JP2015519395A5 - - Google Patents
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- Publication number
- JP2015519395A5 JP2015519395A5 JP2015517245A JP2015517245A JP2015519395A5 JP 2015519395 A5 JP2015519395 A5 JP 2015519395A5 JP 2015517245 A JP2015517245 A JP 2015517245A JP 2015517245 A JP2015517245 A JP 2015517245A JP 2015519395 A5 JP2015519395 A5 JP 2015519395A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- acid
- matrix
- compound
- forming compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 16
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 claims description 8
- 239000000227 bioadhesive Substances 0.000 claims description 7
- 239000011159 matrix material Substances 0.000 claims description 6
- 208000019802 Sexually transmitted disease Diseases 0.000 claims description 5
- 239000003433 contraceptive agent Substances 0.000 claims description 5
- 230000002254 contraceptive effect Effects 0.000 claims description 5
- 239000003937 drug carrier Substances 0.000 claims description 3
- 239000000783 alginic acid Substances 0.000 claims 4
- 235000010443 alginic acid Nutrition 0.000 claims 4
- 229920000615 alginic acid Polymers 0.000 claims 4
- 229960001126 alginic acid Drugs 0.000 claims 4
- 150000004781 alginic acids Chemical class 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 244000005700 microbiome Species 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 229920001661 Chitosan Polymers 0.000 claims 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 2
- 229960001484 edetic acid Drugs 0.000 claims 2
- 239000000230 xanthan gum Substances 0.000 claims 2
- 229920001285 xanthan gum Polymers 0.000 claims 2
- 235000010493 xanthan gum Nutrition 0.000 claims 2
- 229940082509 xanthan gum Drugs 0.000 claims 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 1
- 208000004926 Bacterial Vaginosis Diseases 0.000 claims 1
- 239000005711 Benzoic acid Substances 0.000 claims 1
- 241000606161 Chlamydia Species 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 229920002148 Gellan gum Polymers 0.000 claims 1
- 206010018612 Gonorrhoea Diseases 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 239000005642 Oleic acid Substances 0.000 claims 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 1
- 229920000148 Polycarbophil calcium Polymers 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- 208000005448 Trichomonas Infections Diseases 0.000 claims 1
- 206010044620 Trichomoniasis Diseases 0.000 claims 1
- 208000037009 Vaginitis bacterial Diseases 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000010233 benzoic acid Nutrition 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 235000015165 citric acid Nutrition 0.000 claims 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims 1
- 239000001530 fumaric acid Substances 0.000 claims 1
- 235000011087 fumaric acid Nutrition 0.000 claims 1
- 230000000855 fungicidal effect Effects 0.000 claims 1
- 239000000417 fungicide Substances 0.000 claims 1
- 239000000216 gellan gum Substances 0.000 claims 1
- 235000010492 gellan gum Nutrition 0.000 claims 1
- 208000001786 gonorrhea Diseases 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 1
- 239000001630 malic acid Substances 0.000 claims 1
- 235000011090 malic acid Nutrition 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
- 235000021313 oleic acid Nutrition 0.000 claims 1
- 229920001983 poloxamer Polymers 0.000 claims 1
- 229960000502 poloxamer Drugs 0.000 claims 1
- 229950005134 polycarbophil Drugs 0.000 claims 1
- AVTYONGGKAJVTE-OLXYHTOASA-L potassium L-tartrate Chemical compound [K+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O AVTYONGGKAJVTE-OLXYHTOASA-L 0.000 claims 1
- 239000001472 potassium tartrate Substances 0.000 claims 1
- 229940111695 potassium tartrate Drugs 0.000 claims 1
- 235000011005 potassium tartrates Nutrition 0.000 claims 1
- 210000000582 semen Anatomy 0.000 claims 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 1
- 239000004334 sorbic acid Substances 0.000 claims 1
- 235000010199 sorbic acid Nutrition 0.000 claims 1
