JP2015175782A - Automatic analysis apparatus - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an automatic analysis apparatus that can prevent deterioration of analysis data beforehand.SOLUTION: An automatic analysis apparatus comprises: a sample dispensation probe 16 that performs dispensation for sucking a sample in a sample container 17 to discharge the sample to a reaction container 3; a position detection unit 31 that detects a position of the sample dispensation probe 16; a liquid level detector 32 that detects a contact with respect to the sample in the sample container 17 of the sample dispensation probe 16, and a clearance from the sample; and a determination unit 40 that determines whether the dispensation of the sample by the sample dispensation probe 16 is normal. The determination unit is configured to determine that the dispensation thereof is normal on the basis of information on the clearance of the sample dispensation probe 16 to be detected by the liquid level detector 32 in a clearance position P3 of the sample dispensation probe 16 having sucked the sample, and determine that the dispensation thereof is abnormal on the basis of information on the contact of the sample dispensation probe 16.

Description

  Embodiments described herein relate generally to an automatic analyzer that dispenses a sample and a reagent into a reaction container and measures a mixed solution of the sample and the reagent dispensed into the reaction container.

  The automatic analyzer is intended for biochemical test items and immunological test items, etc., and changes in color and turbidity caused by the reaction of the mixture of the sample collected from the specimen and the reagent of each test item are measured with a spectrophotometer or a ratio. Optical data is measured by a photometric unit such as a turbidimeter to generate analysis data represented by the concentration of each test item component contained in the sample, the activity of the enzyme, and the like.

  The automatic analyzer includes a sample dispensing probe that sucks the sample in the sample container and discharges it to the reaction container, and a reagent dispensing probe that sucks the reagent in the reagent container and discharges it to the reaction container. In addition, if the sample contains an insoluble matter such as fibrin, the insoluble matter may be clogged in the sample dispensing probe, and some of them are equipped with a pressure sensor that can detect the clogging.

JP 2010-38578 A

  However, if the sample is dispensed into the reaction vessel with the insoluble matter adhering to the outer wall of the sample dispensing probe without clogging, the insoluble matter will also be dispensed, resulting in reduced sample dispensing accuracy and analysis data. There is a problem that gets worse.

  The embodiment has been made to solve the above-described problems, and an object thereof is to provide an automatic analyzer that can prevent deterioration of analysis data.

  In order to achieve the above object, the automatic analyzer according to the embodiment dispenses the sample in the sample container and the reagent in the reagent container into the reaction container, and measures the mixed liquid. A position detection unit that detects the position of a dispensing probe that dispenses one of the reagents that is dispensed into the reaction vessel, and a detection that detects the contact of the dispensing probe with the one and the separation from the one Based on the contact or separation information of the dispensing probe detected by the detector at a separation position where the dispensing probe in which contact with the one is detected is separated from the one, the dispensing And a determination unit that determines whether or not the one dispensing by the probe is normal.

The block diagram which shows the structure of the automatic analyzer which concerns on embodiment. The perspective view which shows the structure of the analysis part which concerns on embodiment. The top view of the reaction container which concerns on embodiment, the sample container hold | maintained at the sample disc, and the sample dispensing probe hold | maintained at the sample dispensing arm. The figure which shows the position of the sample dispensing probe which dispenses the sample which concerns on embodiment. The figure which shows the output of the detection circuit in a liquid level detector when detecting the separation | spacing and contact of the sample dispensing probe which concern on embodiment. The figure which shows the output of the differentiation circuit in the liquid level detector when detecting the separation and contact of the sample dispensing probe which concerns on embodiment. The figure which shows the other separation position which concerns on embodiment. The figure which shows the position of the sample dispensing probe which dispenses the sample which concerns on embodiment. The figure which shows the output of the detection circuit in a liquid level detector when it determines with dispensing of the sample which concerns on embodiment being abnormal. The figure which shows an example of the state in the separation position of the sample probe determined that the dispensing of the sample which concerns on embodiment is abnormal. The figure for demonstrating the other separation position which concerns on embodiment. The figure for demonstrating the other separation position which concerns on embodiment.

  Hereinafter, embodiments will be described with reference to the drawings.

