JP2014208697A - Agent for the skin of animals - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide medicines excellent in especially a cosmetic preparation for whitening, spots, wrinkles, rough skin, hair growth, and hair restoration, a medical beautiful skin effect, an atopic dermatitis treating action, a dermatitis group treating action, a skin fungus treating action, a wart treating action, a pigmentation treating action, a psoriasis vulgaris treating action, a senile xerosis treating action, a keratoma-senile treating action, a skin injury treating action, a hair-growing promoting action, a digestive-juices secretion promoting action, a sudomotor effect, a bowel movement promoting action, and a diuretic effect and the like, by using materials which generate monosaccharides and improving blood and body fluid.SOLUTION: The application invention relates to a preparation for skin, especially an external preparation for animal skin comprising isoflavone and/or acyl isoflavone and/or isoflavone glucoside, and a cholic acid.

Description

  This invention relates to a new animal skin preparation.

  Conventionally, it is known that monosaccharides such as glucose and galactose moisturize the skin.

JP 2000-103718 A Japanese Patent Laid-Open No. 10-120558 JP-A-10-114649 JP-A-6-316528 JP 2000-302678 A JP-A-2-193920 JP-A-1-96106 Japanese Patent Publication No. 60-19885 Japanese Patent Laid-Open No. 10-114665 JP-A-10-120579 JP-A-5-9119 JP-A-61-263909 JP-A-6-227959 Japanese Patent Laid-Open No. 10-194938 JP 2000-191525 A JP-A-7-285833 JP 2001-039849 A Japanese Patent Laid-Open No. 10-175860 Japanese Patent Laid-Open No. 11-255617

However, although these monosaccharides are applied by applying to the skin, there is a problem that the monosaccharides must always be applied because they are peeled off from the skin by friction, washing or the like.
The invention of this application relates to a dermatological agent that recovers damage, deterioration, and deterioration of the skin by producing a monosaccharide in the body after having been absorbed into the body without acting directly on the skin, in particular, an external preparation for skin. The purpose is to provide.

The present invention relates to A. Cholic acid Soybean isoflavone or soybean isoflavone glycoside C.I. The present invention relates to a veterinary dermatological agent comprising the components A, B and C of curcumin.

The invention of the present application treats skin symptoms by utilizing a so-called substance that improves the liquid, especially whitening, spots, wrinkles, hair growth, hair growth cosmetics, or skin beautifying, atopy. Dermatitis treatment effect, dermatitis group treatment effect, skin fungus treatment effect, wart treatment effect, pigmentation treatment effect, psoriasis vulgaris, senile xerosis, senile keratoma treatment effect, skin Excellent effects as a medicament such as damage treatment action, hair growth promoting action, digestive juice secretion promoting action, sweating promoting action, bowel movement promoting action, internal bleeding treatment action and diuretic action can be obtained.
It is also effective for side effects caused by anticancer agents such as hair loss and internal bleeding. Therefore, these side effects can be suppressed by using together with an anticancer agent.

The isoflavones, acylisoflavones and isoflavone glycosides of the present invention are particularly preferably soy isoflavones, acyl soy isoflavones and soy isoflavone glycosides contained in soybeans.
As the acyl group of the acyl isoflavone, an acid residue of a saturated or unsaturated fatty acid having 2 to 18 carbon atoms is preferable, and an acid residue of acetic acid, palmitic acid or stearic acid is particularly preferable. In addition, all of the hydroxyl groups of isoflavone may be acylated or a part thereof may be acylated.
Since acylation can increase oil solubility, in the case of an oil agent, a large amount of acyl isoflavones can be dissolved. In addition, the skin irritation can be reduced by acylation.

  Moreover, it is preferable to add a pungent substance, a bitter substance, or a sour substance, and more preferably a food.

トウガラシのカプサイシン、

コショウのピペリン、

ショウガのジンゲロン、

ショウガの［６］−ショーガオール、

ショウガの［６］−ジンゲロール

であることが好ましく、クルクミンがとくに好ましい。
苦味物質は、スウェルチアマリン、ゲンチオピクリン、ロガニンが好ましい。
また、酸味物質は、クエン酸、乳酸が好ましい。 The pungent substance, bitter substance or sour substance is preferably a pungent substance.
The pungent substance is turmeric curcumin,

Capsicum capsicum,

Pepperine with pepper,

Ginger gingeron,

Ginger [6]-Shogaol,

[6] -gingerol of ginger

And curcumin is particularly preferred.
The bitter substance is preferably swell thiamarin, gentiopicrin, or loganin.
The sour substance is preferably citric acid or lactic acid.

