JP2014144922A5 - - Google Patents
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- Publication number
- JP2014144922A5 JP2014144922A5 JP2013012868A JP2013012868A JP2014144922A5 JP 2014144922 A5 JP2014144922 A5 JP 2014144922A5 JP 2013012868 A JP2013012868 A JP 2013012868A JP 2013012868 A JP2013012868 A JP 2013012868A JP 2014144922 A5 JP2014144922 A5 JP 2014144922A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- pharmaceutically acceptable
- alkyl group
- optionally substituted
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 102100028704 Acetyl-CoA acetyltransferase, cytosolic Human genes 0.000 claims 2
- 101000837584 Homo sapiens Acetyl-CoA acetyltransferase, cytosolic Proteins 0.000 claims 2
- 101000642613 Homo sapiens Sterol O-acyltransferase 2 Proteins 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 1
- 125000005199 aryl carbonyloxy group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013012868A JP2014144922A (ja) | 2013-01-28 | 2013-01-28 | Ａｃａｔ２阻害活性を示すピリピロペンａ構造簡略型誘導体 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013012868A JP2014144922A (ja) | 2013-01-28 | 2013-01-28 | Ａｃａｔ２阻害活性を示すピリピロペンａ構造簡略型誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014144922A JP2014144922A (ja) | 2014-08-14 |
| JP2014144922A5 true JP2014144922A5 (enrdf_load_html_response) | 2016-06-09 |
Family
ID=51425484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013012868A Pending JP2014144922A (ja) | 2013-01-28 | 2013-01-28 | Ａｃａｔ２阻害活性を示すピリピロペンａ構造簡略型誘導体 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2014144922A (enrdf_load_html_response) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5946100B2 (ja) | 2014-06-24 | 2016-07-05 | 学校法人北里研究所 | コレステロールアシル転移酵素アイソザイム２（ａｃａｔ２）阻害活性を有する新規医薬化合物 |
| CN106032383B (zh) * | 2015-03-19 | 2019-08-13 | 中国科学院上海药物研究所 | 一类三环类似物、其制备方法和用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08269063A (ja) * | 1995-03-28 | 1996-10-15 | Kitasato Inst:The | ピリピロペン誘導体 |
| JPH08269065A (ja) * | 1995-04-03 | 1996-10-15 | Kitasato Inst:The | ピリピロペン誘導体 |
| US8519128B2 (en) * | 2007-12-25 | 2013-08-27 | The Kitasato Institute | Pyripyropene derivatives having an ACAT2-inhibiting activity |
| WO2010150739A1 (ja) * | 2009-06-23 | 2010-12-29 | 学校法人北里研究所 | Ａｃａｔ２阻害活性を示す水酸基含有ピリピロペン誘導体 |
| BR112012024816A2 (pt) * | 2010-03-31 | 2019-09-24 | School Juridical Person Kitasato Inst | derivado de piripiropeno com atividade inibidores de acat2 e estável contra enzimas metabolizadoras |
-
2013
- 2013-01-28 JP JP2013012868A patent/JP2014144922A/ja active Pending
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