JP2014518274A5 - - Google Patents
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- Publication number
- JP2014518274A5 JP2014518274A5 JP2014519082A JP2014519082A JP2014518274A5 JP 2014518274 A5 JP2014518274 A5 JP 2014518274A5 JP 2014519082 A JP2014519082 A JP 2014519082A JP 2014519082 A JP2014519082 A JP 2014519082A JP 2014518274 A5 JP2014518274 A5 JP 2014518274A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical formulation
- epigenetic
- use according
- unit dose
- spb
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- OBKXEAXTFZPCHS-UHFFFAOYSA-N 4-phenylbutyric acid Chemical compound OC(=O)CCCC1=CC=CC=C1 OBKXEAXTFZPCHS-UHFFFAOYSA-N 0.000 claims 13
- 229960002232 Sodium phenylbutyrate Drugs 0.000 claims 13
- 229950009215 phenylbutanoic acid Drugs 0.000 claims 13
- 230000001973 epigenetic Effects 0.000 claims 12
- 239000003607 modifier Substances 0.000 claims 12
- 229960001285 Quercetin Drugs 0.000 claims 7
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims 7
- 235000005875 quercetin Nutrition 0.000 claims 7
- 229930002344 quercetin Natural products 0.000 claims 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 5
- PMMURAAUARKVCB-DQBDMIDPSA-N 2-Deoxy-D-glucose Chemical compound OCC1O[C@H](O)C[C@H](O)[C@@H]1O PMMURAAUARKVCB-DQBDMIDPSA-N 0.000 claims 4
- 229940094952 Green Tea Extract Drugs 0.000 claims 4
- XOAAWQZATWQOTB-UHFFFAOYSA-N Taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims 4
- 230000000111 anti-oxidant Effects 0.000 claims 4
- 239000003963 antioxidant agent Substances 0.000 claims 4
- 235000006708 antioxidants Nutrition 0.000 claims 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 4
- 230000034659 glycolysis Effects 0.000 claims 4
- 235000020688 green tea extract Nutrition 0.000 claims 4
- MHAJPDPJQMAIIY-UHFFFAOYSA-N hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 238000010253 intravenous injection Methods 0.000 claims 4
- 239000007800 oxidant agent Substances 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 3
- 238000001647 drug administration Methods 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- DEQANNDTNATYII-OULOTJBUSA-N (4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 claims 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims 2
- JXTHNDFMNIQAHM-UHFFFAOYSA-N Dichloroacetic acid Chemical compound OC(=O)C(Cl)Cl JXTHNDFMNIQAHM-UHFFFAOYSA-N 0.000 claims 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N Glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 2
- 229960003180 Glutathione Drugs 0.000 claims 2
- 108010024636 Glutathione Proteins 0.000 claims 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 229960002700 Octreotide Drugs 0.000 claims 2
- 108010016076 Octreotide Proteins 0.000 claims 2
- 229960002429 Proline Drugs 0.000 claims 2
- 229960003080 Taurine Drugs 0.000 claims 2
- 229930003268 Vitamin C Natural products 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 2
- 229960005215 dichloroacetic acid Drugs 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 claims 2
- 229910052732 germanium Inorganic materials 0.000 claims 2
- 229960002163 hydrogen peroxide Drugs 0.000 claims 2
- 229960003646 lysine Drugs 0.000 claims 2
- 239000000546 pharmaceutic aid Substances 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 235000019154 vitamin C Nutrition 0.000 claims 2
- 239000011718 vitamin C Substances 0.000 claims 2
- 150000003700 vitamin C derivatives Chemical class 0.000 claims 2
- 230000004049 epigenetic modification Effects 0.000 claims 1
- XKOHIWVZKSEQHP-UHFFFAOYSA-N phenyl butanoate;sodium Chemical compound [Na].CCCC(=O)OC1=CC=CC=C1 XKOHIWVZKSEQHP-UHFFFAOYSA-N 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161505393P | 2011-07-07 | 2011-07-07 | |
| US61/505,393 | 2011-07-07 | ||