  FIG. 1 is a block diagram illustrating a configuration of an automatic analyzer according to the embodiment. This automatic analyzer 100 dispenses the standard sample of each inspection item or the sample of the test sample and the reagent used for the analysis of each inspection item, measures the mixed solution of the sample and the reagent, and standard data or test data. The analysis part 24 which produces | generates is provided. In addition, a drive unit 26 that drives each analysis unit of the analysis unit 24 and an analysis control unit 27 that controls the drive unit 26 are provided.

  In addition, the automatic analyzer 100 detects whether the analysis unit 24 is normally dispensed based on the detection unit 30 that detects the position of each analysis unit of the analysis unit 24 and the position information detected by the detection unit 30. And a determination unit 40 for determining whether or not. Further, the standard data and test data generated by the analysis unit 24 are processed to generate calibration data and analysis data, and the output of the calibration data and analysis data generated by the data processing unit 50 is output. Part 60.

  Further, the automatic analyzer 100 includes an operation unit 70 for inputting the analysis parameters of each inspection item, the ID of the sample to be inspected, the inspection item, and the like. In addition, a system control unit 80 that controls the analysis control unit 27, the detection unit 30, the determination unit 40, the data processing unit 50, and the output unit 60 is provided.

  FIG. 2 is a perspective view showing the configuration of the analysis unit 24. The analysis unit 24 includes a sample container 17 that stores a sample such as a standard sample or a test sample, and a sample disk 5 that holds the sample container 17 so as to be movable. In addition, a reagent container 6 containing a first reagent or a two-reagent system first reagent containing a component that reacts with a component of a test item included in a sample, and a reagent rack 1a holding the reagent container 6 movably are provided. I have.

  In addition, the reagent container 1 that keeps the reagent container 6 held in the reagent rack 1a cold, the reagent container 7 that accommodates the second reagent paired with the first reagent of the two-reagent system, and the reagent container 7 are held movably. Reagent rack 2a. In addition, a reagent storage 2 that keeps the reagent container 7 held in the reagent rack 2a cool, a plurality of reaction containers 3 arranged on the circumference, and a reaction disk 4 that holds each reaction container 3 movably are provided. ing.

  In addition, a sample dispensing probe 16 for dispensing the sample in the sample container 17 held on the sample disk 5 and sucking it into the reaction container 3, and a sample portion for holding the sample dispensing probe 16 movably. A note arm 10 is provided. In addition, a cleaning tank 16b for cleaning the sample dispensing probe 16 every time when dispensing of the same sample is completed is provided.

  Further, the first reagent dispensing probe 14 for dispensing the first reagent in the reagent container 6 held in the reagent rack 1a and sucking it into the reaction container 3 and the first reagent dispensing probe 14 are moved. And a first reagent dispensing arm 8 that holds the first reagent. Moreover, the cleaning tank 14b which wash | cleans the 1st reagent dispensing probe 14 whenever the dispensing of the 1st reagent is complete | finished is provided.

  The second reagent dispensing probe 15 for aspirating the second reagent in the reagent container 7 held in the reagent rack 2a and dispensing it into the reaction container 3 from which the first reagent has been discharged; A second reagent dispensing arm 9 that holds the reagent dispensing probe 15 in a movable manner is provided. In addition, a cleaning tank 15b is provided for cleaning the second reagent dispensing probe 15 every time the second reagent is dispensed.

  Moreover, the measurement part 13 which irradiates light to the reaction container 3 and measures a liquid mixture, and the washing nozzle 12 which wash | cleans the inside of the reaction container 3 which complete | finished the measurement by the measurement part 13 are provided. Then, the measurement unit 13 irradiates light to the reaction container 3 at the measurement position that is rotating, and by this irradiation, the mixture of the standard sample and the first reagent in the reaction container 3 or the standard sample and the first and second samples. Light transmitted through the mixed solution with the reagent, the mixed solution of the test sample and the first reagent, or the mixed solution of the test sample and the first and second reagents is detected. Then, the detected signal is processed, for example, standard data represented by absorbance or test data is generated and output to the data processing unit 50.

