JP2009517478A - Water-in-oil emulsion composition containing siloxane elastomer - Google Patents

Abstract

  The present invention provides about 0.1% to about 15% non-emulsifying crosslinked siloxane elastomer, about 0.1% to about 15% emulsifying crosslinked siloxane elastomer, about 1% to about 40% of the non-emulsifying and emulsifying. A water-in-oil emulsion composition comprising a solvent for the crosslinkable siloxane elastomer, optionally 0% to about 5% additional emulsifier, and about 50% to about 99% aqueous phase, said composition being applied to the skin The water phase is released from the emulsion when shear stress is applied during spreading.

Description

  The present invention relates to a water-in-oil emulsion type skin care composition comprising a combination of emulsifying and non-emulsifying siloxane elastomers. Such compositions are useful for the release of skin care actives in products with user acceptable aesthetics. In particular, the amount and rate of aqueous phase released from the composition when spread on the skin can provide the user with acceptable aesthetics and non-sticky feel.

  Many personal care products currently available to consumers are primarily aimed at improving skin and / or hair health and / or physical appearance. Many skin care products delay or minimize skin wrinkles and other tissue structural changes related to hydration, whitening, oil conditioning, or generally related to skin aging and environmental damage to human skin. The purpose is to suppress or even eliminate it. A number of compounds have been described in the art as being useful for modulating skin conditions as described above.

  The skin is susceptible to damage by a number of extrinsic and intrinsic factors. External factors include ultraviolet radiation (eg due to sun exposure), environmental pollution, wind, heat, low humidity, strong surfactants, abrasives and the like. Intrinsic factors include aging and other biochemical changes from within the skin. While it is of course important to release certain skin care actives or compounds that can help regulate the skin and / or reduce the damage caused by such damage, the user may feel It is also important to accept certain skin care compositions from a functional and aesthetic point of view. For example, when the concentration of a humectant such as glycerin that is generally contained increases, the stickiness of the skin also increases. Many users prefer a composition that does not like a sticky, greasy, or sticky composition, but that spreads smoothly, has a fresh feel like water, and can provide a smooth feel afterwards.

  Skin care and cosmetic compositions containing the preceding silicone elastomers are, for example, WO 02/03930, WO 02/03950, WO 02/03951, WO 02/03952, EP 1,166,746 A1, EP 1 , 068,851A1, Japanese Patent Publication No. 2003-081757, and Japanese Publication No. 2003-55141. In these disclosures, a composition is described which gives a refreshing aqueous component and a “liquid splash” impression upon application. However, such prior disclosures present compositions that contain only silicone emulsifiers, or compositions that use different silicone elastomer systems. Similarly, the previously disclosed compositions are believed not to provide the content of the aqueous component of the emulsion provided by the composition of the present invention and its release.

  From the above, there is still a need to formulate a skin care composition that can improve the release of skin care actives and provide a sensory and aesthetic effect, especially with respect to the refreshing feel that is not sticky and the release of the aqueous phase. . None of the existing art provides all of the advantages and benefits of the present invention.

  The present invention provides about 0.1% to about 15% non-emulsifying crosslinked siloxane elastomer, about 0.1% to about 15% emulsifying crosslinked siloxane elastomer, about 1% to about 40% non-emulsifying and emulsifying. A water-in-oil emulsion composition comprising a solvent for a crosslinked siloxane elastomer, optionally 0% to about 5% additional emulsifier, and about 50% to about 99% aqueous phase, when the composition is spread on the skin When a shearing stress is applied to the emulsion, an aqueous phase is released from the emulsion.

  The invention also relates to methods of using such compositions to condition mammalian skin conditions. The method generally includes the step of topically applying a safe and effective amount of the composition to the skin of a mammal in need of such treatment.

  Upon reading this disclosure, these and other features, aspects, and advantages of the present invention will become apparent to those skilled in the art.

While the specification concludes with claims that particularly point out and distinctly claim the invention, it is believed the present invention will be better understood by the following description.
Unless otherwise specified, all percentages and ratios used herein are by weight of the entire composition and all measurements were made at 25 ° C.

  As used herein, a “skin care product” is one that is used to treat or care for the skin, or to somehow moisturize, improve, or clean. Products intended by the phrase “skin care products” include moisturizers, personal cleansing products, occlusive drug delivery patches, nail polishes, powders, wipes, hair conditioners, skin treatment emulsions, shaving creams, etc. However, it is not limited to these.

  As used herein, the term “ambient conditions” refers to ambient conditions at about 0.1 MPa (1 atm), about 50% relative humidity and about 25 ° C., unless otherwise indicated. .

  The compositions of the present invention can include, consist essentially of, or consist of components of the present invention as well as other components described herein. As used herein, “consisting essentially of” means that the composition or component may include additional ingredients, but those additional ingredients are fundamental and novel of the claimed composition or method. This means that only when the characteristics are not changed significantly.

  All percentages, ratios and ratios are based on the total weight of the skin care composition of the present invention unless otherwise specified. All such weights associated with the listed ingredients are based on activity level and do not include carriers or by-products that may be included in commercially available materials unless otherwise specified.

  All publications cited herein are hereby incorporated by reference in their entirety.

  As used herein, the term “keratinous tissue” refers to a keratin-containing layer that is placed as the outermost protective skin of a mammal (eg, a human, dog, cat, etc.) and includes the skin, lips, hair, feet Examples include but are not limited to nails, fingernails, cuticles, and hooves.

  As used herein, the term “dermatologically acceptable” refers to a composition or component thereof as described that exhibits excessive toxicity, incompatibility, instability, allergic reaction, etc. Without being meant, it is suitable for use in contact with mammalian keratinous tissue.

  As used herein, the term “safe and effective amount” refers to positive benefits, preferably affirmation of the appearance or feel of keratinous tissue, including any individual benefit or combination of benefits disclosed herein. The amount of a compound or composition that is sufficient to produce a significant benefit, or a positive benefit to the appearance or feel of the hair, but sufficient to avoid serious side effects, i.e., sound judgment of one skilled in the art Means an amount that provides a reasonable benefit-to-risk ratio within the range of

  As used herein, the terms “smooth” and “soften” mean a modification of the surface of the keratinous tissue, such as an improvement in tactile sensation.

  For skin care effects such as regulating skin conditions, it is desirable to contain one or more skin care actives in high concentrations. However, there are drawbacks when using high concentrations of skin care actives in conventional skin care products. For example, residues resulting from “salting out” of niacinamide give the skin an undesirable whitening effect. Similarly, skin conditioning agents such as high concentrations of glycerin give the skin a greasy and sticky feel.

  Silicone elastomers are known in the art as useful components in skin care compositions. Such silicone elastomers are used to reduce the stickiness and stickiness associated with skin conditioning agents containing glycerin. For example, the use of a silicone emulsifier as described in EP 1,068,851 A1 is said to provide a composition comprising as much as 91% aqueous phase. However, the water-in-oil emulsion composition of the present invention comprising a combination of emulsifying and non-emulsifying siloxane elastomers is better than previously thought possible in the process of being released from the emulsion when spread and applied to the skin. It has been found that a skin care composition comprising an aqueous phase that provides even a sensory effect can be provided. Furthermore, the rate at which the aqueous phase is released from the emulsions of the present invention can be controlled to give the user a desirable aesthetic and sensory effect. In addition, when the composition is spread on the skin, it can be incorporated in the composition of the present invention by increasing the concentration of a skin conditioning agent such as glycerin without causing a feeling of greasy or stickiness.

  The compositions of the present invention are useful for regulating skin conditions, and especially for regulating keratinous tissue conditions. Regulation of the skin condition, ie the skin condition of mammals, in particular humans, is often required for conditions that can be induced or caused by endogenous and / or exogenous factors to the body. Examples include environmental damage, exposure to radiation (including ultraviolet radiation), aging, menopause (eg, postmenopausal skin changes), stress, illness, and the like. For example, “conditioning of the skin condition” includes prophylactic and / or therapeutic adjustment of the skin condition, and thickening of the skin to reduce skin atrophy (ie, construction of the epidermis and / or dermis, And / or subcutaneous (eg, subcutaneous fat or muscle) layers of skin, and nail and hair shaft stratum corneum if applicable), increased rotation of the dermis-epidermal interface (also known as interpapillary ridge), elasticity Prevention of loss of skin elasticity (loss of skin elastin function, damage and / or inactivation) such as loss of recovery from fibrosis, sagging and skin deformation, non-melanic skin such as bears under the eyes Prevention of discoloration, stains (eg, uneven redness due to rosacea) (hereinafter referred to as “red spots”), poor color (pale color), distension caused by telangiectasia or spider vessels ,Such It may include one or more benefits.

  The compositions of the present invention provide additional benefits including stability, absence of significant (user unacceptable) skin irritation and good aesthetics.

  The composition of the present invention comprises a non-emulsifying crosslinked siloxane elastomer, an emulsifying crosslinked siloxane elastomer, a solvent for the non-emulsifying and emulsifying crosslinked siloxane elastomer, optionally an additional emulsifier, and an aqueous phase. The composition also preferably contains one or more skin care actives.

  The compositions herein may also include a wide variety of other ingredients. The compositions of the present invention are described in detail below.

