JP2016088860A - Cosmetic or external preparation for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a cosmetic or an external preparation for skin containing stearyl glycyrrhetinate and polyoxyethylene hardened castor oil, in which the skin penetrability of the stearyl glycyrrhetinate is promoted.SOLUTION: The invention provides a cosmetic or an external preparation for skin containing stearyl glycyrrhetinate and polyoxyethylene hardened castor oil. Preferably, the average addition mole number of the polyoxyethylene hardened castor oil is 20-50, and furthermore, polyoxyethylene hardened castor oil is contained at a ratio of 0.1-10 mass% to the total mass. The invention also provides a skin penetration promoter of the stearyl glycyrrhetinate containing the polyoxyethylene hardened castor oil; and also provides a method for promoting skin penetrability of the stearyl glycyrrhetinate.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a cosmetic or an external preparation for skin in which the skin permeability of stearyl glycyrrhetinate is promoted. More specifically, the present invention relates to a cosmetic or an external preparation for skin containing stearyl glycyrrhetinate and polyoxyethylene hydrogenated castor oil.

  Traditionally, transdermal administration has attracted attention because it has no side effects such as gastrointestinal disturbances in the human body and is difficult to be metabolized in the liver. As a result, skin external preparations by transdermal administration and melanin produced from melanocytes have been attracted. Targeted cosmetics by transdermal administration have been developed. The human skin is composed of the epidermis, dermis and subcutaneous tissue including the stratum corneum, and in recent years, the active ingredients of the above-mentioned external preparations for skin and cosmetics are permeated toward specific parts of the skin such as the stratum corneum and the epidermis. Have been developed (Patent Documents 1 and 2).

  On the other hand, the stearyl glycyrrhetinate can be obtained from plants such as Glycyrrhiza Glabra, and is known to have high safety to the human body. This stearyl glycyrrhetinate is known to have anti-inflammatory, anti-allergic action, and bacterial growth-inhibiting action. Therefore, the stearyl glycyrrhetinate is used in a wide variety of external preparations for skin and cosmetics. Thus, although stearyl glycyrrhetinate is used in many skin preparations and cosmetics, little knowledge has been shown regarding the skin permeability of stearyl glycyrrhetinate.

  Further, the stearyl glycyrrhetinate is an oil-soluble drug, and in order to contain this stearyl glycyrrhetinate as a skin external preparation or cosmetic composition, part of the oil phase component of the emulsion composition using a large amount of oil or emulsifier The technique of making it contain as is known.

  As the emulsifier, polyoxyethylene hydrogenated castor oil is present. This polyoxyethylene hydrogenated castor oil is a nonionic surfactant, and is known to have high safety to the human body, and is often used in skin external preparations and cosmetics.

JP 2010-189351 A JP 2011-1270 A

  Thus, although the said stearyl glycyrrhetinate is used for cosmetics and a skin external preparation, the effect | action of the polyoxyethylene hydrogenated castor oil with respect to the skin permeability of the said stearyl glycyrrhetinate has not been clarified.

As a result of intensive studies for solving the above problems, the present inventors have newly found that polyoxyethylene hydrogenated castor oil has an action of promoting the skin permeability of stearyl glycyrrhetinate and completes the present invention. It came to.
That is, the present invention relates to a cosmetic or skin external preparation containing stearyl glycyrrhetinate and polyoxyethylene hydrogenated castor oil.
Moreover, in this cosmetic or skin external preparation, the average added mole number of the polyoxyethylene hydrogenated castor oil can be 20-50.
Furthermore, in this cosmetic or skin external preparation, polyoxyethylene hydrogenated castor oil can be contained in a proportion of 0.1 to 10% by mass.
Moreover, in this cosmetic or external preparation for skin, isopropyl myristate and / or isotridecyl isononate can be contained.
Furthermore, in this cosmetic or external preparation for skin, the cosmetic or external preparation for skin can be made into an oil-in-water emulsion composition.
The present invention also relates to a skin penetration enhancer of stearyl glycyrrhetinate containing polyoxyethylene hydrogenated castor oil.
The present invention also relates to a method for promoting the skin permeability of stearyl glycyrrhetinate by mixing stearyl glycyrrhetinate with polyoxyethylene hydrogenated castor oil.

