JP2016029182A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016029182A5 JP2016029182A5 JP2015211581A JP2015211581A JP2016029182A5 JP 2016029182 A5 JP2016029182 A5 JP 2016029182A5 JP 2015211581 A JP2015211581 A JP 2015211581A JP 2015211581 A JP2015211581 A JP 2015211581A JP 2016029182 A5 JP2016029182 A5 JP 2016029182A5
- Authority
- JP
- Japan
- Prior art keywords
- poly
- polymer
- alkyl
- group
- polymer composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000642 polymer Polymers 0.000 claims description 12
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 4
- 125000002947 alkylene group Chemical group 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 229920005604 random copolymer Polymers 0.000 claims description 3
- 229920001897 terpolymer Polymers 0.000 claims description 3
- 229920001400 block copolymer Polymers 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- 229920001584 poly(acrylomorpholines) Polymers 0.000 claims 2
- 229920001583 poly(oxyethylated polyols) Polymers 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 229920001451 Polypropylene glycol Polymers 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical class OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 230000001588 bifunctional Effects 0.000 description 1
- 125000002791 glucosyl group Chemical class C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
Description
式−ＣＨ2ＣＨ2−（ＣＨ2ＣＨ2Ｏ）n−ＣＨ2ＣＨ2−（式中、ｎは約８〜４０００である）を有するＰＥＧは、本発明の実施における有用なポリマーの１つである。ＰＥＧ以外の他の二官能価で水溶性の非ペプチドポリマーもまた本発明に有用である。これらの他のポリマーには、ポリ（ビニルアルコール）（「ＰＶＡ」）；他のポリ（アルキレンオキシド（ポリ（プロピレングリコール）（「ＰＰＧ」）など）；およびポリ（オキシエチル化ポリオール（ポリ（オキシエチル化グリセロール）、ポリ（オキシエチル化ソルビトール）、およびポリ（オキシエチル化グルコース）など）が含まれる。ポリマーは、ホモポリマーまたはランダムもしくはブロックコポリマーおよび上記ポリマーのモノマーを基本単位とする直鎖もしくは分岐ターポリマーであり得る。 PEG having the formula —CH 2 CH 2 — (CH 2 CH 2 O) n —CH 2 CH 2 —, where n is about 8 to 4000, is one of the useful polymers in the practice of this invention. It is. Other bifunctional, water-soluble, non-peptidic polymers other than PEG are also useful in the present invention. These other polymers include poly (vinyl alcohol) (“PVA”); other poly (alkylene oxides such as poly (propylene glycol) (“PPG”)); and poly (oxyethylated polyols (poly (oxyethylated)). Glycerol), poly (oxyethylated sorbitol), and poly (oxyethylated glucose) etc.) The polymer is a linear or branched terpolymer based on homopolymers or random or block copolymers and monomers of the above polymers. possible.
Claims (3)
Ｒ−Ｏ−ポリ−Ｏ−Ｒ構造を有し、ポリがポリ（アルキレンオキシド）、ポリ（オキシエチル化ポリオール）、ポリビニルアルコール、ポリ（アクリロイルモルホリン）、または前記ポリマーのモノマーからなるランダムコポリマー、ブロックコポリマーもしくはターポリマーを示し、Ｒがアルキル又はアリール基を示すポリマー誘導体と、
の混合物を含むことを特徴とするポリマー組成物。 Has R-O- poly -R 'structure, poly Gapo Li (alkylene oxide), poly (oxyethylated polyol), poly (vinyl alcohol), poly (acryloyl morpholine), or random copolymer comprising a monomer of the polymer, block copolymer Or a terpolymer, R represents an alkyl or aryl group, R ′ represents —O—CO 2 R 3 (wherein R 3 is H 2 , an alkyl group or an N-succinimidyl group) or —O— (CH 2 ) n. -CO 2 R 3 (where n is 1 to 6, R 3 is H, alkyl or N- succinimidyl group), a polymer derivative,
It has R-O- poly -O-R structure, poly Gapo Li (alkylene oxide), poly (oxyethylated polyol), poly (vinyl alcohol), poly (acryloyl morpholine), or random copolymer comprising a monomer of the polymer, block A polymer derivative representing a copolymer or terpolymer, wherein R represents an alkyl or aryl group;
A polymer composition comprising a mixture of:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015211581A JP6184462B2 (en) | 2015-10-28 | 2015-10-28 | Heterobifunctional polyethylene glycol derivatives and methods for their preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015211581A JP6184462B2 (en) | 2015-10-28 | 2015-10-28 | Heterobifunctional polyethylene glycol derivatives and methods for their preparation |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012071638A Division JP5953459B2 (en) | 2012-03-27 | 2012-03-27 | Heterobifunctional polyethylene glycol derivatives and methods for their preparation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017125105A Division JP6361083B2 (en) | 2017-06-27 | 2017-06-27 | Heterobifunctional polyethylene glycol derivatives and methods for their preparation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016029182A JP2016029182A (en) | 2016-03-03 |
