JP2017527614A - 重水素化又は非重水素化分子及び医薬製剤 - Google Patents

重水素化又は非重水素化分子及び医薬製剤 Download PDF

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JP2017527614A
JP2017527614A JP2017531457A JP2017531457A JP2017527614A JP 2017527614 A JP2017527614 A JP 2017527614A JP 2017531457 A JP2017531457 A JP 2017531457A JP 2017531457 A JP2017531457 A JP 2017531457A JP 2017527614 A JP2017527614 A JP 2017527614A
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tetrahydrocurcumin
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ブピンダー シン
ブピンダー シン
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JP2017531457A 2014-09-02 2015-08-31 重水素化又は非重水素化分子及び医薬製剤 Pending JP2017527614A (ja)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021526221A (ja) * 2018-05-24 2021-09-30 レニバス・セラピューティクス・インコーポレイテッド 腎障害及び腎不全のリスクのある患者を治療する方法
JP2024028798A (ja) * 2019-11-07 2024-03-05 サイビン ユーケー リミテッド 化合物
JP2024513775A (ja) * 2021-03-25 2024-03-27 サミ-サビンサ グループ リミテッド 腎症を管理するための組成物及び方法

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1888548E (pt) 2005-05-26 2012-10-30 Neuron Systems Inc Derivado de quinolina para o tratamento de doenças da retina
WO2011072141A1 (en) 2009-12-11 2011-06-16 Neuron Systems, Inc. Compositions and methods for the treatment of macular degeneration
CA2898631C (en) 2013-01-23 2023-06-13 Aldeyra Therapeutics, Inc. Toxic aldehyde related diseases and treatment
EP3628640B1 (en) 2014-09-02 2023-08-09 Hub Therapeutics Methods of making a deuterated or a non-deuterated molecule and pharmaceutical formulations for treatment
CN118724806A (zh) 2015-08-21 2024-10-01 奥尔德拉医疗公司 氘化化合物和其用途
US11129823B2 (en) 2016-05-09 2021-09-28 Aldeyra Therapeutics, Inc. Combination treatment of ocular inflammatory disorders and diseases
WO2017218004A1 (en) * 2016-06-17 2017-12-21 Michael Hudnall Medical food for patients with chronic liver disease
MX2019010576A (es) 2017-03-16 2019-10-07 Aldeyra Therapeutics Inc Compuestos polimorficos y usos de los mismos.
US10934241B2 (en) * 2017-06-16 2021-03-02 University Of North Florida Board Of Trustees Curcuminoid-inspired synthetic compounds as anti-tumor agents
US11117907B2 (en) 2017-06-16 2021-09-14 University Of North Florida Board Of Trustees Curcuminoid-inspired synthetic compounds as anti-tumor agents
JP7311162B2 (ja) 2017-10-10 2023-07-19 アルデイラ セラピューティクス, インコーポレイテッド 炎症性障害の処置
WO2020033344A1 (en) 2018-08-06 2020-02-13 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
WO2020181256A1 (en) * 2019-03-06 2020-09-10 Renibus Therapeutics, Inc. Novel tetrahydrocurcumin compositions, methods of making, and methods of using the same
CN113784954A (zh) 2019-05-02 2021-12-10 奥尔德拉医疗公司 多晶型化合物和其用途
US12098132B2 (en) 2019-05-02 2024-09-24 Aldeyra Therapeutics, Inc. Process for preparation of aldehyde scavenger and intermediates
CA3142023A1 (en) * 2019-05-28 2020-12-03 Case Western Reserve University Compositions and methods for preserving dna methylation
CN111017878B (zh) * 2019-12-18 2021-12-17 中国原子能科学研究院 一种用于制备平衡态h2-hd-d2标准气体的装置和方法
WO2021138561A1 (en) * 2019-12-31 2021-07-08 Renibus Therapeutics, Inc. Novel tetrahydrocurcumin compositions, methods of making, and methods of using the same
US11883371B2 (en) * 2020-03-23 2024-01-30 Renibus Therapeutics, Inc. Stress test and treatment of chronic kidney disease
CA3175856A1 (en) 2020-05-13 2021-11-18 Todd Brady Pharmaceutical formulations and uses thereof
AU2021281223A1 (en) 2020-05-27 2023-01-05 Case Western Reserve University Compositions and methods for preserving DNA methylation
CN111759820B (zh) * 2020-08-24 2022-04-19 武汉人福药业有限责任公司 一种奥卡西平片剂及其制备方法