Crosslinked Siloxane Elastomer An essential component of the present invention is a crosslinked organopolysiloxane elastomer. There is no particular limitation on the type of curable organopolysiloxane composition that can act as a starting material for the crosslinked organopolysiloxane elastomer. Related examples include addition reaction cured organopolysiloxane compositions that cure under platinum metal catalysts by addition reaction of SiH containing diorganopolysiloxanes with organopolysiloxanes having silicon-bonded vinyl groups; hydroxyl-terminated diorganopolysiloxanes -Cured organopolysiloxane composition cured in the presence of an organotin compound by dehydrogenation of SiH-containing diorganopolysiloxane; condensation reaction of hydroxyl-terminated diorganopolysiloxane and hydrolyzable organosilanes (this condensation reaction) Is dehydration, alcohol-free, oxime-free, amine-free, amide-free, carboxyl-free, and ketone-free reactions) to cure in the presence of organotin compounds or titanates. Polysiloxa Composition; a and gamma rays, ultraviolet rays or organopolysiloxane compositions which are cured by high-energy radiation such as electron beams; the organo peroxide curable organopolysiloxane composition is thermally cured in the presence of a peroxide catalyst.

Addition reaction curable organopolysiloxane compositions are preferred because of their rapid cure speed and excellent cure uniformity. Particularly preferred addition reaction curable organopolysiloxane compositions are:
(A) an organopolysiloxane having at least two lower alkenyl groups in each molecule;
(B) prepared from an organopolysiloxane having at least two silicon-bonded hydrogen atoms in each molecule, and (C) a platinum type catalyst.

In relation to the above, component (A) is a basic component of organopolysiloxane that yields a siloxane elastomer, and is cured by an addition reaction between this component and component (B) under a catalyst by component (C). move on. This component (A) must contain at least two silicon-bonded lower alkenyl groups in each molecule, and if less than two lower alkenyl groups are formed, a network structure will not be formed, resulting in a fully cured product. I can't. The lower alkenyl group is exemplified by vinyl, allyl, and propenyl. The lower alkenyl group can be present at any position in the molecule, but is preferably present at the molecular end. The molecular structure of this component may be linear, branched linear, cyclic, or network, but is preferably linear and possibly slightly branched. Since there is no particular limitation on the molecular weight of the constituent components, the viscosity may be from a low viscosity liquid to a very high viscosity rubber. In order to obtain a cured product in the form of a rubbery elastomer, it is preferred that the viscosity at 25 ° C. is at least 0.0001 m ² / s (100 centistokes). These organopolysiloxanes include methylvinylsiloxane, methylvinylsiloxane-dimethylsiloxane copolymer, dimethylvinylsiloxy-terminated dimethylpolysiloxane, dimethylvinylsiloxy-terminated dimethylsiloxane-methylphenylsiloxane copolymer, dimethylvinylsiloxy-terminated dimethylsiloxane-diphenylsiloxane-methyl. Vinylsiloxane copolymer, trimethylsiloxy-terminated dimethylsiloxane-methylvinylsiloxane copolymer, trimethylsiloxy-terminated dimethylsiloxane-methylphenylsiloxane-methylvinylsiloxane copolymer, dimethylvinylsiloxy-terminated methyl (3,3,3-trifluoropropyl) polysiloxane, and Dimethylvinylsiloxy-terminated dimethylsiloxane-methyl 3,3, - it is exemplified by trifluoropropyl) siloxane copolymers.

  Component (B) is an organopolysiloxane having at least two silicon-bonded hydrogen atoms in each molecule, and is a crosslinking agent for component (A). Curing proceeds by an addition reaction between the silicon-bonded hydrogen atom in the component and the lower alkenyl group in component (A) under the catalyst of component (C). This component (B) must contain at least two silicon-bonded hydrogen atoms in each molecule in order to function as a crosslinking agent. Furthermore, the sum of the number of alkenyl groups in each molecule of component (A) and the number of silicon-bonded hydrogen atoms in each molecule of component (B) should be at least 5. Since the network structure is not essentially formed, it should not be less than 5.

The molecular structure of this constituent component is not particularly limited and may be any of linear, branched linear, cyclic, and the like. The molecular weight of this constituent component is not particularly limited, but in order to obtain good miscibility with the constituent component (A), the viscosity at 25 ° C. is from 1E-6 m ² / s ( ¹ cst) to 0.05 m ² / s ( (50,000 centistokes). This component has a molar ratio between the total amount of silicon-bonded hydrogen atoms in this component and the total amount of all lower alkenyl groups in component (A) of (1.5: 1) to (20: 1). It is preferable to add in such an amount as to fall within the range. When this molar ratio is lower than 0.5: 1, it becomes difficult to obtain good curing characteristics. If it exceeds (20: 1), the hardness tends to increase to a high level when the cured product is heated. Further, when an organosiloxane containing a large amount of alkenyl is supplementarily added for reinforcement purposes, for example, this component containing SiH may be supplementarily added in an amount that offsets these alkenyl groups. preferable. This component is specifically exemplified by trimethylsiloxy-terminated methylhydrogen polysiloxane, trimethylsiloxy-terminated dimethylsiloxane-methylhydrogensiloxane copolymer, and dimethylsiloxane-methylhydrogen-siloxane cyclic copolymer.

  Component (C) is a catalyst for the addition reaction between a silicon-bonded hydrogen atom and an alkenyl group. Specifically, the component (C) is dissolved in chloroplatinic acid, optionally an alcohol or ketone, and the solution is optionally aged. Illustrated by chloroplatinic acid, chloroplatinic acid-olefin complexes, chloroplatinic acid-alkenylsiloxane complexes, chloroplatinic acid-diketone complexes, platinum black, and carrier-supported platinum.

  This component is preferably platinum in which the total amount of components (A) and (B) is strictly 0.1 to 1,000, more preferably 1 to 100 parts by weight per 1,000,000 parts by weight. Add as mold metal. Other organic groups capable of bonding with silicon in the organopolysiloxane that forms the basis of the cured organopolysiloxane composition are, for example, alkyl groups such as methyl, ethyl, propyl, butyl, and octyl, 2-phenylethyl Substituted alkyl groups such as 2-phenylpropyl and 3,3,3-trifluoropropyl, aryl groups such as phenyl, tolyl and xylyl, substituted aryl groups such as phenylethyl, and A monovalent hydrocarbon group substituted with an epoxy group, a carboxylate ester group, a mercapto group or the like.

  A production example of the organopolysiloxane elastomer powder is as follows. In the presence of a surfactant (nonionic, anionic, cationic or amphoteric), the above-mentioned organopolysiloxane composition (addition-curing, condensation-curing or peroxide-curing) is mixed with water and homogenized. An organopolysiloxane composition (addition curing type, which is mixed with a mixer, a colloid mill, a homogenizer, a propeller mixer, etc. until homogeneous, then discharged into warm water (at least at a temperature of 50 ° C.), cured, and then dried. A powder is obtained by spraying and curing a radiation curable organopolysiloxane composition under high energy radiation, which is cured by spraying a condensation curable type or peroxide curable type directly in a heated stream. Siloxane composition (addition curing type, condensation curing type, or peroxide curing type) or A high energy curable organopolysiloxane composition is cured (the high energy curable organopolysiloxane composition is cured by high energy radiation) and the product is then applied to a ball mill, atomizer, kneader, roll mill, etc. A known pulverizer is used to form a powder. Suitable organopolysiloxane elastomer powders include vinyl dimethicone / methicone silesquioxane crosspolymers such as KSP-100, KSP-101, KSP-102, KSP-103, KSP-104, KSP-105 from Shin-Etsu Chemical Co., Ltd. And hybrid silicone powders containing fluoroalkyl groups such as KSP-200 from Shin-Etsu Chemical Co., and phenyl group-containing hybrid silicone powders such as KSP-300 from Shin-Etsu Chemical Co., Ltd. and DC9506 from Dow Corning.

  A preferred organopolysiloxane composition is a dimethicone / vinyl dimethicone crosspolymer. Such dimethicone / vinyl dimethicone crosspolymers include Dow Corning (DC9040 and DC9041), General Electric (SFE839), Shin Etsu (KSG-15, 16, 18 [ Dimethicone / phenylvinyl dimethicone crosspolymer]), and Grant Industries (Gransil ™ line material) and also supplied by Shin Etsu Lauryl dimethicone / vinyl dimethicone crosspolymers such as KSG-21, KSG-210, KSG-310, KSG-320, KSG-41, KSG-42, KSG-43, KSG-44, KSG-710, and KSG -810) A. Crosslinked organopolysiloxane elastomers useful in the present invention and methods for making them are described in US Pat. No. 4,970,252 (Sakuta et al.), US Pat. No. 5,760,116 (Kilgour et al.), Also described in US Pat. No. 5,654,362 (Schulz, Jr. et al.) And Japanese Patent Application No. 61-18708 (Pola Kasei Kogyo KK). ing.

  The composition of the present invention comprises a combination of emulsified and non-emulsifiable crosslinked organopolysiloxane elastomers. As used herein, the term “non-emulsifying” defines a crosslinked organopolysiloxane elastomer that is free of polyoxyalkylene or polyglycerin units. As used herein, the term “emulsifying” means a cross-linked organopolysiloxane elastomer having at least one polyoxyalkylene (eg, polyoxyethylene or polyoxypropylene) unit or polyglycerin unit.

