JP2017502015A - 乾燥注腸製品 - Google Patents
乾燥注腸製品 Download PDFInfo
- Publication number
- JP2017502015A JP2017502015A JP2016540562A JP2016540562A JP2017502015A JP 2017502015 A JP2017502015 A JP 2017502015A JP 2016540562 A JP2016540562 A JP 2016540562A JP 2016540562 A JP2016540562 A JP 2016540562A JP 2017502015 A JP2017502015 A JP 2017502015A
- Authority
- JP
- Japan
- Prior art keywords
- mesalazine
- pharmaceutical composition
- granules
- agent
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/606—Salicylic acid; Derivatives thereof having amino groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
以下の表1に示す各実験において、活性成分は、回転混合造粒機(RMG)において、表に示されたそれぞれの量および重量比で賦形剤と混合され、結合剤に水を用いて造粒される。ついで、顆粒は、60℃で60分間乾燥機内で乾燥された。その後、乾燥した顆粒を1.0mmメッシュ篩により篩過した。
メサラジン2gを含む3.95gの顆粒(実施例1と同様に製造)を、5分間の静止期間をはさんで30秒間を2回、手動で振とうすることにより容器内において水(25℃)で100mlに再構成した。懸濁液の粘度を、50rpmで操作されるスピンドル3を備えたブルックフィールド(Brookfield's)粘度計を用いて測定した。
Claims (12)
- a.注腸剤への再構成に適したメサラジン顆粒、および
b.一方向弁を含む注腸ボトル
を含む医薬組成物。 - 注腸ボトルが生分解性である請求項1記載の医薬組成物。
- メサラジン顆粒が、等張化剤、粘性剤および/または崩壊剤を含む請求項1または2記載の医薬組成物。
- 等張化剤および崩壊剤が、1:0.8〜1:2.5、好ましくは1:0.8〜1:1.5、より好ましくは1:0.9〜1:1.2の範囲の重量比で存在する請求項3記載の医薬組成物。
- 崩壊剤および粘性剤が、1:0.1〜1:0.5、好ましくは1:0.2〜1:0.5の範囲の重量比で存在する請求項3記載の医薬組成物。
- メサラジン顆粒が、顆粒全重量に対して:
a.30%〜70%w/wのメサラジン、好ましくは34〜65%w/wのメサラジン、および
b.5%〜15%w/wの粘性剤、好ましくは7%〜13%w/wの粘性剤、および
c.10%〜30%w/wの崩壊剤、好ましくは15%〜25%w/wの崩壊剤、および
d.10〜30%w/wの等張化剤、好ましくは13%〜28%w/wの等張化剤
を含む請求項1〜5のいずれか1項に記載の医薬組成物。 - 等張化剤が塩化ナトリウムである請求項3〜6のいずれか1項に記載の医薬組成物。
- 粘性剤がガムである請求項3〜6のいずれか1項に記載の医薬組成物。
- 崩壊剤がクロスカルメロースナトリウムである請求項3〜6のいずれか1項に記載の医薬組成物。
- メサラジン顆粒が、25℃で100mlの容量に水で再構成された場合、200cpsより大きく500cps未満、好ましくは220cps〜480cpsの粘度を有する懸濁液を形成する請求項1〜9のいずれか1項に記載の医薬組成物。
- メサラジンまたはその薬学的に許容され得る塩を500〜5000mgの量で含有する請求項1〜10のいずれか1項に記載の医薬組成物。
- メサラジン顆粒が、小袋またはスティックパックなどの一回用量の容器中に存在する請求項1〜11のいずれか1項に記載の医薬組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13199035.0 | 2013-12-20 | ||
EP13199035 | 2013-12-20 | ||
PCT/NL2014/050881 WO2015093955A1 (en) | 2013-12-20 | 2014-12-18 | Dry enema product |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2017502015A true JP2017502015A (ja) | 2017-01-19 |
Family
ID=49880552
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016540562A Pending JP2017502015A (ja) | 2013-12-20 | 2014-12-18 | 乾燥注腸製品 |
Country Status (7)
Country | Link |
---|---|
US (1) | US20170000727A1 (ja) |
EP (1) | EP3082770A1 (ja) |
JP (1) | JP2017502015A (ja) |
CN (1) | CN105658205A (ja) |
AR (1) | AR098883A1 (ja) |
CA (1) | CA2932313A1 (ja) |
WO (1) | WO2015093955A1 (ja) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023230223A1 (en) * | 2022-05-25 | 2023-11-30 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Tenofovir spray drying sachet enema powder formulation for hiv prevention |
