JP2016538539A5 - - Google Patents
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- JP2016538539A5 JP2016538539A5 JP2016527380A JP2016527380A JP2016538539A5 JP 2016538539 A5 JP2016538539 A5 JP 2016538539A5 JP 2016527380 A JP2016527380 A JP 2016527380A JP 2016527380 A JP2016527380 A JP 2016527380A JP 2016538539 A5 JP2016538539 A5 JP 2016538539A5
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- cancer
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- cancer treatment
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- 206010028980 Neoplasm Diseases 0.000 claims description 93
- 238000000034 method Methods 0.000 claims description 89
- 201000011510 cancer Diseases 0.000 claims description 78
- 238000011282 treatment Methods 0.000 claims description 63
- 206010067484 Adverse reaction Diseases 0.000 claims description 28
- 230000006838 adverse reaction Effects 0.000 claims description 28
- 210000004027 cell Anatomy 0.000 claims description 24
- 230000001225 therapeutic effect Effects 0.000 claims description 16
- 239000002875 cyclin dependent kinase inhibitor Substances 0.000 claims description 8
- 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 claims description 8
- 229940126074 CDK kinase inhibitor Drugs 0.000 claims description 7
- 102100034770 Cyclin-dependent kinase inhibitor 3 Human genes 0.000 claims description 7
- 101000945639 Homo sapiens Cyclin-dependent kinase inhibitor 3 Proteins 0.000 claims description 7
- 210000001700 mitochondrial membrane Anatomy 0.000 claims description 7
- 239000002246 antineoplastic agent Substances 0.000 claims description 6
- 230000007608 epigenetic mechanism Effects 0.000 claims description 6
- 201000005787 hematologic cancer Diseases 0.000 claims description 6
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims description 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 6
- 229940127089 cytotoxic agent Drugs 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 239000003607 modifier Substances 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical group O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims description 4
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 4
- 101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 claims description 4
- 102100026539 Induced myeloid leukemia cell differentiation protein Mcl-1 Human genes 0.000 claims description 4
- 206010045170 Tumour lysis syndrome Diseases 0.000 claims description 4
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- 229960000684 cytarabine Drugs 0.000 claims description 4
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- RZCJYMOBWVJQGV-UHFFFAOYSA-N 2-naphthyloxyacetic acid Chemical compound C1=CC=CC2=CC(OCC(=O)O)=CC=C21 RZCJYMOBWVJQGV-UHFFFAOYSA-N 0.000 claims description 2
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 claims description 2
- XAUDJQYHKZQPEU-KVQBGUIXSA-N 5-aza-2'-deoxycytidine Chemical compound O=C1N=C(N)N=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XAUDJQYHKZQPEU-KVQBGUIXSA-N 0.000 claims description 2
- NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 claims description 2
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims description 2
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 claims description 2
- -1 BCLXL Proteins 0.000 claims description 2
- HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 claims description 2
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 claims description 2
- XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 claims description 2
- XDXDZDZNSLXDNA-UHFFFAOYSA-N Idarubicin Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XDXDZDZNSLXDNA-UHFFFAOYSA-N 0.000 claims description 2
- 102000010638 Kinesin Human genes 0.000 claims description 2
- 108010063296 Kinesin Proteins 0.000 claims description 2
- 229940079156 Proteasome inhibitor Drugs 0.000 claims description 2
- 230000006907 apoptotic process Effects 0.000 claims description 2
- 229960002756 azacitidine Drugs 0.000 claims description 2
- 239000000090 biomarker Substances 0.000 claims description 2
- 210000004748 cultured cell Anatomy 0.000 claims description 2
- 229960000975 daunorubicin Drugs 0.000 claims description 2
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims description 2
