JP2016065872A5 - - Google Patents
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- JP2016065872A5 JP2016065872A5 JP2015215544A JP2015215544A JP2016065872A5 JP 2016065872 A5 JP2016065872 A5 JP 2016065872A5 JP 2015215544 A JP2015215544 A JP 2015215544A JP 2015215544 A JP2015215544 A JP 2015215544A JP 2016065872 A5 JP2016065872 A5 JP 2016065872A5
- Authority
- JP
- Japan
- Prior art keywords
- tissue
- target
- deoxyuridine
- minutes
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 27
- 210000001519 tissue Anatomy 0.000 claims 17
- -1 C-5 modified pyrimidine Chemical class 0.000 claims 11
- 108020004707 nucleic acids Proteins 0.000 claims 11
- 150000007523 nucleic acids Chemical class 0.000 claims 11
- 102000039446 nucleic acids Human genes 0.000 claims 11
- 108091023037 Aptamer Proteins 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 8
- 125000003917 carbamoyl group Chemical class [H]N([H])C(*)=O 0.000 claims 6
- 239000012530 fluid Substances 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 238000010494 dissociation reaction Methods 0.000 claims 3
- 230000005593 dissociations Effects 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 claims 2
- 210000000845 cartilage Anatomy 0.000 claims 2
- 210000002808 connective tissue Anatomy 0.000 claims 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
- 238000007865 diluting Methods 0.000 claims 2
- 230000002124 endocrine Effects 0.000 claims 2
- 210000000981 epithelium Anatomy 0.000 claims 2
- 210000005003 heart tissue Anatomy 0.000 claims 2
- 210000003563 lymphoid tissue Anatomy 0.000 claims 2
- 210000003205 muscle Anatomy 0.000 claims 2
- 210000002345 respiratory system Anatomy 0.000 claims 2
- 210000000626 ureter Anatomy 0.000 claims 2
- 230000002792 vascular Effects 0.000 claims 2
- LLYCQTXTSYWQNS-PLDAJOQYSA-N 5-bromo-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,3-diazinane-2,4-dione Chemical group BrC1(C(NC(N([C@H]2C[C@H](O)[C@@H](CO)O2)C1)=O)=O)C LLYCQTXTSYWQNS-PLDAJOQYSA-N 0.000 claims 1
- WOVKYSAHUYNSMH-RRKCRQDMSA-N 5-bromodeoxyuridine Chemical group C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-RRKCRQDMSA-N 0.000 claims 1
- LQLQRFGHAALLLE-UHFFFAOYSA-N 5-bromouracil Chemical group BrC1=CNC(=O)NC1=O LQLQRFGHAALLLE-UHFFFAOYSA-N 0.000 claims 1
- WOVKYSAHUYNSMH-UHFFFAOYSA-N BROMODEOXYURIDINE Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-UHFFFAOYSA-N 0.000 claims 1
- 102100038196 Chitinase-3-like protein 1 Human genes 0.000 claims 1
- 101150039808 Egfr gene Proteins 0.000 claims 1
- 101000883515 Homo sapiens Chitinase-3-like protein 1 Proteins 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 241000341655 Human papillomavirus type 16 Species 0.000 claims 1
- 102000007066 Prostate-Specific Antigen Human genes 0.000 claims 1
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
- 230000003187 abdominal effect Effects 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 229950004398 broxuridine Drugs 0.000 claims 1
- 238000007385 chemical modification Methods 0.000 claims 1
- 229940104302 cytosine Drugs 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 230000011987 methylation Effects 0.000 claims 1
- 238000007069 methylation reaction Methods 0.000 claims 1
- 239000008267 milk Substances 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- AGNZLVLRTYTRNY-UHFFFAOYSA-N n-(naphthalen-1-ylmethyl)formamide Chemical compound C1=CC=C2C(CNC=O)=CC=CC2=C1 AGNZLVLRTYTRNY-UHFFFAOYSA-N 0.000 claims 1
- 230000008520 organization Effects 0.000 claims 1
- 239000002096 quantum dot Substances 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 claims 1
- 229940045145 uridine Drugs 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/499,967 US7964356B2 (en) | 2007-01-16 | 2009-07-09 | Method for generating aptamers with improved off-rates |
| US12/499,967 | 2009-07-09 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012519765A Division JP5926178B2 (ja) | 2009-07-09 | 2010-07-09 | 向上したオフ速度を有するアプタマーを生成するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016065872A JP2016065872A (ja) | 2016-04-28 |
| JP2016065872A5 true JP2016065872A5 (https=) | 2016-06-30 |
Family
ID=43429566
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012519765A Active JP5926178B2 (ja) | 2009-07-09 | 2010-07-09 | 向上したオフ速度を有するアプタマーを生成するための方法 |
| JP2015215544A Pending JP2016065872A (ja) | 2009-07-09 | 2015-11-02 | 向上したオフ速度を有するアプタマーを生成するための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012519765A Active JP5926178B2 (ja) | 2009-07-09 | 2010-07-09 | 向上したオフ速度を有するアプタマーを生成するための方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7964356B2 (https=) |
| EP (1) | EP2451981B1 (https=) |
| JP (2) | JP5926178B2 (https=) |
| AU (1) | AU2010271271B2 (https=) |
| CA (2) | CA2982304A1 (https=) |
| ES (1) | ES2610633T3 (https=) |
| WO (1) | WO2011006075A1 (https=) |
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-
2009
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2010
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- 2010-07-09 WO PCT/US2010/041540 patent/WO2011006075A1/en not_active Ceased
- 2010-07-09 CA CA2765857A patent/CA2765857C/en active Active
- 2010-07-09 ES ES10797920.5T patent/ES2610633T3/es active Active
- 2010-07-09 AU AU2010271271A patent/AU2010271271B2/en active Active
- 2010-07-09 JP JP2012519765A patent/JP5926178B2/ja active Active
- 2010-07-09 EP EP10797920.5A patent/EP2451981B1/en active Active
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2015
- 2015-11-02 JP JP2015215544A patent/JP2016065872A/ja active Pending
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