The dermatological agent of the present invention preferably contains a monosaccharide.
As monosaccharides, glucose, galactose and the like are preferable, and galactose is particularly preferable.
As the saccharide, sugar or an acyl ester of sugar is used, and an acyl ester is preferable.
As acyl, a fatty acid is preferable, and in the ester, one to all of the alcohols may be acylated.

  It is preferable to add liver oil to the dermatological agent of the present invention, and rib oil and fish liver oil are particularly preferable.

The dermatological agent of the invention of this application is preferably added with a crude drug, preferably a crude drug that produces a monosaccharide having a so-called lyostatic action, that is, a so-called crude drug having a so-called supplemental / active blood action.
Herbal medicines that have a lyostatic effect are bukuryo, sekibukuryo, bukushin, bukuryohi, chorei, taksya, inchinkou, mokuboui, kanboui, kaseki, yokuinin, tokanin, toukahi, mokutsu, tsuso, shinshu, genji, fushi, Shazensou, Tokihi, Hikai, Ginseng, Sekisho, Hanpenren, Gokumaish, Shajin, Ginseng, Tenmondou, Bakumondo, Sekkoku, Ginkgo biloba, Sukisei, Kandenso, Jotei, Sesame, Kokuzu, Kokusui, Koki, Kou Maou, Keishi, Shisoyou, Keigai, Kyokatsu, Kouhon, Beakushi, Saishin, Shokyo, Sohaku, Kouju, Gensui, Se Ryuka, Shinyi, Hatsuka, Burdock, Centai, Parakeet, Chrysanthemum, Chrysanthemum, Giant hawk, Manneshi, Fuhei, Mokuzok, Kokuseiiso, Cuckoo, Psycho, Daio, Bowshaw, Banshayo, Rokai, Machinin, Ikrinin, Kengoshi, Kansui, Genka, Genki, Ginger Zokuzui, Tailleki, Ukumikopi, Gypsum, Chimo, Sanshishi, Tanshikuyo, Kagosou, Kansuiseki, Renshin, Lokon, Ketsumeishi, Seisoushi, Mitsumouka, Yamusha, Yutan, Seiteki, Saikaku, Shojiku, Genji, Bibipi, Shikonji, Bikopi Ougon, Auren, Aubaku, Ryutan, Kujin, Simpi, Aurelia, Kingfisher, Forsythia, Atlantic antelope, Banglancon, Hokoei, Swordfish, ginger, cypress, ginseng, senshinren, sandalwood jessou, ditanto, bald beetle, ground beetle, bakken, hornbill, burdock, kanju, babot, sandskon, yakan, dogosit, kenjin, kinkaran, kayou, kakuhaku, kyouku Zuken, Seiko, Rokujou, Gokukai, Gecko, Red-crowned Clover, Nikujou, Sasayo, Ino-kaku, Vultures, Fenugreek, Kotonik, Pteropus, Yakutinin, Senbou, Tochu, Kuseki, Zokudan, Hokusaiho, Tokushi, Azalea, Azalea Ganseki, Shajin, Eurasian Jin, Tenmondo, Sekkoku, Kyogiku, Hyakugo, Sokisei, Kangiso, Jyoteishi, Go There are ma, kokuzu, kiban, bekko.
Herbal medicines with supplementary and active blood effects include Senkyu, Tanjin, Keiketto, Motousei, Engosaku, Turmeric, Kyowo, Yakumoso, Juwishi, Takran, Ryoshouka, Geckika, Sakubai, Shikarak, Sekishaku, Tonin, Kouka, Bankouka, Gajutsu, Sanryo, Nyuko, Motsuyaku, Goshutsu, Ohurugyou, Rorotsu, Ryukid, Lactocuda, Shizendou, Ketsuketsu, Soboku, Kyusei, Hoseika, Goreishi, Garyoushi, Pangolin, Sweats, Shachu, Sunfish, Cyprus, Cyprus, Cushion There are Soujin, Longannik, Gooh, Beast and Fish.