CN116173044A (zh) * | 2023-03-24 | 2023-05-30 | 优畅达(武汉)医疗科技有限公司 | 一种含美沙拉嗪的组合物,制剂及其制备方法和应用 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179051A (en) * | 1977-08-01 | 1979-12-18 | Ryder International Corporation | One-piece check valve for use in a fluid dispenser |
JPH05148159A (ja) * | 1991-09-11 | 1993-06-15 | Euro Celtique Sa | 医薬用放出制御組成物 |
JP2000042101A (ja) * | 1998-07-31 | 2000-02-15 | Gureitochiren:Kk | 浣腸方法及び浣腸補助具 |
US20030143261A1 (en) * | 2000-06-09 | 2003-07-31 | The Procter & Gamble Company | Method of and items for reducing latex exposure |
JP2006104194A (ja) * | 2004-09-10 | 2006-04-20 | Otsuka Pharmaceut Co Ltd | 用時調製型レバミピド注腸製剤 |
JP2013503150A (ja) * | 2009-08-26 | 2013-01-31 | ノルディック ファーマ | Ibd治療のための医薬組成物 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5378470A (en) * | 1989-07-25 | 1995-01-03 | Henning Berlin Gmbh | Rectally administered pharmaceutical preparation |
GB2318511A (en) | 1996-10-23 | 1998-04-29 | Eurand Int | Process for the preparation of a pharmaceutical composition for rapid suspension in water |
CN1887346A (zh) * | 2005-06-28 | 2007-01-03 | 长春生物制品研究所 | 重组人干扰素α-胸腺肽药物组合物及其应用剂型 |
-
2014
- 2014-12-18 JP JP2016540562A patent/JP2017502015A/ja active Pending
- 2014-12-18 CA CA2932313A patent/CA2932313A1/en not_active Abandoned
- 2014-12-18 WO PCT/NL2014/050881 patent/WO2015093955A1/en active Application Filing
- 2014-12-18 EP EP14825463.4A patent/EP3082770A1/en not_active Withdrawn
- 2014-12-18 CN CN201480057775.0A patent/CN105658205A/zh active Pending
- 2014-12-18 US US15/104,284 patent/US20170000727A1/en not_active Abandoned
- 2014-12-19 AR ARP140104822A patent/AR098883A1/es unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179051A (en) * | 1977-08-01 | 1979-12-18 | Ryder International Corporation | One-piece check valve for use in a fluid dispenser |
JPH05148159A (ja) * | 1991-09-11 | 1993-06-15 | Euro Celtique Sa | 医薬用放出制御組成物 |
JP2000042101A (ja) * | 1998-07-31 | 2000-02-15 | Gureitochiren:Kk | 浣腸方法及び浣腸補助具 |
US20030143261A1 (en) * | 2000-06-09 | 2003-07-31 | The Procter & Gamble Company | Method of and items for reducing latex exposure |
JP2006104194A (ja) * | 2004-09-10 | 2006-04-20 | Otsuka Pharmaceut Co Ltd | 用時調製型レバミピド注腸製剤 |
JP2013503150A (ja) * | 2009-08-26 | 2013-01-31 | ノルディック ファーマ | Ibd治療のための医薬組成物 |
Also Published As
Publication number | Publication date |
---|---|
WO2015093955A1 (en) | 2015-06-25 |
EP3082770A1 (en) | 2016-10-26 |
AR098883A1 (es) | 2016-06-22 |
US20170000727A1 (en) | 2017-01-05 |
CA2932313A1 (en) | 2015-06-25 |
CN105658205A (zh) | 2016-06-08 |
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Legal Events
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Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20161129 |
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Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20170619 |
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