a user interface device (not shown) such as a display device or an input device. The display device is a device such as an LCD or a CRT display that displays a screen corresponding to drawing data processed by the CPU 1 or the like. The input device is a device that receives an input of a user operation such as a keyboard and a mouse. The display device and the input device may be integrated and realized as a touch panel.
The communication unit 4 communicates with other computers via the communication network 8 and exchanges signals with other devices such as a printer. A portable recording medium or the like can be connected to the communication unit 4.

  The hardware configuration of the ordering server 20 is not limited to the example of FIG. The ordering server 20 may include other hardware elements not shown. Further, the number of hardware elements is not limited to the example of FIG. For example, the ordering server 20 may have a plurality of CPUs 1. The ordering server 20 may be realized by a plurality of computers.

  The order server 20 is communicably connected to an order receiving system 31, a production management system 32, a delivery management system 33, a provision facility terminal 35, and the like. Communication between the ordering server 20 and other terminals or systems is one of Wi-Fi (Wireless Fidelity) line network, Internet communication network, dedicated line network, LAN (Local Area Network), WAN (Wide Area Network), etc. The communication network 9 is formed by one or a combination thereof. The specific form of the communication is not limited.

The order receiving system 31 is a system for the preparation facility FC5, and is a system for managing orders for radiopharmaceuticals (radiopharmaceuticals) from the use facility FC3. The order receiving system 31 provides order receiving information to the production management system 32. The order receiving system 31 only needs to have a known general function.
The production management system 32 is a system for the pharmaceutical facility FC5 and manages the production (production) of the radiopharmaceutical in the pharmaceutical facility FC5. The production management system 32 receives order information from the order receiving system 31, creates a radiopharmaceutical production plan for each preparation facility FC 5 based on the order information, and provides the production plan information to the ordering server 20. The production plan information includes at least necessary amount information indicating the amount of RI required for each production lot for each preparation facility FC5.
The delivery management system 33 is a system that manages the delivery of the radiopharmaceutical that is shipped from the preparation facility FC5. The delivery management system 33 only needs to have a known general function.
The providing facility terminal 35 is a stationary or portable computer included in each providing facility FC1.

FIG. 4 is a diagram conceptually illustrating a processing configuration example of the ordering server 20 according to the present embodiment.
The order server 20 includes, as software elements, a facility management unit 21, an order adjustment unit 22, a formulation management unit 23, an ordering unit 24, a transport management unit 25, a delivery management unit 26, and a provided facility information database (hereinafter abbreviated as DB). 27 etc. Each of these software elements is realized, for example, by executing a computer program stored in the memory 2 by the CPU 1. The program may be installed from a portable recording medium such as a CD or a memory card or another computer via the communication unit 4 and stored in the memory 2.

The DB 27 stores information related to the providing facility FC1.
FIG. 5 is a diagram illustrating an example of information stored in the DB 27.
As illustrated in FIG. 5, the DB 27 stores a provision facility ID, a preparation facility ID, a manufacturing plan, an RI transport time, and the like for each provision facility FC1.

The provided facility ID is identification information of the individual provided facility FC1.
The formulation facility ID is identification information of each formulation facility FC5. In the preparation facility ID, an ID of the preparation facility FC5 that can receive provision of RI from the providing facility FC1 specified by the providing facility ID is set. In the example of FIG. 1, for example, information on the provision facility FC1-1 includes information on the formulation facility FC5-1, and information on the provision facility FC1-6 includes information on the formulation facilities FC5-1 and FC5-2. It is. In FIG. 5, only one field for the formulation facility ID is provided, but a plurality of fields may be provided.

The production plan is production information of a radionuclide (RI) in the providing facility FC1 specified by the providing facility ID. The production plan may be fixed information determined in advance, or may be information arbitrarily determined at a predetermined timing by each providing facility FC1.
If the manufacturing plan is information that allows the ordering server 20 to know when and how much RI can be provided for each providing facility FC1, the specific contents thereof are not limited. In the example of FIG. 5, the planned supply amount and the supply date / time are set as the production plan.
The planned supply amount indicates the amount of RI that can be provided by the providing facility FC1 at the corresponding supply date and time. For the planned supply amount, for example, an upper limit amount and a lower limit amount are set. However, instead of the planned supply amount, the planned production amount at the providing facility FC1 may be set in the production plan. In this case, the information regarding the RI manufacturing performance (maximum manufacturable amount) in the providing facility FC1 is stored in the DB 27, so that the ordering server 20 subtracts the planned manufacturing amount for the providing facility from the manufacturable maximum amount. Thus, the supply amount can be calculated.

