JP2009538122A5 - - Google Patents
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- Publication number
- JP2009538122A5 JP2009538122A5 JP2009505996A JP2009505996A JP2009538122A5 JP 2009538122 A5 JP2009538122 A5 JP 2009538122A5 JP 2009505996 A JP2009505996 A JP 2009505996A JP 2009505996 A JP2009505996 A JP 2009505996A JP 2009538122 A5 JP2009538122 A5 JP 2009538122A5
- Authority
- JP
- Japan
- Prior art keywords
- otc
- disease
- ornithine transcarbamylase
- brain
- individual
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000007981 Ornithine carbamoyltransferase Human genes 0.000 claims 31
- 101710198224 Ornithine carbamoyltransferase, mitochondrial Proteins 0.000 claims 31
- 238000000034 method Methods 0.000 claims 31
- 208000024827 Alzheimer disease Diseases 0.000 claims 9
- 208000014644 Brain disease Diseases 0.000 claims 8
- 230000000694 effects Effects 0.000 claims 7
- 238000000338 in vitro Methods 0.000 claims 7
- 208000015122 neurodegenerative disease Diseases 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 230000009261 transgenic effect Effects 0.000 claims 5
- 241001465754 Metazoa Species 0.000 claims 4
- 201000004559 cerebral degeneration Diseases 0.000 claims 4
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 4
- 238000003745 diagnosis Methods 0.000 claims 4
- 239000000523 sample Substances 0.000 claims 4
- 230000003321 amplification Effects 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 230000004770 neurodegeneration Effects 0.000 claims 3
- 238000003199 nucleic acid amplification method Methods 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 210000003556 vascular endothelial cell Anatomy 0.000 claims 3
- QSJXEFYPDANLFS-UHFFFAOYSA-N Diacetyl Chemical compound CC(=O)C(C)=O QSJXEFYPDANLFS-UHFFFAOYSA-N 0.000 claims 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 2
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims 2
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims 2
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 2
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- 239000004098 Tetracycline Substances 0.000 claims 2
- 108700019146 Transgenes Proteins 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- FFQKYPRQEYGKAF-UHFFFAOYSA-N carbamoyl phosphate Chemical compound NC(=O)OP(O)(O)=O FFQKYPRQEYGKAF-UHFFFAOYSA-N 0.000 claims 2
- 230000002490 cerebral effect Effects 0.000 claims 2
- 229960002173 citrulline Drugs 0.000 claims 2
- 235000013477 citrulline Nutrition 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 102000054766 genetic haplotypes Human genes 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 208000027061 mild cognitive impairment Diseases 0.000 claims 2
- 229960003104 ornithine Drugs 0.000 claims 2
- 229960002180 tetracycline Drugs 0.000 claims 2
- 229930101283 tetracycline Natural products 0.000 claims 2
- 235000019364 tetracycline Nutrition 0.000 claims 2
- 150000003522 tetracyclines Chemical class 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102100029761 Cadherin-5 Human genes 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 208000034826 Genetic Predisposition to Disease Diseases 0.000 claims 1
- 101000986595 Homo sapiens Ornithine transcarbamylase, mitochondrial Proteins 0.000 claims 1
- 101150057876 OTC gene Proteins 0.000 claims 1
- 108091023040 Transcription factor Proteins 0.000 claims 1
- 102000040945 Transcription factor Human genes 0.000 claims 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 238000001574 biopsy Methods 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 108010018828 cadherin 5 Proteins 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 102000053926 human OTC Human genes 0.000 claims 1
- 238000003018 immunoassay Methods 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 238000003752 polymerase chain reaction Methods 0.000 claims 1