  ADVANTAGE OF THE INVENTION By this invention, the cosmetics or skin external preparation by which the skin permeability of stearyl glycyrrhetinate is accelerated | stimulated can be provided. In addition, according to the present invention, it is possible to provide a skin penetration enhancer that promotes the skin permeability of stearyl glycyrrhetinate or a method of promoting the skin permeability of stearyl glycyrrhetinate.

It is a drawing substitute graph which shows the skin penetration promotion effect of the stearyl glycyrrhetinate by polyoxyethylene hydrogenated castor oil.

  Hereinafter, the present invention will be described in detail. In the present specification, “skin penetration enhancement” means to promote penetration into the stratum corneum and epidermis unless otherwise specified. Moreover, when a range is represented by "-" in this specification, except the case where it describes especially, both ends are included. In the present invention, the values shown for the ratio or ratio (%, etc.) are values based on mass, unless otherwise specified.

(1) Stearyl Glycyrrhetinate Stearyl Glycyrrhetinate of the present invention is a compound obtained by esterifying stearic acid to the hydroxyl group of glycyrrhetinic acid obtained by hydrolysis of glycyrrhetinic acid contained in licorice etc. .
The systematic name is (20S) -3β-hydroxy-11-oxo-5α-oleana-12-ene-29-acid octadecyl.
The molecular formula is C ₄₈ H ₈₂ O ₄ and the molecular weight is 723.16. Due to its high molecular weight, skin permeability to the stratum corneum and epidermis is said to be low.
The molecular structure of glycyrrhetinic acid has planarity and has anti-inflammatory action because the 3rd and 11th positions are similar to cortisone. The stearic acid may be branched, for example, starting with isostearic acid.
Stearyl glycyrrhetinate has been widely used as an anti-inflammatory component in technical fields such as external preparations for skin and cosmetics where safety is required because stearic acid is added to enhance safety.

(2) Content of stearyl glycyrrhetinate The content of stearyl glycyrrhetinate in the cosmetic, topical skin preparation, or skin penetration enhancer (hereinafter referred to as “cosmetics”) of the present invention is not particularly limited. The ratio of 0.01 to 5% by mass is preferable, the ratio of 0.05 to 2.0% by mass, and still more preferably the ratio of 0.1 to 1.0% by mass with respect to the total mass of It is. Within this range, since it has excellent permeability to the skin, various skin effects of stearyl glycyrrhetinate are excellent, and the stability of the preparation is also excellent.

(3) Polyoxyethylene hydrogenated castor oil The polyoxyethylene hydrogenated castor oil of the present invention is a nonionic surfactant and is known to have high safety to the human body, and is often used in skin external preparations and cosmetics. (Hereinafter, polyoxyethylene may be referred to as POE).
Specifically, POE (5) hydrogenated castor oil, POE (10) hydrogenated castor oil, POE (20) hydrogenated castor oil, POE (30) hydrogenated castor oil, POE (40) hydrogenated castor oil, POE (50) hydrogenated castor oil Oil, POE (60) hydrogenated castor oil, POE (80) hydrogenated castor oil, POE (100) hydrogenated castor oil, monoisostearate polyoxyethylene hydrogenated castor oil, etc., one or two of these depending on the purpose The above can be appropriately selected and used. The polyoxyethylene hydrogenated castor oil of the present invention is preferably selected from those added with 20 to 50 moles of polyoxyethylene, more preferably POE (40) hydrogenated castor oil. Within this range, the permeability of stearyl glycyrrhetinate is excellent and the stability of the preparation is also excellent.

(4) Content of polyoxyethylene hydrogenated castor oil The content of polyoxyethylene hydrogenated castor oil in the cosmetics and the like of the present invention is not particularly limited, but is 0.01 to the total mass of the cosmetics and the like. A proportion of 10% by mass is preferable from the viewpoint of stability, more preferably 0.1 to 5% by mass from the viewpoint of the permeability of stearyl glycyrrhetinate, and further preferably 1 from the viewpoint of usability such as stickiness. It is a ratio of ˜3 mass%.

  The mass ratio of stearyl glycyrrhetinate and polyoxyethylene hydrogenated castor oil in the cosmetics of the present invention is not particularly limited, but is preferably 25: 1 to 1:50, more preferably 10: 1 to 1:25. Yes, and more preferably 2: 1 to 1:10, and this range is preferable because of its excellent permeability.