The dermatological agent of the present invention is preferably a cosmetic.
As a cosmetic, it has excellent effects on whitening, spots, wrinkles, hair growth and hair growth.
The cosmetic may be an internal preparation, but is particularly preferably an external preparation.

The dermatological agent of the present invention is preferably a medicine.
Medicines include skin beautification, atopic dermatitis treatment, dermatitis group treatment, dermatomycotic treatment, wart treatment, pigmentation treatment, vulgaris treatment, senile xeroderma, elderly It is preferably a keratinoma therapeutic action, skin damage therapeutic action, hair growth promoting action, digestive juice secretion promoting action, sweating promoting action, bowel movement promoting action, internal bleeding treatment action and diuretic action.
The medicine can be used in a dosage form such as an internal medicine, a suppository, an injection, or an external medicine.

  Moreover, it is preferable that the dermatological agent of this invention of this application, especially the external preparation for skin, is a bath preparation.

  In the invention of this application, pharmaceuticals in general are used as other components, and vitamins and amino acids are used.

また、シムノール硫酸エステルナトリウム塩はつぎの構造式で表される。

Simnole and / or Simnol ester is contained in the bile of salmon.
Simnol is represented by the following structural formula:

Simnol sulfate sodium salt is represented by the following structural formula.

Another material used in the invention of this application is isoflavone, acylisoflavone and isoflavone glycoside.
Active ingredients for this purpose contained in soybeans are several isoflavone glycosides such as soybean-in (Gaidin), glycitin (Glycitin), genistin (Genitin), and the aglycone genin, daidzein (Daizein) , Several isoflavones such as glycitein and genistein.
Soybean is a raw material for producing soybean oil, but the demand for soybean oil is large, and soybean meal, a by-product, is produced in large quantities at the same time. A part of soybean meal is used as a raw material for producing soybean protein as a raw material for food, but it is mainly used as fertilizer and feed, and its price is extremely low. Soybean isoflavone, acyl soybean isoflavone, and soybean isoflavone glycoside can be produced at high purity and at low cost using soybean meal that is close to industrial waste.

Cholic acid is preferably 0.01% to 10%, particularly preferably 0.06% to 5%.
The daily dose of cholic acid is preferably 1 to 1000 mg, more preferably 2 to 300 mg, and particularly preferably 10 to 100 mg.
Soy isoflavone, acyl soy isoflavone, and soy isoflavone glycoside are preferably 0.01% to 30%, more preferably 0.05% to 20%.
The daily dose of isoflavone, acylisoflavone and isoflavone glycoside is preferably 1 to 500 mg, more preferably 5 to 200 mg, and particularly preferably 10 to 100 mg.
Simnole is preferably 0.01 to 5%, particularly preferably 0.05 to 3%.
The daily dose of simnole and / or simnol ester is preferably 0.1 to 100 mg, more preferably 0.1 to 50 mg, and particularly preferably 0.3 to 10 mg.
Curcumin is preferably 1 to 30%, particularly preferably 5 to 20%.
The daily dose is preferably 1 to 500 mg, particularly preferably 10 to 100 mg.
Galactose is preferably 0.1% to 30%, particularly preferably 1% to 5%.
The daily dose is preferably 0.5 to 500 mg, particularly preferably 1 to 100 mg.
Acetyl galactose is preferably 0.1% to 30%, particularly preferably 1% to 5%.
The daily dose is preferably 0.5 to 500 mg, particularly preferably 1 to 100 mg.
Although it does not specifically limit as a dosage form which administers the skin preparation of this application invention as an external preparation, It is preferable to use as a cream, an emulsion, a liquid agent, an ointment, etc.
Moreover, those compounding components used for ordinary creams, emulsions, solutions, and ointments are used.
Moreover, when administering the dermatological agent of this invention as an internal use medicine, a suppository, or an injection, a normal digestive agent, an excipient | filler, etc. are used.

