JP2009539348A5 - - Google Patents
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- JP2009539348A5 JP2009539348A5 JP2009513297A JP2009513297A JP2009539348A5 JP 2009539348 A5 JP2009539348 A5 JP 2009539348A5 JP 2009513297 A JP2009513297 A JP 2009513297A JP 2009513297 A JP2009513297 A JP 2009513297A JP 2009539348 A5 JP2009539348 A5 JP 2009539348A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- sequence
- cdr
- antibody
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000004965 antibodies Human genes 0.000 claims description 9
- 108090001123 antibodies Proteins 0.000 claims description 9
- 239000000427 antigen Substances 0.000 claims description 4
- 102000038129 antigens Human genes 0.000 claims description 4
- 108091007172 antigens Proteins 0.000 claims description 4
- 102100008989 IGHV1-2 Human genes 0.000 claims description 3
- 101710003461 IGHV1-2 Proteins 0.000 claims description 3
- 101710009640 IGKV1D-8 Proteins 0.000 claims description 3
- 101710024481 IGKV2-29 Proteins 0.000 claims description 3
- 101710009635 IGKV2D-26 Proteins 0.000 claims description 3
- 102100005978 IGKV3-20 Human genes 0.000 claims description 3
- 101710024987 IGKV3-20 Proteins 0.000 claims description 3
- 101710009651 IGKV3D-15 Proteins 0.000 claims description 3
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 claims 3
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 claims 3
- 102000020664 human HGF protein Human genes 0.000 claims 3
- 108091002800 human HGF protein Proteins 0.000 claims 3
- 102000005614 monoclonal antibodies Human genes 0.000 claims 3
- 108010045030 monoclonal antibodies Proteins 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 1
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 1
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 1
- 102000024070 binding proteins Human genes 0.000 description 3
- 108091007650 binding proteins Proteins 0.000 description 3
- 108010032595 Antibody Binding Sites Proteins 0.000 description 1
- 230000001851 biosynthetic Effects 0.000 description 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81071406P | 2006-06-02 | 2006-06-02 | |
US86046106P | 2006-11-21 | 2006-11-21 | |
PCT/US2007/012950 WO2007143098A2 (en) | 2006-06-02 | 2007-06-01 | Hepatocyte growth factor (hgf) binding proteins |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010167648A Division JP5528246B2 (ja) | 2006-06-02 | 2010-07-26 | 肝細胞成長因子(hgf)結合蛋白質 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2009539348A JP2009539348A (ja) | 2009-11-19 |
JP2009539348A5 true JP2009539348A5 (ru) | 2010-08-05 |
JP4560582B2 JP4560582B2 (ja) | 2010-10-13 |
Family
ID=38802082
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009513297A Expired - Fee Related JP4560582B2 (ja) | 2006-06-02 | 2007-06-01 | 肝細胞成長因子(hgf)結合蛋白質 |
JP2010167648A Expired - Fee Related JP5528246B2 (ja) | 2006-06-02 | 2010-07-26 | 肝細胞成長因子(hgf)結合蛋白質 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010167648A Expired - Fee Related JP5528246B2 (ja) | 2006-06-02 | 2010-07-26 | 肝細胞成長因子(hgf)結合蛋白質 |
Country Status (16)
Country | Link |
---|---|
US (5) | US7659378B2 (ru) |
EP (2) | EP2029627B1 (ru) |
JP (2) | JP4560582B2 (ru) |
KR (1) | KR101196184B1 (ru) |
AR (1) | AR061170A1 (ru) |
AT (1) | ATE533787T1 (ru) |
AU (1) | AU2007254853B2 (ru) |
BR (1) | BRPI0712223A2 (ru) |
CA (1) | CA2654019A1 (ru) |
ES (1) | ES2378097T3 (ru) |
HK (1) | HK1129394A1 (ru) |
IL (2) | IL195038A0 (ru) |
MX (1) | MX2008015138A (ru) |
NO (1) | NO20085422L (ru) |
NZ (1) | NZ573819A (ru) |
WO (1) | WO2007143098A2 (ru) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2027156E (pt) * | 2006-06-02 | 2011-04-18 | Aveo Pharmaceuticals Inc | Proteínas de ligação ao factor de crescimento de hepatócito (hgf) |
