JP2012072158A - Wearing liquid composition for soft contact lens - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a wearing liquid composition for soft contact lens which suppresses stickiness during wearing and using and has excellent feeling in use.SOLUTION: The wearing liquid composition for soft contact lens contains: polyvinyl alcohol or polyvinyl pyrrolidone; a cellulose derivative such as hydroxypropylmethylcellulose or the like; sorbic acid and/or a salt thereof; and a sesquiterpenoid compound.

Description

  The present invention relates to a mounting liquid for soft contact lenses.

  Wearing a contact lens has various problems such as feeling a foreign object during wearing or wearing from the viewpoint of inserting a foreign object into the eye. In order to solve these problems, contact lens mounting liquids have been developed. For example, a contact lens mounting liquid containing a polymer compound such as a cellulose polymer compound or a polyvinyl polymer compound is known. However, these conventional contact lens mounting liquids are limited to use in hard contact lenses because of concerns about the adsorption of preservatives and the like to soft contact lenses. Further, when the mounting liquid is used as a soft contact lens mounting liquid, there is a problem that the feeling of use at the time of mounting such as stickiness is inferior. Therefore, it has been desired to develop a mounting liquid for a soft contact lens that has an excellent usability during mounting and wearing.

International Publication No. 94/04028 Pamphlet International Publication No. 97/28827 Pamphlet Japanese Patent Publication No. 48-37910 JP-A-11-130667

  The present invention provides a mounting liquid composition for a soft contact lens that is less sticky during mounting and wearing and has an excellent feeling of use.

  As a result of intensive studies to solve the above problems, the present inventors have found that an aqueous liquid in which the stickiness peculiar to a polymer compound is suppressed by blending the polymer compound with sorbic acid and / or a salt thereof. Has been found, and the present invention has been completed.

  That is, this invention provides the mounting liquid composition for soft contact lenses characterized by containing a high molecular compound, sorbic acid, and / or its salt. Hereinafter, the present invention will be described in detail.

  According to the present invention, by adding the polymer compound and sorbic acid and / or a salt thereof, a mounting solution for soft contact lenses having no stickiness and excellent usability can be obtained.

  The first essential component in the ophthalmic composition for contact lenses of the present invention is a polymer compound. Examples of the polymer compound include polyvinyl polymer compounds such as polyvinyl alcohol, polyvinyl pyrrolidone, carboxyvinyl polymer, and polyvinyl methyl ether; methyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl methyl cellulose, hydroxypropyl cellulose, ethyl cellulose, carboxymethyl cellulose, and the like. Cellulose polymer compounds; glucose; polyalkylene glycols such as polyethylene glycol and polypropylene glycol; Preferred are polyvinyl polymer compounds and cellulose polymer compounds, and particularly preferred are polyvinyl alcohol, polyvinyl pyrrolidone, methyl cellulose, hydroxyethyl cellulose, and hydroxypropyl methyl cellulose.

  A preferable molecular weight of the polymer compound is a weight average molecular weight of 5,000 to 2,000,000. More preferably, in the case of a polyvinyl polymer compound, the weight average molecular weight is 10,000 to 300,000, particularly preferably 20000 to 150,000. In the case of a cellulose polymer compound, a weight average molecular weight of 10,000 to 1,000,000 is preferable.

  The content of the polymer compound in the mounting solution composition for soft contact lenses of the present invention is preferably 0.2 to 10 g / 100 ml, particularly preferably 0.3 to 5 g / 100 ml, more preferably 0.5 to 4 g / 100 ml. Within this range, the appropriate solution viscosity and wettability to the lens can be obtained when the soft contact lens is mounted, so that the mounting property is particularly good.

  In the composition of the present invention, one type or two or more types of the above-described polymer compounds are used, but it is preferable to use two or more types since the feeling in use is improved. Preferably, a polyvinyl polymer compound and a cellulose polymer compound are combined. The content ratio (mass ratio) of the preferred polyvinyl polymer compound and cellulose polymer compound is polyvinyl polymer compound / cellulose polymer compound = 99/1 to 10/90, particularly preferably 90/10 to 20 /. 80.