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11246398A (ja) * 1998-03-02 1999-09-14 Kyowa Hakko Kogyo Co Ltd 生体内過酸化脂質増加に起因する疾患の予防または治療剤
JP2006512943A (ja) * 2002-11-20 2006-04-20 アイソテクニカ, インターナショナル インコーポレイテッド 重水素化ラパマイシンの制御された送達のための、重水素化ラパマイシンを組み込む医療用デバイス
JP2007517909A (ja) * 2004-01-14 2007-07-05 ギリアード サイエンシーズ, インコーポレイテッド 薬物送達に有用な脂質ベースの分散物
JP2007320864A (ja) * 2006-05-30 2007-12-13 Toshihiko Osawa 非アルコール性脂肪肝炎予防・治療用組成物
JP2008133272A (ja) * 2006-10-31 2008-06-12 Ito En Ltd Cpt活性亢進剤及び飲食物
WO2008093848A1 (ja) * 2007-02-02 2008-08-07 Sunstar Inc. ホスファチジルコリンを含有する炎症マーカー低減組成物
JP2008201768A (ja) * 2006-11-24 2008-09-04 Mizu Kk 抗炎症剤及びシクロオキシゲナーゼ阻害剤
JP2009502872A (ja) * 2005-07-26 2009-01-29 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 同位体置換されたパントプラゾール
JP2009511481A (ja) * 2005-10-06 2009-03-19 オースペックス・ファーマシューティカルズ・インコーポレイテッド 増強された治療特性を持つ、胃H+,K+−ATPaseの重水素化阻害剤
CN101627969A (zh) * 2009-07-30 2010-01-20 浙江工业大学 一种新型的姜黄素自乳化给药系统及其制备
CN101732292A (zh) * 2010-01-25 2010-06-16 四川省中医药科学院 四氢姜黄素的新用途
JP2010260816A (ja) * 2009-05-07 2010-11-18 Theravalues Corp ウコン色素組成物による心機能改善効果

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5276182A (en) 1990-07-09 1994-01-04 The Dow Chemical Company Process for preparing polyurea oligomers
DE4039602A1 (de) 1990-12-12 1992-06-17 Bauer Kurt Heinz Prof Dr Pharmazeutische formulierungen
KR100221695B1 (ko) 1991-08-12 1999-09-15 그린 마틴, 브라이언 쥐 테슬리 약학적 구상 제형
US5683676A (en) 1991-12-12 1997-11-04 Glaxo Group Limited Canister containing aerosol formulations containing P134a and particulate medicaments
ES2224200T3 (es) 1992-11-27 2005-03-01 Mayne Pharma (Usa) Inc. Composicion inyectable estable de paclitaxel.
US5654286A (en) 1993-05-12 1997-08-05 Hostetler; Karl Y. Nucleotides for topical treatment of psoriasis, and methods for using same
CZ301771B6 (cs) 1993-10-01 2010-06-16 Syntex (U.S.A.) Llc. Farmaceutický prostredek ve forme suchého granulátu obsahující mofetil mykofenolát nebo kyselinu mykofenolovou a zpusob jeho prípravy
US5707641A (en) 1994-10-13 1998-01-13 Pharmaderm Research & Development Ltd. Formulations comprising therapeutically-active proteins or polypeptides
IE80468B1 (en) 1995-04-04 1998-07-29 Elan Corp Plc Controlled release biodegradable nanoparticles containing insulin
US5653987A (en) 1995-05-16 1997-08-05 Modi; Pankaj Liquid formulations for proteinic pharmaceuticals
US5726181A (en) 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
US5667809A (en) 1995-06-07 1997-09-16 Alliance Pharmaceutical Corp. Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents
US6342507B1 (en) * 1997-09-05 2002-01-29 Isotechnika, Inc. Deuterated rapamycin compounds, method and uses thereof
US7442720B2 (en) * 2003-12-19 2008-10-28 Omega Bio-Pharma (I.P.3) Limited Compositions and methods for treating diabetes
US8841326B2 (en) * 2004-02-12 2014-09-23 Stc.Unm Therapeutic curcumin derivatives
CN1283237C (zh) 2004-11-22 2006-11-08 山东大学 姜黄素磷脂复合物及其制备方法
US7776915B2 (en) 2005-03-24 2010-08-17 Tracie Martyn International, Llc Topical formulations and methods of use
WO2010097643A1 (en) * 2009-02-24 2010-09-02 Novatech Istrazivanje D.O.O. Formulation based on micronized zeolite, green tea extract, and genistein as a therapeutic agent for reduction of body weight and cellulite
WO2011047309A2 (en) * 2009-10-16 2011-04-21 The Research Foundation Of State University Of New York Treatment of ischemic tissue
CN102526003B (zh) * 2010-01-25 2014-02-19 四川省中医药科学院 四氢姜黄素的用途
WO2011116066A1 (en) * 2010-03-17 2011-09-22 Concert Pharmaceuticals, Inc. Derivatives of dimethylcurcumin
WO2013033250A1 (en) * 2011-09-01 2013-03-07 Xiangping Qian Certain chemical entities, compositions, and methods
CN104739813A (zh) * 2013-12-26 2015-07-01 四川省中医药科学院 四氢姜黄素的新用途
EP3628640B1 (en) * 2014-09-02 2023-08-09 Hub Therapeutics Methods of making a deuterated or a non-deuterated molecule and pharmaceutical formulations for treatment