  The drive unit 26 of FIG. 1 includes a drive source and a mechanism such as a stepping motor that drives each analysis unit of the analysis unit 24. Then, the sample disk 5, the reagent rack 1a, and the reagent rack 2a are rotationally driven to move the sample container 17, the reagent container 6, and the reagent container 7. Further, each reaction vessel 3 is moved by driving the reaction disk 4 to rotate. Further, the sample dispensing arm 10, the first reagent dispensing arm 8, and the second reagent dispensing arm 9 are rotated and driven up and down, respectively, so that the sample dispensing probe 16, the first reagent dispensing probe 14, and the second reagent are driven. The dispensing probe 15 is moved horizontally and vertically.

  The analysis control unit 27 controls the drive unit 26 based on the input information such as the analysis parameters of each inspection item, the ID of the test sample, and the inspection items input from the operation unit 70. Then, a drive pulse is supplied to the stepping motor of the drive unit 26, and the sample dispensing arm 10, the first reagent dispensing arm 8, the second reagent dispensing arm 9 and the like of the analysis unit 24 are driven, and the sample dispensing probe is driven. 16, The first reagent dispensing probe 14 and the second reagent dispensing probe 15 are moved.

  The detection unit 30 includes a position detection unit 31 that detects the positions of the sample dispensing probe 16, the first reagent dispensing probe 14, and the second reagent dispensing probe 15 of the analysis unit 24. Further, a liquid level detector 32 for detecting the contact of the sample dispensing probe 16 with the sample in the sample container 17 held on the sample disk 5 of the analysis unit 24 and the separation of the sample dispensing probe 16 from the sample is provided. ing. Further, the contact of the first reagent dispensing probe 14 with the first reagent in the reagent container 6 held in the reagent rack 1a of the analysis unit 24 and the separation of the first reagent dispensing probe 14 from the first reagent are detected. A liquid level detector 33 is provided. Further, the contact of the second reagent dispensing probe 15 with the second reagent in the reagent container 7 held in the reagent rack 2a of the analysis unit 24 and the separation of the second reagent dispensing probe 15 from the second reagent are detected. A liquid level detector 34 is provided.

  The position detection unit 31 detects the position of the sample dispensing probe 16 based on the number of drive pulses required for the movement of the sample dispensing probe 16 of the analysis unit 24 supplied from the analysis control unit 27 to the drive unit 26. Further, the position of the first reagent dispensing probe 14 is detected based on the number of drive pulses required for the movement of the first reagent dispensing probe 14 supplied from the analysis control unit 27 to the driving unit 26. Further, the position of the second reagent dispensing probe 15 is detected based on the number of drive pulses required for the movement of the second reagent dispensing probe 15 supplied from the analysis control unit 27 to the driving unit 26.

  The liquid level detector 32 includes a detection circuit 32 a including an oscillation circuit, a bridge circuit, a differential amplifier, a synchronous detection circuit, an integration circuit, an amplification circuit, and the like, and one end is electrically connected to the sample dispensing probe 16. . The contact of the sample dispensing probe 16 with the sample is detected by, for example, a change in capacitance when the sample dispensing probe 16 comes into contact with the sample in the sample container 17 held on the sample disk 5. Further, the separation of the sample dispensing probe 16 from the sample is detected by a change in capacitance when the sample dispensing probe 16 is separated from the sample in the sample container 17 held on the sample disk 5.

  The liquid level detector 33 includes a detection circuit 33a configured similarly to the detection circuit 32a, and one end thereof is connected to the first reagent dispensing probe 14. Then, the first reagent dispensing probe 14 to the first reagent is changed by the change in capacitance when the first reagent dispensing probe 14 contacts the first reagent in the reagent container 6 held in the reagent rack 1a. Detects contact. Further, the first reagent dispensing probe 14 from the first reagent is changed due to a change in capacitance when the first reagent dispensing probe 14 is separated from the first reagent in the reagent container 6 held in the reagent rack 1a. Detect the separation.

  The liquid level detector 34 includes a detection circuit 34 a configured similarly to the detection circuit 32 a, and one end thereof is connected to the second reagent dispensing probe 15. Then, the second reagent dispensing probe 15 to the second reagent is changed by the change in capacitance when the second reagent dispensing probe 15 comes into contact with the second reagent in the reagent container 7 held in the reagent rack 2a. Detects contact. Further, the second reagent dispensing probe 15 from the second reagent is changed due to a change in capacitance when the second reagent dispensing probe 15 is separated from the second reagent in the reagent container 7 held in the reagent rack 2a. Detect the separation.