(5) Isopropyl myristate The isopropyl myristate of the present invention is a compound of myristic acid and isopropanol obtained from coconut oil, palm kernel oil or the like. Note that myristic acid may be branched. Isopropyl myristate dissolves relatively well in ethanol, has good permeability to the skin, has a refreshing feel, and can impart moderate oiliness and flexibility to the skin.
Isopropyl myristate is not particularly limited as long as it is usually used for external preparations for skin, cosmetics and the like. Specifically, NIKKOL (registered trademark) IPM-EX (Nikko Chemicals Corporation), Kurodamol (registered trademark) IPM (Croda Japan Corporation), and the like can be mentioned.

(6) Isotridecyl isononanoate Isotridecyl isononanoate of the present invention is an ester of isononanoic acid and isotridecyl alcohol. The position of branching of isononanoic acid and isotridecyl alcohol is not limited, and may be multi-branched. Isotridecyl isononanoate can be used as an emulsification aid and is suitable for obtaining a water-in-oil emulsion composition having no stickiness and good spreading. Isotridecyl isononanoate can impart adhesion and retention to the skin, permeability and spread.
Isotridecyl isononanoate is not particularly limited as long as it is normally used for external preparations for skin, cosmetics and the like. Specifically, SUPER REREFED CRODAMOL (registered trademark) TN-LQ- (JP) (Cloda Japan Co., Ltd.), Saracos (registered trademark) 913 (Nisshin Oillio Group Co., Ltd.) and the like can be mentioned.

(7) Content of isopropyl myristate and / or isotridecyl isononanoate The content of isopropyl myristate is not particularly limited, but from the viewpoint of permeability with respect to the total mass of the cosmetic or external preparation for skin of the present invention. A ratio of 0.01 to 20% by mass is preferable, more preferably a ratio of 0.1 to 15% by mass from the viewpoint of the stability of the preparation, and further preferable from the viewpoint of improving the feeling of use (smoothness). Is a ratio of 4 to 10% by mass.
Further, the content of isotridecyl isononanoate is not particularly limited, but is preferably 0.01 to 20% by mass from the viewpoint of permeability with respect to the total mass of the cosmetic or external preparation for skin of the present invention. From the viewpoint of the stability of the preparation, the ratio is more preferably 0.1 to 15% by mass, and further preferably 4 to 10% by mass from the viewpoint of improving the feeling of use (smoothness).
Further, when isopropyl myristate and isotridecyl isononanoate are contained, the content of isopropyl myristate and isotridecyl isononanoate is 0.01 to 20 in total with respect to the total mass of the cosmetic or skin external preparation of the present invention. The ratio of mass% is preferable, more preferably the ratio is 0.1 to 15 mass%, and still more preferably the ratio is 4 to 10 mass%.

  The ratio of the total content of stearyl glycyrrhetinate and polyoxyethylene hydrogenated castor oil to the content of isopropyl myristate and / or isotridecyl isononanoate in the cosmetics of the present invention is not particularly limited, but is 0.01 to 25. Is preferable, more preferably 0.05 to 5, and still more preferably 0.1 to 1. If it is within this range, stearyl glycyrrhetinate is difficult to precipitate, can be efficiently penetrated, and has excellent permeability. Therefore, it is preferable.

(8) Properties and form of cosmetic or external preparation for skin The properties of the cosmetic or external preparation for skin of the present invention are not particularly limited as long as they can be applied to the skin, and are liquid, gel, cream, semi-solid. Any of solid, stick, powder and the like may be used. Examples include solid preparations for external use, liquid preparations for external use, sprays, ointments, creams, gels, patches, etc. More specifically, emulsions, lotions, cosmetics, pack cosmetics, face wash, body Cosmetics for massage, cosmetics for massage, base materials for makeup, and the like.
In addition, the form of the cosmetic or skin external preparation of the present invention may be any of oil-in-water type, water-in-oil type, multiple emulsion, microemulsion, etc., and can be appropriately selected depending on the application and purpose. Considering the permeability to the oil, the oil-in-water type is preferable.

