JP2016523957A - 発毛および育毛促進用組成物 - Google Patents
発毛および育毛促進用組成物 Download PDFInfo
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- JP2016523957A JP2016523957A JP2016525284A JP2016525284A JP2016523957A JP 2016523957 A JP2016523957 A JP 2016523957A JP 2016525284 A JP2016525284 A JP 2016525284A JP 2016525284 A JP2016525284 A JP 2016525284A JP 2016523957 A JP2016523957 A JP 2016523957A
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- Prior art keywords
- hair growth
- ginseng extract
- composition
- hair
- ginseng
- Prior art date
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Abstract
Description
本発明の一実施例は、高麗人参抽出物総質量に対して、ジンセノサイドRb2を2.5質量%以上、ジンセノサイドRcを3質量%以上、およびジンセノサイドRg1を2質量%以上含む高麗人参抽出物を提供する。
高麗人参に、水、有機溶媒、または水および有機溶媒の混合物を加えた後、加圧および減圧抽出工程を順次的に繰返し実施しながら抽出するステップ;および
前記ステップによって得られた高麗人参抽出物を水に溶かした後、有機溶媒で抽出して有機溶媒層を除去し、水層をさらに有機溶媒で抽出して高麗人参抽出物を製造するステップを含む高麗人参抽出物の製造方法を提供する。
前記ステップによって得られた高麗人参抽出物を水に溶かした後、有機溶媒で抽出し、有機溶媒層を除去した後、水層を有機溶媒でさらに抽出するステップを含む方法によって、高麗人参抽出物を製造してよい。
本発明の剤形がペースト、クリームまたはゲルである場合には、担体成分として、動物繊維、植物繊維、ワックス、パラフィン、澱粉、トラガカント、セルロース誘導体、ポリエチレングリコール、シリコン、ベントナイト、シリカ、タルクまたは酸化亜鉛等が利用されてよい。
高麗人参(錦山人参、購入先:錦山人参農協)を精製水で洗浄し、乾燥させた後、粉砕して細かく粉末化した高麗人参粉末を得た。得られた高麗人参粉末2gを、50%エタノールを20mL加えた後、圧力循環型抽出装置で加圧および減圧抽出工程をそれぞれ30分間順次的に循環実施しながら、計2時間抽出した。このとき、加圧抽出時の圧力は2kgf/cm2、減圧抽出時の圧力は600±50mmHgとし、抽出温度は75℃に設定した。前記工程により得られた高麗人参抽出物を濾過し、その上澄み液を減圧乾燥して乾燥質量0.57gを得た。その次に、乾燥物を水に溶かした後、酢酸エチルで抽出して、酢酸エチル層を除去し、水層をブタノールで抽出した後、減圧乾燥して乾燥質量2.7gを得た。これを実施例1とした。
機器:Waters 2998 PDA detecter,1525 pump,2707 autosampler
カラム:Sun fire C18 305μm、4.6×150mm
検出器(detector):UV 203nm
流量(Flow rate):1mL/min
注入体積(Injection volumn):20μl
条件:gradient(A‐水、B‐アセトニトリル)
高麗人参(錦山人参、購入先:錦山人参農協)を精製水で洗浄し、乾燥させた後、粉砕して細かく粉末化した高麗人参粉末を得た。得られた高麗人参粉末2gを、50%エタノール100mLで、75℃で2時間抽出した後、試料を濾過して、その上澄み液を減圧乾燥して乾燥質量0.30gを得た。これを比較例1とした。
高麗人参抽出物が、血管形成に必要な成長因子であって毛髪の成長期に移動するのに必要な成長因子である血管内皮細胞増殖因子(Vascular endothelial growth factor;VEGF)を発現させる程度を評価するために、生体外(in vitro)システムを適用して高麗人参抽出物適用後の活性を評価した。
毛髪を構成するケラチンタンパク質は、毛根部ケラチン形成細胞(keratinocyte)で生成され、このケラチン形成細胞は、毛乳頭細胞から分化される。したがって、本発明に係る高麗人参抽出物が毛乳頭細胞の活性を促進するのであれば、それから分化されるケラチン形成細胞の活性を促進させることができ、ひいては毛髪生成を促進することができるであろう。
本発明の、実際の人体毛嚢器官における毛髪成長促進能を確認した実験を実施した。