In the capsule, the gelatin film is heated to about 60 ° C., and all the ingredients are uniformly dissolved. The gelatin film of this solution in the sol state is set in a rotary filling machine.
Further, the contents are warmed and stirred until homogeneous. After complete mixing and dispersing, the solution is set in a rotary filling machine. Start operation after setting the gelatin film and the solution of the contents.
The capsule immediately after production contains 34-40% of moisture in the film, and is dried by blowing low-humidity air in a dryer such as a rotary tumbler until the shape is fixed. Thereafter, drying is continued to the desired product moisture in a low humidity drying chamber.
The content of the capsule is preferably 150 mg to 400 mg.
The tablets are pulverized to a certain particle size by using a pulverizer for soy isoflavone, acyl soy isoflavone, soy isoflavone glycoside, cholic acid and galactose which are raw materials of uncoated tablets. Next, the pulverized product is put into a mixer, and the remaining raw materials for the uncoated tablets are added and mixed thoroughly. After homogeneous mixing, it is granulated by a granulator. It is particularly preferred to dry the granulated granules, adjust the water content, and perform tableting through a granulation step.
A coated layer is formed on the uncoated tablet thus produced by an automatic coating pan apparatus (Dria Coater DRC-1600 type machine) to produce a sugar-coated tablet.
The purpose of the sugar coating is to improve the stability by imparting light resistance, moisture resistance and low oxygen permeability to make the tablet easy to squeeze.
For example, the coating layer is formed by an automatic coating pan apparatus (Doria Coater DRC-1600 type machine).
The weight per uncoated tablet at this time is preferably 100 mg to 300 mg.
Further, the weight of the sugar coating is preferably 40% to 70% with respect to the weight of the uncoated tablet.

Hereinafter, the present invention will be described in detail.
Example 1
Nutrition cream (O / W)
(A) POE (40) monostearate 3.0 parts sorbitan monopalmitate 1.0 part cetyl isooctanoate 10.0 parts isopropyl myristate 5.0 parts liquid paraffin (# 70) 5.0 parts MC stearic acid 10 0 parts Cetanol 3.0 parts Paraffin wax (135 ° F) 3.0 parts Dehydrated lanolin 2.0 parts Pyridoxine dipalmitate 0.3 parts Methyl parapenes 0.1 parts Butyl parapenes 0.1 parts Cholic acid 0.1 parts Soybean isoflavone (100% purity conversion) 0.5 parts Acetylgalactose 2.0 parts Curcumin 0.1 parts (B) Shelf sand 0.5 parts Propylene glycol 5.0 parts Purified water Suitable amount Total quantity 100.0 parts (C) Fragrance 0.3-0.6 parts

Example 2
Emulsion (A) POE (20) Behenyl ether 2.4 parts Sorbitan monopalmitate 1.6 parts Isostearyl palmitate 5.0 parts Isopropyl myristate 3.0 parts Dehydrated lanolin 1.5 parts MC stearic acid 1.0 part Cetanol 1.0 part Beeswax 2.0 parts Paraffin wax (135 ° F) 2.0 parts Whale wax 2.0 parts Methyl parapenes 0.1 parts Butyl parapenes 0.1 parts Cholic acid 0.1 parts Acetylated galactose 2.0 Part Curcumin 0.1 part (B) Shelf sand 0.5 part Carbopol 940 (2% aqueous solution) 10.0 parts Propylene glycol 10.0 parts Soy isoflavone (100% purity conversion) 0.1 part Galactose 2.0 parts Purified water Appropriate amount Total amount 100.0 parts (C) Fragrance 0.2-0.4 parts

Example 3
Nutrition cream (W / ○)
(A) POE ((15) glycerin vegetable oil fatty acid ester 1.5 parts sorbitan sesquioleate 3.5 parts isopropyl palmitate 10.0 parts liquid paraffin (# 70) 10.0 parts cetanol 4.0 parts paraffin wax (135 ° F) 5.0 parts Beeswax 10.0 parts Methylparaben 0.1 part Butylparaben 0.1 part Cholic acid 0.5 part Acetylgalactose 2.0 part Curcumin 0.1 part (B) Shelf sand 0.5 part Propylene Glycol 2.0 parts Soy isoflavone (100% equivalent) 1.0 part Purified water Suitable amount Total 100.0 parts (C) Fragrance 0.3-0.5 parts

