JP2013528375A5 - - Google Patents
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- JP2013528375A5 JP2013528375A5 JP2013510320A JP2013510320A JP2013528375A5 JP 2013528375 A5 JP2013528375 A5 JP 2013528375A5 JP 2013510320 A JP2013510320 A JP 2013510320A JP 2013510320 A JP2013510320 A JP 2013510320A JP 2013528375 A5 JP2013528375 A5 JP 2013528375A5
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- Japan
- Prior art keywords
- composition
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- kidney
- cells
- enriched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 58
- 239000000203 mixture Substances 0.000 claims 55
- 102000003951 Erythropoietin Human genes 0.000 claims 16
- 108090000394 Erythropoietin Proteins 0.000 claims 16
- 229940105423 erythropoietin Drugs 0.000 claims 16
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 16
- 210000003292 kidney cell Anatomy 0.000 claims 15
- 210000003734 kidney Anatomy 0.000 claims 11
- 230000000975 bioactive effect Effects 0.000 claims 8
- 230000007705 epithelial mesenchymal transition Effects 0.000 claims 8
- 210000003904 glomerular cell Anatomy 0.000 claims 8
- 210000005167 vascular cell Anatomy 0.000 claims 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 239000001301 oxygen Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 108091070501 miRNA Proteins 0.000 claims 4
- 239000002679 microRNA Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 238000001727 in vivo Methods 0.000 claims 3
- 230000008929 regeneration Effects 0.000 claims 3
- 238000011069 regeneration method Methods 0.000 claims 3
- 230000033115 angiogenesis Effects 0.000 claims 2
- 239000000560 biocompatible material Substances 0.000 claims 2
- 239000000090 biomarker Substances 0.000 claims 2
- 239000013068 control sample Substances 0.000 claims 2
- 238000000432 density-gradient centrifugation Methods 0.000 claims 2
- 230000002124 endocrine Effects 0.000 claims 2
- 210000001808 exosome Anatomy 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 208000017169 kidney disease Diseases 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 201000008383 nephritis Diseases 0.000 claims 2
- 230000003076 paracrine Effects 0.000 claims 2
- 230000001172 regenerating effect Effects 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 210000005239 tubule Anatomy 0.000 claims 2
- 206010023421 Kidney fibrosis Diseases 0.000 claims 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
- 230000008512 biological response Effects 0.000 claims 1
- 239000002771 cell marker Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000001338 necrotic effect Effects 0.000 claims 1
- 201000002793 renal fibrosis Diseases 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 230000035899 viability Effects 0.000 claims 1
Applications Claiming Priority (21)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33403210P | 2010-05-12 | 2010-05-12 | |
| US61/334,032 | 2010-05-12 | ||
| US35389510P | 2010-06-11 | 2010-06-11 | |
| US61/353,895 | 2010-06-11 | ||
| US37207710P | 2010-08-09 | 2010-08-09 | |
| US37188810P | 2010-08-09 | 2010-08-09 | |
| US61/372,077 | 2010-08-09 | ||
| US61/371,888 | 2010-08-09 | ||
| US37658610P | 2010-08-24 | 2010-08-24 | |
| US61/376,586 | 2010-08-24 | ||
| US38876510P | 2010-10-01 | 2010-10-01 | |
| US61/388,765 | 2010-10-01 | ||
| US41338210P | 2010-11-12 | 2010-11-12 | |
| US41293310P | 2010-11-12 | 2010-11-12 | |
| US61/412,933 | 2010-11-12 | ||
| US61/413,382 | 2010-11-12 | ||
| US201161441423P | 2011-02-10 | 2011-02-10 | |
| US61/441,423 | 2011-02-10 | ||
| US201161473111P | 2011-04-07 | 2011-04-07 | |
| US61/473,111 | 2011-04-07 | ||
| PCT/US2011/036347 WO2011143499A1 (en) | 2010-05-12 | 2011-05-12 | Bioactive renal cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016080335A Division JP6385976B2 (ja) | 2010-05-12 | 2016-04-13 | 生理活性腎臓細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013528375A JP2013528375A (ja) | 2013-07-11 |
| JP2013528375A5 true JP2013528375A5 (https=) | 2014-06-26 |
| JP5974215B2 JP5974215B2 (ja) | 2016-08-24 |
Family
ID=44121234
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013510320A Active JP5974215B2 (ja) | 2010-05-12 | 2011-05-12 | 生理活性腎臓細胞 |
| JP2016080335A Active JP6385976B2 (ja) | 2010-05-12 | 2016-04-13 | 生理活性腎臓細胞 |
| JP2018149199A Active JP6744368B2 (ja) | 2010-05-12 | 2018-08-08 | 生理活性腎臓細胞 |
| JP2020128752A Active JP7123426B2 (ja) | 2010-05-12 | 2020-07-30 | 生理活性腎臓細胞 |
| JP2022124203A Active JP7442852B2 (ja) | 2010-05-12 | 2022-08-03 | 生理活性腎臓細胞 |
