JP2015036375A - ボタンボウフウ又はその抽出物を含む精子改善剤及び精液改善剤 - Google Patents
ボタンボウフウ又はその抽出物を含む精子改善剤及び精液改善剤 Download PDFInfo
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- JP2015036375A JP2015036375A JP2013168559A JP2013168559A JP2015036375A JP 2015036375 A JP2015036375 A JP 2015036375A JP 2013168559 A JP2013168559 A JP 2013168559A JP 2013168559 A JP2013168559 A JP 2013168559A JP 2015036375 A JP2015036375 A JP 2015036375A
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Abstract
本発明の目的は、従来技術に比して、原料の入手が比較的容易であることから工業的な生産に適した精子数改善作用を有する組成物を提供することにある。
【解決手段】
上記目的は、ボタンボウフウ又はその抽出物を含む精子改善剤及び精液改善剤、ボタンボウフウ又はその抽出物を有効成分として含む男性不妊症を予防及び/又は治療するための医薬品並びに一日摂取量としてボタンボウフウの乾燥葉1.5〜10g又はその抽出物を含む経口投与用組成物により解決される。
【選択図】なし
Description
本発明の精子改善剤は、本発明の精子改善剤を摂取する前後において、被験者の精子濃度、運動率又はこれらの両方を改善又は維持する作用を奏する。本発明の精液改善剤は、本発明の精液改善剤を摂取する前後において、被験者の精液量を改善又は維持する作用を奏する。このような本発明の精子改善剤及び精液改善剤が有する作用は、含有するボタンボウフウ又はその抽出物により達成される。ボタンボウフウ又はその抽出物を有効成分として含む医薬品は、男性不妊症を予防及び/又は治療するために有益である。本発明の経口投与用組成物は、例えば、食品、特に健康食品として、ボタンボウフウ又はその抽出物を経口的に投与されることに適した形態をとるものである。本発明の精子改善剤、精液改善剤、医薬品及び経口投与用組成物については、ボタンボウフウ若しくはその抽出物、又はボタンボウフウ及びその抽出物を含有する点で共通する。以下では、まず、本発明に共通するボタンボウフウ及びその抽出物について説明する。なお、本明細書では、A、B又はA及びBの両方を表わす際に、「A及び/又はB」と省略して表わす場合もある。
1.精液試料採取前の準備
前回の射精から、最低3日間の禁欲期間を設けた。精液採取用容器は1種類の容器を用いた。
次の手順で、被験者は採精室にて精液試料を採取した。すなわち、被験者は排尿を済ませた後、手及び生殖器を石鹸で洗い、精液への皮膚からの共生微生物の汚染リスクを減じた。次いで、被験者は、手及び生殖器の石鹸を水でよく洗い流した後、使い捨てタオルで手及び生殖器を乾かした。次いで、被験者が用手的に射精することにより、用意した無菌容器内に射精精液の全量を採取した。採取した精液を検査部に速やかに輸送した。精液は、約30分間室温で放置して液化を図った後、保存液を添加して蓋をして攪拌混合に供した。
1.測定方法
(1)精子濃度
被験者から採取した精液試料の5.7μLをスライドグラスに滴下し、カバーガラスをかけ、位相差顕微鏡(観察倍率400倍率)により検鏡及び写真撮影して測定した。
総精子数の測定は精子濃度に採取した精液試料量を乗じることにより、被験者から採取した精液試料に含まれる総精子数を算出した。
運動率は被験者から採取した精液試料の5.7μLをスライドグラスに滴下し、カバーガラスをかけ、位相差顕微鏡(観察倍率200倍率)により検鏡及び動画撮影して測定した。精子の運動率は、前進運動精子(直線的又は円弧を描くように動く精子)、非前進運動精子及び不動精子の数に対する前進運動精子数の割合によって算出した。
精子について、精子濃度、運動率はWHOラボマニュアルに従って判定した。なお、WHOラボマニュアルの表A1.1では、精液所見に対しての下限基準値(5パーセンタイルと95%の信頼範囲)を以下の表1のとおりに定めている。
宮古島産のボタンボウフウの葉を、大気圧下、15〜25℃で1週間以上乾燥させた。乾燥した葉15〜25枚の葉身を細かくしたもの2.5〜3.5gを500mLの水に入れ沸騰させた。約2分間沸騰を続けた後、煎じた液体物をボタンボウフウ含有液体物として被験者に供した。
2012年8月1日(第1日目)に被験者から精液試料を採取し、精子量、精子濃度、総精子数及び運動率を測定した。各測定結果を表2に示す。被験者は、同日より2012年10月30日までの約3か月に渡って、ツムラ25桂枝茯苓丸エキス顆粒(医療用)2.5gを毎食前に3回摂取した。
以下に、本発明の具体例を非限定的に示す。
Claims (4)
- ボタンボウフウ又はその抽出物を含む精子改善剤。
- ボタンボウフウ又はその抽出物を含む精液改善剤。
- ボタンボウフウ又はその抽出物を有効成分として含む、男性不妊症を予防及び/又は治療するための医薬品。
- 一日摂取量としてボタンボウフウの乾燥葉1.5〜10g又はその抽出物を含む、経口投与用組成物。
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JP2016192913A (ja) * | 2015-03-31 | 2016-11-17 | 株式会社東洋新薬 | 食物の胃からの排出遅延剤 |
JP2020128436A (ja) * | 2015-04-30 | 2020-08-27 | 株式会社東洋新薬 | 骨強化剤 |
JP2021063139A (ja) * | 2021-01-28 | 2021-04-22 | 株式会社東洋新薬 | 食物の胃からの排出遅延剤 |
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CN102357179A (zh) * | 2011-11-03 | 2012-02-22 | 刘玉兰 | 治疗抗精子抗体致不孕症或习惯性流产的药物及制备方法 |
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JP2016192913A (ja) * | 2015-03-31 | 2016-11-17 | 株式会社東洋新薬 | 食物の胃からの排出遅延剤 |
JP2020128436A (ja) * | 2015-04-30 | 2020-08-27 | 株式会社東洋新薬 | 骨強化剤 |
JP2021063139A (ja) * | 2021-01-28 | 2021-04-22 | 株式会社東洋新薬 | 食物の胃からの排出遅延剤 |
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