The RI transport time means the time required for transporting RI from the providing facility FC1 to the preparation facility FC5. The ordering server 20 can determine the RI order quantity for each providing facility FC1 based on the RI transport time and the required RI half-life. Since the time required for transporting RI may vary depending on road conditions and the like, a plurality of RI transport times may be set for each providing facility FC1. For example, a plurality of RI transport times may be set according to the date, day of the week, and time of transport, and the normal RI transport time and the transport time when an abnormal situation such as a traffic accident occurs are set. May be.
In addition, not the RI transport time but the transport distance from the providing facility FC1 to the preparation facility FC5 may be set in the manufacturing information. In this case, the ordering server 20 can predict the transportation time in consideration of the transportation distance and the traffic situation.
The DB 27 may be realized not on the ordering server 20 but on an external server.

The facility management unit 21 extracts the formulation facility ID, the manufacturing plan (manufacturing information), and the RI transport time from the DB 27 for each provided facility FC1. When the DB 27 exists on an external server, the facility management unit 21 accesses the external server by communication and acquires the information from the external server. The facility management unit 21 corresponds to the facility management unit 11 of FIG.
In addition, when the planned irradiation amount and the planned usage amount of the cyclotron in the providing facility FC1 are indicated in the manufacturing plan stored in the DB 27, the facility management unit 21 determines the planned usage amount for the providing facility from the planned irradiation amount. Can be calculated to calculate the planned supply amount at the corresponding supply date and time.

  The facility management unit 21 may receive the manufacturing plan of the providing facility FC1 from the providing facility terminal 35 and reflect the manufacturing plan in the DB 27. In this case, the facility management unit 21 may display a user interface (UI) screen on the providing facility terminal 35 and acquire a manufacturing plan input to the UI screen. On the UI screen, for example, a planned supply amount and a supply date and time as a production plan are input. In addition, the facility management unit 21 may acquire manufacturing information by e-mail or file transfer.

  The formulation management unit 23 acquires production plan information for each formulation facility FC5 from the production management system 32. This production plan information includes at least the identification information of the preparation facility FC5 and the necessary amount information indicating the amount of RI required for the production lot in the preparation facility FC5 (hereinafter referred to as the RI required amount). For this reason, the formulation management unit 23 corresponds to the formulation management unit 13 of FIG.

The order adjustment unit 22 uses the manufacturing plan (manufacturing information) for each providing facility FC1 acquired by the facility management unit 21 and the RI required amount of the production plan information acquired by the formulation management unit 23 to provide the plurality of providing facilities. One or more providing facilities FC1 are selected from among FC1 as the RI ordering facility for the target production lot that is the target of the production plan information.
At this time, the order adjustment unit 22 specifies the target providing facility FC1 for each formulation facility FC5 based on the formulation facility ID acquired by the facility management unit 21, and places an order from the specified providing facility FC1. Select the destination facility. In addition, the condition of the target providing facility FC1 includes that the supply date and time that can reach the preparation facility FC5 by the time of the target manufacturing lot is set in the manufacturing plan.

Further, when selecting a plurality of ordering destination facilities, the ordering adjustment unit 22 sets each ordering destination facility so that each of the ordering destination facilities can provide an amount (planned supply amount) and satisfies the RI requirement. Determine the RI order quantity for each.
This “RI order quantity” is also set as a quantity at a certain reference time as described above. For example, the reference time point of the RI required amount is set to the time point when the RI is delivered to the preparation facility FC5, and the reference time point of the RI order amount is set to the RI delivery available time (the supply date and time of the production plan) from the providing facility FC1. If set, the order adjustment unit 22 further determines the RI order quantity for each providing facility FC1 by further using the RI transport time and the RI half-life for the providing facility FC1.