  The determination unit 40 is based on the position information of the sample dispensing probe 16 detected by the position detection unit 31 of the detection unit 30 and the contact or separation information of the sample dispensing probe 16 detected by the liquid level detector 32. It is determined whether or not the sample dispensing by the sample dispensing probe 16 is normal. Further, based on the position information of the first reagent dispensing probe 14 detected by the position detector 31 and the contact or separation information of the first reagent dispensing probe 14 detected by the liquid level detector 33, the first reagent It is determined whether or not the dispensing of the first reagent by the dispensing probe 14 is normal. The second medicine is based on the position information of the second reagent dispensing probe 15 detected by the position detector 31 and the contact or separation information of the second reagent dispensing probe 15 detected by the liquid level detector 34. It is determined whether or not the dispensing of the second reagent by the dispensing probe 15 is normal.

  The data processing unit 50 processes the standard data and test data generated by the measurement unit 13 of the analysis unit 24 to generate calibration data and analysis data for each inspection item, and is generated by the calculation unit 51. And a data storage unit 52 for storing standard data and analysis data.

  The calculation unit 51 generates calibration data indicating the relationship between the standard data generated by the measurement unit 13 and the standard value preset in the standard sample, outputs the generated calibration data to the output unit 60 and the data storage unit 52. Save to. Also, calibration data corresponding to the test data generated by the measurement unit 13 is read from the data storage unit 52 to generate analysis data expressed as a concentration value or an enzyme activity value. The generated analysis data is output to the output unit 60 and stored in the data storage unit 52.

  The data storage unit 52 includes a memory device such as a hard disk, and stores the calibration data output from the calculation unit 51 for each inspection item. In addition, the analysis data of each inspection item output from the calculation unit 51 is stored for each test sample.

  The output unit 60 includes a printing unit 61 that prints out the calibration data and analysis data output from the calculation unit 51 of the data processing unit 50 and a display unit 62 that displays the output. The printing unit 61 includes a printer or the like, and prints the calibration data and analysis data output from the calculation unit 51 on printer paper or the like according to a preset format.

  The display unit 62 includes a monitor such as a CRT or a liquid crystal panel, and displays calibration data and analysis data output from the calculation unit 51. Also, an analysis parameter setting screen for setting analysis parameters for each inspection item, setting of test identification information such as name and ID for identifying the test sample for each test sample, and setting of inspection items necessary for the test To display the inspection item setting screen and so on.

  The operation unit 70 includes input devices such as a keyboard, a mouse, a button, and a touch key panel, and is used to set input for setting analysis parameters of each test item, test identification information of a test sample, and test items. Perform input etc.

  The system control unit 80 includes a CPU and a storage circuit, and stores input information such as analysis parameters, test identification information, and test items input from the operation unit 70 in the storage circuit. Based on the above, the analysis control unit 27, the detection unit 30, the determination unit 40, the data processing unit 50, and the output unit 60 are integrated to control the entire system.

  Hereinafter, the operation of the automatic analyzer 100 related to sample dispensing will be described.

FIG. 3 is a top view of the reaction container 3, the sample container 17 held on the sample disk 5, and the sample dispensing probe 16 held on the sample dispensing arm 10.
The sample dispensing probe 16 is made of a conductive material, and moves horizontally in the directions of the horizontal arrows R1 and R2 along the circular orbit indicated by the broken lines, so that the cleaning position T1, the sample position T2, and the reaction container position T3. Stop at each upper stop position. Moreover, after moving downward from each stop position, it moves upward and stops at each upper stop position.

  In sample dispensing, the sample dispensing probe 16 horizontally moves in the R2 direction from the upper stop position of the cleaning position T1, which is the home position, and then, as shown in FIG. 4A, the upper stop position of the sample position T2. Stop at P1. Next, as shown in FIG. 4B, the sample moves in the downward direction from the upper stop position P1 and comes into contact with the liquid level of the sample in the sample container 17 stopped at the sample position T2.

  As shown in FIG. 5, while the sample dispensing probe 16 is separated from the sample in the sample container 17 held by the sample disk 5, the liquid level detector 32 outputs the detection circuit 32a within the separation range Oa. The separation of the sample dispensing probe 16 from the sample in the sample container 17 is detected.