| JP2016029182A5 true JP2016029182A5 (en) | 2017-08-10 |
| JP6184462B2 JP6184462B2 (en) | 2017-08-23 |
Family
ID=55435196
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015211581A Expired - Lifetime JP6184462B2 (en) | 2015-10-28 | 2015-10-28 | Heterobifunctional polyethylene glycol derivatives and methods for their preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP6184462B2 (en) |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5849725A (en) * | 1981-09-21 | 1983-03-24 | Nippon Shokubai Kagaku Kogyo Co Ltd | Preparation of polyethylene glycol dibutyl ether |
| JPS5852321A (en) * | 1981-09-24 | 1983-03-28 | Nippon Shokubai Kagaku Kogyo Co Ltd | Production of polyethylene glycol dipropyl ether |
| JPS6028429A (en) * | 1983-07-26 | 1985-02-13 | Nippon Shokubai Kagaku Kogyo Co Ltd | Catalyst for preparing polyethylene glycol dialkyl ether |
| JPH0468023A (en) * | 1990-07-09 | 1992-03-03 | Sanyo Chem Ind Ltd | Polyalkylene glycol ether composition and its production |
| JP3465307B2 (en) * | 1993-08-05 | 2003-11-10 | 日本油脂株式会社 | Polyalkylene oxide derivative and production method |
| JP3508207B2 (en) * | 1994-05-30 | 2004-03-22 | 日本油脂株式会社 | Method for producing polyoxyalkylene derivative |
| JP3508234B2 (en) * | 1994-09-22 | 2004-03-22 | 日本油脂株式会社 | Method for producing polyoxyalkylene derivative |
| US20020064546A1 (en) * | 1996-09-13 | 2002-05-30 | J. Milton Harris | Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor |
| JP3855344B2 (en) * | 1997-02-19 | 2006-12-06 | 日本油脂株式会社 | Process for producing polyoxyalkylene carboxylic acid |
| JP3131572B2 (en) * | 1997-03-17 | 2001-02-05 | 旭電化工業株式会社 | Organic gas absorbent |
| JP3143076B2 (en) * | 1997-05-06 | 2001-03-07 | 昭和アルミニウム株式会社 | Flux composition for brazing aluminum material |
| ZA9811379B (en) * | 1997-12-12 | 1999-08-27 | Macromed Inc | Hetero-functionalized star-shaped poly(ethylene glycols) for protein modification. |
| US6187335B1 (en) * | 1997-12-31 | 2001-02-13 | Orasomal Technologies, Inc. | Polymerizable fatty acids, phospholipids and polymerized liposomes therefrom |
| DK1053019T3 (en) * | 1998-01-07 | 2004-04-13 | Debio Rech Pharma Sa | Degradable heterobifunctional polyethylene glycol acrylates and gels and conjugates derived therefrom |
| JP2000300994A (en) * | 1999-04-16 | 2000-10-31 | Nippon Shokubai Co Ltd | Catalyst for manufacturing alkylene glycol monoalkyl ether and its method of use |
-
2015
- 2015-10-28 JP JP2015211581A patent/JP6184462B2/en not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012031421A5 (en) | ||
| ES2659525T3 (en) | Controlled hydrolysis of poly-4-hydroxybutyrate and copolymers | |
| RU2013151313A (en) | POLYMERS OF MALEIC ANHYDRIDE AS A SOLUBLE AUXILIARY MATERIAL FOR THE PRINTER USING THE LAYERED APPLICATION TECHNOLOGY OF THE MELTED POLYMER THREAD (FDM) | |
| DE50102650D1 (en) | Hard capsules containing polymers of vinyl esters and polyethers, their use and manufacture | |
| JP2015513788A5 (en) | ||
| AR063931A1 (en) | PEOL TYPE COPOLYMERS | |
| JP2010100862A5 (en) | ||
| JP2015532345A5 (en) | ||
| JP2020513301A5 (en) | ||
| BR112014029253A2 (en) | nanogel polymers and materials and methods of fabrication and use thereof | |
| ATE534690T1 (en) | NANOPARTICLES MADE OF FUNCTIONALIZED VINYL POLYMER | |
| EP2204397A3 (en) | Biodegradable copolymer hydrogels | |
| JP2009544725A5 (en) | ||
| CO2018013019A2 (en) | Low to medium range water reducing polymer with mixed polyoxyalkylene side chains | |
| JP2018510792A5 (en) | ||
| JP2010235499A5 (en) | ||
| JP2014169462A5 (en) | ||
| WO2011025035A9 (en) | Coating composition | |
| JP2013023516A5 (en) | ||
| MX2017001925A (en) | Ethylene copolymers produced with single site catalyst. | |
| JP2016029182A5 (en) | ||
| JP2016539337A5 (en) | ||
| JP2015530473A5 (en) | ||
| JP2008266635A5 (en) | Active energy ray-curable liquid composition, aqueous ink, and liquid cartridge | |
| MX352177B (en) | Use of amphiphilic polymers as agents that improve the thermal stability and the uv resistance of chlorinated and filled thermoplastic materials, process for manufacturing said materials. |