- 229960003603 decitabine Drugs 0.000 claims description 2
- 239000003534 dna topoisomerase inhibitor Substances 0.000 claims description 2
- 229960004679 doxorubicin Drugs 0.000 claims description 2
- INVTYAOGFAGBOE-UHFFFAOYSA-N entinostat Chemical compound NC1=CC=CC=C1NC(=O)C(C=C1)=CC=C1CNC(=O)OCC1=CC=CN=C1 INVTYAOGFAGBOE-UHFFFAOYSA-N 0.000 claims description 2
- 229950005837 entinostat Drugs 0.000 claims description 2
- 230000001973 epigenetic effect Effects 0.000 claims description 2
- 229960001904 epirubicin Drugs 0.000 claims description 2
- 229960000908 idarubicin Drugs 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 229960001156 mitoxantrone Drugs 0.000 claims description 2
- KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 claims description 2
- 231100001143 noxa Toxicity 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 239000003207 proteasome inhibitor Substances 0.000 claims description 2
- 229940044693 topoisomerase inhibitor Drugs 0.000 claims description 2
- WAEXFXRVDQXREF-UHFFFAOYSA-N vorinostat Chemical compound ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1 WAEXFXRVDQXREF-UHFFFAOYSA-N 0.000 claims description 2
- 229960000237 vorinostat Drugs 0.000 claims description 2
- 238000011275 oncology therapy Methods 0.000 claims 2
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- 230000035572 chemosensitivity Effects 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 230000002489 hematologic effect Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 210000003470 mitochondria Anatomy 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 102000054765 polymorphisms of proteins Human genes 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 230000004044 response Effects 0.000 description 5
- 230000008823 permeabilization Effects 0.000 description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical group [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- 230000002411 adverse Effects 0.000 description 3
- 102000003964 Histone deacetylase Human genes 0.000 description 2
- 108090000353 Histone deacetylase Proteins 0.000 description 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 2
- RGHILYZRVFRRNK-UHFFFAOYSA-N anthracene-1,2-dione Chemical compound C1=CC=C2C=C(C(C(=O)C=C3)=O)C3=CC2=C1 RGHILYZRVFRRNK-UHFFFAOYSA-N 0.000 description 2
- 229940045799 anthracyclines and related substance Drugs 0.000 description 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 1
- 108010079882 Bax protein (53-86) Proteins 0.000 description 1
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 description 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 1
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 description 1
- 208000034578 Multiple myelomas Diseases 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 206010063092 Trisomy 12 Diseases 0.000 description 1
- 238000009098 adjuvant therapy Methods 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 229960004562 carboplatin Drugs 0.000 description 1
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- 230000022131 cell cycle Effects 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
- 229960004316 cisplatin Drugs 0.000 description 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
- 210000004443 dendritic cell Anatomy 0.000 description 1
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 description 1
- 201000003444 follicular lymphoma Diseases 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
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- 238000009099 neoadjuvant therapy Methods 0.000 description 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
- 210000003924 normoblast Anatomy 0.000 description 1
- 201000003733 ovarian melanoma Diseases 0.000 description 1
- 229960001756 oxaliplatin Drugs 0.000 description 1
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 229940124272 protein stabilizer Drugs 0.000 description 1
- 230000022983 regulation of cell cycle Effects 0.000 description 1
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- 210000000130 stem cell Anatomy 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361897547P | 2013-10-30 | 2013-10-30 | |
| US61/897,547 | 2013-10-30 | ||