Hereinafter, a method for selecting an ordering facility and a method for determining an RI order quantity will be described more specifically.
The order adjustment unit 22 selects a plurality of ordering candidate facilities as ordering candidate candidates for the target manufacturing lot from the plurality of providing facilities FC1.
At this time, the order adjustment unit 22 places an order by preferentially selecting the providing facility FC1 having a large RI amount (planned supply amount) or having a short RI transport time from the plurality of providing facilities FC1. It is preferable to limit the number of candidate facilities. By reducing the number of candidate ordering facilities, RI transportation costs and transportation risks can be reduced. The amount of RI that can be provided (planned supply amount) may be included in the manufacturing information for each providing facility FC1 as described above, or may be derived based on the manufacturing information.
When the planned supply amount is indicated with the arrival time at the preparation facility FC5 or the verification time at the use facility FC3 as a reference point, the order adjustment unit 22 preferentially selects the providing facility FC1 with a large planned supply amount. Just choose. This is because the planned supply amount in this case is a value that takes into account the radioactive decay associated with the RI transport time from the providing facility FC1 to the preparation facility FC5. On the other hand, when the planned supply amount is indicated based on the shipping time from the providing facility FC1, the order adjustment unit 22 preferentially selects the providing facility FC1 having a large planned supply amount and a short RI transport time. do it. If the difference in the planned supply amount is not so large between the providing facilities FC1, the providing facility FC1 with a short RI transport time may be selected with priority.

  Further, the order adjustment unit 22 determines a desired order quantity for each candidate ordering facility selected as described above. Specifically, the order adjustment unit 22 determines the desired order quantity of each candidate ordering facility so as not to exceed the planned supply amount of the candidate ordering facility obtained from the manufacturing information and satisfy the RI requirement. For example, the order adjustment unit 22 determines the desired order quantity of the providing facility FC1 each time while selecting the providing facility FC1 as an ordering candidate facility one by one in the order of the large planned supply amount or the short RI transport time. The provision facility FC1 is selected until the required amount is exceeded. The desired order quantity may be set to be the same as the planned supply quantity or may be set to an amount smaller than the planned supply quantity.

When the ordering candidate facility and the desired order quantity are determined in this way, the order adjustment unit 22 transmits the ordering preference information including the desired order quantity and the supply date and time to the ordering candidate facility. The ordering request information may be sent by electronic mail or file transfer, or may be displayed and output on the providing facility terminal 35.
Further, the order adjustment unit 22 may output the order candidate facility and the desired order quantity to the output device connected to the input / output I / F 3 without transmitting the order request information. In this case, the user of the ordering server 20 may view the output information, and the user himself / herself may transmit the ordering request information to the ordering candidate facility by telephone or FAX.

  The order adjustment unit 22 determines whether or not each candidate ordering facility is an ordering destination facility based on response information from each candidate ordering facility for the desired order quantity. The response information may be received from the providing facility terminal 35 by e-mail or file transfer, or may be acquired by input to the UI screen displayed on the providing facility terminal 35. Further, the answer information may be input to the ordering server 20 by operating the input device of the ordering server 20.

When the response information indicates that the order can be received, the order adjustment unit 22 determines the ordering candidate facility that is the transmission source of the response information as an ordering destination candidate, and sets the desired order quantity of the ordering candidate facility to the RI order quantity. And
When the reply information indicates that the order cannot be received, the order adjustment unit 22 excludes the order candidate facility corresponding to the reply information from the order candidate candidates of the target production lot based on the reply information, and the remaining provided facilities Select a new supplier candidate from FC1.
If the response information indicates that the order can be received if the amount is smaller than the desired order quantity, the order adjustment unit 22 reselects a new order destination candidate or responds to the reply information according to the quantity. A candidate ordering facility is determined as a candidate for a supplier. In the latter case, the order adjustment unit 22 changes the initial desired order quantity of the determined order candidate, and the RI order quantity is different from the original desired order quantity (for example, the amount set in the response information). To decide.

The ordering unit 24 performs an RI ordering process for each ordering destination facility (providing facility FC1) based on the ordering destination facility and the RI order quantity determined by the ordering adjustment unit 22. The ordering process may be executed according to a method for each ordering facility. For example, when the ordering facility requests an order by FAX, the ordering unit 24 may transmit the ordering information including the RI order quantity and the supply date / time by FAX. Further, the ordering unit 24 may print the ordering information on a printing device (output device) connected to the input / output I / F 3, and the ordering person may manually send the printed ordering information by FAX. If it is decided to place an order by e-mail with all the ordering facilities, the ordering unit 24 transmits the ordering information to an address corresponding to the ordering facility by e-mail. Good. Thus, the specific content of the ordering process executed by the ordering unit 24 is not limited.
When the ordering process is completed, the ordering unit 24 may transmit information on the ordering facility and the RI order quantity to the production management system 32.