前記実施例1の高麗人参抽出物2%を含む頭皮エッセンスと、実施例1の高麗人参抽出物成分を除いた対照群を、満20〜60歳の成人女性のうち脱毛症状のある者を対象に、試験群(実施例1)と対照群とにそれぞれ23人ずつ分けた後、1日夕方1回、脱毛部位に塗布して使用させた。塗布期間は16週とし、育毛効果を、被験者の主観的評価、臨床写真による研究者の評価、および客観的毛髪測定法のうち非侵襲的方法であるフォトトリコグラム(Phototrichogram)を利用した毛髪密度、毛髪の太さ、毛髪の成長速度および脱落毛髪数を含む毛髪の生物学的変数の測定を通じて、脱毛防止および育毛効果を評価した。本試験は、無作為割付、二重盲検、活性対照臨床試験で構成された。実験結果を表4〜8に示した。
下記表9に記載された組成に従って、通常の方法でシャンプーを製造した。
下記表10に記載された組成に従って、通常の方法でリンスを製造した。
下記表11に記載された組成に従って、通常の方法で軟膏を製造した。
下記表12に記載された組成に従って、通常の方法でローションを製造した。
下記表13に記載された組成に従って、通常の方法でクリームを製造した。
下記表15に記載された組成に従って、通常の方法で美容液型製剤を製造した。
実施例1の抽出物50mg、L‐カルニチン80〜140mg、大豆油180mg、パーム油2mg、植物性硬化油8mg、黄蝋4mgおよびレシチン6mgを混合し、通常の方法に従って、1カプセルあたり400mgずつ充填して軟質カプセルを製造した。
実施例1の抽出物50mg、ガラクトオリゴ糖200mg、乳糖60mgおよび麦芽糖140mgを混合し、流動層乾燥機を利用して顆粒した後、糖エステル(sugar ester)6mgを添加して、打錠機で打錠して錠剤を製造した。
実施例1の抽出物50mg、無水結晶ブドウ糖250mgおよび澱粉550mgを混合し、流動層造粒機を使用して顆粒に成形した後、包に充填して顆粒剤を製造した。
実施例1の抽出物50mg、ブドウ糖10g、クエン酸0.6gおよび液状オリゴ糖25gを混合した後、精製水300mlを加えて各瓶に200mlずつ充填した。瓶に充填した後、130℃で4〜5秒間殺菌して、ドリンク剤飲料を製造した。
Claims (13)
- 高麗人参抽出物総質量に対して、ジンセノサイドRb2を2.5質量%以上、ジンセノサイドRcを3質量%以上、およびジンセノサイドRg1を2質量%以上含む高麗人参抽出物。
- 前記高麗人参抽出物は、ジンセノサイドReを、高麗人参抽出物総質量に対して6質量%以上さらに含むことを特徴とする、請求項1に記載の高麗人参抽出物。
- 前記高麗人参抽出物は、高麗人参の根から抽出することを特徴とする、請求項1に記載の高麗人参抽出物。
- 前記高麗人参抽出物は、高麗人参のひげ根から抽出することを特徴とする、請求項1に記載の高麗人参抽出物。
- 請求項1の高麗人参抽出物の製造方法であって、
高麗人参に、水、有機溶媒、または水および有機溶媒の混合物を加えた後、加圧および減圧抽出工程を順次的に繰返し実施しながら抽出するステップ;および
前記ステップによって得られた高麗人参抽出物を水に溶かした後、有機溶媒で抽出し、有機溶媒層を除去した後、水層をさらに有機溶媒で抽出して高麗人参抽出物を製造するステップ;
を含む高麗人参抽出物の製造方法。 - 請求項5の製造方法によって製造された高麗人参抽出物。
- 請求項1〜4のいずれか1項の高麗人参抽出物を有効成分として含む発毛および育毛促進用組成物。
- 前記高麗人参抽出物を組成物総質量に対して2質量%以上含む、請求項7に記載の発毛および育毛促進用組成物。
- 前記高麗人参抽出物に含まれるジンセノサイドは、毛髪の成長周期のうち休止期から成長期へ移行される周期を短縮させるものであることを特徴とする、請求項7に記載の発毛および育毛促進用組成物。
- 前記組成物は、薬学組成物であることを特徴とする、請求項7に記載の発毛および育毛促進用組成物。
- 前記組成物は、化粧料組成物であることを特徴とする、請求項7に記載の発毛および育毛促進用組成物。
- 前記組成物は、皮膚外用剤であることを特徴とする、請求項7に記載の発毛および育毛促進用組成物。
- 前記組成物は、食品組成物であることを特徴とする、請求項7に記載の発毛および育毛促進用組成物。
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Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS52151712A (en) * | 1976-06-03 | 1977-12-16 | Inverni Della Beffa Spa | Composition for medical preparation |
JPS60222409A (ja) * | 1984-04-20 | 1985-11-07 | Kenichi Kido | ヘアトニック組成物 |
JPS63139133A (ja) * | 1986-12-02 | 1988-06-10 | Nitto Electric Ind Co Ltd | 薬用人参エキス製品およびその製造法 |
JP2003230360A (ja) * | 2002-02-08 | 2003-08-19 | Noji:Kk | 健康増進および美容・ダイエット効果を有するアイスクリームおよびその製造方法 |