  In addition, the cosmetic or skin external preparation of the present invention includes components used in preparations such as cosmetics, that is, water (purified water, hot spring water, deep layers) as long as the effects of the present invention are not impaired as necessary. Water, alcohol, oil agent, surfactant, metal soap, gelling agent, powder, alcohol, water-soluble polymer, film-forming agent, resin, UV protection agent, inclusion compound, antibacterial agent, perfume Odorant, salt, pH adjuster, refresher, animal / microbe-derived extract, plant extract, blood circulation promoter, astringent, antiseborrheic agent, whitening agent, anti-inflammatory agent, active oxygen scavenger, cell activator , Moisturizers, chelating agents, keratolytic agents, enzymes, hormones, vitamins and the like can be added.

(9) Method for producing cosmetic or skin external preparation The cosmetic or skin external preparation of the present invention can be produced according to a conventional method, for example, mainly oily components such as polyoxyethylene hydrogenated castor oil and stearyl glycyrrhetinate. A pH adjuster or the like is added, and the mixture is heated to about 80 ° C. and dissolved uniformly to produce Composition 1. On the other hand, purified water, a thickener, etc. are mixed uniformly and the composition 2 is manufactured. A composition 2 heated to about 80 ° C. is added to the composition 1 and emulsified to produce a composition 3. The composition 3 can be cooled to obtain an emulsion.

(10) Skin penetration enhancer The skin penetration enhancer of the present invention contains the polyoxyethylene hydrogenated castor oil, and is mixed with a skin external preparation and cosmetics together with stearyl glycyrrhetinate. As a result, the skin permeability of stearyl glycyrrhetinate is promoted when applied to the skin. This skin penetration enhancer can be mixed with the above-mentioned various cosmetics, and can also be mixed with external medicines such as dispersions, ointments, patches, and poultices. And, since the skin permeation enhancer of stearyl glycyrrhetinate is improved in the skin external preparation etc. in which the skin permeation enhancer and stearyl glycyrrhetinate are mixed, stearyl glycyrrhetinate is treated with a specific site (keratin layer or epidermis) ) Can be efficiently infiltrated and stored.

(11) Method for Promoting Skin Permeability of Stearyl Glycyrrhetinate As a result of intensive studies, the present inventors have found that the skin permeability of stearyl glycyrrhetinate can be significantly improved by using polyoxyethylene hydrogenated castor oil. I found it. That is, by mixing stearyl glycyrrhetinate and polyoxyethylene hydrogenated castor oil, the skin permeability of stearyl glycyrrhetinate can be promoted.

  Hereinafter, the present invention will be described in more detail based on examples. In addition, the Example demonstrated below shows an example of the typical Example of this invention, and, thereby, the range of this invention is not interpreted narrowly.

<1> Manufacture of cosmetics Cosmetics were manufactured according to the formulation shown in Table 1 below. Moreover, the comparative example 1 and the comparative example 2 containing stearyl glycyrrhetinate were manufactured by the prescription which does not contain polyoxyethylene hydrogenated castor oil as a comparative example.

  Raw materials 1 to 13 in Table 1 were heated to 80 ° C. and uniformly dissolved. Raw materials 14 to 16 were uniformly dispersed and mixed. Next, after heating the mixture of the raw materials 14-16 to 80 degreeC, it added to the melt | dissolution mixture of the raw materials 1-13, and cooled and obtained emulsion.

<2> Examination of cosmetics According to the method of Fujii et al. Described in the Journal of Cosmetic Society, 31 (1), 1-7 (2007), a commercially available skin is set in a Franz-type cell and PBS is placed on the dermis side (receptor phase). Each sample solution was applied at 10 μL / cm ² to the stratum corneum side (donor phase). After application for a certain time, the epidermis and the dermis were separated, and stearyl glycyrrhetinate contained in each site was quantified using HPLC (Jasco LC-2000plus PDA detector). The ratio (GS concentration) of the recovered amount of stearyl glycyrrhetinate from the stratum corneum and epidermis to the total recovered amount of stearyl glycyrrhetinate was determined.