  The transportation management unit 25 acquires information on the ordering facility from the ordering unit 24, and generates transportation information indicating the arrival time of the RI transportation means at the ordering facility or the arrival time at the preparation facility FC5. Each arrival time information may be information input via the UI screen. When the transportation company of RI is requested from the shipping company, the information on the arrival time at the ordering facility may be transmitted from the system of the shipping company. The arrival time at the formulation facility FC5 may be automatically calculated by the transport management unit 25 based on the supply date and time of the manufacturing information acquired by the facility management unit 21 and the RI transport time.

The transportation management unit 25 provides the generated transportation information to the ordering facility. For example, the transport management unit 25 may display the transport information on the providing facility terminal 35. From this transportation information, the ordering facility can grasp the arrival time of the transportation means.
In addition, the transportation management unit 25 provides the transportation information to the formulation facility FC5. Thereby, the arrival time of RI can be notified to the formulation facility FC5.
In addition, the transportation management unit 25 may perform transportation means arrangement processing for each ordering facility. For example, the transport management unit 25 may transmit ordering information for ordering vehicle arrangements to the ordering facility to the shipping company.

  After the RI arrives at the formulation facility FC5, the delivery management unit 26 accepts registration completion of RI delivery and performs an inspection process. Registration of RI delivery completion is performed, for example, from a portable terminal held by the driver or a terminal provided in the preparation facility FC5. The inspection process may be a general process, such as a process of sending delivery completion information to the accounting system.

[Radiopharmaceutical manufacturing support method]
Next, a radiopharmaceutical manufacturing support method executed by the ordering server 20 will be described in detail.
FIG. 6 is a flowchart showing a radiopharmaceutical production support method according to the present embodiment (hereinafter also referred to as the present method). This method is realized, for example, by the operation of the above-described software element. That is, the present method is realized by executing a computer program stored in the memory 2 by the CPU 1. For this reason, it can be said that the execution subject of this method is the order server 20, the CPU 1, the computer, or each of the software elements described above. However, this method allows manual intervention in each step.

  The ordering server 20 acquires production plan information from the production management system 32 (S11). This production plan information includes ID of the target preparation facility FC5 and necessary amount information indicating the RI required amount of the target production lot in the preparation facility FC5. In the following description, for convenience of explanation, it is assumed that the target formulation facility is the formulation facility FC5-1 and the target production lot is a production lot at 4 am.

The ordering server 20 extracts information (records) related to the target providing facility FC1 from the DB 27 by referring to the DB 27 based on the ID of the formulation facility FC5-1 (S12). That is, the ordering server 20 acquires the manufacturing plan and the RI transport time for each target providing facility FC1.
Here, the target providing facility FC1 is associated with the ID of the formulation facility FC5-1, and the RI is delivered to the formulation facility FC5-1 by the time of the target production lot (4 am) in the production plan. It is the providing facility FC1 that has set the supply date and time. When the supply date / time of the production plan is the shipping date / time of the providing facility FC1, the delivery time of the RI to the preparation facility FC5-1 can be predicted based on the supply date / time and the RI transport time.
In this example, it is assumed that the providing facilities FC1-1, FC1-2, FC1-3, FC1-4, and FC1-6 associated with the ID of the formulation facility FC5-1 are identified as the target providing facilities.

The ordering server 20 is based on the production plan information (particularly the RI required amount) acquired in the step (S11), the manufacturing plan for each target providing facility FC1 acquired in the step (S12), and the RI transport time. The ordering facility and the RI order quantity of each ordering facility are determined from the target providing facilities FC1-1, FC1-2, FC1-3, FC1-4, and FC1-6 (S13).
Details of the determination method in the step (S13) will be described later.

  The ordering server 20 performs RI ordering processing for each ordering destination facility (providing facility FC1) based on the ordering destination facility and the RI order quantity determined in step (S13) (S14). This ordering process is as described in the ordering part 24 process. The ordering server 20 may simply output the ordering information list indicating the ordering destination facility, the RI order quantity for the ordering destination facility, and the supply date and time of the ordering destination facility to the output device connected to the input / output I / F 3. In this case, the actual ordering work may be performed by an ordering person who has viewed the output ordering information list.

When the ordering process is completed, the ordering server 20 performs transportation means arrangement processing for each ordering destination facility (S15). As this arrangement process, the ordering server 20 can generate transportation information indicating the arrival time of the RI transportation means at the ordering facility or the arrival time at the preparation facility FC5. The process related to such transport information is as described in the process of the transport management unit 25.
The arrangement of the transportation means itself may be carried out by a person in charge. In this case, the ordering server 20 sends ordering information indicating information on each ordering destination facility and the supply date and time of each ordering destination facility to an output device connected to the input / output I / F 3 in order to support the arrangement work of the person in charge. It may be output.