Example 4
Cold cream (W / O)
(A) POE (6) sorbitan monooleate 1.0 part sorbitan monoisostearate 4.0 parts batyl monoisostearate 1.0 part liquid paraffin (# 70) 25.0 parts lanolin alcohol 4.0 parts beeswax 15 0.0 parts Paraffin wax (135 ° F) 5.0 parts Methyl parapenes 0.1 parts Butyl parapenes 0.1 parts Acetylated galactose 2.0 parts Soy isoflavone (100% purity conversion) 0.1 parts Cholic acid 0.1 parts (B) Shelf sand 0.8 parts Purified water Appropriate amount Total 100.0 parts (C) Fragrance 0.3-0.5 parts

Example 5
Double emulsion (○ / W / ○)
(A) Cyclic pentamer silicone (Shin-Etsu KF995) 30 parts Polyether-modified silicone (Shin-Etsu KF6017) 4 parts Benton 38 (Rheox) 2 parts (B) Glycerin 10 parts Emulsion of Example 2 Appropriate amount 100 parts (C) Fragrance 0.2-0.4 part

Example 6
(A) Gelatin film liquid formulation Gelatin 48 parts Glycerin 15 parts Pearl agent (fish scale foil) 0.7 part Paraben 0.3 part Purified water 36.5 parts (B) Solution formulation Safflower oil 70 parts Beeswax 2 parts Soy isoflavone (Purity 100% conversion) 12.5 parts Cholic acid 12.5 parts Galactose 1 part Sucrose ester 2 parts

Example 7
(A) Gelatin film liquid formulation Gelatin 48 parts Glycerin 15 parts Pearl agent (fish scale foil) 0.7 part Paraben 0.3 part Purified water 36.5 parts (B) Solution formulation Curcumin 2.0 parts Simnol sulfate Na 0 .1 part Soy isoflavone 10.4 parts Cod liver oil 6.7 parts Tocopherol acetate 0.4 parts Heptadecanoic acid 2.5 parts Inosinic acid 8.3 parts Carrot extract 16.7 parts Beeswax 4.6 parts Safflower oil 49.3 Part

Example 8
(A) Gelatin film liquid formulation Gelatin 48 parts Glycerin 15 parts Pearl agent (fish scale foil) 0.7 part Paraben 0.3 part Purified water 36.5 parts (B) Solution formulation Curcumin 2.5 parts Cholic acid 5.0 Part Soy isoflavone glycosides 10.4 parts Heptadecanoic acid 2.5 parts Inosinic acid 8.3 parts Beeswax 4.5 parts Safflower oil 67.8 parts

Capsule preparation A is heated to about 60 ° C. and all ingredients are homogeneously dissolved. This solution A in the sol state is set in a rotary filling machine.
Further, heat B and stir until homogeneous. After complete mixing and dispersing, the solution is set in a rotary filling machine. The operation is started after the solutions A and B are set.
The capsule immediately after production contains 34-40% of moisture in the film, and is dried by blowing low-humidity air in a dryer such as a rotary tumbler until the shape is fixed. Thereafter, drying is continued to the desired product moisture in a low humidity drying chamber.
The content of the capsule is 200 mg. Take 2 capsules per day as a guide.
The active ingredient soy isoflavone, acyl soy isoflavone or soy isoflavone glycoside, simnol or simnol sulfate, curcumin, and galactose is preferably 35 parts or less in total. It is free to change each ratio within this range.
In addition, the total amount of these may be reduced, and safflower oil is increased by the reduced amount.
For example, soy isoflavone, acyl soy isoflavone or soy isoflavone glycoside 20 parts, simnol or simnol sulfate 0.5 part, curcumin 11.5 parts, galactose 3 parts may be used.