  Particularly useful emulsifying elastomers are polyoxyalkylene modified elastomers formed from divinyl compounds, especially siloxane polymers having at least two free vinyl groups, reacted with Si-H bonds on a polysiloxane backbone. It is. Preferably, the elastomer is dimethylpolysiloxane in which the molecules are cross-linked by Si-H sites on a spherical MQ resin.

  The non-emulsifying cross-linked organopolysiloxane elastomer of the present invention can be subjected to a high shear treatment (about 34) in the presence of a solvent for siloxane elastomer using Sonolator, regardless of whether it is passed through 10 to 60 times and reused. Further processing is preferably performed at 5 MPa (5,000 psi).

  The emulsifying crosslinked organopolysiloxane elastomer is about 0.1% to about 15%, preferably about 0.2% to about 5%, most preferably about 0.2% by weight in the composition of the present invention. % To about 2% by weight.

  The non-emulsifying cross-linked organopolysiloxane elastomer is about 0.1% to about 15%, preferably about 0.1% to about 5%, most preferably about 0.1% by weight in the composition of the present invention. It is present at a concentration of from wt% to about 2 wt%.

Solvent of non-emulsifying and emulsifying cross-linked siloxane elastomer The composition of the present invention contains a solvent of the above-mentioned cross-linked organopolysiloxane elastomer. This solvent, when combined with the crosslinked organopolysiloxane elastomer particles of the present invention, serves to suspend and swell the elastomer particles to provide an elastic gel-like network or matrix. The solvent for the cross-linked siloxane elastomer is liquid under ambient conditions and preferably has a low viscosity to improve diffusivity to the skin.

  The concentration of the solvent of the cosmetic composition of the present invention varies depending on the type and amount of the solvent used and the crosslinked siloxane elastomer. A preferred concentration of solvent is from about 1% to about 50%, preferably from about 4% to about 50%, more preferably from about 5% to about 40% by weight of the composition.

The solvent for the crosslinked siloxane elastomer includes one or more liquid carriers suitable for topical application to human skin. A liquid carrier with a selected crosslinked siloxane elastomer at a concentration of the selected siloxane elastomer at a temperature of from about 28 to about 250 ° C., preferably from about 28 to about 100 ° C., preferably from about 28 to about 78 ° C. The liquid carrier may be organic, silicone-containing or fluorine-containing, volatile or non-volatile, polar or non-polar when forming a solution or other homogeneous liquid or liquid dispersion between them. The solvent for the crosslinked siloxane elastomer is preferably from about 3 to about 13 (cal / cm ³ ) ^0.5 , more preferably from about 5 to about 11 (cal / cm ³ ) ^0.5 , most preferably from about 5 to about 9 (cal / cm). ³ ) ^Has a solubility parameter of ^0.5 . The solubility parameters of liquid carriers or other substances and methods for determining the solubility parameters are well known in the chemical art. A description of solubility parameters and means for determining them can be found in C.I. D. CD Vaughan, “Solubility Effects in Product, Package, Penetration and Preservation” 103, Cosmetics and Toiletries 47-69 (October 1988) Month), and C.I. D. CD Vaughan's “Using Solubility Parameters in Cosmetics Formulation” 36, J. Soc. Cosmetic Chemists, pages 319-333 (September / October 1988) And these articles are incorporated herein by reference.

Solvents preferably include volatile, non-polar oils; non-volatile, relatively polar oils; non-volatile, non-polar oils; and non-volatile paraffinic hydrocarbon oils; Explained. As used herein, the term “non-volatile” refers to 0.1 MPa (1 atm), a material that exhibits a vapor pressure of about 26.7 Pa (0.2 mmHg) or less at 25 ° C., and / or 0.1 MPa ( Refers to a substance having a boiling point at 1 atm) of at least about 300 ° C. As used herein, the term “volatile” refers to any material that does not fall within the meaning of “nonvolatile” as defined herein. As used herein, the term “relatively polar” means that the polarity of the solubility parameter is higher than another material, that is, the higher the solubility parameter, the higher the polarity of the liquid. Become. The term “non-polar” usually means that the solubility parameter of the substance is less than about 6.5 (cal / cm ³ ) ^0.5 .

1. Non-polar and volatile oils Non-polar and volatile oils tend to impart highly desirable aesthetic properties to the compositions of the present invention. Thus, non-polar and volatile oils are preferably utilized at fairly high levels. Non-polar volatile oils particularly useful in the present invention are selected from the group consisting of silicone oils, hydrocarbons, and mixtures thereof. Such non-polar, volatile oils are described, for example, in Balsam and Sagarin “Cosmetics, Science, and Technology”, Vol. 1, pages 27-104 ( 1972). Nonpolar, volatile oils useful in the present invention may be either saturated or unsaturated, may have aliphatic character, may be linear or branched, or oily. It may contain a cyclic or aromatic ring. Examples of preferred non-polar volatile hydrocarbons include polydecanes such as isododecane and isodecane (eg, Permethyl-99A available from Presperse Inc.), and C7-C8 C12-C15 isoparaffins (e.g. Isopar series available from Exxon Chemicals). Nonpolar, volatile liquid silicone oils are disclosed in U.S. Pat. No. 4,781,917 (issued to Luebbe et al. On Nov. 1, 1988). In addition, a description of various volatile silicone materials can be found in Todd et al., “Volatile Silicone Fluids for Cosmetics”, Cosmetics and Toiletries, 91: 27-32 (1976). (Year). Particularly preferred volatile silicone oils are selected from the group consisting of cyclic volatile silicones corresponding to the formula:

式中、ｎは約３〜約７である。直鎖状揮発性シリコーンは次式に相当する：
（ＣＨ₃）₃Ｓｉ−Ｏ−［Ｓｉ（ＣＨ₃）₂−Ｏ］_m−Ｓｉ（ＣＨ₃）₃
式中、ｍは約１〜約７である。線状揮発性シリコーン類は、一般に、２５℃で約５Ｅ−６ｍ²／ｓ（５センチストークス）未満の粘度を有するが、環状シリコーン類は２５℃で約１Ｅ−５ｍ²／ｓ（１０センチストークス）未満の粘度を有する。揮発性シリコーン油の非常に好ましい例としては、様々な粘度のシクロメチコン類、例えば、ダウ・コーニング（Dow Corning）２００、ダウ・コーニング２４４、ダウ・コーニング（Dow Corning）２４５、ダウ・コーニング（Dow Corning）３４４、およびダウ・コーニング（Dow Corning）３４５（ダウ・コーニング社（Dow Corning Corp.）から市販）；ＳＦ−１２０４およびＳＦ−１２０２シリコーン流体（Ｇ．Ｅ．シリコーンズ社（G．E．Silicones）から市販）、ＧＥ７２０７および７１５８（ゼネラル・エレクトリック社（General Electric Co.）から市販）；ならびにＳＷＳ−０３３１４（ＳＷＳシリコーンズ社（SWS Silicones Corp.）から市販）が挙げられる。

Where n is from about 3 to about 7. Linear volatile silicones correspond to the following formula:
_{(CH 3) 3 Si-O-} [Si (CH 3) 2 -O] m -Si (CH 3) 3
Where m is from about 1 to about 7. Linear volatile silicones generally have a viscosity of less than about 5E-6 m ² / s (5 centistokes) at 25 ° C., while cyclic silicones are about 1E-5 m ² / s (10 centistokes) at 25 ° C. ) Having a viscosity of less than Highly preferred examples of volatile silicone oils include cyclomethicones of various viscosities such as Dow Corning 200, Dow Corning 244, Dow Corning 245, Dow Corning Corning 344, and Dow Corning 345 (commercially available from Dow Corning Corp.); SF-1204 and SF- 1202 silicone fluids (GE Silicones, G.E. (Commercially available from Silicones), GE7207 and 7158 (commercially available from General Electric Co.); and SWS-03314 (commercially available from SWS Silicones Corp.).

2. Non-volatile oils with relatively high polarity Non-volatile oils are “relatively high in polarity” compared to the non-polar and volatile oils described above. Thus, the non-volatile cosolvent is more polar (ie, has a higher solubility parameter) than at least one of the nonpolar, volatile oils. Relatively polar non-volatile oils potentially useful in the present invention include, for example, “Cosmetics, Science, and Technology” edited by Balsam and Sagarin (see “Cosmetics, Science, and Technology”). (1972) Volume 1, pages 27-104; U.S. Pat. No. 4,202,879 (Shelton, May 13, 1980); U.S. Pat. No. 4,816,261 (Luebbe et al.). , March 28, 1989). The relatively polar, non-volatile oils useful in the present invention are preferably silicone oils; hydrocarbon oils; aliphatic alcohols; fatty acids; esters of mono- and dibasic carboxylic acids with mono- and polyhydric alcohols. Selected from the group consisting of: polyoxyethylenes, polyoxypropylenes, mixtures of polyoxyethylene ethers and polyoxypropylene ethers of aliphatic alcohols; and mixtures thereof. The relatively polar non-volatile cosolvents useful in the present invention may be either saturated or unsaturated, may have aliphatic character, may be linear or branched, or alicyclic It may contain a ring or an aromatic ring. More preferably, the relatively polar non-volatile liquid co-solvent is an aliphatic alcohol having about 12-26 carbon atoms; a fatty acid having about 12-26 carbon atoms; a monobasic carboxylic acid and about 14 An ester with an alcohol having -30 carbon atoms; an ester with a dibasic carboxylic acid and an alcohol having about 10-30 carbon atoms; a polyhydric alcohol and a carboxylic acid having about 5-26 carbon atoms; Esters of aliphatic alcohols having about 12 to 26 carbon atoms and having a degree of ethoxylation and propoxylation of less than about 50, ethers of ethoxylation, propoxylation, ethoxylation and propoxylation of aliphatic alcohols As well as a mixture thereof. More preferred are propoxylated ethers of C14-C18 aliphatic alcohols having a degree of propoxylation of less than about 50, esters of C2-C8 alcohols with C12-C26 carboxylic acids (eg, ethyl myristate). Isopropyl palmitate), esters of C12-C26 alcohols and benzoic acid (for example, Finesolv TN supplied by Finetex), C2-C8 alcohols and adipic acid, sebacine Acids and diesters with phthalic acid (eg diisopropyl sebacate, diisopropyl adipate, di-n-butyl phthalate), polyhydric alcohol esters of C6-C26 carboxylic acids (eg propylene dicapric acid / dicaprylic acid) Glycol, propylene glycol isostearate Call); a and mixtures thereof. Even more preferred are branched chain aliphatic fatty alcohols having about 12 to 26 carbon atoms.