The results of this test are shown in FIG. As shown in FIG. 1, the GS concentration in Example 1 containing polyoxyethylene hydrogenated castor oil was 45.2%, the GS concentration in Example 2 was 61.7%, and the GS concentration in Example 3 was 57.3. %, And the GS concentration in Example 4 was 49.4%.
On the other hand, the GS concentration of Comparative Example 1 containing no polyoxyethylene hydrogenated castor oil was 33.1%, and the GS concentration of Comparative Example 2 was 32.4%.
That is, in the Example containing polyoxyethylene hydrogenated castor oil, the GS concentration contained in the epidermis was higher than that of the comparative example having a relatively high GS concentration.
Moreover, in Example 4 in which isopropyl myristate was contained in addition to polyoxyethylene hydrogenated castor oil, the GS concentration contained in the epidermis was higher than in Example 1 in which isopropyl myristate was not contained.
Further, in Examples 2 and 3 containing isopropyl myristate and isotridecyl isonate in addition to polyoxyethylene hydrogenated castor oil, compared to Example 1 containing no isopropyl myristate and isotridecyl isonate, isopropyl myristate was also used. The GS concentration contained in the epidermis was higher than in Example 4 containing only

  From the results of this test, it became clear that polyoxyethylene hydrogenated castor oil has an action of promoting the skin permeability of stearyl glycyrrhetinate. Moreover, it became clear that the skin permeability of stearyl glycyrrhetinate is more reliably promoted by coexisting isopropyl myristate and / or isotridecyl isonate in addition to polyoxyethylene hydrogenated castor oil.

<3> Application Example of the Invention Example 5: Oil-in-water lotion (component) (%)
(1) Stearyl glycyrrhetinate 0.05
(2) Isotridecyl isononanoate 0.2
(3) Phospholipid 0.3
(4) Polyoxyethylene (20 mol) hydrogenated castor oil 0.1
(5) Purified water 10
(6) 1,3-butylene glycol 20
(7) Phenoxyethanol 0.1
(8) Ethanol 12
(9) Residual amount of purified water

A lotion was prepared by the following production method.
(Production method)
A: Components (1) to (4) are heated to 75 ° C. and mixed uniformly.
B: The component (5) is heated to 75 ° C. and mixed uniformly.
C: B is gradually added to A and emulsified with a despa mixer.
D: C was cooled to room temperature and mixed with components (6) to (9) to obtain an oil-in-water lotion.

Example 6: Oil-in-water emulsion (component) (%)
(1) Stearyl glycyrrhetinate 0.7
(2) Isopropyl myristate 8
(3) Palmitic acid 0.2
(4) Stearic acid 0.5
(5) Polyoxyethylene (40 mol) hydrogenated castor oil 0.3
(6) Methyl paraoxybenzoate 0.1
(7) Carboxyvinyl polymer 0.1
(8) Sodium hydroxide 0.15
(9) Glycerin 5
(10) 1,3-butylene glycol 7
(11) Sodium stearoyl methyl taurine 0.2
(12) Residual amount of purified water (13) Ethanol 3
(14) Fragrance 0.05

An emulsion was prepared by the following production method.
(Production method)
A: Components (1) to (6) are heated to 75 ° C. and mixed uniformly.
B: Components (7) to (12) are heated to 75 ° C. and mixed uniformly.
C: A is gradually added to B and emulsified with a despa mixer.
D: C was cooled to room temperature and mixed with components (13) and (14) to obtain an oil-in-water emulsion.

Example 7: Oil-in-water cream (ingredient) (%)
(1) Stearyl glycyrrhetinate 1
(2) Isotridecyl isononate 5
(3) Isononyl isononanoate 5
(4) Isopropyl myristate 5
(5) Stearic acid 2
(6) Behenic acid 0.5
(7) Behenyl alcohol 1
(8) Methyl paraoxybenzoate 0.1
(9) Polyoxyethylene (40 mol) hydrogenated castor oil 0.5
(10) Remaining amount of purified water (11) Carboxyvinyl polymer 0.2
(12) Sodium hydroxide 0.4
(13) Glycerin 7
(14) 1,3-butylene glycol 3
(15) Stearoyl-sodium glutamate 0.2
(16) Xanthan gum 0.1
(17) Ethanol 7
(18) Fragrance 0.1

A cream was prepared by the following production method.
(Production method)
A: Components (1) to (9) are heated to 75 ° C. and mixed uniformly.
B: Components (10) to (16) are heated to 75 ° C. and mixed uniformly.
C: A is gradually added to B and emulsified with a despa mixer.
D: C was cooled to room temperature and mixed with components (17) and (18) to obtain an oil-in-water cream.