| US201161507950P | 2011-07-14 | 2011-07-14 | |
| US61/507,950 | 2011-07-14 | ||
| PCT/US2012/045821 WO2013006821A1 (en) | 2011-07-07 | 2012-07-06 | Systems, methods, and formulations for treating cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017009055A Division JP6401317B2 (ja) | 2011-07-07 | 2017-01-23 | がんを治療するためのシステム、方法、および製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014518274A JP2014518274A (ja) | 2014-07-28 |
| JP2014518274A5 true JP2014518274A5 (US07981874-20110719-C00313.png) | 2015-08-13 |
| JP6082737B2 JP6082737B2 (ja) | 2017-02-15 |
Family
ID=47437478
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014519082A Active JP6082737B2 (ja) | 2011-07-07 | 2012-07-06 | がんを治療するためのシステム、方法、および製剤 |
| JP2017009055A Active JP6401317B2 (ja) | 2011-07-07 | 2017-01-23 | がんを治療するためのシステム、方法、および製剤 |
| JP2018166950A Pending JP2018203767A (ja) | 2011-07-07 | 2018-09-06 | がんを治療するためのシステム、方法、および製剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017009055A Active JP6401317B2 (ja) | 2011-07-07 | 2017-01-23 | がんを治療するためのシステム、方法、および製剤 |
| JP2018166950A Pending JP2018203767A (ja) | 2011-07-07 | 2018-09-06 | がんを治療するためのシステム、方法、および製剤 |
Country Status (13)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8933078B2 (en) | 2011-07-14 | 2015-01-13 | Research Cancer Institute Of America | Method of treating cancer with combinations of histone deacetylase inhibitors (HDAC1) substances |
| US20140363523A1 (en) * | 2012-01-18 | 2014-12-11 | Concert Pharmaceuticals, Inc. | Deuterated alpha-lipoic acid |
| CN103877066B (zh) * | 2014-02-21 | 2016-08-24 | 中国人民解放军第二军医大学 | 载多西他赛和莱菔硫烷的自组装纳米粒的制备方法与应用 |
| US11890292B2 (en) | 2017-02-27 | 2024-02-06 | Research Cancer Institute Of America | Compositions, methods, systems and/or kits for preventing and/or treating neoplasms |
| WO2018170457A1 (en) * | 2017-03-17 | 2018-09-20 | Research Cancer Institute Of America | Compositions, methods, systems and/or kits for preventing and/or treating neoplasms |
| US20220087946A1 (en) * | 2017-10-06 | 2022-03-24 | Research Cancer Institute Of America | Compositions, methods, systems and/or kits for preventing and/or treating neoplasms |
| WO2020061254A1 (en) * | 2018-09-19 | 2020-03-26 | Virginia Tech Intellectual Properties, Inc. | Brca1 modulating compounds, formulations thereof, and uses thereof |
| WO2021119298A1 (en) * | 2019-12-10 | 2021-06-17 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Combination therapies for the treatment of cancer |
| CN112336716A (zh) * | 2020-11-25 | 2021-02-09 | 四川大学华西医院 | 维生素c和双硫仑在制备抗肿瘤联合用药物中的用途 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4569836A (en) * | 1981-08-27 | 1986-02-11 | Gordon Robert T | Cancer treatment by intracellular hyperthermia |
| JP2514500B2 (ja) * | 1991-09-14 | 1996-07-10 | 呉羽化学工業株式会社 | 多剤耐性抑制剤及び発現阻害剤 |
| ATE233098T1 (de) * | 1996-06-11 | 2003-03-15 | Novartis Ag | Kombination eines somatostatin analogs und eines rapamycins |
| US5865722A (en) | 1997-04-04 | 1999-02-02 | Numotech, Incorporated | Shape-adaptable topical hyperbaric oxygen chamber |
| US6299925B1 (en) * | 1999-06-29 | 2001-10-09 | Xel Herbaceuticals, Inc. | Effervescent green tea extract formulation |
| US6376525B1 (en) * | 2000-09-15 | 2002-04-23 | Qingzhong Kong | Method and composition for treating cancer using cellular organelle crystallizing agents |
| AU3104102A (en) * | 2000-12-18 | 2002-07-01 | Univ Texas | Local regional chemotherapy and radiotherapy using in situ hydrogel |
| WO2003012085A1 (en) * | 2001-07-30 | 2003-02-13 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Antigen presenting cells, method for their preparation and their use for cancer vaccines |
| US7435725B2 (en) * | 2001-11-06 | 2008-10-14 | The Quigly Corporation | Oral compositions and methods for prevention, reduction and treatment of radiation injury |