| PCT/US2014/063121 WO2015066305A1 (en) | 2013-10-30 | 2014-10-30 | Methods for determining chemosensitivity and chemotoxicity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016538539A JP2016538539A (ja) | 2016-12-08 |
| JP2016538539A5 true JP2016538539A5 (https=) | 2017-12-14 |
| JP6538044B2 JP6538044B2 (ja) | 2019-07-03 |
Family
ID=53005110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016527380A Expired - Fee Related JP6538044B2 (ja) | 2013-10-30 | 2014-10-30 | 化学療法感受性および化学毒性を判定する方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10640803B2 (https=) |
| EP (1) | EP3063302B1 (https=) |
| JP (1) | JP6538044B2 (https=) |
| AU (1) | AU2014342269B2 (https=) |
| WO (1) | WO2015066305A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102062416B1 (ko) * | 2012-05-10 | 2020-01-03 | 유트로픽스 파마슈티컬스, 인크. | 실용 가능한 암 진단 대체 법 |
| US10793915B2 (en) | 2015-01-12 | 2020-10-06 | Eutropics Pharmaceuticals, Inc. | Context dependent diagnostics test for guiding cancer treatment |
| US9901574B2 (en) * | 2015-04-20 | 2018-02-27 | Tolero Pharmaceuticals, Inc. | Predicting response to alvocidib by mitochondrial profiling |
| ES2739749T3 (es) | 2015-05-18 | 2020-02-03 | Tolero Pharmaceuticals Inc | Profármacos de alvocidib que tienen biodisponibilidad aumentada |
| MX2018001289A (es) | 2015-08-03 | 2018-04-30 | Tolero Pharmaceuticals Inc | Terapias de combinacion para el tratamiento del cancer. |
| WO2018094275A1 (en) | 2016-11-18 | 2018-05-24 | Tolero Pharmaceuticals, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
| KR20190099260A (ko) | 2016-12-19 | 2019-08-26 | 톨레로 파마수티컬스, 인크. | 프로파일링 펩티드 및 감도 프로파일링을 위한 방법 |
| WO2019055579A1 (en) | 2017-09-12 | 2019-03-21 | Tolero Pharmaceuticals, Inc. | TREATMENT REGIME FOR CANCERS THAT ARE INSENSITIVE TO BCL-2 INHIBITORS USING THE MCL-1 ALVOCIDIB INHIBITOR |
| US20210379042A1 (en) * | 2018-10-12 | 2021-12-09 | Sumitomo Dainippon Pharma Oncology, Inc. | Methods for monitoring tumor lysis syndrome |
| US11034710B2 (en) | 2018-12-04 | 2021-06-15 | Sumitomo Dainippon Pharma Oncology, Inc. | CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer |
| US11793802B2 (en) | 2019-03-20 | 2023-10-24 | Sumitomo Pharma Oncology, Inc. | Treatment of acute myeloid leukemia (AML) with venetoclax failure |
| EP4100955A4 (en) * | 2020-02-06 | 2024-02-28 | Oncohost Ltd | MACHINE LEARNING PREDICTION OF THERAPEUTIC RESPONSE |
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| EP2596366A4 (en) | 2010-07-21 | 2014-04-16 | Joseph P Errico | COMBINATION THERAPY WITH MDM2 AND EFGR INHIBITORS |
| US8716295B2 (en) | 2010-10-27 | 2014-05-06 | Yves Pommier | Fluoroquinolone derivatives or sulfonamide moiety-containing compounds as inhibitors of tyrosyl-dnaphosphodiesterase (TDP1) |
| WO2012088438A1 (en) | 2010-12-22 | 2012-06-28 | Eutropics Pharmaceuticals, Inc. | Compositions and methods useful for treating diseases |
| US9051305B2 (en) | 2011-03-08 | 2015-06-09 | Eutropics Pharmaceuticals, Inc. | Compositions and methods useful for treating diseases |
| US9012215B2 (en) | 2011-09-22 | 2015-04-21 | The Johns Hopkins University | Methods for identifying leukemia stem cells and distinguishing them from normal hematopietic stem cells in patients with acute myeloid leukemia: uses in diagnosis, treatment, and research |
| WO2013138702A2 (en) | 2012-03-15 | 2013-09-19 | Bristol-Myers Squibb Company | Methods for predicting gastrointestinal immune-related adverse events (gi-irae) in patients treated with modulation of the co-stimulatory pathway |
| KR102062416B1 (ko) | 2012-05-10 | 2020-01-03 | 유트로픽스 파마슈티컬스, 인크. | 실용 가능한 암 진단 대체 법 |
| WO2016196358A1 (en) * | 2015-05-29 | 2016-12-08 | Epicentre Technologies Corporation | Methods of analyzing nucleic acids |
-
2014
- 2014-10-30 WO PCT/US2014/063121 patent/WO2015066305A1/en not_active Ceased
- 2014-10-30 JP JP2016527380A patent/JP6538044B2/ja not_active Expired - Fee Related
- 2014-10-30 EP EP14857789.3A patent/EP3063302B1/en active Active
- 2014-10-30 US US15/033,810 patent/US10640803B2/en active Active
- 2014-10-30 AU AU2014342269A patent/AU2014342269B2/en not_active Ceased
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2020
- 2020-03-24 US US16/828,240 patent/US11519015B2/en active Active
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