EP2029627B1 (en) | 2006-06-02 | 2011-11-16 | Aveo Pharmaceuticals, Inc. | Hepatocyte growth factor (hgf) binding proteins |
ES2694018T3 (es) | 2007-07-02 | 2018-12-17 | Oncomed Pharmaceuticals, Inc. | Composiciones y métodos para el tratamiento y el diagnóstico del cáncer |
US8846036B2 (en) | 2007-10-19 | 2014-09-30 | Abbott Laboratories | Antibodies that bind to mammalian NGAL and uses thereof |
US20090124022A1 (en) * | 2007-10-19 | 2009-05-14 | Abbott Laboratories | Antibodies that bind to mammalian ngal and uses thereof |
US20090123946A1 (en) * | 2007-10-19 | 2009-05-14 | Abbott Laboratories | Immunoassays and kits for the detection of ngal |
US20100260668A1 (en) * | 2008-04-29 | 2010-10-14 | Abbott Laboratories | Dual Variable Domain Immunoglobulins and Uses Thereof |
BRPI0910482A2 (pt) * | 2008-04-29 | 2019-09-24 | Abbott Lab | imunoglobinas de domínio variável duplo e usos das mesmas |
MX2010012616A (es) | 2008-05-29 | 2010-12-21 | Galaxy Biotech Llc | Anticuerpos monoclonales para factor de crecimiento de fibroblastos basico. |
BRPI0913406A2 (pt) | 2008-06-03 | 2018-01-09 | Abbott Lab | imunoglobulinas de domínio variável duplo e usos das mesmas |
JP5723769B2 (ja) * | 2008-06-03 | 2015-05-27 | アッヴィ・インコーポレイテッド | 二重可変ドメイン免疫グロブリン及びその使用 |
EP2313435A4 (en) * | 2008-07-01 | 2012-08-08 | Aveo Pharmaceuticals Inc | FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) BINDING PROTEINS |
JP5674654B2 (ja) * | 2008-07-08 | 2015-02-25 | アッヴィ・インコーポレイテッド | プロスタグランジンe2二重可変ドメイン免疫グロブリンおよびその使用 |
CN102089004B (zh) * | 2008-07-10 | 2018-06-01 | 东丽株式会社 | 癌的治疗及预防用药物组合物 |
CA3166399A1 (en) | 2008-11-07 | 2010-05-14 | Galaxy Biotech, Llc. | Monoclonal antibodies to fibroblast growth factor receptor 2 |
JP2012508563A (ja) * | 2008-11-12 | 2012-04-12 | シェーリング コーポレイション | 抗IGF1R発現の増強のためのβGl−IGGイントロン |
WO2010119991A2 (en) | 2009-04-17 | 2010-10-21 | Takeda Pharmaceutical Company Limited | Novel method of treating cancer |
TW201109438A (en) * | 2009-07-29 | 2011-03-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
US8586714B2 (en) * | 2009-09-01 | 2013-11-19 | Abbvie, Inc. | Dual variable domain immunoglobulins and uses thereof |
BR112012008833A2 (pt) | 2009-10-15 | 2015-09-08 | Abbott Lab | imunoglobulinas de dominio variavel duplo e usos das mesmas |
UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
US20130315895A1 (en) | 2010-07-01 | 2013-11-28 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
KR20130100118A (ko) | 2010-08-03 | 2013-09-09 | 아비에 인코포레이티드 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
RU2013113225A (ru) | 2010-08-26 | 2014-10-10 | Эббви Инк. | Иммуноглобулины с двумя вариабельными доменами и их применение |
MX2013005847A (es) * | 2010-11-24 | 2013-12-12 | Glaxo Group Ltd | Proteinas de union a antigeno multiespecificas que eligen como blanco a hgf. |
WO2013012747A1 (en) | 2011-07-15 | 2013-01-24 | Oncomed Pharmaceuticals, Inc. | Rspo binding agents and uses thereof |
WO2013078223A1 (en) * | 2011-11-23 | 2013-05-30 | Children's Hospital & Research Center Oakland | Anti-factor h binding protein antibodies and methods of use thereof |
BR112014015851A2 (pt) | 2011-12-30 | 2019-09-24 | Abbvie Inc | proteínas de ligação específicas duplas direcionadas contra il-13 e/ou il-17 |
WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
SG11201500233PA (en) | 2012-07-13 | 2015-04-29 | Oncomed Pharm Inc | Rspo3 binding agents and uses thereof |
UY35110A (es) | 2012-11-01 | 2014-05-30 | Abbvie Inc | Inmunoglobulinas de dominio variable dual anti-vegf/dll4 y usos de las mismas |
US9481725B2 (en) | 2013-03-14 | 2016-11-01 | Alderbio Holdings, Llc | Antibodies to HGF and compositions containing |