3. Non-polar, non-volatile oils The solvent of the crosslinked siloxane elastomer may optionally include non-volatile, non-polar oils in addition to the liquids described above. Typical non-volatile, non-polar emollients are described, for example, in Balsam and Sagarin “Cosmetics, Science, and Technology” (1972) Vol. 1, 27. -104, U.S. Pat. No. 4,202,879 (Shelton, issued May 13, 1980), U.S. Pat. No. 4,816,261 (Luebbe et al., March 28, 1989). Issue). Non-volatile oils useful in the present invention are essentially non-volatile polysiloxanes, paraffinic hydrocarbon oils, and mixtures thereof. The polysiloxanes useful in the present invention are selected from the group consisting of polyalkyl siloxanes, polyaryl siloxanes, polyalkylaryl siloxanes, polyether siloxane copolymers, and mixtures thereof. Examples of these include polydimethylsiloxanes having a viscosity of from about 1E-6 m ² / s (1 cst) to about 0.1 m ² / s (100,000 centistokes) at 25 ° C. Of the preferred non-volatile silicone emollients, useful in the present compositions are polydimethylsiloxanes having a viscosity of from about 2E-6 m ² / s ( ² cst) to about 0.0004 m ² / s (400 centistokes) at 25 ° C. It is kind. Such polyalkylsiloxanes include the Viscasil series (sold by General Electric Company) and the Dow Corning 200 series (from Dow Corning Corp.). Sales). Polyalkylaryl siloxanes include polymethylphenylsiloxanes having a viscosity at 25 ° C. of about 1.5E-5 m ² / s (15 cst) to about 6.5E-5 m ² / s (65 centistokes). These are commercially available, for example, as SF1075 methylphenyl fluid (sold by General Electric Company) and 556 cosmetic grade fluid (sold by Dow Corning Corp.).

Nonvolatile paraffinic hydrocarbon oils useful in the present invention include mineral oils and certain branched hydrocarbons. Examples of these fluids are disclosed in US Pat. No. 5,019,375 (issued March 29, 1991 to Tanner et al.). Preferred mineral oils have the following properties:
(1) Viscosity at 40 ° C. of about 5E-6 m ² / s (5 centistokes) to about 7E-5 m ² / s (70 centistokes),
(2) The density at 25 ° C. is about 0.82 to 0.89 g / cm ³ ,
(3) Flash point of about 138 to about 216 ° C, and (4) Carbon chain length of about 14 to about 40 carbon atoms.

Preferred branched hydrocarbon oils have the following characteristics:
(1) The density at 20 ° C. is about 0.79 to about 0.89 g / cm ³ ,
(2) The boiling point is more than about 250 ° C, and (3) the flash point is about 110 to about 200 ° C.

  Suitable branched hydrocarbons include Permethyl 103A containing an average of about 24 carbon atoms; Permethyl 104A containing an average of about 68 carbon atoms; Permethyl 102A containing; these may all be purchased from Permethyl Corporation; and Ethylflo 364 containing a mixture of 30 and 40 carbon atoms (Ethylflo Ethyl Corp.) may be purchased.

  Additional solvents useful in the present invention are described in US Pat. No. 5,750,096 (issued May 12, 1998 to Gerald J. Gusky et al.).

Aqueous Phase The cosmetic composition of the present invention comprises about 50% to about 99%, preferably about 50% to about 95%, more preferably about 65% to about 90%, by weight of the aqueous phase of the composition. including.

  The composition of the present invention is a water-in-oil emulsion. In such compositions, there is generally a weak bond of the aqueous phase to the oil phase. This makes it possible to change the composition at the time of application, for example giving a sensation of water droplets when spreading on the skin. For example, when first applied to the skin before spreading on the skin, the composition is in the form of a gel or cream. It is thought that the emulsion is broken by finger shear stress when spreading, thereby releasing the aqueous phase from the emulsion. Thereby, since the water phase discharged | emitted as mentioned above can be recognized visually also in addition to a tactile sense, a favorable sensory effect is provided to a user.

  In certain embodiments, the visually recognizable aqueous phase release is characterized by the microscopy described in Test Methods. Microscopy is a method of visually analyzing the presence and size of an aqueous region emulsified in an oil phase using a microscope. After applying the shear force to the emulsion in increments of time, a micrograph of the emulsion is taken. The release of the aqueous phase can be visually recognized when an amorphous aqueous region with a maximum linear dimension of at least about 10 μm becomes visible at 500 × magnification within about 1 minute of shear. In another embodiment, the release of the aqueous phase is visible when an amorphous aqueous region having a dimension of at least about 25, 50, or 75 μm becomes visible at a magnification of 500 times within about 1 minute of shear. Can be recognized. In another preferred embodiment, when an amorphous aqueous region having a dimension of at least about 10 μm is visible at a magnification of 500 times within about 45 seconds, 30 seconds, or 15 seconds of shear, the aqueous phase Can be visually recognized.

  In certain embodiments, the visually recognizable water phase release is characterized by phase separation after milling according to the milling method described in Test Methods. The milling method bulk mills a 30 g sample of an emulsion. In certain embodiments, the release of a portion of the aqueous phase can be visually recognized if at least about 0.5 g of the aqueous phase separates after 1 minute of milling at a rate of 24000 rpm. In another embodiment, at least about 1.0 g, 2.5 g, or 5.0 g of the aqueous phase separates after 1 minute of milling at a speed of 24000 rpm. In yet another embodiment, if at least 0.25 g of the aqueous phase separates after 1 minute of milling at a speed of 13500 rpm, the release of a portion of the aqueous phase can be visually recognized. In another embodiment, the composition may separate at least about 0.5 g of the aqueous phase after 1 minute of milling at a speed of 24000 rpm, but visually recognizable water after 1 minute of milling at a speed of 8000 rpm. No phase release occurs (ie, the aqueous phase is less than 0.1 g). Such an embodiment would still be able to recognize the release of the aqueous phase when applied topically to the skin and at the same time would have good storage and processing stability.

  In certain embodiments, the release of the tactilely recognizable aqueous phase is characterized by a decrease in viscosity as measured by the rheological method described in the test method. The rheological method applies rheological properties by logarithm of shear stress (x axis) versus logarithm of viscosity (y axis) by applying controlled stress to a sample of emulsion. For emulsions that release an aqueous phase when shear is applied, the shear vs. viscosity plot shows a shape where the viscosity decreases at the limit of shear stress. The slope of the portion showing a sharp drop in the plot is less than about -5. In another embodiment, the slope of the portion exhibiting a sharp drop in the plot is less than about −10, −25, −50, −75, or −100.

  Without being bound by theory, the amount of water phase released from the emulsion and its rate can be controlled depending on how the oil phase is combined with the water phase within the emulsion. Further, the amount of aqueous phase released from the emulsion and its rate can be determined, for example, by adding additional emulsifiers or dispersing emulsifying crosslinked siloxane elastomer concentrations as described below. It is considered that the control can be performed by changing the ratio within the range or by changing the ratio of the water phase / oil phase.

Additional emulsifiers for dispersing the aqueous phase The water-in-oil emulsions of the present invention can optionally include an emulsifier in addition to the emulsifying elastomer. In certain embodiments, the composition comprises additional emulsifier from about 0% to about 5%, preferably from about 0.01% to about 5%, more preferably from about 0.1% to about 5% by weight of the composition. It may contain 3% by weight, more preferably about 0.1% to about 2% by weight. If additional emulsifier is present, the emulsifier assists in the dispersion and suspension of the aqueous phase within the continuous silicone phase.

  A wide variety of emulsifiers can be used herein to form the preferred water-in-silicone emulsion. Known or conventional emulsifiers are used in the composition provided that the selected emulsifier is chemically and physically compatible with the components of the composition of the present invention and provides the desired dispersion properties. be able to. Suitable emulsifiers include silicone emulsifiers, non-silicone containing emulsifiers, and mixtures thereof known to those skilled in the art for use in topical personal care products. Preferably, these emulsifiers have an HLB value of about 14 or less, more preferably from about 2 to about 14, and even more preferably from about 4 to about 10. Emulsifiers with HLB values outside these ranges can be used in combination with other emulsifiers to obtain an effective weight average HLB that falls within these ranges.