Example 9
(A) uncoated tablet soy isoflavone 12 parts cholic acid 12 parts galactose 2 parts lactose 30 parts crystalline cellulose 26 parts sucrose ester 8 parts corn protein 4 parts potato starch 4 parts gelatin 1 part talc 1 part (B) film coating solution formulation
Hydroxypropyl methylcellulose 2910 10 parts Polyethylene glycol 6000 1 part Titanium oxide 2 parts Purified water 87 parts

Example 10
(A) Uncoated tablet soy isoflavone 12 parts Cholic acid 12 parts Galactose 2 parts Lactose 30 parts Crystalline cellulose 26 parts Sucrose ester 8 parts Corn protein 4 parts Potato starch 4 parts Gelatin 1 part Talc 1 part (B) Sugar-coated formula Granulated sugar 50 Part Lactose 39 parts Shellac 4 parts Gelatin 2 parts Calcium carbonate 2 parts Titanium dioxide 1 part Talc 1 part Arabic gum powder 1 part

Example 11
Tablet Production Method Soy isoflavone, cholic acid, and galactose, which are raw materials for the uncoated tablet shown in Example 8 (A), are pulverized to a certain particle size using a pulverizer. Next, the pulverized product is put into a mixer, and the remaining raw materials for the uncoated tablets are added and mixed thoroughly. After homogeneous mixing, it is granulated by a granulator. The granulated granule is dried, the moisture is adjusted, and tableting is performed through a granulating step.
A coated layer is formed on the uncoated tablet thus produced by an automatic coating pan apparatus (Dria Coater DRC-1600 type machine) to produce a sugar-coated tablet.
The purpose of the sugar coating is to improve the stability by imparting light resistance, moisture resistance and low oxygen permeability to make the tablet easy to squeeze.
In terms of manufacturing, a coating layer is formed by an automatic coating pan apparatus (Dria Coater DRC-1600 type machine).
At this time, the weight per uncoated tablet is 200 mg, and the weight of the sugar coating is 140 mg with respect to the uncoated tablet weight.

Example 12
Film-coated (FC) tablets The purpose of FC tablets is to improve food properties by masking bitterness and odor, and to adjust the expression of effects by providing enteric and sustained-release functions.
Using a coating apparatus (High coater HCF-150 type machine), 2-5% by weight is coated on the uncoated tablet.
The uncoated tablet is 200 mg, and the film weight is 8 mg.
Take or eat 2 tablets per day as a guide.

Example 13
Nutrition cream (O / W)
(A) POE (40) monostearate 3.0 parts sorbitan monopalmitate 1.0 part cetyl isooctanoate 10.0 parts isopropyl myristate 5.0 parts liquid paraffin (# 70) 5.0 parts MC stearic acid 10.0 parts Cetanol 3.0 parts Paraffin wax (135 ° F) 3.0 parts Dehydrated lanolin 2.0 parts Pyridoxine dipalmitate 0.3 parts Methyl parapenes 0.1 parts Pityl parapenes 0.1 parts Cholic acid 0.1 parts Acetyl soybean isoflavone 0.5 parts (all hydroxyl group acetylated 100% purity conversion)
Acetylgalactose 2.0 parts (B) Borax 0.5 parts Propylene glycol 5.0 parts Purified water Suitable amount Total 100.0 parts (C) Fragrance 0.3-0.6 parts

Example 14
Latex (O / W)
(A) POE (20) behenyl ether 2.4 parts sorbitan monopalmitate 1.6 parts isostearyl palmitate 5.0 parts isoprovir myristate 3.0 parts dehydrated lanolin 1.5 parts MC stearic acid 1.0 part Cetanol 1.0 part Beeswax 2.0 parts Paraffin wax (135 ° F) 2.0 parts Whale wax 2.0 parts Methyl parapenes 0.1 parts Butyl parapenes 0.1 parts Cholic acid 0.1 parts Acetyl galactose 2.0 parts 0.1 parts of acetyl soy isoflavone (all hydroxyl groups are acetylated. Purity 100% conversion)
(B) Borax 0.5 parts Carbopol 940 (2% aqueous solution) 10.0 parts Propylene glycol 10.0 parts Galactose 2.0 parts Purified water Suitable amount Total amount 100.0 parts (C) Fragrance 0.2-0. 4 copies

Example 15
Cold cream (W / O)
(A) POE (6) sorbitan monooleate 1.0 part sorbitan monoisostearate 4.0 parts batyl monoisostearate 1.0 part liquid paraffin (# 70) 25.0 parts lanolin alcohol 4.0 parts beeswax 15 0.0 parts paraffin wax (135 ° F) 5.0 parts methyl parapenes 0.1 parts butyl parapenes 0.1 parts acetylated galactose 2.0 parts acetyl soy isoflavone 0.1 parts (all hydroxyl groups acetylated. Purity) (100% conversion)
Cholic acid 0.1 part (B) Borax 0.8 part Purified water Appropriate amount Total 100.0 part (C) Fragrance 0.3-0.5 part