  The ordering server 20 provides the transport information generated as the ordering process in the step (S15) to the ordering facility and the preparation facility FC5 (S16). The method for providing the transportation information is as described in the processing of the transportation management unit 25.

FIG. 7 is a flowchart showing a method for determining the ordering facility and the RI order quantity.
Hereinafter, the content of the step (S13) of FIG. 6 will be described in more detail.

  The ordering server 20 selects one of the target providing facilities FC1 as an ordering candidate facility in the descending order of the planned supply amount of the manufacturing plan acquired in the step (S12) or the RI transport time (S21). . At this time, when the planned irradiation amount and the planned usage amount are included in the production plan extracted from the DB 27, the ordering server 20 subtracts the planned usage amount from the planned irradiation amount, thereby providing each provision facility FC1. The planned supply amount may be calculated. This can be calculated in the same manner even if the manufacturing performance (maximum manufacturable amount) is set instead of the planned irradiation amount.

In this example, one of the target providing facilities FC1-1, FC1-2, FC1-3, FC1-4, and FC1-6 is selected as an ordering candidate facility.
Thus, the number of candidate ordering facilities can be limited by preferentially selecting the providing facility FC1 having a large RI amount (planned supply amount) or a short RI transport time as an ordering candidate facility. By reducing the number of candidate ordering facilities in this way, RI transportation costs and transportation risks can be reduced.

  The ordering server 20 determines a desired ordering quantity for the candidate ordering facility based on the planned supply quantity of the candidate ordering facility selected in the step (S21) (S22). At this time, the planned supply amount may be used as the desired order amount as it is, or an amount obtained by subtracting a predetermined amount from the planned supply amount may be used as the desired order amount.

The ordering server 20 adds up the desired ordering quantities of the candidate ordering facilities, and determines whether or not the total quantity satisfies the RI requirement quantity of the production plan information acquired in step (S11) (S23).
Here, the determination that “the total amount satisfies the RI requirement amount” may be made based on whether the total amount is larger than the RI requirement amount by a predetermined amount. According to this, when the quantity of RI of appropriate quality actually manufactured at the supplier's facility is less than the quantity ordered, the transportation is longer due to the influence of traffic conditions, etc. than the estimated RI transportation time. It can deal with risks such as when it takes time.

When the ordering server 20 determines that the total amount does not satisfy the RI requirement (S23; NO), the ordering server 20 further selects one providing facility FC1 with the next largest planned supply amount as an ordering candidate facility (S21). Then, the desired order quantity of the newly selected order candidate facility is determined (S22). Thereafter, the steps (S21) to (S23) are repeatedly executed until the total amount satisfies the RI required amount.
Here, for convenience of explanation, the providing facilities FC1-2, FC1-3, and FC1-4 among the target providing facilities FC1-1, FC1-2, FC1-3, FC1-4, and FC1-6. Is selected as an ordering candidate facility.

When the ordering server 20 determines that the total amount satisfies the RI required amount (S23; YES), it sends the ordering request information indicating the desired ordering amount and the supply date and time to each ordering candidate facility (S24). In this example, the ordering request information is transmitted to the providing facilities FC1-2, FC1-3, and FC1-4 selected as the ordering candidate facilities.
At this time, the ordering server 20 may simply output the desired order quantity and supply date and time for each candidate ordering facility to the output device connected to the input / output I / F 3 without transmitting the ordering desired information. In this case, the user of the ordering server 20 may view the output information, and the user himself / herself may transmit the ordering request information to the ordering candidate facility by telephone or FAX.

  The ordering server 20 receives response information for the ordering request information transmitted in the step (S24) from each ordering candidate facility (S25). The response information acquisition method is as described in the processing of the order adjustment unit 22. For example, the answer information may be acquired by the ordering server 20 by an input operation using an input device connected to the input / output I / F 3. In this case, the answer from each ordering candidate facility may be obtained manually by telephone, FAX, e-mail, or the like.