  Silicone emulsifiers are preferred. A wide variety of silicone emulsifiers are useful herein. These silicone emulsifiers are typically organically modified organopolysiloxanes, also known to those skilled in the art as silicone surfactants. Useful silicone emulsifiers include dimethicone copolyols. These materials have been modified to include polyether side chains such as polyethylene oxide chains, polypropylene oxide chains, mixtures of these chains, and polyether chains containing moieties derived from both ethylene oxide and propylene oxide. Polydimethylsiloxanes. Other examples include alkyl-modified dimethicone copolyols, i.e. compounds containing C2-C30 pendant side chains. Still other useful dimethicone copolyols include materials having various cationic, anionic, amphoteric, and zwitterionic pendant moieties.

  Non-limiting examples of dimethicone copolyols and other silicone surfactants useful herein as emulsifiers include polydimethylsiloxane polyether copolymers having pendant polyethylene oxide side chains, pendant polypropylene oxide side chains. , Polydimethylsiloxane polyether copolymer having pendant mixed with polyethylene oxide side chain and polypropylene oxide side chain, polydimethylsiloxane poly having pendant mixed poly (ethylene) (propylene) oxide side chain Ether copolymer, polydimethylsiloxane polyether copolymer with pendant organobetaine side chain, polydimethylsilco with pendant carboxylate side chain Sun polyether copolymers, polydimethylsiloxane polyether copolymers having pendant quaternary ammonium side chains; and further modifications of said copolymers containing pendant C2-C30 linear, branched, or cyclic alkyl moieties is there. Examples of commercially available dimethicone copolyols useful herein as sold by Dow Corning Corporation are Dow Corning® 190, 193, Q2-5220, 2501 waxes. , 2-5324 fluid, and 3225C (this latter material is sold as a mixture with cyclomethicone). Cetyl dimethicone copolyol is commercially available under the trade name ABIL® EM-90, and is also available as a mixture with polyglyceryl-4 isostearate (and) hexyl laurate. It is sold under the trade name ABIL® WE-09 (available from Goldschmidt). Cetyl dimethicone copolyol is also commercially available as a mixture of hexyl laurate (and) polyglyceryl-3 oleate (and) cetyl dimethicone, trade name ABIL® WS-08 (also commercially available from Goldschmidt) It is sold at. Polydimethylsiloxyethyl dimethicone copolyol is commercially available (from Shin-Etsu) under the trade names KF-6028, KF-6104, KF-6105, and KF-6106. Other non-limiting examples of dimethicone copolyols include lauryl dimethicone copolyol, lauryl polydimethylsiloxyethyl dimethicone copolyol, dimethicone copolyol acetate, dimethicone copolyol adipate, dimethicone copolyolamine, dimethicone copolyol. Also included are behenate, dimethicone copolyol butyl ether, dimethicone copolyol hydroxystearate, dimethicone copolyol isostearate, dimethicone copolyol laurate, dimethicone copolyol methyl ether, dimethicone copolyol phosphate, and dimethicone copolyol stearate.

  Dimethicone copolyol emulsifiers useful herein are, for example, US Pat. No. 4,960,764 (Figueroa, Jr. et al.); European Patent 330,369 (SaNogueira). G. H. Dahms et al. “New Formulation Possibilities Offered by Silicone Copolyols” (Cosmetics & Toiletries, 110, 91-100, 1995). March); E. Carlotti et al. “Optimization of W / OS Emulsions And Study Of The Quantitative Relationships Between Ester Structure And Emulsion Properties” (J. Dispersion Science And Technology, 13 (3), 315-336, 1992); Hameyer, “Comparative Technological Investigations of Organic and Organosilicone Emulsifiers in Cosmetic Water-in-Oil Emulsion Preparations” (HAPPI 28 (4 ), 88-128, 1991); Smid-Korbar et al. “Efficiency and usability of silicone surfactants in emulsions” (Provisional Communication), International Journal of Cosmetic Science of Cosmetic Science), 12, 135-139, 1990); G. Krzysik et al. “A New Silicone Emulsifier For Water-in-Oil Systems” (Drug and Cosmetic Industry, Volume 146 (4), 28-81, April 1990).

  Non-silicone-containing emulsifiers useful herein include sugar esters and polyesters, alkoxylated sugar esters and polyesters, C1-C30 fatty acid esters of C1-C30 aliphatic alcohols, C1-C30 aliphatic alcohols. C1-C30 fatty acid esters alkoxylated derivatives, C1-C30 fatty alcohols alkoxylated ethers, C1-C30 fatty acid polyglyceryl esters, polyols C1-C30 esters, polyols C1-C1 There are a variety of nonionic and anionic emulsifiers such as C30 ethers, alkyl phosphates, polyoxyalkylene aliphatic ether phosphates, fatty acid amides, acyl lactylates, soaps, and mixtures thereof.

Skin Care Active Substance The topical composition of the present invention preferably further comprises at least one skin care active substance. For the formulations herein, active substances generally characterized as “oil-soluble” are preferred in addition to those generally characterized as “water-soluble”. Without being bound by theory, it is believed that the composition of the present invention provides versatility by blending various active substances.

  However, in any embodiment of the present invention, the active substances useful herein can be classified according to the effects they provide or their mode of action assumed. However, it should be understood that the active substances useful herein can in some cases produce more than one effect or function through more than one mechanism of action. Accordingly, the classifications herein are for convenience only and are not intended to limit the active material to the specific uses or uses listed.

  Non-limiting examples of skin care actives suitable herein include niacinamide, hexamidine compounds, whitening actives, peptides, sugar amines, and mixtures thereof.

Niacinamide Niacinamide (or another vitamin B ₃ compound that is soluble in solvents and solid at room temperature) is a preferred skin care active for use herein. The present invention preferably comprises from about 2% to about 30%, more preferably from about 2% to about 20%, and even more preferably from about 2% to about 10% vitamin B ₃ compound.

  As used herein, “niacinamide” means a compound having the formula:

式中、Ｒは−ＣＯＮＨ₂である。

In the formula, R is —CONH ₂ .

Niacinamide may be included as a substantially pure material or as an extract obtained from natural (eg, plant) resources by suitable physical and / or chemical isolation. The vitamin B ₃ compound is preferably substantially pure, more preferably essentially pure.

Hexamidine compounds Topically applied compositions of the present invention also comprise a safe and effective amount of one or more hexamidine and salts thereof. More preferably, the hexamidine is hexamidine diisethionate.

  As used herein, “hexamidine” includes any isomers and tautomers thereof, and may be referred to as Laboratories CelloBiologics as hexamidine diisethionate under the trade name Elestab® HP100. Laboratoires Serobiologiques (Pulnoy, France).

  In the compositions of the present invention, hexamidine is preferably from about 0.0001% to 25%, more preferably from about 0.001% to about 10%, more preferably about 0.01% by weight of the composition. To about 5% by weight, most preferably from about 0.02% to about 2.5% by weight.

Whitening Agent The present composition may contain a whitening agent. A whitening agent useful herein refers to an active ingredient that not only alters the appearance of the skin, but further improves abnormal pigmentation as compared to before treatment. Whitening agents useful herein include ascorbic acid compounds, vitamin B ₃ compounds, azelaic acid, butylhydroxyanisole, gallic acid and its derivatives, hydroquinoine, kojic acid, arbutin, mulberry extract, undecile Noylphenylalanine, and mixtures thereof. The use of a combination of whitening agents is also considered advantageous in that they can have a whitening effect by different mechanisms.

  When used, the composition preferably contains from about 0.1% to about 10%, more preferably from about 0.2% to about 5% by weight of the whitening agent of the composition.

  Ascorbic acid compounds are useful as whitening agents and have the following formula (I):

式中、ＶおよびＷは独立して−ＯＨであり、Ｒ¹は−ＣＨ（ＯＨ）−ＣＨ₂ＯＨおよびこれらの塩である。

In the formula, V and W are independently —OH, and R ¹ is —CH (OH) —CH ₂ OH and salts thereof.

  Preferably, the ascorbic acid compound useful herein is ascorbate or a derivative thereof, such as sodium, potassium, lithium, calcium, magnesium, barium prepared by methods well known in the art. Non-toxic alkali metal, alkaline earth metal, and ammonium salts known to those skilled in the art, such as, but not limited to, ammonium, and protamine salts.

  More preferably, the ascorbate useful herein is a metal ascorbic acid having the following formula (II):

式中、Ｒ²およびＲ³は独立して水素および炭素数が１〜約８個の直鎖または分枝鎖アルキルから選択され、Ｍ¹は金属であり、×は１〜約３の整数である。より好ましくは、Ｒ²およびＲ³は独立して水素および炭素数が１〜約３個の直鎖または分枝鎖アルキルから選択され、Ｍ¹はナトリウム、カリウム、マグネシウム、またはカルシウムである。

Wherein R ² and R ³ are independently selected from hydrogen and straight-chain or branched alkyl having 1 to about 8 carbon atoms, M ¹ is a metal, and x is an integer from 1 to about 3. is there. More preferably, R ² and R ³ are independently selected from hydrogen and straight-chain or branched alkyl having 1 to about 3 carbon atoms, and M ¹ is sodium, potassium, magnesium, or calcium.

