JP2009523760A5 - - Google Patents
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- Publication number
- JP2009523760A5 JP2009523760A5 JP2008550742A JP2008550742A JP2009523760A5 JP 2009523760 A5 JP2009523760 A5 JP 2009523760A5 JP 2008550742 A JP2008550742 A JP 2008550742A JP 2008550742 A JP2008550742 A JP 2008550742A JP 2009523760 A5 JP2009523760 A5 JP 2009523760A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- amino
- phenyl
- alkyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 39
- 229910052739 hydrogen Inorganic materials 0.000 claims description 22
- 239000001257 hydrogen Substances 0.000 claims description 22
- -1 hydroxy, amino Chemical group 0.000 claims description 14
- 125000003545 alkoxy group Chemical group 0.000 claims description 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 12
- 125000001475 halogen functional group Chemical group 0.000 claims description 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 8
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims description 7
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 7
- 125000001544 thienyl group Chemical group 0.000 claims description 7
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims description 6
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims description 5
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims description 4
- 125000000304 alkynyl group Chemical group 0.000 claims description 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 4
- 125000002541 furyl group Chemical group 0.000 claims description 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 3
- 125000004981 cycloalkylmethyl group Chemical group 0.000 claims description 3
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims description 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 2
- 150000001204 N-oxides Chemical class 0.000 claims description 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 2
- 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 claims description 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 2
- 125000001041 indolyl group Chemical group 0.000 claims description 2
- 125000000842 isoxazolyl group Chemical group 0.000 claims description 2
- 125000004076 pyridyl group Chemical group 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 11
- 150000002431 hydrogen Chemical class 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 229910052783 alkali metal Chemical group 0.000 claims 1
- 150000001340 alkali metals Chemical group 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000002585 base Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000002062 proliferating Effects 0.000 claims 1
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 description 6
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06100584 | 2006-01-19 | ||
EP06100584.9 | 2006-01-19 | ||
PCT/EP2007/050376 WO2007082878A1 (en) | 2006-01-19 | 2007-01-16 | Aminophenyl derivatives as novel inhibitors of histone deacetylase |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2009523760A JP2009523760A (ja) | 2009-06-25 |
JP2009523760A5 true JP2009523760A5 (US07846941-20101207-C00217.png) | 2012-01-19 |
JP5225104B2 JP5225104B2 (ja) | 2013-07-03 |
Family
ID=36579211
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008550742A Active JP5225104B2 (ja) | 2006-01-19 | 2007-01-16 | 新しい、ヒストンデアセチラーゼのインヒビターとしてのアミノフェニル誘導体 |
Country Status (19)
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
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AU2003218735B2 (en) * | 2002-03-13 | 2009-03-12 | Janssen Pharmaceutica N.V. | Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase |
AU2003218737B2 (en) | 2002-03-13 | 2008-04-10 | Janssen Pharmaceutica N.V. | Inhibitors of histone deacetylase |
PL214279B1 (pl) | 2002-03-13 | 2013-07-31 | Janssen Pharmaceutica Nv | Pochodna sulfonyloaminowa, sposób jej wytwarzania i zastosowanie oraz kompozycja farmaceutyczna i sposób jej wytwarzania |