The ordering server 20 confirms the presence of reply information indicating that an order cannot be received (S26).
If there is response information indicating that the order cannot be received (S26; YES), the ordering server 20 excludes the provision facility that is the reply source of the response information from the ordering candidate facilities, and plans the next from the remaining provision facilities FC1. The providing facility FC1 having a large supply amount is selected again as a new ordering candidate facility (S21).
Here, when the reply information of the providing facility FC1-3 indicates that the answer is not possible, the ordering server 20 excludes the providing facility FC1-3 from the ordering candidate facilities and sets the remaining providing facilities FC1-1 and FC1-6. Reselect one of them as a candidate facility for ordering. For example, the providing facility FC1-6 is newly selected as an ordering candidate facility.
Thereafter, the process (S22) to the process (S25) are executed for the newly selected ordering candidate facility. At this time, additional ordering candidate facilities may be additionally selected based on the determination in the step (S23).

  When there is no answer information indicating that the order cannot be received in this way (S26; NO), the ordering server 20 confirms the presence of the answer information indicating that the order cannot be received under certain conditions (S27). This response information indicates that an order can be accepted if the amount is smaller than the desired order quantity. If such answer information exists (S27: YES), the ordering server 20 changes the original desired order quantity within a range not exceeding the quantity indicated by the answer information (S28).

The ordering server 20 determines again whether or not the total amount of the desired order quantity satisfies the RI requirement quantity because the total quantity of the desired order quantity decreases in the step (S28) (S29).
When the total amount does not satisfy the RI requirement amount (S29: NO), the ordering server 20 returns to the step (S21) and additionally selects one ordering candidate facility from the remaining provided facilities FC1.

  In this way, when there is no response information indicating that the order cannot be accepted and the conditional order cannot be accepted (S26; NO), (S27; NO) or (S29; YES), the ordering server 20 assigns all ordering candidate facilities to the ordering destination. The facility is determined (S30), and the desired order quantity of each candidate ordering facility is determined as the RI order quantity of each ordering facility (S31).

The ordering facility and the RI order quantity determination method in the step (S13) of FIG. 6 are not limited to the method shown in FIG. For example, each time one candidate ordering facility is selected, transmission of ordering request information and reception of response information may be performed to determine each time whether or not the candidate ordering facility is the ordering destination facility.
Also in the step (S21), an ordering candidate facility may be selected in consideration of other priorities in addition to the magnitude of the planned supply amount. Examples of the priority include the reliability of the providing facility FC1. In other words, ordering candidate facilities may be selected in descending order of reliability and planned supply amount.
Further, before executing the step (S28), the amount indicated by the response information is compared with the planned supply amount of the remaining providing facility FC1, and the amount is larger than the planned supply amount of the remaining providing facility FC1. In addition, the step (S28) may be executed. If the planned supply amount of the remaining provision facility FC1 is larger than the amount, the provision facility FC1 that is the reply source of the reply information may be excluded from the ordering candidate facilities.

In the flowcharts shown in FIGS. 6 and 7, a plurality of steps (processes) are described in order, but the execution order of the steps is not limited to the description order. The order of the steps shown in the figure can be changed within a range that does not hinder the contents.
Moreover, it is desirable to complete this method on the day before the date of the production lot to be processed. On the other hand, between the execution time of the step (S24) and the execution time of the step (S25), a study time on the side of the providing facility FC1 is required, and therefore a certain amount of time is required. That is, a certain amount of time is required from the start to the completion of the method. In consideration of this point, it is only necessary to determine the start time of execution of the method based on the date and time of the production lot to be processed.

[Supplement]
As described above, the item referred to as “amount of RI” is set as an amount at a certain reference time point. Items referred to as “amount of RI” include the required RI amount of production plan information, the planned supply amount of the production plan, the desired order amount of RI, and the RI order amount. All of these may be indicated based on a common reference time point, or may be indicated based on different reference time points individually. In the latter case, for example, the required amount of RI is indicated by an amount with the time of drug production at the preparation facility FC5 as a reference time, and the planned supply amount, desired order amount, and RI order amount are the same as the shipment time at the providing facility FC1. It is shown in the amount used as the reference time point. Note that the method of setting the reference time point is not limited at all.
Further, the ordering server 20, the order receiving system 31, the production management system 32, and the delivery management system 33 shown in FIG. 3 may be operated within a company that operates the pharmaceutical facility FC5 (on-premises) or outside the company ( For example, it may be operated in the cloud). Of course, only the order server 20 may be operated outside the company (cloud). Further, as described above, when the ordering server 20 is realized by a plurality of computers, a part of the software elements (see FIG. 4) of the ordering server 20 is operated on a computer operated outside the company (cloud). It may be realized with. For example, the provided facility information DB 27 may be realized on a server on the cloud.