  Examples of other preferred ascorbates having the formula (II) include monovalent metal salts of ascorbic acid (eg, sodium ascorbate, potassium ascorbate), divalent metal salts (eg, magnesium ascorbate, ascorbine) Acid calcium), and trivalent metal salts (for example, aluminum ascorbate).

  Preferably, the ascorbate useful herein is a water-soluble ascorbyl ester having the following formula (III):

式中、Ａは硫酸またはリン酸であり、Ｒ⁴およびＲ⁵は独立して水素および炭素数が１〜約８個の直鎖または分枝鎖アルキルから選択され、Ｍ²は金属であり、ｙは１〜約３の整数である。より好ましくは、Ｒ⁴およびＲ⁵は独立して水素および炭素数が１〜約３個の直鎖または分枝鎖アルキルから選択され、Ｍ²はナトリウム、カリウム、マグネシウム、またはカルシウムである。

In which A is sulfuric acid or phosphoric acid, R ⁴ and R ⁵ are independently selected from hydrogen and straight-chain or branched alkyl having 1 to about 8 carbon atoms, M ² is a metal, y is an integer from 1 to about 3. More preferably, R ⁴ and R ⁵ are independently selected from hydrogen and straight-chain or branched alkyl having 1 to about 3 carbon atoms, and M ² is sodium, potassium, magnesium, or calcium.

  Another particularly preferred ascorbic acid compound is 2-o-α-D-glucopyranosyl-L-ascorbic acid, commonly referred to as L-ascorbic acid 2-glucoside or ascorbyl glucoside, and metal salts thereof. Such compounds are available from Hayashibara.

  Magnesium ascorbate phosphate is a stable form of vitamin C. This compound is converted into vitamin C in vivo. It is soluble in various solvents such as water, propylene glycol, 1,3-butylene glycol, maltitol, and glycerin, and is stable in these solvents. Unlike vitamin C, magnesium ascorbate is transdermally absorbed into the skin. Magnesium ascorbate phosphate is commercially available from Barnet Products Corp. as NIKKOL VC-PMG.

  Typical water-soluble salt derivatives include L-ascorbic acid 2-glucoside, L-ascorbyl sodium phosphate, L-ascorbyl potassium phosphate, L-ascorbyl magnesium phosphate, L-ascorbyl calcium phosphate, L phosphate -Examples include, but are not limited to, L-ascorbyl phosphate salts such as ascorbyl aluminum. Sulfuric acid L-ascorbyl ester salts can also be used. Examples include sodium L-ascorbyl sulfate, potassium L-ascorbyl sulfate, magnesium L-ascorbyl sulfate, calcium L-ascorbyl sulfate, and aluminum L-ascorbyl sulfate.

  Undecylenoylphenylalanine is also a suitable substituted amino acid for use herein as a whitening agent. This compound is available from Seppic under the trade name Sepiwhite Msh. Cetylpyridinium chloride and tetrahydrocurcumin are also suitable for use herein as whitening agents.

  Glycyrrhizic acid, which is a natural substance derived from licorice, and glycyrrhetic acid, a derivative thereof, are also suitable for use herein. Such materials are available from Maurzen or Ichimaru Pharcos.

Peptides including, but not limited to, peptide di-, tri-, tetra-, pentapeptides, and derivatives thereof can be included in the compositions of the present invention in a safe and effective amount. . As used herein, the term “peptide” refers to both naturally occurring and synthetic peptides. Also useful herein are naturally occurring and commercially available compositions containing peptides.

Suitable dipeptides for use herein include Carnosine (β-Ala-His). Suitable tripeptides for use herein include Gly-His-Lys, Arg-Lys-Arg, and His-Gly-Gly. Preferred tripeptides and derivatives thereof include Palmitoyl-Gly-His-Lys (100 ppm available from Sederma, France) which can be purchased as Biopeptide CL®. ); peptide CK (Arg-Lys-Arg) ; peptide CK + (Ac-Arg-Lys -Arg-NH 2); and Iamin (Iamin) as sigma (St. Louis, MO) copper possible His-Gly-Gly purchased from Derivatives. Tetrapeptides and pentapeptides are also suitable for use herein.

  A preferred commercially available pentapeptide derivative-containing composition is Matrixyl®, which contains 100 ppm palmitoyl-lys-thr-thr-lys-ser (pal-KTTTS, Sederma, France). ). Another preferred peptide is available as a composition known under the names palmitoyl-lysine-threonine (pal-KT) and palmitoyl-glycine-glutamine-proline-arginine (pal-GQPR, RIGIN®). Are also commercially available from Sederma, France.

  When included in the composition, the peptide is preferably from about 0.000001% to about 10%, more preferably from about 0.000001% to about 0.1%, more preferably about 0% by weight of the composition. Included at a concentration of 0.0001% to about 0.01% by weight. In certain compositions that include Carnosine® as a peptide, the composition preferably includes the peptide at a concentration of about 0.1% to about 5% by weight of the composition. . In another embodiment, where the peptide or peptide-containing composition includes palmitoyl-Lys-Thr-Thr-Lys-Ser and / or biopeptide CL®, the composition preferably has about 0.0001% ˜about 10% Palmitoyl-Lys-Thr-Thr-Lys-Ser and / or Biopeptide CL® peptide-containing composition is included.

Sugar Amines The compositions of the present invention may include a safe and effective amount of a sugar amine, also known as an amino sugar. As used herein, “sugar amine” refers to an amine derivative of a 6 carbon sugar. Preferably, the composition comprises from about 0.001% to about 20%, more preferably from about 1% to about 10%, even more preferably from about 2% to about 5% by weight of the composition. Contains sugar amines.

  Examples of sugar amines useful herein include glucosamine, N-acetylglucosamine, mannosamine, N-acetylmannosamine, galactosamine, N-acetylgalactosamine. Preferred for use herein is glucosamine. In addition, a combination of two or more sugar amines may be used.

Skin Conditioning Agent The topical composition of the present invention contains from about 1% to about 60% by weight of the composition of a skin conditioning agent. Preferably, the composition contains about 2% to about 50%, more preferably about 5% to about 40%, by weight of the composition of a skin conditioning agent. In general, compositions containing a high proportion of skin conditioning agents may be perceived as greasy or sticky by the user. The compositions of the present invention can surprisingly contain skin conditioning agents in relatively high proportions (eg, over 25% by weight of the composition) without significantly increasing the perception of greasy or sticky. I know it.

  Suitable skin conditioning agents for use herein include polyhydric alcohols such as polyalkylene glycols. Preferred for use herein are alkylene polyols and their derivatives. Examples of polyhydric alcohols useful herein include propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol, sorbitol, trehalose, hydroxypropyl sorbitol, hexylene glycol, 1,3-butylene glycol, 1,2, 6-hexentriol, glycerin, 1,2-hexanediol, pentylene glycol, ethoxylated glycerin, propoxylated glycerin, butanetriol, and mixtures thereof. A preferred polyhydric alcohol for use herein is glycerin.

  The skin conditioning agents used herein can be obtained from conventional manufacturing means and purification methods.

Thickener The composition of the present invention may further comprise one or more thickeners in some embodiments. When present, the composition is preferably from about 0.1% to about 5%, more preferably from about 0.1% to about 4%, even more preferably about 0.25% by weight of the composition. Contains about 3% by weight thickener.

Non-limiting classes of thickeners include those selected from:
a) Carboxylic acid polymers These polymers are crosslinked compounds containing acrylic acid, substituted acrylic acid, and one or more monomers derived from salts and esters of these acrylic acids and substituted acrylic acids, The crosslinker contains two or more carbon-carbon double bonds and is derived from a polyhydric alcohol.

Examples of commercially available carboxylic acid polymers useful herein include carbomers, which include homopolymers of acrylic acid crosslinked with sucrose or allyl ethers of pentaerytritol. The carbomer is F. Available from BF Goodrich as the Carbopol® 900 series (eg, Carbopol® 954). In addition, other suitable carboxylic acid polymer agents include _C10-30 alkyl acrylates and one or more acrylic acid monomers, methacrylic acid monomers, or one of these short chains (ie, _C1-4 alcohols). And the cross-linking agent is sucrose or an allyl ether of pentaerythritol. These copolymers are known as acrylate / C _10-30 alkyl acrylate crosspolymers and include Carbopol® 1342, Carbopol® 1382, Pemulen TR-1, and Pemlen TR-. 2 as B. F. Commercially available from BFGoodrich. In other words, examples of carboxylic acid polymer thickeners useful herein are carbomers, acrylates / C ₁₀ -C ₃₀ alkyl acrylate cross polymers, and those mixtures thereof.

b) Crosslinked Polyacrylate Polymers The compositions of the present invention can optionally comprise a crosslinked polyacrylate polymer, useful as a thickening or gelling agent comprising both cationic and nonionic polymers, In general, a conducting polymer is preferred.

c) Polyacrylamide polymers The compositions of the present invention can optionally include polyacrylamide polymers, particularly non-ionic polyacrylamide polymers, including substituted branched or unbranched polymers. Of these polyacrylamide polymers, the CTFA designation polyacrylamide and the nonionic polymers of isoparaffin and laureth-7 are more preferred, and the brand name Sepicel 305 is Seppic Corporation (Fairfield, New Jersey, USA). More commercially available.