  In addition, the liquid level detector 32 has a capacitance as shown in FIG. 5 at the contact position P2 where the sample dispensing probe 16 shown in FIG. 4B contacts the sample liquid level in the sample container 17. Due to the change, the output of the detection circuit 32a falls within the contact range Oc. Thereby, the contact of the sample dispensing probe 16 with the sample in the sample container 17 is detected.

  Further, when the sample dispensing probe 16 that has sucked the sample moves upward and is separated from the sample in the sample container 17, the liquid level detector 32 causes the output of the detection circuit 32a to be within the separation range as shown in FIG. Enter Oa. Thereby, the separation of the sample dispensing probe 16 from the sample in the sample container 17 is detected.

  Note that the liquid level detector 32 may be provided with a differentiation circuit that differentiates the output of the detection circuit 32a. In this case, as shown in FIG. 6, when the output of the differentiating circuit enters the separation range Oc1, the contact of the sample dispensing probe 16 with the sample in the sample container 17 is detected. When the output of the differentiating circuit enters the separation range Oa1, the separation of the sample dispensing probe 16 from the sample in the sample container 17 is detected.

  The position detection unit 31 moves the sample dispensing probe 16 from the upper stop position P1 to the contact position P2 based on the number of drive pulses required to move the sample dispensing probe 16 from the upper stop position P1 to the contact position P2. By calculating the distance D1, the contact position P2 in the vertical direction is detected from the upper stop position P1 as a starting point. Next, as shown in FIG. 4C, the lower end of the sample dispensing probe 16 before the sample is aspirated, which is a position above the contact position P <b> 2 by the distance D <b> 2, is slightly separated from the sample liquid level in the sample container 17. The separation position P3 to be calculated is calculated.

  A plurality of types having different inner horizontal cross-sectional areas such as a sample container 17 having a small inner horizontal cross-sectional area capable of accommodating a small amount of sample for children and a sample container 17 having a large horizontal cross-sectional area such as a blood collection tube. When the sample container 17 is present, information on the horizontal cross-sectional area inside the sample container 17 is input from the operation unit 70 in advance in association with each holding position of the sample container 17 of the sample disk 5. Information on the horizontal cross-sectional area inside the sample container 17 stopped at the sample position T2, information on the suction amount by which the sample dispensing probe 16 sucks the sample in the sample container 17, and the contact position P2 of the sample dispensing probe 16 As shown in FIG. 7, the distance to the separation position P3a where the lower end of the sample dispensing probe 16 that has sucked the sample of the suction amount is separated from the sample liquid surface in the sample container 17 by the distance D3 is calculated. You may carry out like.

  As shown in FIG. 8A, the sample dispensing probe 16 is separated from the contact position P2 by the control of the analysis control unit 27 based on the contact information of the sample dispensing probe 16 detected by the liquid level detector 32. D4 moves downward and stops at the suction position P4 where the sample can be sucked. Then, after sucking a sample of a suction amount corresponding to a dispensing amount set in advance at the suction position P4, the sample moves upward from the suction position P4.

  As described above, the sample dispensing probe 16 is sucked into the suction position 4 based on the information on the contact position P2 when the liquid level detector 32 detects the contact of the sample dispensing probe 16 with the sample liquid surface in the sample container 17. By stopping at, the contact with the unnecessary sample can be avoided and contamination of the outer wall of the sample dispensing probe 16 by the sample can be reduced.

  When the sample dispensing probe 16 that has sucked the sample moves upward from the suction position P4 and is separated from the sample in the sample container 17, the output of the detection circuit 32a enters the separation range Oa. Thus, the separation of the sample dispensing probe 16 from the sample in the sample container 17 is detected.

  Based on the position information of the sample dispensing probe 16 in the position detector 31 and the contact or separation information of the sample dispensing probe 16 in the liquid level detector 32, the determination unit 40 sucks the sample at the separation position P3. By detecting the separation or contact of the injection probe 16, it is determined whether or not the sample dispensing by the sample dispensing probe 16 is normal.