- 108091008146 restriction endonucleases Proteins 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 108091006106 transcriptional activators Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06290619A EP1847615A1 (en) | 2006-04-18 | 2006-04-18 | Expression and polymorphism of the ornithine transcarbamylase (OTC) gene as markers for diagnosing Alzheimer's disease |
| EP06290619.3 | 2006-04-18 | ||
| PCT/IB2007/002166 WO2007119179A2 (en) | 2006-04-18 | 2007-04-18 | Use of the ornithine transcarbamylase (otc), as a marker for diagnosing brain damages |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009538122A JP2009538122A (ja) | 2009-11-05 |
| JP2009538122A5 true JP2009538122A5 (https=) | 2010-05-27 |
| JP5433410B2 JP5433410B2 (ja) | 2014-03-05 |
Family
ID=36698800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009505996A Expired - Fee Related JP5433410B2 (ja) | 2006-04-18 | 2007-04-18 | 脳の損傷を診断するためのマーカーとしてのオルニチントランスカルバミラーゼ（ｏｔｃ）の使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8114624B2 (https=) |
| EP (2) | EP1847615A1 (https=) |
| JP (1) | JP5433410B2 (https=) |
| KR (1) | KR101393204B1 (https=) |
| AU (1) | AU2007237839B2 (https=) |
| CA (1) | CA2649462C (https=) |
| DK (1) | DK2013365T3 (https=) |
| ES (1) | ES2449573T3 (https=) |
| WO (1) | WO2007119179A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2240781T3 (en) | 2008-01-18 | 2018-03-26 | Harvard College | METHODS FOR DETECTING DISEASE OR STATE SIGNATURES IN BODY FLUIDS |
| AU2011280997A1 (en) | 2010-07-23 | 2013-02-28 | President And Fellows Of Harvard College | Methods of detecting autoimmune or immune-related diseases or conditions |
| EP2596134B1 (en) | 2010-07-23 | 2020-04-08 | President and Fellows of Harvard College | Methods of detecting diseases or conditions using phagocytic cells |
| WO2012012693A2 (en) | 2010-07-23 | 2012-01-26 | President And Fellows Of Harvard College | Methods for detecting signatures of disease or conditions in bodily fluids |
| CA2806304A1 (en) | 2010-07-23 | 2012-01-26 | President And Fellows Of Harvard College | Methods of detecting prenatal or pregnancy-related diseases or conditions |
| WO2013188846A1 (en) | 2012-06-15 | 2013-12-19 | Harry Stylli | Methods of detecting diseases or conditions |
| EP2861788B1 (en) | 2012-06-15 | 2018-10-10 | Progenity, Inc. | Methods of detecting diseases or conditions using circulating diseased cells |
| GB201212084D0 (en) * | 2012-07-06 | 2012-08-22 | Randox Lab Ltd | Tropomyosin isoforms related to alzheimers disease and mild cognitive impairment |
| US11585814B2 (en) | 2013-03-09 | 2023-02-21 | Immunis.Ai, Inc. | Methods of detecting prostate cancer |
| EP2965077B1 (en) | 2013-03-09 | 2022-07-13 | Harry Stylli | Methods of detecting cancer |
| MA40636A (fr) | 2014-09-11 | 2015-09-11 | Colleen Kelly | Procédés pour détecter le cancer de la prostate |
| KR102770667B1 (ko) | 2022-04-22 | 2025-02-21 | 사회복지법인 삼성생명공익재단 | 유럽-동아시아인 데이터 기반 알츠하이머병 치매의 발병 위험군 또는 조기 증상 발현 위험군, 기억상실형 경도인지장애의 발병 위험군 및/또는 아밀로이드β 침착에 대한 PET 양성 위험군을 예측하기 위한 정보를 제공하는 방법 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09500526A (ja) * | 1993-06-14 | 1997-01-21 | ベーアーエスエフ アクツィエンゲゼルシャフト | テトラサイクリン反応性プロモーターによる真核細胞の遺伝子発現の厳密な制御 |
-
2006
- 2006-04-18 EP EP06290619A patent/EP1847615A1/en not_active Withdrawn
-
2007
- 2007-04-18 DK DK07766636.0T patent/DK2013365T3/en active
- 2007-04-18 JP JP2009505996A patent/JP5433410B2/ja not_active Expired - Fee Related
- 2007-04-18 AU AU2007237839A patent/AU2007237839B2/en not_active Ceased
- 2007-04-18 US US12/226,413 patent/US8114624B2/en not_active Expired - Fee Related
- 2007-04-18 EP EP07766636.0A patent/EP2013365B1/en not_active Not-in-force
- 2007-04-18 CA CA2649462A patent/CA2649462C/en not_active Expired - Fee Related
- 2007-04-18 ES ES07766636.0T patent/ES2449573T3/es active Active
- 2007-04-18 KR KR1020087028166A patent/KR101393204B1/ko not_active Expired - Fee Related
- 2007-04-18 WO PCT/IB2007/002166 patent/WO2007119179A2/en not_active Ceased
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