TW201444868A (zh) * | 2013-03-14 | 2014-12-01 | Alder Biopharmaceuticals Inc | Hgf抗體及其組成物 |
US9062108B2 (en) | 2013-03-15 | 2015-06-23 | Abbvie Inc. | Dual specific binding proteins directed against IL-1 and/or IL-17 |
WO2015031578A1 (en) * | 2013-08-28 | 2015-03-05 | Abbvie Inc. | Hgf assay |
MX2016012285A (es) | 2014-03-24 | 2017-01-23 | Genentech Inc | Tratamiento de cáncer con antagonista de c-met y correlación de estos con la expresión de hgf. |
CA2958144A1 (en) * | 2014-08-15 | 2016-02-18 | Oncomed Pharmaceuticals, Inc. | Rspo1 binding agents and uses thereof |
TW201628648A (zh) | 2014-09-16 | 2016-08-16 | 安可美德藥物股份有限公司 | 纖維變性疾病之治療 |
WO2016065329A1 (en) * | 2014-10-24 | 2016-04-28 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for inducing phagocytosis of mhc class i positive cells and countering anti-cd47/sirpa resistance |
WO2016065245A1 (en) | 2014-10-24 | 2016-04-28 | Incept, Llc | Extra luminal scaffold |
US10093733B2 (en) | 2014-12-11 | 2018-10-09 | Abbvie Inc. | LRP-8 binding dual variable domain immunoglobulin proteins |
TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗vegf、pdgf及/或其受體之結合蛋白 |
WO2016205566A1 (en) * | 2015-06-16 | 2016-12-22 | The Regents Of The University Of California | Fzd7 specific antibodies and vaccines to treat cancer and control stem cell function |
EP3436476A4 (en) | 2016-03-28 | 2020-04-29 | The Regents of The University of California | ANTI-RYK ANTIBODIES AND METHOD FOR USE THEREOF |
NL2017267B1 (en) * | 2016-07-29 | 2018-02-01 | Aduro Biotech Holdings Europe B V | Anti-pd-1 antibodies |
EP3634486A4 (en) | 2017-06-05 | 2021-03-31 | Janssen Biotech, Inc. | GENETICALLY PRODUCED MULTISPECIFIC ANTIBODIES AND OTHER MULTIMERIC PROTEINS WITH ASYMMETRIC MUTATIONS OF THE CH2-CH3 REGION |
CA3067351A1 (en) * | 2017-06-15 | 2018-12-20 | Nai-Kong Cheung | Anti-l1-cam antibodies and uses thereof |
CN111902148B (zh) | 2017-12-06 | 2024-07-05 | 艾维迪提生物科学公司 | 治疗肌萎缩和强直性肌营养不良的组合物和方法 |
WO2019217450A1 (en) | 2018-05-08 | 2019-11-14 | Rhode Island Hospital | Anti-chi3l1 antibodies for the detection and/or treatment of nonalcoholic fattly liver disease/nonalcoholic steatohepatitis and subsequent complications |
WO2020191293A1 (en) * | 2019-03-20 | 2020-09-24 | Javelin Oncology, Inc. | Anti-adam12 antibodies and chimeric antigen receptors, and compositions and methods comprising |
JP2022543555A (ja) | 2019-08-12 | 2022-10-13 | インテアールエヌエー テクノロジーズ ビー.ヴイ. | miRNA-193aに関する新たな処置 |
EP4110917A1 (en) | 2020-02-28 | 2023-01-04 | InteRNA Technologies B.V. | Mirna-193a for promoting immunogenic cell death |
JP2023527638A (ja) | 2020-03-27 | 2023-06-30 | アビディティー バイオサイエンシーズ,インク. | 顔面肩甲上腕型筋ジストロフィーを処置するための組成物および方法 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
US6893625B1 (en) | 1986-10-27 | 2005-05-17 | Royalty Pharma Finance Trust | Chimeric antibody with specificity to human B cell surface antigen |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
JPH02500329A (ja) | 1987-05-21 | 1990-02-08 | クリエイテイブ・バイオマリキユールズ・インコーポレーテツド | ターゲット化多機能蛋白質 |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
CA2103887C (en) | 1991-12-13 | 2005-08-30 | Gary M. Studnicka | Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof |
US5869619A (en) | 1991-12-13 | 1999-02-09 | Xoma Corporation | Modified antibody variable domains |
EP1514934B1 (en) | 1992-02-06 | 2008-12-31 | Novartis Vaccines and Diagnostics, Inc. | Biosynthetic binding protein for cancer marker |
US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
US6066718A (en) | 1992-09-25 | 2000-05-23 | Novartis Corporation | Reshaped monoclonal antibodies against an immunoglobulin isotype |
US5837676A (en) * | 1993-10-18 | 1998-11-17 | Long Island Jewish Medical Center | Use of scatter factor to enhance angiogenesis |