BR0307607A (pt) | 2002-03-13 | 2004-12-21 | Janssen Pharmaceutica Nv | Derivados de carbonilamino como inibidores de histona desacetilase |
NZ552865A (en) | 2004-07-28 | 2009-09-25 | Janssen Pharmaceutica Nv | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
RS51189B (sr) * | 2004-07-28 | 2010-10-31 | Janssen Pharmaceutica N.V. | Supstituisani derivati propenil piperazina kao novi inhibitori histonske deacetilaze |
WO2006122926A1 (en) | 2005-05-18 | 2006-11-23 | Janssen Pharmaceutica N.V. | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase |
JP5070214B2 (ja) * | 2005-10-27 | 2012-11-07 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼの阻害剤としてのスクエア酸誘導体 |
US8101616B2 (en) | 2006-01-19 | 2012-01-24 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
CN101370791B (zh) * | 2006-01-19 | 2012-05-02 | 詹森药业有限公司 | 作为组蛋白脱乙酰基酶抑制剂的吡啶和嘧啶衍生物 |
RS51191B (sr) | 2006-01-19 | 2010-10-31 | Janssen Pharmaceutica N.V. | Derivati aminofenila kao novi inhibitori histon deacetilaze |
AU2007206950B2 (en) | 2006-01-19 | 2012-02-02 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
AU2007206942B2 (en) | 2006-01-19 | 2012-08-23 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
AU2009228931B2 (en) | 2008-03-27 | 2013-05-23 | Janssen Pharmaceutica Nv | Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
CN102118969B (zh) | 2008-06-12 | 2017-03-08 | 詹森药业有限公司 | 组胺h4受体的二氨基吡啶、二氨基嘧啶和二氨基哒嗪调节剂 |
AU2009289649B2 (en) | 2008-09-03 | 2016-05-05 | Biomarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors |
US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
WO2012118782A1 (en) | 2011-02-28 | 2012-09-07 | Repligen Corporation | Histone deacetylase inhibitors |
CN103648492A (zh) | 2011-03-09 | 2014-03-19 | 赛伦诺科学有限公司 | 利用组蛋白脱乙酰酶抑制物改善受损的内源纤维蛋白溶解作用的化合物和方法 |
US10029988B2 (en) | 2013-03-15 | 2018-07-24 | Biomarin Pharmaceutical Inc. | HDAC inhibitors |
DE102015106979B4 (de) * | 2015-05-05 | 2023-01-12 | Infineon Technologies Austria Ag | Halbleiterwafer und Verfahren zum Herstellen von Halbleitervorrichtungen in einem Halbleiterwafer |
WO2023044364A1 (en) | 2021-09-15 | 2023-03-23 | Enko Chem, Inc. | Protoporphyrinogen oxidase inhibitors |
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US8101616B2 (en) * | 2006-01-19 | 2012-01-24 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
RS51191B (sr) | 2006-01-19 | 2010-10-31 | Janssen Pharmaceutica N.V. | Derivati aminofenila kao novi inhibitori histon deacetilaze |
CN101370791B (zh) | 2006-01-19 | 2012-05-02 | 詹森药业有限公司 | 作为组蛋白脱乙酰基酶抑制剂的吡啶和嘧啶衍生物 |
AU2007206950B2 (en) | 2006-01-19 | 2012-02-02 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
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-
2007
- 2007-01-16 RS RSP-2009/0384A patent/RS51191B/sr unknown
- 2007-01-16 US US12/160,140 patent/US8119650B2/en active Active
- 2007-01-16 EP EP07703891A patent/EP1981874B1/en active Active
- 2007-01-16 CA CA2631876A patent/CA2631876C/en active Active
- 2007-01-16 ME MEP-2009-276A patent/ME01060B/me unknown
- 2007-01-16 SI SI200730065T patent/SI1981874T1/sl unknown
- 2007-01-16 DE DE602007001190T patent/DE602007001190D1/de active Active
- 2007-01-16 AU AU2007206946A patent/AU2007206946B2/en not_active Ceased
- 2007-01-16 WO PCT/EP2007/050376 patent/WO2007082878A1/en active Application Filing
- 2007-01-16 PL PL07703891T patent/PL1981874T3/pl unknown
- 2007-01-16 JP JP2008550742A patent/JP5225104B2/ja active Active
- 2007-01-16 CN CN2007800030170A patent/CN101370804B/zh active Active
- 2007-01-16 ES ES07703891T patent/ES2327972T3/es active Active
- 2007-01-16 PT PT07703891T patent/PT1981874E/pt unknown
- 2007-01-16 AT AT07703891T patent/ATE432272T1/de active
- 2007-01-16 DK DK07703891T patent/DK1981874T3/da active
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2009
- 2009-06-26 HK HK09105785.9A patent/HK1128283A1/xx not_active IP Right Cessation
- 2009-08-25 HR HR20090459T patent/HRP20090459T1/hr unknown
- 2009-08-27 CY CY20091100896T patent/CY1109331T1/el unknown