[Modification]
The above-described embodiment can be modified as appropriate within a range that does not hinder the contents.
For example, the ordering server 20 may not include the ordering unit 24, the transportation management unit 25, and the delivery management unit 26. That is, after the ordering facility and the RI order quantity are determined, the actual ordering process may not be performed by the ordering server 20. Similarly, the ordering server 20 does not have to carry out transportation means arrangement processing to the ordering facility or RI delivery management. In this case, the manufacturing support method shown in FIG. 6 may not include the step (S14), the step (S15), and the step (S16).

The above contents can also be specified as follows. However, the following description does not limit the above-mentioned content.
(Supplementary note 1) Facility management department for acquiring radionuclide production information in a plurality of providing facilities having cyclotrons,
A preparation management unit for obtaining necessary amount information indicating the amount of the radionuclide required in a production lot in a preparation facility that receives the provision of the radionuclide and produces a radiopharmaceutical;
Based on the acquired manufacturing information and necessary amount information, an order adjusting unit that selects one or more providing facilities as the ordering facility of the radionuclide for the production lot from the plurality of providing facilities;
A radiopharmaceutical manufacturing support apparatus.
(Supplementary Note 2) When the ordering adjustment unit selects a plurality of the ordering destination facilities, the ordering adjustment unit is an amount that each of the plurality of ordering destination facilities can provide and satisfies the necessary amount indicated by the necessary amount information. Determining an order quantity for each of the plurality of customer facilities;
The radiopharmaceutical manufacturing support apparatus according to (Appendix 1).
(Appendix 3) The order adjustment unit is
Selecting a plurality of ordering candidate facilities as candidates for the order of the radionuclide for the production lot from the plurality of providing facilities,
Determining a desired order quantity for each of the plurality of candidate ordering facilities;
Based on the response information from the plurality of candidate ordering facilities for the desired order quantity, it is determined whether or not each of the plurality of candidate ordering facilities is the ordering destination facility.
The radiopharmaceutical manufacturing support apparatus according to (Appendix 1) or (Appendix 2).
(Supplementary Note 4) Based on the response information, the order adjustment unit excludes the order candidate facility corresponding to the response information from the order candidate candidates for the radionuclide for the production lot, and Re-select new supplier candidates
The radiopharmaceutical manufacturing support apparatus according to (Appendix 3).
(Appendix 5) The order adjustment unit determines, based on the answer information, an ordering candidate facility corresponding to the answer information as the ordering facility, and changes the desired order quantity of the ordering facility.
The radiopharmaceutical manufacturing support apparatus according to (Appendix 3) or (Appendix 4).
(Appendix 6) The order adjustment unit preferentially selects a providing facility having a large amount of the radionuclide that can be provided or a short transportation time of the radionuclide from the plurality of providing facilities, Limit the number of candidate facilities
The radiopharmaceutical production support apparatus according to any one of (Appendix 3) to (Appendix 5).
(Supplementary Note 7) A transport management unit that generates transport information indicating an arrival time of the radionuclide transportation means at the ordering facility or an arrival time at the preparation facility,
(Appendix 1) to (Appendix 6) The radiopharmaceutical production support device according to any one of (Appendix 1) to (Appendix 6).
(Appendix 8) Obtaining radionuclide production information at multiple provision facilities with cyclotrons,
Obtain necessary amount information indicating the amount of the radionuclide required in a production lot in a pharmaceutical facility that receives the provision of the radionuclide and produces a radiopharmaceutical,
Based on the acquired manufacturing information and necessary amount information, one or more providing facilities are selected from the plurality of providing facilities as an ordering facility of the radionuclide for the production lot.
A manufacturing support method for a radiopharmaceutical.
(Supplementary Note 9) When a plurality of the ordering destination facilities are selected, the plurality of ordering destination facilities are such that each of the plurality of ordering destination facilities can provide and satisfy the necessary amount indicated by the necessary amount information. Determine the order quantity for each
The manufacturing support method of the radiopharmaceutical as described in (Appendix 8).
(Supplementary Note 10) Select a plurality of ordering candidate facilities as the ordering candidates of the radionuclide for the production lot from the plurality of providing facilities,
Determining a desired order quantity for each of the plurality of candidate ordering facilities;
Based on the response information from the plurality of candidate ordering facilities for the desired order quantity, it is determined whether or not each of the plurality of candidate ordering facilities is the ordering destination facility.
(Supplementary Note 8) or (Supplementary Note 9).
(Additional remark 11) Based on the said reply information, the ordering candidate facility corresponding to this reply information is excluded from the said ordering party candidate of the said radionuclide for the said production lot,
Re-select a new supplier candidate from the plurality of providing facilities,
The manufacturing support method of the radiopharmaceutical as described in (Appendix 10).
(Supplementary Note 12) Based on the answer information, the ordering candidate facility corresponding to the answer information is determined as the ordering destination facility, and the desired order quantity of the ordering destination facility is changed.
(Appendix 10) or (Appendix 11), further comprising:
(Additional remark 13) In selection of the said order candidate facility, by selecting preferentially a providing facility with a large amount of the radionuclide that can be provided or a short transportation time of the radionuclide from among the plurality of providing facilities. Limit the number of candidate ordering facilities;
The manufacturing support method for a radiopharmaceutical according to any one of (Appendix 10) to (Appendix 12).
(Supplementary Note 14) Generate transportation information indicating arrival time of the radionuclide transportation means at the ordering facility or arrival time at the preparation facility,
The manufacturing support method for a radiopharmaceutical according to any one of (Appendix 8) to (Appendix 13).