| US20030105104A1 (en) * | 2001-11-27 | 2003-06-05 | Burzynski Stanislaw R. | Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy |
| US6572897B1 (en) * | 2002-07-03 | 2003-06-03 | Vitacost.Com, Inc. | Insulin sensitivity maintenance and blood sugar level maintenance formulation for the prevention and treatment of diabetes |
| AU2004270150C1 (en) * | 2003-08-29 | 2011-07-14 | Merck Hdac Research, Llc | Combination methods of treating cancer |
| EP1571225A1 (en) * | 2004-03-02 | 2005-09-07 | PrimaGen Holding B.V. | Diagnosis of a disease and monitoring of therapy using the AC133 gene |
| CA2582255A1 (en) * | 2004-08-30 | 2006-08-08 | Lunamed, Inc. | 4-phenylbutyric acid controlled-release formulations for therapeutic use |
| JP2006298781A (ja) * | 2005-04-15 | 2006-11-02 | Geno Membrane:Kk | エストロン３硫酸トランスポーター活性阻害剤 |
| JP2009532346A (ja) * | 2006-03-31 | 2009-09-10 | イラスマス・ユニバーシティ・メディカル・センター・ロッテルダム | 腫瘍増殖制御のための新規組成物 |
| EP1847274A1 (en) * | 2006-04-21 | 2007-10-24 | CIPROSA LLC - Corporate Creations Network, Inc. | Association of phenylbutyrate, ATRA and cytidine and its use in anti-tumour therapy |
| EP2040708B1 (en) * | 2006-07-17 | 2018-03-14 | Thomas Christian Lines | Quercetin-containing compositions |
| RU2446796C2 (ru) * | 2006-12-26 | 2012-04-10 | Фармасайкликс, Инк. | Способ использования ингибиторов гистондеацетилазы и мониторинга биомаркеров в комбинированной терапии |
| US20080305096A1 (en) * | 2007-06-07 | 2008-12-11 | Unicity International, Inc. | Method and composition for providing controlled delivery of biologically active substances |
| US20110104100A1 (en) * | 2007-10-04 | 2011-05-05 | Medistem Laboratories, Inc. | Compositions and methods of stem cell therapy for autism |
| CA2716321A1 (en) * | 2008-02-21 | 2009-08-27 | The Regents Of The University Of Colorado | Methods for treating cancer using combination therapy |
| MX2011000719A (es) * | 2008-07-18 | 2011-03-01 | Novartis Ag | Uso de inhibidores de desacetilasa de histona (hdac) para el tratamiento de enfermedad de hodgkin. |
| US20100316733A1 (en) * | 2009-06-15 | 2010-12-16 | Locklear Kenneth R | Hyperbaric Oxygen Therapy and Treatment Method |
-
2012
- 2012-07-06 EP EP12806902.8A patent/EP2729008B1/en active Active
- 2012-07-06 CN CN201280033815.9A patent/CN103796514A/zh active Pending
- 2012-07-06 CN CN201910036937.7A patent/CN109675041A/zh active Pending
- 2012-07-06 WO PCT/US2012/045821 patent/WO2013006821A1/en active Application Filing
- 2012-07-06 ES ES12806902.8T patent/ES2630306T3/es active Active
- 2012-07-06 KR KR1020197026111A patent/KR20190107166A/ko not_active Application Discontinuation
- 2012-07-06 MX MX2014000150A patent/MX354383B/es active IP Right Grant
- 2012-07-06 EP EP17163492.6A patent/EP3326625A1/en not_active Withdrawn
- 2012-07-06 PL PL12806902T patent/PL2729008T3/pl unknown
- 2012-07-06 JP JP2014519082A patent/JP6082737B2/ja active Active
- 2012-07-06 US US13/543,563 patent/US20130011488A1/en not_active Abandoned
- 2012-07-06 CA CA2839727A patent/CA2839727C/en active Active
- 2012-07-06 RU RU2014101261A patent/RU2644635C2/ru active
- 2012-07-06 AU AU2012278813A patent/AU2012278813B2/en active Active
- 2012-07-06 KR KR1020147003161A patent/KR102020939B1/ko active IP Right Grant
-
2014
- 2014-01-09 IN IN195DEN2014 patent/IN2014DN00195A/en unknown
-
2016
- 2016-03-21 US US15/076,371 patent/US20170014376A1/en not_active Abandoned
- 2016-12-08 AU AU2016269491A patent/AU2016269491B2/en active Active
-
2017
- 2017-01-23 JP JP2017009055A patent/JP6401317B2/ja active Active
-
2018
- 2018-09-06 JP JP2018166950A patent/JP2018203767A/ja active Pending
-
2019
- 2019-02-05 US US16/268,279 patent/US20200206183A1/en not_active Abandoned
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