Example 16
Double emulsion formulation (O / W / O)
(A) Cyclic pentamer silicone (Shin-Etsu KF995) 30.0 parts Polyether-modified silicone (Shin-Etsu KF6017) 4.0 parts Benton 38 (Rheox Corporation) 2.0 parts (B) Glycerin 10.0 parts Example 11 Emulsion Appropriate amount Total amount 100.0 parts (C) Fragrance 0.2 to 0.4 parts Double emulsion is mixed with (B), then (A) is added and mixed, and finally (C) is added and mixed. To do.
In this way, an O / W / O double emulsion is produced.

When the capsule of Example 7 was administered for 16 weeks, for example, hair had the following effects.
Black hair grew along the hairline of a 62-year-old man with silver hair. A 61-year-old man's “sideburn” and the hair in the middle of the forehead became black. Two thick black hairs of a 55-year-old man grew up in the forehead. Black hair grew along the forehead of a 68-year-old woman, and her forearm hair became unusually long. The hair growth phenomenon was prominent in the left half. The hair turned black like a wig along the forehead of a 68-year-old woman. The eyebrows of an 82-year-old woman became darker. 9 to 12 black hairs grew at the back of the forehead of a 55-year-old man. A 64-year-old woman's hair grew and the wrinkles disappeared. The 74-year-old woman's eyebrows turned black. A 64-year-old woman with alopecia hypofunction and alopecia was cured by taking it for 16 weeks. A 74-year-old woman in a healthy body cured her hair loss by taking it for 16 weeks. Alopecia due to side effects in a 34-year-old woman with lung cancer and brain tumor was markedly improved. A vitiligo 69-year-old woman took red skin on her skin after taking it for 2 weeks. A 55-year-old vitiligo woman got better after taking it for 4 weeks.
Similarly, skin beautification, atopic dermatitis treatment, dermatitis treatment, skin fungus treatment, wart treatment, pigmentation treatment, vulgaris treatment, senile xeroderma, senile Effects were also confirmed for keratinoma therapeutic action, skin damage therapeutic action, hair growth promoting action, digestive juice secretion promoting action, sweating promoting action, bowel movement promoting action, diuretic action and the like.

  This invention relates to a new dermatological preparation.

Claims (13)

A. Cholic acid Soybean isoflavone or soybean isoflavone glycoside C.I. A veterinary dermatological agent comprising ingredients A, B and C of curcumin. The animal skin preparation according to claim 1, comprising a monosaccharide. The animal skin preparation according to claim 2, wherein the monosaccharide is an acyl ester. Liver oil is added, The animal skin preparation in any one of Claims 1-3 characterized by the above-mentioned. The animal skin preparation according to any one of claims 1 to 4, wherein a crude drug is added. The animal skin preparation according to any one of claims 1 to 5, which is a cosmetic. The animal skin preparation according to claim 6, wherein the cosmetic is a cosmetic for whitening, blotting, wrinkles, rough skin, hair growth, and hair growth. The animal skin preparation according to claim 6, wherein the cosmetic is an external preparation. The animal skin preparation according to any one of claims 1 to 5, which is a medicine. Medicine for skin beautification, atopic dermatitis treatment, dermatitis treatment, skin fungus treatment, wart treatment, pigmentation treatment, vulgaris treatment, senile xerosis, senile 10. The animal according to claim 9, which has a keratinoma therapeutic action, a skin damage therapeutic action, a hair growth promoting action, a digestive juice secretion promoting action, a sweat promoting action, a bowel movement promoting action, an internal bleeding treating action and a diuretic action. Skin preparation. The animal skin preparation according to claim 9 or 10, wherein the medicine is an external medicine. The animal skin preparation according to claim 9 or 10, wherein the medicine is an internal medicine, a suppository, or an injection. The animal skin preparation according to any one of claims 1 to 5, which is a bath preparation.