Example 8: Oil-in-water cosmetic liquid (component) (%)
(1) Stearyl glycyrrhetinate 0.8
(2) Isopropyl myristate 10
(3) Hydrogenated soybean phospholipid 2
(4) Polyoxyethylene sorbitan monostearate 3
(5) Cetanol 1
(6) Phenoxyethanol 0.1
(7) Polyoxyethylene (40 mol) hydrogenated castor oil 0.1
(8) Polyoxyethylene (5 mol) hydrogenated castor oil 0.1
(9) Xanthan gum 0.3
(10) Alkaligenes-producing polysaccharide 0.1
(11) Glycerin 5
(12) 1,3-butylene glycol 15
(13) Residual amount of purified water (14) Ethanol 12
(15) Cholesteryl pullulan hexidylcarbamate 0.05
(16) Fragrance 0.05

A serum was prepared by the following production method.
(Production method)
A: Components (1) to (8) are heated to 75 ° C. and mixed uniformly.
B: Components (9) to (13) are heated to 75 ° C. and mixed uniformly.
C: B is gradually added to A and emulsified with a despa mixer.
D: C was cooled to room temperature and mixed with components (14) to (16) to obtain an oil-in-water cosmetic liquid.

Example 9: Oil-in-water cosmetic for body
(Ingredient) (%)
(1) Stearyl glycyrrhetinate 1.5
(2) Isotridecyl isononanoate 2
(3) Isopropyl myristate 3
(4) Squalane 3
(5) Hydrogenated soybean phospholipid 1
(6) Polyoxyethylene sorbitan monostearate 0.5
(7) Polyoxyethylene (80 mol) hydrogenated castor oil 0.1
(8) Cetanol 0.5
(9) Methyl paraoxybenzoate 0.1
(10) Hydroxyethyl cellulose 0.2
(11) Carrageenan 0.1
(12) Glycerin 10
(13) Dipropylene glycol 15
(14) Remaining amount of purified water (15) Sodium stearoyl methyl taurate 0.5
(16) Ethanol 10
(17) Fragrance 0.1

Body cosmetics were prepared by the following production method.
(Production method)
A: Components (1) to (9) are heated to 75 ° C. and mixed uniformly.
B: Components (10) to (15) are heated to 75 ° C. and mixed uniformly.
C: A is gradually added to B and emulsified with a despa mixer.
D: C was cooled to room temperature and mixed with ingredients (16) and (17) to obtain an oil-in-water body cosmetic.

Example 10: Oil-in-water pack cosmetic (component) (%)
(1) Stearyl glycyrrhetinate 0.05
(2) Isononyl isononanoate 0.03
(3) Isopropyl myristate 0.02
(4) Polyoxyethylene (40 mol) hydrogenated castor oil 0.05
(5) Purified water 15
(6) Sodium stearoyl methyl taurate 0.1
(7) Stearoyl-sodium glutamate 0.1
(8) Ethanol 15
(9) Sorbic acid 0.01
(10) Polyethylene glycol 6000 5
(11) Carboxyvinyl polymer 1
(12) Sodium hydroxide 0.3
(13) Purified water remaining amount (14) Fragrance 0.05

A pack cosmetic was prepared by the following production method.
(Production method)
A: Components (1) to (4) are heated to 75 ° C. and mixed uniformly.
B: Components (5) to (7) are heated to 75 ° C. and mixed uniformly.
C: B is gradually added to A and emulsified with a despa mixer.
D: C was cooled to room temperature and mixed with components (8) to (14) to obtain an oil-in-water emulsion.
E: The emulsified product obtained in D was impregnated into a non-woven fabric (substantially facial shape having holes and cuts in the eyes, nose and mouth) about 10 times the mass of the non-woven fabric to prepare a pack cosmetic.