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11246398A (ja) * 1998-03-02 1999-09-14 Kyowa Hakko Kogyo Co Ltd 生体内過酸化脂質増加に起因する疾患の予防または治療剤
JP2006512943A (ja) * 2002-11-20 2006-04-20 アイソテクニカ, インターナショナル インコーポレイテッド 重水素化ラパマイシンの制御された送達のための、重水素化ラパマイシンを組み込む医療用デバイス
JP2007517909A (ja) * 2004-01-14 2007-07-05 ギリアード サイエンシーズ, インコーポレイテッド 薬物送達に有用な脂質ベースの分散物
JP2009502872A (ja) * 2005-07-26 2009-01-29 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 同位体置換されたパントプラゾール
JP2009511481A (ja) * 2005-10-06 2009-03-19 オースペックス・ファーマシューティカルズ・インコーポレイテッド 増強された治療特性を持つ、胃H+,K+−ATPaseの重水素化阻害剤
JP2007320864A (ja) * 2006-05-30 2007-12-13 Toshihiko Osawa 非アルコール性脂肪肝炎予防・治療用組成物
JP2008133272A (ja) * 2006-10-31 2008-06-12 Ito En Ltd Cpt活性亢進剤及び飲食物
JP2008201768A (ja) * 2006-11-24 2008-09-04 Mizu Kk 抗炎症剤及びシクロオキシゲナーゼ阻害剤
WO2008093848A1 (ja) * 2007-02-02 2008-08-07 Sunstar Inc. ホスファチジルコリンを含有する炎症マーカー低減組成物
JP2010260816A (ja) * 2009-05-07 2010-11-18 Theravalues Corp ウコン色素組成物による心機能改善効果
CN101627969A (zh) * 2009-07-30 2010-01-20 浙江工业大学 一种新型的姜黄素自乳化给药系统及其制备
CN101732292A (zh) * 2010-01-25 2010-06-16 四川省中医药科学院 四氢姜黄素的新用途

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AAPS PHARMSCITECH, vol. 12, no. 1, JPN6019025333, 2011, pages 152 - 164, ISSN: 0004385304 *
BIOCHEMICAL PHARMACOLOGY, vol. 75, JPN6019025337, 2008, pages 787 - 809, ISSN: 0004069716 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021526221A (ja) * 2018-05-24 2021-09-30 レニバス・セラピューティクス・インコーポレイテッド 腎障害及び腎不全のリスクのある患者を治療する方法
US11965896B2 (en) 2018-05-24 2024-04-23 Renibus Therapeutics, Inc. Methods of treating patients at risk for renal injury and renal failure
JP2024028798A (ja) * 2019-11-07 2024-03-05 サイビン ユーケー リミテッド 化合物
JP7748437B2 (ja) 2019-11-07 2025-10-02 サイビン ユーケー リミテッド 化合物
JP2024513775A (ja) * 2021-03-25 2024-03-27 サミ-サビンサ グループ リミテッド 腎症を管理するための組成物及び方法

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