  When the separation of the sample dispensing probe 16 is detected at the separation position P3 of the sample dispensing probe 16, it is determined that the sample dispensing by the sample dispensing probe 16 is normal. In this case, as shown in FIG. 8B, the sample dispensing probe 16 is separated from the sample in the sample container 17 at the separation position P3. Further, as shown in FIG. 9, when contact of the sample dispensing probe 16 is detected at the separation position P3 of the sample dispensing probe 16, it is determined that the sample dispensing by the sample dispensing probe 16 is abnormal. .

FIG. 10 is a diagram illustrating an example of a state at the separation position P3 of the sample probe 16 that is determined to be abnormal in dispensing the sample.
Since the sample dispensing probe 16 moves upward in a state where insoluble matter such as fibrin contained in the sample such as dust or serum mixed in the sample in the sample container 17 is attached to the lower end portion, the inside of the sample container 17 In the separation position P3 slightly separated from the sample liquid surface, the insoluble matter attached to the sample dispensing probe 16 is in contact with the sample in the sample container 17. At this time, since the electrical resistance between the sample dispensing probe 16 and the sample in the sample container 17 is low, the liquid level detector 32 detects the contact of the sample dispensing probe 16 with the sample in the sample container 17.

  Here, if insoluble matter adheres to the sample dispensing probe 16 at the separation position P3, the insoluble matter adheres to the sample dispensing probe 16 up to the discharge position where the sample is discharged into the reaction container 3, and the discharged sample. There is a high possibility that insoluble matter will be mixed in. When insoluble matter is mixed, a sample larger than the dispensing amount is discharged, and the dispensing accuracy of the sample is lowered. Moreover, when the insoluble matter is contained in the liquid mixture of a sample and a reagent, it will interfere with the light irradiated from the measurement part 13, and a measurement precision will fall. And the analysis data will be deteriorated.

  Thus, by detecting the contact or separation of the sample dispensing probe 16 at the separation position P3, it is possible to detect whether or not insoluble matter is attached to the sample dispensing probe 16.

  The separation or contact of the sample dispensing probe 16 that has sucked the sample at the separation position P3a is detected to determine whether or not the sample dispensing by the sample dispensing probe 16 is normal. Also good. Thereby, regardless of the horizontal cross-sectional area inside the sample container 17 and the suction amount of the sample, whether or not insoluble matter is attached to the sample dispensing probe 16 at a position that is always separated from the sample in the sample container 17 by a certain distance D3. Therefore, it is possible to more accurately detect whether or not the sample dispensing by the sample dispensing probe 16 is normal.

  Further, based on the position information of the sample dispensing probe 16 detected by the position detecting unit 31 when the liquid level detector 32 detects the separation of the sample dispensing probe 16, the sample dispensing by the sample dispensing probe 16 is performed. You may implement so that it may be determined whether a note is normal. In this case, when the position when the separation of the sample dispensing probe 16 that has sucked the sample moving upward from the suction position P4 is detected is the separation position P3 or the separation position P3a, the sample dispensing probe 16 removes the sample. It is determined that the dispensing is normal. Further, when the position of the sample dispensing probe 16 when the separation of the sample dispensing probe 16 is detected is above the separation position P3 or the separation position P3a, the sample dispensing by the sample dispensing probe 16 is abnormal. Judge that there is.

  When the determination unit 40 determines that the sample dispensing by the sample dispensing probe 16 is abnormal, the determination unit 40 outputs abnormality information on the sample dispensing to the analysis control unit 27. The analysis control unit 27 stops dispensing the sample determined to be abnormal into the reaction container 3.

  As described above, when it is determined that the sample dispensing is abnormal, the sample dispensing probe 16 stops the sample dispensing, thereby preventing the analysis data from being deteriorated.

  Note that the separation position (first reagent separation position) where the first reagent dispensing probe 14 that has aspirated the first reagent is separated from the first reagent in the reagent container 6 is the separation position P3 or P3a in the sample dispensing. Calculate in the same manner as above. Then, the separation or contact of the first reagent dispensing probe 14 that has aspirated the first reagent at the first reagent separation position is detected by the liquid level detector 33, and dispensing of the first reagent by the first reagent dispensing probe 14 is performed. You may implement so that it may determine whether it is normal. In this case, when the separation of the first reagent dispensing probe 14 that has sucked the first reagent is detected at the first reagent separation position, it is determined that the dispensing of the first reagent is normal. When contact of the first reagent dispensing probe 14 that has aspirated the first reagent is detected at the first reagent separation position, insoluble matter adheres to the first reagent dispensing probe 14 and the first reagent is dispensed. It is determined that there is an abnormality, and the dispensing of the first reagent by the first reagent dispensing probe 14 is stopped. Thereby, deterioration of analysis data can be prevented beforehand.