  The second essential component in the mounting solution for soft contact lenses of the present invention is sorbic acid and / or a salt thereof. Examples of sorbates include alkali metal salts such as potassium salts and sodium salts, alkaline earth metal salts such as calcium salts and magnesium salts, and organic amine salts. An alkali metal salt is preferable. These may be used alone or in combination of two or more.

  The amount of sorbic acid and / or salt thereof contained in the composition of the present invention is preferably 0.005 to 0.5 g / 100 ml, particularly preferably 0.01 to 0.3 g / 100 ml, most preferably 0. 0.05 to 0.2 g / 100 ml. Within this range, it is possible to obtain a good feeling of use in which stickiness is suppressed, and to obtain a good wearing solution that is not adsorbed to the soft contact lens and has no eye irritation.

  The ophthalmic composition for contact lens of the present invention has a viscosity at 35 ° C. of 1 to 30 mPa · s, preferably 1 to 20 mPa · s. In this range, a particularly good contact lens feeling can be obtained.

  The ophthalmic composition for contact lenses of the present invention contains one or more selected from monoterpenoid compounds, sesquiterpenoid compounds, and derivatives thereof (hereinafter referred to as terpenoids) for the purpose of maintaining a better wearing feeling. It is preferable to contain. Monoterpenoid compounds include menthol, camphor, borneol, geraniol, cineol, limonene, eugenol and the like. Examples of sesquiterpenoid compounds include farnesol and nerolidol. Examples of the derivatives include alkyl or alkenyl esters and ethers of the terpenoid compound.

  The terpenoids can be contained as one kind or a mixture of two or more kinds. These may contain a refined component or a plant essential oil containing the terpenoids. Examples of plant essential oils include rosemary oil, lavender oil, peppermint oil, spearmint oil, eucalyptus oil, bergamot oil, peppermint oil, and fennel oil.

  The amount of the terpenoids contained in the composition of the present invention is preferably 0.0001 to 0.5 g / 100 ml, particularly preferably 0.0005 to 0.2 g / 100 ml, and more preferably 0.001 to 0.00. 05 g / 100 ml.

  Furthermore, the ophthalmic composition for contact lenses of the present invention can contain various active ingredients. Active ingredients include, for example, anti-inflammatory agents such as dipotassium glycyrrhetinate, epsilon aminocaproic acid, allantoin, berberine chloride, sodium azulenesulfonate, zinc sulfate, lysozyme, vitamin B2, vitamin B6, vitamin B12, vitamin E acetate, bread Vitamins such as tenol, calcium pantothenate, sodium pantothenate, vitamin A palmitate, amino acids such as potassium L-aspartate, aminoethylsulfonic acid, sodium chondroitin sulfate, antihistamines such as diphenhydramine hydrochloride, chlorpheniramine maleate, hydrochloric acid Examples include decongestants such as epinephrine, naphazoline hydrochloride, tetrahydrozoline hydrochloride, and other active ingredients such as neostigmine methyl sulfate.

  In addition, as additives contained in normal ophthalmic compositions, for example, preservatives, isotonic agents, buffers, stabilizers, fragrances, and the like can be added within a range that does not impair the effects of the present invention. .

  Examples of preservatives include benzalkonium chloride, chlorhexidine gluconate, sorbic acid, chlorobutanol, and paraoxybenzoic acid esters.

  Examples of tonicity agents include potassium chloride, sodium chloride, calcium chloride, magnesium sulfate, propylene glycol, glycerin and the like.

  Examples of the buffer include citric acid, boric acid, phosphoric acid, sodium hydrogen phosphate, sodium hydrogen carbonate, glacial acetic acid and the like.

  Examples of the stabilizer include sodium edetate, polyoxyethylene (20) sorbitan monooleate, polyoxyethylene hydrogenated castor oil, and the like.