JP2004149457A (ja) * | 2002-10-30 | 2004-05-27 | Kurohime Wakanyaku Kenkyusho:Kk | ウコギ科植物の花部の抽出物とその用途 |
JP2008502711A (ja) * | 2004-06-11 | 2008-01-31 | ユニジェン インク. | 集中力及び記憶力の低下の防止又は改善のためのニンジン組成物 |
JP2009135149A (ja) * | 2007-11-28 | 2009-06-18 | Panasonic Corp | 半導体集積回路 |
JP2010528109A (ja) * | 2007-05-31 | 2010-08-19 | 株式會社アモーレパシフィック | 高麗人参の実抽出物を含有する皮膚外用剤組成物 |
JP2010246470A (ja) * | 2009-04-16 | 2010-11-04 | Kge Japan:Kk | 高麗人参からなる健康食品の製造方法及び高麗人参からなる健康食品 |
JP2011190231A (ja) * | 2010-03-17 | 2011-09-29 | Daiichi Kokusai Kagi Kofun Yugenkoshi | 高血圧、高血糖又は高脂血症を予防/治療する朝鮮人参の花の抽出物、食品組成物および朝鮮人参の花の抽出方法 |
KR20120005195A (ko) * | 2010-07-08 | 2012-01-16 | 세명대학교 산학협력단 | 인삼 열매 추출물을 포함하는 탈모 방지 및 모발 성장 촉진용 조성물 |
JP2012528144A (ja) * | 2009-05-26 | 2012-11-12 | 株式会社アモーレパシフィック | サポニンの生体利用率増進組成物 |
JP2012531247A (ja) * | 2009-06-26 | 2012-12-10 | 株式会社アモーレパシフィック | 陰陽抽出装置及び抽出方法 |
JP2012533535A (ja) * | 2009-07-16 | 2012-12-27 | シージェイ チェイルジェダン コーポレーション | ジンセノサイド濃縮画分を含む血圧降下用組成物 |
WO2013059942A1 (en) * | 2011-10-28 | 2013-05-02 | Afexa Life Sciences Inc. | Use of a ginseng extract to prevent and treat alopecia areata |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20050076057A (ko) * | 2004-01-19 | 2005-07-26 | 대한민국(전남대학교총장) | 진세노사이드를 유효성분으로 함유하는 여성 성기능 개선제 |
KR100805852B1 (ko) * | 2006-12-21 | 2008-02-21 | 한국식품연구원 | 진세노사이드가 강화된 인삼을 제조하는 방법 및 이를이용한 홍삼의 제조방법 |
KR100950426B1 (ko) * | 2009-06-16 | 2010-03-29 | 윤건상 | 진세노사이드 함량이 증가된 인삼 추출물의 제조 방법 |
KR20110010593A (ko) * | 2010-12-24 | 2011-02-01 | 강원대학교산학협력단 | 진세노사이드 추출 효율 향상을 위한 인삼의 추출방법 |
-
2014
- 2014-01-27 WO PCT/KR2014/000749 patent/WO2015005554A1/ko active Application Filing
- 2014-07-09 KR KR1020140086251A patent/KR101698922B1/ko active IP Right Grant
- 2014-07-10 JP JP2016525284A patent/JP6339189B2/ja active Active
- 2014-07-10 MY MYPI2016700016A patent/MY170694A/en unknown
- 2014-07-10 CN CN201480050020.8A patent/CN105555285B/zh active Active
- 2014-07-10 SG SG11201600120VA patent/SG11201600120VA/en unknown
-
2016
- 2016-01-08 PH PH12016500067A patent/PH12016500067A1/en unknown
- 2016-06-23 HK HK16107306.6A patent/HK1219230A1/zh unknown
Patent Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS52151712A (en) * | 1976-06-03 | 1977-12-16 | Inverni Della Beffa Spa | Composition for medical preparation |