  Further, when the second reagent dispensing probe 15 that has sucked the second reagent is separated from the second reagent in the reagent container 7 (second reagent separation position) is the separation position P3 or P3a in the sample dispensing. Calculate in the same manner as above. Then, the separation or contact of the second reagent dispensing probe 15 at the second reagent separation position is detected by the liquid level detector 34, and whether or not the second reagent dispensing by the second reagent dispensing probe 15 is normal. You may implement so that it may determine. In this case, when the separation of the second reagent dispensing probe 15 that has aspirated the second reagent is detected at the second reagent separation position, it is determined that the second reagent dispensing is normal. When contact of the second reagent dispensing probe 15 that has aspirated the second reagent is detected at the second reagent separation position, insoluble matter adheres to the second reagent dispensing probe 15 and the second reagent is dispensed. It is determined that there is an abnormality, and the dispensing of the second reagent by the second reagent dispensing probe 15 is stopped. Thereby, deterioration of analysis data can be prevented beforehand.

  According to the embodiment described above, the position detection unit 31 that detects the position of the sample dispensing probe 16 and the contact of the sample dispensing probe 16 with the sample in the sample container 17 and the sample distribution from the sample in the sample container 17. A liquid level detector 32 capable of detecting the separation of the injection probe 16 is provided, and the separation or contact of the sample dispensing probe 16 that has sucked the sample at the separation position P3 is detected, thereby separating the sample by the sample dispensing probe 16. It can be determined whether or not the note is normal.

  When the separation of the sample dispensing probe 16 is detected at the separation position P3, it can be determined that the sample dispensing is normal. When contact of the sample dispensing probe 16 is detected at the separation position P3, it is determined that the sample dispensing is abnormal, and the sample dispensing by the sample dispensing probe 16 can be stopped. Thereby, deterioration of analysis data can be prevented beforehand.

  In addition, it is not limited to the said embodiment, As shown in FIG. 11, it is spaced apart from the sample dispensing probe 16 which moves between the upper stop position P1 of sample position T2 and the upper stop position of reaction container position T3. A rod-shaped detector 18 having conductivity is provided between the sample position T2 and the reaction container position T3 and can detect contact and separation with the sample dispensing probe 16 by the liquid level detector 32. Then, as shown in FIG. 12, the sample dispensing probe 16 that sucks the sample moving in the R1 direction, which is the direction of the upper stop position of the reaction container position T3 from the upper stop position P1 of the sample position T2, approaches the detection body 18. A position where the lower end of the sample dispensing probe 16 is separated from the upper end of the detection body 18 by, for example, a distance D3 is defined as a separation position P3b. When the separation of the sample dispensing probe 16 from the detection body 18 is detected by the liquid level detector 32 at the separation position P3b, it is determined that the sample dispensing is normal. Further, when contact of the sample dispensing probe 16 with the detection body 18 is detected at the separation position P3b, insoluble matter attached to the sample dispensing probe 16 contacts the detection body 18 and the sample dispensing is abnormal. And the sample dispensing by the sample dispensing probe 16 is stopped. Thereby, deterioration of analysis data can be prevented beforehand.

  In addition, the first reagent position where the reagent container 6 containing the first reagent that can be aspirated by the first reagent dispensing probe 14 is stopped, and the first reagent dispensing probe 14 discharges the first reagent. The reaction vessel 3 where the possible reaction vessel 3 is stopped (first reagent reaction vessel position) is disposed away from the first reagent dispensing probe 14 that moves between the upper stop positions, and the first reagent is detected by the liquid level detector 33. A conductive rod-shaped detector (first reagent detector) capable of detecting contact and separation with the dispensing probe 14 is provided. Then, the first reagent dispensing probe 14 that sucks the first reagent moving from the upper stop position of the first reagent position toward the upper stop position of the first reagent reaction container position approaches the first reagent detector, The position at which the lower end of the one reagent dispensing probe 14 is separated from the upper end of the first reagent detector by the distance D3 is defined as a separated position (first reagent separated position). If the separation of the first reagent dispensing probe 14 from the first reagent detector is detected by the liquid level detector 33 at the first reagent separation position, it is determined that the dispensing of the first reagent is normal. In addition, when contact of the first reagent dispensing probe 14 with the first reagent detector is detected at the first reagent separation position, insoluble matter attached to the first reagent dispensing probe 14 contacts the first reagent detector. Then, it is determined that the dispensing of the first reagent is abnormal, and the dispensing of the first reagent by the first reagent dispensing probe 14 is stopped. Thereby, deterioration of analysis data can be prevented beforehand.