Example 11: Oil-in-water massage cosmetic (component) (%)
(1) Stearyl glycyrrhetinate 1
(2) Isotridecyl isononanoate 3
(3) Hydrogenated soybean lysophospholipid 0.5
(4) Hydrogenated egg yolk phospholipid 0.5
(5) Cetanol 0.5
(6) Behenyl alcohol 0.5
(7) Methyl paraoxybenzoate 0.1
(8) Polyoxyethylene (30 mol) hydrogenated castor oil 0.2
(9) Carboxyvinyl polymer 0.3
(10) Sodium hydroxide 0.1
(11) Sodium polyacrylate 0.05
(12) 1,3-butylene glycol 10
(13) Residual amount of purified water (14) Ethanol 0.5
(15) Fragrance 0.05

Massage cosmetics were prepared by the following production method.
(Production method)
A: Components (1) to (8) are heated to 75 ° C. and mixed uniformly.
B: Components (9) to (13) are heated to 75 ° C. and mixed uniformly.
C: A is gradually added to B and emulsified with a despa mixer.
D: C was cooled to room temperature and mixed with components (14) and (15) to obtain an oil-in-water massage cosmetic.

Example 12: Oil-in-water cosmetic base cosmetic (component) (%)
(1) Stearyl glycyrrhetinate 0.5
(2) Isotridecyl isononanoate 10
(3) Stearic acid 1.5
(4) Polyoxyethylene sorbitan monostearate 2
(5) Polyoxyethylene (20 mol) hydrogenated castor oil 0.1
(6) Purified water 50
(7) Polyethylene glycol 400 1.5
(8) Carboxyvinyl polymer 0.2
(9) Arginine 0.95
(10) Residual amount of purified water (11) Ethanol 7
(12) Salicylic acid 0.05
(13) Polyvinylpyrrolidone 0.5
(14) Synthetic phlogopite 1
(15) Methyl methacrylate cross polymer 0.5
(16) Zinc oxide 0.1
(17) Silica 0.05
(18) Iron oxide 0.05
(19) Talc 0.5

A cosmetic base cosmetic was prepared by the following production method.
(Production method)
A: Components (1) to (5) are heated to 75 ° C. and mixed uniformly.
B: Components (6) to (9) are heated to 75 ° C. and mixed uniformly.
C: B is gradually added to A and emulsified with a despa mixer.
D: Components (10) to (13) are added to C and mixed uniformly.
E: D was cooled to room temperature and mixed with components (14) to (19) to obtain an oil-in-water cosmetic base cosmetic.

Example 13: Solubilized lotion (component) (%)
(1) Polyoxyethylene (40 mol) hydrogenated castor oil 0.5
(2) Polyoxyethylene (12 mol) dioleate 0.3
(3) Stearyl glycyrrhetinate 0.2
(4) 1,3-butylene glycol 2
(5) Glycerin 2
(6) Ethanol 15
(7) 1,2-pentanediol 2
(8) Chamomile extract 1
(9) Sodium lactate 0.2
(10) Sodium benzoate 0.05
(11) Purified water remaining amount (production method)
A. Components 1 to 6 are mixed and dissolved.
B. Components 7 to 11 are mixed and dissolved.
C. A was added to B to obtain a solubilized lotion.

  Examples 5 to 13 all had high skin permeability of stearyl glycyrrhetinate and excellent usability.

  ADVANTAGE OF THE INVENTION According to this invention, the pharmaceutical with which the skin permeability of stearyl glycyrrhetinate is accelerated | stimulated, a quasi-drug, cosmetics, medicinal cosmetics, etc. can be provided.

Claims (7)

A cosmetic or external preparation for skin containing stearyl glycyrrhetinate and polyoxyethylene hydrogenated castor oil. The cosmetic or external preparation for skin according to claim 1, wherein the polyoxyethylene hydrogenated castor oil has an average added mole number of 20 to 50. The cosmetic or skin external preparation according to claim 1 or 2, wherein the polyoxyethylene hydrogenated castor oil is contained in a proportion of 0.1 to 10% by mass relative to the total mass. The cosmetic or external preparation for skin according to any one of claims 1 to 3, comprising isopropyl myristate and / or isotridecyl isonanoate. The cosmetic or external preparation for skin according to any one of claims 1 to 4, which is an oil-in-water emulsion composition. A skin permeation enhancer of stearyl glycyrrhetinate containing polyoxyethylene hydrogenated castor oil. A method of promoting the skin permeability of stearyl glycyrrhetinate by mixing stearyl glycyrrhetinate and polyoxyethylene hydrogenated castor oil.

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