1 CPU
2 Memory 3 Input / output I / F
4 Communication Unit 10 Radiopharmaceutical Manufacturing Support Server (Support Server)
DESCRIPTION OF SYMBOLS 11 Facility management part 13 Formulation management part 15 Order adjustment part 20 Order server 21 Facility management part 22 Order adjustment part 23 Formulation management part 24 Ordering part 25 Transport management part 26 Delivery management part 27 Provided facility information DB (DB)
31 Order receiving system 32 Production management system 33 Delivery management system 35 Provided facility terminal

Claims (8)

A facility management section for obtaining radionuclide production information at a plurality of facilities having cyclotrons;
A preparation management unit for obtaining necessary amount information indicating the amount of the radionuclide required in a production lot in a preparation facility that receives the provision of the radionuclide and produces a radiopharmaceutical;
Based on the acquired manufacturing information and necessary amount information, an order adjusting unit that selects one or more providing facilities as the ordering facility of the radionuclide for the production lot from the plurality of providing facilities;
A radiopharmaceutical manufacturing support apparatus. The order adjustment unit, when a plurality of the ordering facility is selected, the ordering unit is an amount that each of the plurality of ordering facility can provide and satisfies the required amount indicated by the required amount information. Determine the order quantity for each facility
The manufacturing support apparatus of the radiopharmaceutical of Claim 1. The order adjustment unit
Selecting a plurality of ordering candidate facilities as candidates for the order of the radionuclide for the production lot from the plurality of providing facilities,
Determining a desired order quantity for each of the plurality of candidate ordering facilities;
Based on the response information from the plurality of candidate ordering facilities for the desired order quantity, it is determined whether or not each of the plurality of candidate ordering facilities is the ordering destination facility.
The manufacturing support apparatus of the radiopharmaceutical of Claim 1 or 2. The order adjustment unit excludes an ordering candidate facility corresponding to the answer information from the ordering candidate for the radionuclide for the production lot based on the answer information, and creates a new one from the plurality of providing facilities. Re-select supplier candidates,
The manufacturing support apparatus of the radiopharmaceutical of Claim 3. The order adjustment unit determines an ordering candidate facility corresponding to the answer information as the ordering destination facility based on the answer information, and changes the desired order quantity of the ordering destination facility.
The manufacturing support apparatus of the radiopharmaceutical of Claim 3 or 4. The order adjustment unit preferentially selects a providing facility having a large amount of the radionuclide that can be provided or a short transportation time of the radionuclide from the plurality of providing facilities, thereby Limit the number,
The manufacturing support apparatus of the radiopharmaceutical as described in any one of Claim 3 to 5. A transport management unit that generates transport information indicating an arrival time of the radionuclide transportation means at the ordering facility or an arrival time at the preparation facility;
The manufacturing support apparatus for a radiopharmaceutical according to any one of claims 1 to 6, further comprising: Obtain radionuclide production information at multiple facilities with cyclotrons,
Obtain necessary amount information indicating the amount of the radionuclide required in a production lot in a pharmaceutical facility that receives the provision of the radionuclide and produces a radiopharmaceutical,
Based on the acquired manufacturing information and necessary amount information, one or more providing facilities are selected from the plurality of providing facilities as an ordering facility of the radionuclide for the production lot.
A manufacturing support method for a radiopharmaceutical.

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