  Other polyacrylamide polymers useful herein include multi-block copolymers of acrylamides and substituted acrylamides with acrylic acids and substituted acrylic acids. Commercial examples of such multi-block copolymers include Hypan SR150H, SS500V, SS500W, SSSA100H from Lipo Chemicals, Inc. (Patterson, NJ).

d) Polysaccharides A wide variety of polysaccharides are useful herein. By “polysaccharide” is meant a gelling agent that contains a backbone of repeating sugar (ie, carbohydrate) units. Non-limiting examples of polysaccharide gelling agents include cellulose, carboxymethyl hydroxyethyl cellulose, cellulose acetate propionate carboxylate, hydroxyethyl cellulose, hydroxyethyl ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl hydroxyethyl cellulose, Those selected from crystalline cellulose, sodium cellulose sulfate, and mixtures thereof. Also useful herein are alkyl substituted celluloses. In these polymers, the hydroxy group of the cellulose polymer is hydroxyalkylated (preferably hydroxyethylated or hydroxypropylated) to form a hydroxyalkylated cellulose, which is then a C ₁₀ -C ₃₀ linear or Further modification through ether linkages by branched alkyl groups. Typically, these polymers are ethers of C ₁₀ -C ₃₀ linear or branched alcohols with hydroxyalkylcelluloses. Examples of alkyl groups useful herein include stearyl, isostearyl, lauryl, myristyl, cetyl, isocetyl, cocoyl (ie, alkyl groups derived from coconut oil alcohols), palmityl, oleyl, linoleyl, linolenyl. , Ricinoleyl, behenyl, and mixtures thereof. Preferred among the alkylhydroxyalkylcellulose ethers is a substance of the CTFA designation cetylhydroxyethylcellulose, which is an ether of cetyl alcohol and hydroxyethylcellulose. This material is sold under the trade name Natrosol (R) CS Plus (Plus) by Aqualon Corporation (Wilmington, Delaware).

  Other useful polysaccharides include scleroglucans, which are linear (1-3) linked glucose units with (1-6) linked glucose every 3 units, but commercially available examples thereof are: Clearogel® CS11 manufactured by Michel Mercier Products Inc. (Mountainside, NJ).

e) Rubbers Other thickeners and gelling agents useful herein include materials derived primarily from natural sources. Non-limiting examples of these gelling gums include acacia, agar, algin, alginic acid, ammonium alginate, amylopectin, calcium alginate, carrageenan calcium, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyl Trimonium chloride, hectorite, hyaluronic acid, silicon hydroxide, hydroxypropyl chitosan, hydroxypropyl guar, Karaya gum, kelp, carob gum, natto gum, potassium alginate, carrageenan potassium, propylene glycol alginate, sclerotium gum, carboxymethyl dextran Sodium, carrageenan sodium, tragacanth gum, xanthan gum, and mixtures thereof.

Particulate matter The composition of the present invention may, in certain embodiments, contain a particulate matter to change the feel or appearance. Examples of suitable particulate materials are disclosed in US Pat. No. 5,997,887 (Ha et al.). For example, inorganic particulate materials such as TiO ₂ , ZnO, or ZrO ₂ are commercially available from multiple sources. Examples of suitable particulate materials include U.S. S. Substances available from US Cosmetics (TRONOX TiO ₂ series, SAT-T CR837, rutile TiO ₂ ). An example of a particulate material having a combination with an inorganic chemical is COVERLEAF AR-, a layered inorganic chemical available from Catalysts and Chemicals Ind. Co. Ltd. 80, and the silica powder Godbal that encloses one or more inorganic chemicals available from Suzuki Yushi Ind. Co. Ltd. Preferably, the particulate material is in the composition from about 0.01% to about 20%, more preferably from about 0.05% to about 15%, more preferably from about 0.1% by weight of the composition. It is present at a concentration of from wt% to about 12 wt%.

  Suitable organic powders / fillers include polymer particles selected from methylsilsesquioxane resin microspheres (such as those sold by Toshiba Silicone under the name Tospearl 145A); polymethyl methacrylate microspheres (Micropearl M100) Spherical particles of crosslinked polydimethylsiloxane (especially those sold by Dow Corning Toray Silicon under the name Trefil E506C or Trefil E505C), polyamide spherical particles, and more specifically Are nylon 12 (especially those sold by Atochem under the name Orgasol 2002D NatC05), polystyrene microspheres (Dynospheres and Cormorants such as those sold by Dyno the Particles under the name), ethylene acrylate copolymer (sold by Kobo under the name FloBead EA209) and combinations thereof, without limitation.

  The particles may be subjected to a hydrophobic treatment so that they are more easily dispersed in the delivery solvent. It may also be useful to treat the pigment with a material that is compatible with the silicone phase. Particularly useful hydrophobic pigment treatments for use in water-in-silicone emulsions include polysiloxane treatments such as those disclosed in US Pat. No. 5,143,722. This document is incorporated herein by reference in its entirety. Also preferred are particles having a primary average particle size of about 10 to about 100,000 nm, more preferably about 50 to about 5,000 nm, and most preferably about 100 to about 1000 nm. Also useful herein are mixtures of identical or different particles having different particle sizes (eg, TiO 2 having a primary particle size of about 100 nm to about 400 nm and TiO 2 having a primary particle size of about 10 nm to about 50 nm). And).

Optional Ingredients The compositions of the present invention may contain one or more additional skin care actives. In a preferred embodiment where the composition is contacted with human keratinous tissue, the additional components should be suitable for application to keratinous tissue, i.e., when incorporated into the composition they are correct. It is suitable for use in contact with human keratinous tissue without excessive toxicity, incompatibility, instability, allergic reaction, etc. within the scope of medical judgment.

Non-limiting examples of additional skin care active ingredients that can be used in the present invention include sunscreen actives, oil soluble terpene alcohols, phytosterols, oil soluble vitamin compounds, additional vitamin B ₃ compounds, oil soluble vitamin compounds, skin Softeners and occlusive agents, dehydroacetic acid, anti-acne active substances, β-hydroxy acids, chelating agents, flavonoids, anti-inflammatory agents, anti-cellulite agents, local anesthetics, desquamating active substances, antioxidants / radical scavengers, local anesthesia Agents, suntans, skin soothing and rejuvenating agents, antibacterial and antifungal agents, and mixtures thereof.

  The CTFA Cosmetic Ingredient Handbook, Eleventh Edition (2004) describes a wide variety of non-limiting cosmetic and pharmaceutical ingredients that are commonly used in the skin care industry and are described in the present invention. It is suitable to be used for the composition. Examples of these component classes include abrasives, absorbents, cosmetic ingredients such as fragrances, pigments, dyes / colorants, essential oils, skin sensates, astringents (eg clove oil, menthol, camphor). , Eucalyptus oil, eugenol, menthyl lactate, witch hazel distillate), anti-acne agent, anti-caking agent, antifoaming agent, antioxidant, binder, biological additive, buffer, filler, chelating agent Chemical additives, cosmetic astringents, cosmetic biocides, denaturants, drug astringents, topical analgesics, film formers or substances, eg polymers that aid in the film-forming properties and substance of the composition (eg , Copolymers of eicosene and vinylpyrrolidone), opacifiers, pH adjusters, preservatives, propellants, reducing agents, sequestering agents, skin bleaching and whitening agents (eg hydroquinone, Uric acid, ascorbic acid, ascorbyl glucosamine), skin conditioning agents (eg other humectants and occlusive humectants), skin soothing agents and / or rejuvenating agents (eg panthenol and derivatives (eg ethyl panthenol)), Aloe vera, pantothenic acid and its derivatives, allantoin, bisabolol, and dipotassium glycyrrhizinate), skin treatments, thickeners, vitamins and their derivatives.

  However, in any embodiment of the present invention, the active substances useful herein can be classified according to the effects they provide or their mode of action assumed. However, it should be understood that the active substances useful herein can in some cases produce more than one effect or function through more than one mechanism of action. Accordingly, the classifications herein are for convenience only and are not intended to limit the active material to the specific uses or uses listed.

Sunscreen actives Exposure to ultraviolet light can lead to excessive scaling and texture changes of the stratum corneum. Accordingly, the compositions of the present invention may optionally contain a sunscreen active. As used herein, “sunscreen active” includes both sunscreens and physical sunscreens. Suitable sunscreen actives may be organic or inorganic.

  Inorganic sunscreens useful herein include the following metal oxides: titanium dioxide having an average primary particle size of about 15 nm to 100 nm, zinc oxide having an average primary particle size of about 15 nm to 150 nm, about 15 nm to Zircon oxide having an average primary particle size of 150 nm, iron oxide having an average primary particle size of about 15 nm to 500 nm, and mixtures thereof. As used herein, the inorganic sunscreen is about 0.1% to about 20%, preferably about 0.5% to about 10%, more preferably about 1% by weight of the composition. Present in an amount of about 5% by weight.

  A wide variety of conventional organic sunscreen actives are suitable for use herein. Sagarin et al., Cosmetic Science and Technology (1972), Chapter VIII, p. 189 et seq. Disclose a number of suitable active substances. Particularly preferred organic sunscreen actives useful in the compositions of the present invention include homosalate, octocrylene, 2-ethylhexyl-p-methoxycinnamate (commercially available as PARSOL MCX), phenylbenzimidazole sulfonic acid 2-hydroxy-4-methoxybenzophenone (benzophenone-3), 2-ethylhexyl salicylate, and mixtures thereof.