- 229940075582 sorbic acid Drugs 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 6
- 235000014655 lactic acid Nutrition 0.000 description 3
- 239000004310 lactic acid Substances 0.000 description 3
- SGOIRFVFHAKUTI-UHFFFAOYSA-N 1-(6-aminopurin-9-yl)propan-2-yloxymethylphosphonic acid Chemical compound N1=CN=C2N(CC(C)OCP(O)(O)=O)C=NC2=C1N SGOIRFVFHAKUTI-UHFFFAOYSA-N 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 230000003139 buffering effect Effects 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261659368P | 2012-06-13 | 2012-06-13 | |
| US61/659,368 | 2012-06-13 | ||
| PCT/US2013/032510 WO2013187984A1 (en) | 2012-06-13 | 2013-03-15 | Compositions and methods for enhancing the efficacy of contraceptive microbicides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018026423A Division JP6738573B2 (ja) | 2012-06-13 | 2018-02-16 | 避妊殺菌剤の効果を増強するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015519395A JP2015519395A (ja) | 2015-07-09 |
| JP2015519395A5 true JP2015519395A5 (https=) | 2016-05-12 |
| JP6352907B2 JP6352907B2 (ja) | 2018-07-04 |
Family
ID=49758600
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015517245A Active JP6352907B2 (ja) | 2012-06-13 | 2013-03-15 | 避妊殺菌剤の効果を増強するための組成物および方法 |
| JP2018026423A Active JP6738573B2 (ja) | 2012-06-13 | 2018-02-16 | 避妊殺菌剤の効果を増強するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018026423A Active JP6738573B2 (ja) | 2012-06-13 | 2018-02-16 | 避妊殺菌剤の効果を増強するための組成物および方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (7) | US20150202216A1 (https=) |
| EP (2) | EP2861215A1 (https=) |
| JP (2) | JP6352907B2 (https=) |
| KR (1) | KR102062599B1 (https=) |
| CN (2) | CN104487054A (https=) |
| AP (1) | AP2014008149A0 (https=) |
| AU (2) | AU2013274815B2 (https=) |
| BR (1) | BR112014030984B1 (https=) |
| EA (1) | EA201590008A1 (https=) |
| HK (1) | HK1208809A1 (https=) |
| IL (1) | IL235812B (https=) |
| MX (2) | MX365905B (https=) |
| NZ (1) | NZ703203A (https=) |
| SG (1) | SG11201408243VA (https=) |
| UA (1) | UA115876C2 (https=) |
| WO (1) | WO2013187984A1 (https=) |
| ZA (1) | ZA201500111B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201590008A1 (ru) * | 2012-06-13 | 2015-05-29 | Ивофем, Инк. | Композиции и способы повышения эффективности бактерицидных средств контрацепции |
| JP2017501227A (ja) * | 2013-12-19 | 2017-01-12 | エヴォフェム，インク． | アルギン酸をベースとする抗菌性化合物を使用して炎症と疾患を阻害するための組成物及び方法 |
| US11419835B2 (en) * | 2016-10-04 | 2022-08-23 | Evofem, Inc. | Method of treatment and prevention of bacterial vaginosis |
| USD920853S1 (en) * | 2018-09-14 | 2021-06-01 | Porsche Lizenz—und Handelsgesellschaft mbH & Co. KG | Bicycle |
| US11850303B2 (en) | 2020-10-27 | 2023-12-26 | Uqora, Inc. | Gel and a suppository and methods to provide the gel and suppository |
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| IT1213323B (it) * | 1986-08-07 | 1989-12-20 | Crinos Industria Farmaco | Composizione per uso locale ad atti vita' spermicida virulicida ,disinfettante e/o battericida |
| US4999342A (en) * | 1988-08-16 | 1991-03-12 | Ortho Pharmaceutical Corporation | Long lasting contraceptive suppository composition and methods of use |
| JP3202365B2 (ja) | 1992-12-04 | 2001-08-27 | 株式会社紀文フードケミファ | オリゴマンヌロン酸を重合度によって分離する方法 |
| US5592949A (en) | 1994-06-29 | 1997-01-14 | Moench; Thomas R. | Device for acidic buffering and method for inactivation of pathogens |
| US5667492A (en) * | 1994-10-07 | 1997-09-16 | Columbia Laboratories, Inc. | Use and composition of an anti-sexually transmitted diseases formulation |
| FR2728464B1 (fr) * | 1994-12-22 | 1997-04-30 | Innothera Lab Sa | Forme galenique unitaire, son procede d'obtention et ses utilisations |
| US6093394A (en) | 1997-04-11 | 2000-07-25 | Gynelogix, Inc. | Vaginal lactobacillus medicant |
| AU1661901A (en) | 1999-11-24 | 2001-06-04 | Cargill Dow Llc | Improved lactic acid processing; methods; arrangements; and, products |
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| JP2009102407A (ja) | 2001-03-08 | 2009-05-14 | Rohto Pharmaceut Co Ltd | Ｇリッチなアルギン酸含有組成物 |