  Although several embodiments of the present invention have been described, these embodiments are presented by way of example and are not intended to limit the scope of the invention. These novel embodiments can be implemented in various other forms, and various omissions, replacements, and changes can be made without departing from the scope of the invention. These embodiments and modifications thereof are included in the scope and gist of the invention, and are included in the invention described in the claims and the equivalents thereof.

P1 Upper stop position P2 Contact position P3, P3a, P3b Separation position P4 Suction position T2 Sample position T3 Reaction container position 3 Reaction container 6, 7 Reagent container 16 Sample dispensing probe 14 First reagent dispensing probe 15 Second reagent dispensing Probe 17 Sample container 31 Position detection unit 32, 33, 34 Liquid level detector 40 Determination unit

Claims (8)

In an automatic analyzer that dispenses the sample in the sample container and the reagent in the reagent container into the reaction container and measures the mixture,
A position detection unit that detects the position of a dispensing probe that performs dispensing by sucking one of the sample or the reagent and discharging it to the reaction container;
A detector for detecting contact with and separation from the one of the dispensing probes;
Based on the contact or separation information of the dispensing probe detected by the detector at a separation position where the dispensing probe in which contact with the one is detected is separated from the one, the dispensing probe detects the contact by the dispensing probe. An automatic analyzer comprising: a determination unit that determines whether one dispensing is normal.   The determination unit determines that it is normal when separation of the dispensing probe is detected at the separation position of the dispensing probe that has sucked the one, and when contact of the dispensing probe is detected The automatic analyzer according to claim 1, wherein the automatic analyzer is determined to be abnormal. In an automatic analyzer that dispenses the sample in the sample container and the reagent in the reagent container into the reaction container and measures the mixture,
A position detection unit that detects the position of a dispensing probe that performs dispensing by sucking one of the sample or the reagent and discharging it to the reaction container;
A detector for detecting contact with and separation from the one of the dispensing probes;
Whether the one dispensing by the dispensing probe is normal based on the position information of the dispensing probe detected by the position detector when the detector detects the separation of the dispensing probe An automatic analyzer comprising a determination unit for determining whether or not.   The determination unit determines that the dispensing probe is normal when the dispensing probe that has sucked the one is detected and is in a separated position separated from the one, and the dispensing probe is The automatic analyzer according to claim 3, wherein it is determined that there is an abnormality when the position is above the separation position.   The separation position is a position that is calculated by the position detection unit and is a predetermined distance above a contact position at which a lower end of the dispensing probe before sucking the one contacts the one liquid surface. The automatic analyzer according to claim 1, claim 2, or claim 4. The one is the sample;
The separation position includes a contact position where the lower end of the dispensing probe before the one is aspirated contacts the one liquid surface, a suction amount of the sample by the dispensing probe, and a horizontal sectional area inside the sample container. The lower end of the dispensing probe that has suctioned the sample of the suction amount calculated based on the position detection unit based on the position is a position that is spaced apart from the one liquid surface by a predetermined distance. The automatic analyzer according to claim 1, claim 2 or claim 4. A detector that is arranged apart from the dispensing probe that moves between the one upper stop position and the upper stop position of the reaction vessel, and that can detect contact and separation with the dispensing probe by the liquid level detector. Have
The separation position is a position where a lower end of the dispensing probe that sucks the sample between the one upper stop position and the upper stop position of the reaction container is separated from the upper end of the detection body by a predetermined distance. The automatic analyzer according to claim 1 or 2, characterized by the above.   The automatic analysis according to any one of claims 1 to 7, wherein the dispensing probe stops dispensing to the one reaction container determined to be abnormal by the determination unit. apparatus.

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