  The production of the ophthalmic composition for contact lenses in the present invention is not particularly limited, and each component is dissolved in water such as sterilized purified water or ion exchange water or a mixed solvent of water and a lower alcohol such as ethanol. Thereafter, it can be suitably adjusted with a pH adjuster (preferably pH 5 to 8) or an isotonic agent (preferably osmotic pressure ratio 0.8 to 2).

  EXAMPLES Next, although an Example demonstrates this invention further in detail, this invention is not limited to these examples.

Soft contact lens mounting liquid compositions shown in Tables 1 to 4 were prepared, and the feeling of use of the soft contact lens mounting liquid was evaluated according to the following criteria by 10 panelists each. The results are shown in Tables 1 and 2.
<Stickiness>
5: No stickiness 4: Little stickiness 3: Some stickiness 2: Stickiness 1: Very sticky <Mounting feeling: Feeling of foreign objects during and immediately after mounting work>
5: Very good wearing feeling 4: Good wearing feeling 3: Neither wearing feeling can be said 2: Bad wearing feeling 1: Bad wearing feeling Average score of 5 grades is 4 or more ◎ 3 or more 4 Less than, ◯, 2 or more and less than 3 were evaluated as Δ, and less than 2 was evaluated as ×.

  In each composition of Experiments 1 to 5, Cosenol EG-25 and Cosenol EG-40 (manufactured by Nippon Gosei Kagaku Kogyo Co., Ltd.) as polyvinyl alcohol; ); Metros SM25, Metros SM4000 (manufactured by Shin-Etsu Chemical Co., Ltd.) as methylcellulose; and compositions obtained by using Metros 65SH1500, 65SH4000 (manufactured by Shin-Etsu Chemical Co., Ltd.) as human hydroxyfluoromethylcellulose, and the results of evaluation. Suppression of stickiness with potassium sorbate was confirmed. Moreover, there was no adsorption | suction to the soft contact lens of the sorbic acid (salt) in a composition, and the problem was not recognized with respect to the use to a soft contact lens.

(Example 2)
A mounting solution for soft contact lenses having the composition described in Tables 2 to 4 was prepared, and the usability was evaluated in the same manner as in Example 1.

組成物１５〜２０は、装着直後のみならず、装用中も異物感抑制が持続し、良好な使用感が認められた。また、実施例の組成物中のソルビン酸（塩）のソフトコンタクトレンズへの吸着はなく、ソフトコンタクトレンズへの使用に対して問題は認められなかった。

In Compositions 15 to 20, not only immediately after wearing but also during wearing, the feeling of foreign matter persisted and a good feeling of use was recognized. Moreover, there was no adsorption | suction to the soft contact lens of the sorbic acid (salt) in the composition of an Example, and the problem was not recognized with respect to the use to a soft contact lens.

Claims (7)

(A) One or more selected from polyvinyl alcohol and polyvinylpyrrolidone (B) One or more selected from hydroxypropylmethylcellulose, hydroxyethylcellulose and methylcellulose (C) Sorbic acid and / or a salt thereof (D) A mounting liquid composition for a ft contact lens containing a monoterpenoid compound and / or a sesquiterpenoid compound.   The mounting liquid composition for soft contact lenses according to claim 1, wherein the content ratio (mass ratio) of the component (A) and the component (B) is 99/1 to 10/90.   The mounting liquid composition for soft contact lenses according to claim 1 or 2, wherein the total content of the component (A) and the component (B) is 0.2 to 10 g / 100 mL.   (C) Content of a component is 0.005-0.5g / 100ml, The mounting liquid composition for soft contact lenses of Claim 1, 2, or 3.   (D) Content of a component is 0.001-0.05g / 100ml, The mounting liquid composition for soft contact lenses of any one of Claims 1-4. The weight average molecular weight of (A) polyvinyl alcohol is 20,000 to 150,000, and the weight average molecular weight of (B) hydroxypropylmethylcellulose is 10,000 to 1,000,000. The soft contact lens mounting according to any one of claims 1 to 5. Liquid composition.   The liquid composition for soft contact lenses according to any one of claims 1 to 6, wherein the viscosity at 35 ° C is 1 to 30 mPa · s.