US6498144B1 (en) * | 1993-10-18 | 2002-12-24 | North Shore - Long Island Jewish Research Institute | Use of scatter factor to enhance angiogenesis |
US5707624A (en) * | 1994-06-03 | 1998-01-13 | The Regents Of The University Of Michigan | Treatment of Kaposi's sarcoma by inhibition of scatter factor |
JP4215172B2 (ja) | 1996-12-03 | 2009-01-28 | アムジェン フレモント インク. | 複数のV▲下H▼およびV▲下κ▼領域を含むヒトIg遺伝子座を有するトランスジェニック哺乳動物、ならびにそれから産生される抗体 |
US6872518B2 (en) | 1997-09-22 | 2005-03-29 | University Of Rochester | Methods for selecting polynucleotides encoding T cell epitopes |
WO2001034650A1 (en) | 1999-11-09 | 2001-05-17 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Heatlh And Human Services | Hgf-sf monoclonal antibody combinations |
CN1671416B (zh) | 2001-07-12 | 2013-01-02 | 杰斐逊·富特 | 超人源化抗体 |
US7220410B2 (en) * | 2003-04-18 | 2007-05-22 | Galaxy Biotech, Llc | Monoclonal antibodies to hepatocyte growth factor |
US20040208876A1 (en) | 2003-04-18 | 2004-10-21 | Kim Kyung Jin | Monoclonal antibodies to hepatocyte growth factor |
US8609090B2 (en) | 2003-07-18 | 2013-12-17 | Amgen Inc. | Specific binding agents to hepatocyte growth factor |
KR100556660B1 (ko) | 2003-11-11 | 2006-03-10 | 국립암센터 | Hgf의 중화가능 에피토프 및 이에 결합하는 중화 항체 |
EP1885400A4 (en) | 2005-06-02 | 2011-01-26 | Galaxy Biotech Llc | METHOD FOR THE TREATMENT OF BRAIN TUMORS BY ANTIBODIES |
AR059922A1 (es) * | 2006-04-01 | 2008-05-07 | Galaxy Biotech Llc | Anticuerpos monoclonales humanizados para el factor de crecimiento de hepatocitos |
EP2029627B1 (en) | 2006-06-02 | 2011-11-16 | Aveo Pharmaceuticals, Inc. | Hepatocyte growth factor (hgf) binding proteins |
PT2027156E (pt) * | 2006-06-02 | 2011-04-18 | Aveo Pharmaceuticals Inc | Proteínas de ligação ao factor de crescimento de hepatócito (hgf) |
KR100829972B1 (ko) * | 2006-07-14 | 2008-05-16 | 재단법인서울대학교산학협력재단 | 항-hgf/sf 인간화 항체 및 이의 제조방법 |
-
2007
- 2007-06-01 EP EP07795607A patent/EP2029627B1/en not_active Not-in-force
- 2007-06-01 BR BRPI0712223-3A patent/BRPI0712223A2/pt not_active IP Right Cessation
- 2007-06-01 JP JP2009513297A patent/JP4560582B2/ja not_active Expired - Fee Related
- 2007-06-01 EP EP11159440A patent/EP2380908A1/en not_active Withdrawn
- 2007-06-01 MX MX2008015138A patent/MX2008015138A/es active IP Right Grant
- 2007-06-01 CA CA002654019A patent/CA2654019A1/en not_active Abandoned
- 2007-06-01 US US11/757,094 patent/US7659378B2/en active Active
- 2007-06-01 NZ NZ573819A patent/NZ573819A/en not_active IP Right Cessation
- 2007-06-01 AU AU2007254853A patent/AU2007254853B2/en not_active Ceased
- 2007-06-01 WO PCT/US2007/012950 patent/WO2007143098A2/en active Application Filing
- 2007-06-01 KR KR1020087032082A patent/KR101196184B1/ko not_active IP Right Cessation
- 2007-06-01 AT AT07795607T patent/ATE533787T1/de active
- 2007-06-01 AR ARP070102388A patent/AR061170A1/es not_active Application Discontinuation
- 2007-06-01 ES ES07795607T patent/ES2378097T3/es active Active
-
2008
- 2008-11-02 IL IL195038A patent/IL195038A0/en unknown
- 2008-12-30 NO NO20085422A patent/NO20085422L/no not_active Application Discontinuation
-
2009
- 2009-08-13 HK HK09107469.8A patent/HK1129394A1/xx not_active IP Right Cessation
- 2009-12-07 US US12/632,758 patent/US7935502B2/en not_active Expired - Fee Related
-
2010
- 2010-07-26 JP JP2010167648A patent/JP5528246B2/ja not_active Expired - Fee Related
-
2011
- 2011-03-18 US US13/051,474 patent/US8268315B2/en not_active Expired - Fee Related
-
2012
- 2012-05-08 IL IL219655A patent/IL219655A0/en unknown
- 2012-08-20 US US13/589,652 patent/US8575318B2/en not_active Expired - Fee Related
-
2013
- 2013-09-27 US US14/039,912 patent/US20140178934A1/en not_active Abandoned
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