| US20020177624A1 (en) | 2001-03-16 | 2002-11-28 | Calvin Hanna | Acetate-lactate buffering vaginal gel and for method of making same and treating bacterial vaginosis |
| ITMI20010913A1 (it) | 2001-05-04 | 2002-11-04 | Univ Pavia | Composizioni a rilascio controllato di acido lattico a livello vaginale |
| CA2449247A1 (en) | 2001-06-11 | 2002-12-19 | Merck & Co., Inc. | A method for treating inflammatory diseases by administering a ppar-delta agonist |
| US20060105008A1 (en) | 2002-03-28 | 2006-05-18 | Nawaz Ahmad | Compositions and methods for reducing vaginal pH |
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| JP4712380B2 (ja) | 2002-07-26 | 2011-06-29 | 三笠製薬株式会社 | 外用剤 |
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| JP2010528052A (ja) | 2007-05-24 | 2010-08-19 | ニューヨーク ブラッド センター， インコーポレイテッド | 生体接着性ジェルを提供する迅速に分散し得る膣錠剤 |
| US8464245B2 (en) | 2007-06-27 | 2013-06-11 | Flexera Software Llc | Method and system for software virtualization directly from an installation package |
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| KR20150002676A (ko) | 2012-03-19 | 2015-01-07 | 독토르. 아우구스트 볼프 게엠베하 운트 코. 카게 아르쯔네이미텔 | 질 염증에서의 병원성 질 균막의 예방 및 치료를 위한 양쪽성 계면활성제의 용도 |
| EA201590008A1 (ru) * | 2012-06-13 | 2015-05-29 | Ивофем, Инк. | Композиции и способы повышения эффективности бактерицидных средств контрацепции |
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| WO2015070072A1 (en) | 2013-11-07 | 2015-05-14 | Evofem, Inc. | Methods for manufacturing contraceptive microbicides with antiviral properties |
| JP2017501227A (ja) | 2013-12-19 | 2017-01-12 | エヴォフェム，インク． | アルギン酸をベースとする抗菌性化合物を使用して炎症と疾患を阻害するための組成物及び方法 |
| AU2015201042A1 (en) | 2014-02-28 | 2015-09-17 | Macfarlane Burnet Institute For Medical Research And Public Health Pty Ltd | Therapeutic Method |
| US20190209502A1 (en) | 2016-09-12 | 2019-07-11 | Evofem, Inc. | Combination gel for sexually transmitted infections |
| US11419835B2 (en) | 2016-10-04 | 2022-08-23 | Evofem, Inc. | Method of treatment and prevention of bacterial vaginosis |
-
2013
- 2013-03-15 EA EA201590008A patent/EA201590008A1/ru unknown
- 2013-03-15 WO PCT/US2013/032510 patent/WO2013187984A1/en not_active Ceased
- 2013-03-15 AP AP2014008149A patent/AP2014008149A0/xx unknown
- 2013-03-15 EP EP13804259.3A patent/EP2861215A1/en not_active Withdrawn
- 2013-03-15 CN CN201380030151.5A patent/CN104487054A/zh active Pending
- 2013-03-15 EP EP17200193.5A patent/EP3308771A1/en not_active Withdrawn
- 2013-03-15 KR KR1020157000465A patent/KR102062599B1/ko active Active
- 2013-03-15 BR BR112014030984-1A patent/BR112014030984B1/pt not_active IP Right Cessation
- 2013-03-15 JP JP2015517245A patent/JP6352907B2/ja active Active
- 2013-03-15 MX MX2014015307A patent/MX365905B/es active IP Right Grant
- 2013-03-15 SG SG11201408243VA patent/SG11201408243VA/en unknown
- 2013-03-15 US US14/410,841 patent/US20150202216A1/en not_active Abandoned
- 2013-03-15 HK HK15109540.9A patent/HK1208809A1/xx unknown
- 2013-03-15 NZ NZ703203A patent/NZ703203A/en not_active IP Right Cessation
- 2013-03-15 UA UAA201500194A patent/UA115876C2/uk unknown
- 2013-03-15 CN CN201910881646.8A patent/CN110693812A/zh active Pending
- 2013-03-15 AU AU2013274815A patent/AU2013274815B2/en not_active Ceased
-
2014
- 2014-11-20 IL IL235812A patent/IL235812B/en active IP Right Grant
- 2014-12-11 MX MX2019007176A patent/MX2019007176A/es unknown
-
2015
- 2015-01-08 ZA ZA2015/00111A patent/ZA201500111B/en unknown
- 2015-09-24 US US14/864,673 patent/US9566232B2/en not_active Expired - Fee Related
-
2017
- 2017-01-19 US US15/410,632 patent/US20170128396A1/en not_active Abandoned
- 2017-07-19 AU AU2017206199A patent/AU2017206199B2/en not_active Ceased
-
2018
- 2018-02-16 JP JP2018026423A patent/JP6738573B2/ja active Active
-
2019
- 2019-01-03 US US16/239,314 patent/US10568855B2/en active Active
-
2020
- 2020-01-09 US US16/738,868 patent/US11439610B2/en active Active
-
2022
- 2022-08-29 US US17/823,020 patent/US11992472B2/en active Active
-
2024
- 2024-04-24 US US18/645,334 patent/US20240423936A1/en active Pending
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