| JP2024019878A Pending JP2024056860A (ja) | 2010-05-12 | 2024-02-14 | 生理活性腎臓細胞 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016080335A Active JP6385976B2 (ja) | 2010-05-12 | 2016-04-13 | 生理活性腎臓細胞 |
| JP2018149199A Active JP6744368B2 (ja) | 2010-05-12 | 2018-08-08 | 生理活性腎臓細胞 |
| JP2020128752A Active JP7123426B2 (ja) | 2010-05-12 | 2020-07-30 | 生理活性腎臓細胞 |
| JP2022124203A Active JP7442852B2 (ja) | 2010-05-12 | 2022-08-03 | 生理活性腎臓細胞 |
| JP2024019878A Pending JP2024056860A (ja) | 2010-05-12 | 2024-02-14 | 生理活性腎臓細胞 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US10077442B2 (https=) |
| EP (3) | EP3190177B8 (https=) |
| JP (6) | JP5974215B2 (https=) |
| KR (5) | KR102539589B1 (https=) |
| CN (2) | CN103154236B (https=) |
| AU (5) | AU2011252915B2 (https=) |
| CA (1) | CA2798900C (https=) |
| DK (1) | DK3190177T3 (https=) |
| ES (1) | ES2906750T3 (https=) |
| HU (1) | HUE058155T2 (https=) |
| NZ (1) | NZ603482A (https=) |
| PL (1) | PL3190177T3 (https=) |
| TW (6) | TWI762890B (https=) |
| WO (1) | WO2011143499A1 (https=) |
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| ITRM20030376A1 (it) | 2003-07-31 | 2005-02-01 | Univ Roma | Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia. |
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| US20090104649A1 (en) | 2007-06-11 | 2009-04-23 | Garovic Vesna D | Markers for preeclampsia |
| US20130034861A1 (en) | 2009-12-21 | 2013-02-07 | Mayo Foundation For Medical Education And Research | Early marker of proteinuria in patients treated with an anti-vegf treatment |
| US9845457B2 (en) | 2010-04-30 | 2017-12-19 | Cedars-Sinai Medical Center | Maintenance of genomic stability in cultured stem cells |
| US9249392B2 (en) | 2010-04-30 | 2016-02-02 | Cedars-Sinai Medical Center | Methods and compositions for maintaining genomic stability in cultured stem cells |
| TWI762890B (zh) | 2010-05-12 | 2022-05-01 | 開曼群島商英瑞金公司 | 生物活性腎細胞 |
| CA3065694A1 (en) | 2010-11-10 | 2012-05-18 | Inregen | Methods of forming injectable formulations for providing regenerative effects to an organ such as a kidney |
| WO2013170146A1 (en) | 2012-05-10 | 2013-11-14 | Uab Research Foundation | Methods and compositions for modulating mir-204 activity |
| WO2013184527A1 (en) | 2012-06-05 | 2013-12-12 | Capricor, Inc. | Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy |
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| RU2702721C2 (ru) * | 2012-10-24 | 2019-10-09 | инРиджен | Популяции клеток почек и их применение |
| EP4299721A3 (en) * | 2013-05-08 | 2024-04-24 | ProKidney | Organoids comprising isolated renal cells and uses thereof |
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| CN107641614B (zh) * | 2014-06-30 | 2020-11-20 | 中国人民解放军军事医学科学院野战输血研究所 | 微囊泡在诱导干细胞巨核分化中的用途 |
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| EP3402543B1 (en) | 2016-01-11 | 2021-09-08 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
| KR102467150B1 (ko) | 2016-05-06 | 2022-11-14 | 유니사이트 이브이 에이지 | 고혈당으로 인해 유발되는 섬유성 질환의 치료에 사용하기 위한 miRNA를 함유하는 약제학적 담체 |
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| US11123372B2 (en) | 2016-07-29 | 2021-09-21 | Prokidney | Bioactive renal cells for the treatment of chronic kidney disease |
| US11541078B2 (en) | 2016-09-20 | 2023-01-03 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders |
| KR101725025B1 (ko) * | 2016-11-25 | 2017-04-10 | 서울대학교산학협력단 | 무형성골질환 진단용 miRNA 마커 |
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| CN107236799B (zh) * | 2017-06-15 | 2020-06-09 | 昆明医科大学第六附属医院 | 一种肾纤维化miRNA标记物 |
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| BR112019027086A2 (pt) * | 2017-06-21 | 2020-07-07 | Timothy A. Bertram | células renais bioativas imunoprivilegiadas para o tratamento de doença renal |
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| ES3037279T3 (en) | 2018-04-16 | 2025-09-30 | Icahn School Med Mount Sinai | Method and kits for prediction of acute rejection and renal allograft loss using pre-transplant transcriptomic signatures in recipient blood |
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| US20230212492A1 (en) * | 2020-06-08 | 2023-07-06 | National University Corporation Tokyo Medical And Dental University | Cell culture method |
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| ES2523098T3 (es) | 2007-10-29 | 2014-11-20 | Fresenius Medical Care Deutschland Gmbh | Microvesícula (MV) derivada de células madre para su uso en la inhibición de la apoptosis inducida por un agente citostático |
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