JPS60222409A (ja) * | 1984-04-20 | 1985-11-07 | Kenichi Kido | ヘアトニック組成物 |
JPS63139133A (ja) * | 1986-12-02 | 1988-06-10 | Nitto Electric Ind Co Ltd | 薬用人参エキス製品およびその製造法 |
JP2003230360A (ja) * | 2002-02-08 | 2003-08-19 | Noji:Kk | 健康増進および美容・ダイエット効果を有するアイスクリームおよびその製造方法 |
JP2004149457A (ja) * | 2002-10-30 | 2004-05-27 | Kurohime Wakanyaku Kenkyusho:Kk | ウコギ科植物の花部の抽出物とその用途 |
JP2008502711A (ja) * | 2004-06-11 | 2008-01-31 | ユニジェン インク. | 集中力及び記憶力の低下の防止又は改善のためのニンジン組成物 |
JP2010528109A (ja) * | 2007-05-31 | 2010-08-19 | 株式會社アモーレパシフィック | 高麗人参の実抽出物を含有する皮膚外用剤組成物 |
JP2009135149A (ja) * | 2007-11-28 | 2009-06-18 | Panasonic Corp | 半導体集積回路 |
JP2010246470A (ja) * | 2009-04-16 | 2010-11-04 | Kge Japan:Kk | 高麗人参からなる健康食品の製造方法及び高麗人参からなる健康食品 |
JP2012528144A (ja) * | 2009-05-26 | 2012-11-12 | 株式会社アモーレパシフィック | サポニンの生体利用率増進組成物 |
JP2012531247A (ja) * | 2009-06-26 | 2012-12-10 | 株式会社アモーレパシフィック | 陰陽抽出装置及び抽出方法 |
JP2012533535A (ja) * | 2009-07-16 | 2012-12-27 | シージェイ チェイルジェダン コーポレーション | ジンセノサイド濃縮画分を含む血圧降下用組成物 |
JP2011190231A (ja) * | 2010-03-17 | 2011-09-29 | Daiichi Kokusai Kagi Kofun Yugenkoshi | 高血圧、高血糖又は高脂血症を予防/治療する朝鮮人参の花の抽出物、食品組成物および朝鮮人参の花の抽出方法 |
KR20120005195A (ko) * | 2010-07-08 | 2012-01-16 | 세명대학교 산학협력단 | 인삼 열매 추출물을 포함하는 탈모 방지 및 모발 성장 촉진용 조성물 |
WO2013059942A1 (en) * | 2011-10-28 | 2013-05-02 | Afexa Life Sciences Inc. | Use of a ginseng extract to prevent and treat alopecia areata |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019026634A (ja) * | 2017-07-27 | 2019-02-21 | 共栄化学工業株式会社 | 毛髪用組成物及び皮膚外用組成物 |
JP7265237B2 (ja) | 2017-07-27 | 2023-04-26 | 共栄化学工業株式会社 | 毛髪用組成物及び皮膚外用組成物 |
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Publication number | Publication date |
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KR20150007975A (ko) | 2015-01-21 |
HK1219230A1 (zh) | 2017-03-31 |
SG11201600120VA (en) | 2016-02-26 |
KR101698922B1 (ko) | 2017-01-23 |
WO2015005554A1 (ko) | 2015-01-15 |
MY170694A (en) | 2019-08-26 |
CN105555285A (zh) | 2016-05-04 |
JP6339189B2 (ja) | 2018-06-06 |
CN105555285B (zh) | 2019-11-05 |
PH12016500067B1 (en) | 2016-04-18 |
PH12016500067A1 (en) | 2016-04-18 |
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