  More preferred organic sunscreen actives useful in the compositions useful in the present invention are 2-ethylhexyl-p-methoxycinnamate, butylmethoxydibenzoylmethane, 2-hydroxy-4-methoxybenzophenone, 2-phenylbenzo Imidazole-5-sulfonic acid, octyldimethyl-p-aminobenzoic acid, octocrylene, zinc oxide, titanium dioxide, and mixtures thereof.

  Usually, a safe and effective amount of an organic sunscreen active is used, from about 1% to about 20%, more typically from about 2% to about 10% by weight of the composition. The exact amount depends on the selected sunscreen or sunscreens as well as the desired sun protection factor (SPF).

Oil-Soluble Terpene Alcohol As used herein, “terpene alcohol” refers to two or more 5-carbon isoprene units [CH ₂ ═C (CH ₃ ) —CH═CH ₂ ] having terminal hydroxyl groups. Point to.

  Examples of oil-soluble terpene alcohols useful herein include farnesol, farnesol derivatives, farnesol isomers, geraniol, geraniol derivatives, geraniol isomers, phytantriol, phytantriol derivatives, phytantriol Isomers, and mixtures thereof. Preferred for use herein is farnesol.

  Farnesol is a natural substance believed to act as a precursor and / or intermediate in the biosynthesis of squalene and sterols, particularly cholesterol. Farnesol is also involved in protein modification and regulation (eg, farnesylation of proteins) and there are nuclear receptors that respond to farnesol.

  Chemically, farnesol is [2E, 6E] -3,7,11-trimethyl-2,6,10-dodecatrien-1-ol, as used herein “farnesol” is such Includes isomers and tautomers. Farnesol is, for example, the product name of farnesol (Dragoco, Totowa, NJ, USA, a mixture of isomers from Golden Drive 10) and the product name of trans-trans-farnesol (Sigma Chemical Campany, Commercially available from St. Louis, Missouri, PO Box 14508. A suitable derivative of farnesol is farnesyl acetate commercially available from Aldrich Chemical Company (Milwaukee, Wisconsin, PO Box 2060).

  Geraniol is the general name for a chemical known as 3,7-dimethyl-2,6-octadien-1-ol. As used herein, “geraniol” includes such isomers and tautomers. Geraniol is commercially available from Aldrich Chemical Company (Milwaukee, Wis., PO Box 2060). Suitable derivatives of geraniol include geranyl acetate, geranylgeraniol, geranyl pyrophosphate, and geranylgeranyl pyrophosphate, all of which are commercially available from Sigma Chemical Company (St. Louis, MO, PO Box 14508). Has been. For example, geraniol is a therapeutic agent for spider vasculature / red spot, a treatment for dark circles / swelled eyes around the eyes, a treatment for poor bloodiness, a treatment for sagging, an anti-itch agent, a skin thickener, a pore reducing agent. It is useful as an oil / gloss reducing agent, a post-inflammatory pigmentation therapeutic agent, a wound treatment agent, an anti-cellulite agent, and for the adjustment of the skin texture including wrinkles and small wrinkles.

  Phytantriol is the general name for a chemical known as 3,7,11,15, tetramethylhexadecane-1,2,3, -triol. Phytantriol is commercially available from BASF (Wyandotte, Michigan, USA, Biddle Avenue 1609). For example, phytantriol is a treatment for spider vasculature / red spot, treatment for dark circles / swelling, treatment for paleness, treatment for sagging, anti-itching agent, skin thickener, pore reducing agent, oil content It is useful as a luster reducing agent, a treatment for pigmentation after inflammation, a wound treatment agent, an anti-cellulite agent, and for adjusting the skin texture of wrinkles and small wrinkles.

Phytosterols Phytosterols and their derivatives are known for providing a whitening effect. Non-limiting examples of oil-soluble phytosterol derivatives include β-sitosterol, campesterol, brazicasterol, lupenol, α-spinasterol, stigmasterol, derivatives thereof, and combinations thereof. More preferably, the phytosterol derivative is selected from the group consisting of β-sitosterol, campesterol, brazicasterol, stigmasterol, derivatives thereof, and combinations thereof.

Oil-soluble vitamin compounds Many vitamins known in the art to provide various skin effects are oil-soluble and some or all of their derivatives are oil-soluble. As such, oil soluble vitamin compounds are useful herein as oil soluble skin care actives. Non-limiting examples of such oil-soluble vitamin compounds include retinoids, additional vitamin B ₃ compounds, vitamin C (eg, ascorbyl palmitate), vitamin D, vitamin K, vitamin E, and mixtures thereof. . Preferred for use herein are retinoids, additional vitamin B ₃ compounds, vitamin E, and mixtures thereof, each of which is described below.

  As used herein, “retinoid” refers to all natural and / or synthetic analogs of vitamin A or retinol-like compounds having the biological activity of vitamin A in the skin, as well as geometric isomers of these compounds and Includes stereoisomers. Preferred retinoids are retinol, retinyl palmitate, retinyl acetate, retinyl propionate, retinal and combinations thereof, but any oil-soluble retinoid may be used herein.

The composition of the present invention may, in certain embodiments, contain additional vitamin B ₃ compounds (other than niacinamide). When present, the composition comprises from about 0.01% to about 50% by weight of the composition of the vitamin B ₃ compound, more preferably from about 0.1% to about 10 wt%, more preferably from about 0 From about 5 wt% to about 10 wt%, and even more preferably from about 1 wt% to about 5 wt%.

As used herein, “additional vitamin B ₃ compound” means a compound having the formula:

式中、Ｒは、−ＣＯＯＨ（すなわち、ニコチン酸）または−ＣＨ₂ＯＨ（すなわち、ニコチニルアルコール）、これらの誘導体、および上記いずれかの塩である。前述のビタミンＢ₃化合物の代表的な誘導体には、非血管拡張性のニコチン酸のエステル（例えば、トコフェリルニコチネート）、ニコチニルアミノ酸、カルボン酸のニコチニルアルコールエステル、ニコチン酸−Ｎ−オキシド、およびナイアシンアミド−Ｎ−オキシドを包含するニコチン酸エステルが挙げられる。

Where R is —COOH (ie, nicotinic acid) or —CH ₂ OH (ie, nicotinyl alcohol), derivatives thereof, and salts of any of the above. Representative derivatives of the aforementioned vitamin B ₃ compounds include non-vasodilatory esters of nicotinic acid (eg, tocopheryl nicotinate), nicotinyl amino acids, nicotinyl alcohol esters of carboxylic acids, nicotinic acid-N-oxide. And nicotinic acid esters, including niacinamide-N-oxide.

  Vitamin E and several derivatives thereof are known to be particularly useful as antioxidants / radical scavengers. Such antioxidants / radical scavengers are particularly useful for providing protection against ultraviolet radiation that can cause increased scaly peeling or texture changes of the stratum corneum and other environmental factors that can cause skin damage. is there.

  Non-limiting examples of oil-soluble vitamin E compounds include tocopherol (vitamin E), tocopherol sorbate, tocopherol acetate, and other tocopherol esters. Preferred antioxidants / radical scavengers are selected from tocopherol sorbate, tocopherol acetate, and mixtures thereof. A class of substances, tocotrienol, is also useful herein, which is related to vitamin E.

Emollients and occlusive agents Emollients are cosmetic ingredients that help maintain the appearance of soft, smooth and soft skin. Emollients act as lubricants by their ability to remain on the skin surface or in the stratum corneum, and have the function of reducing exfoliation and improving the appearance of the skin. An occlusive agent is a cosmetic ingredient that suppresses water evaporation from the skin surface. By preventing moisture loss due to evaporation, the occlusive agent increases the moisture content of the skin. An occlusive agent is a lipid that generally tends to stay on the skin surface. Emollients may also be occlusive when applied to the skin, and vice versa. Examples of suitable emollients and occlusive agents include caprylic / capric glycerides, isopropyl isostearate, mineral oil, cetyl ricinoleate, and petrolatum.

Dehydroacetic acid Dehydroacetic acid is a useful compound for regulating the appearance of oily and / or terrible skin, as disclosed in US Pat. No. 6,150,403. The chemical name of dehydroacetic acid is 3-acetyl-6-methyl-2H-pyran-2,4 (3H) -dione, and is under the trademark Unisept DHA®, Universal Preserve-A-Chem ( Universal Preserv-A-Chem (Brooklyn, NY), Tri-K Industries (North Vale, NJ) or GEOGARD® 221 or GEOGARD ( Registered trademark 361, commercially available from Lonza (Annandale, NJ).

  The compositions of the present invention comprise from about 0.1% to about 10%, more preferably from about 0.5% to about 5%, more preferably from about 1% to about 5% dehydroacetic acid or their dermatologically. It may contain acceptable salts, derivatives, or tautomers.

Hexanediol The compositions of the present invention may comprise an effective amount of hexanediol, its isomers, tautomers, salts and derivatives. Some scientific names for hexanediols suitable for use herein include 1,6-dihydroxyhexane, 1,6-hexanediol, hexamethylenediol, hexamethylene glycol, and 1,2-hexanediol. It is done.

  The compositions of the present invention may comprise from about 0.0001% to about 50%, alternatively from about 0.001% to about 10%, alternatively from about 0.01% to about 5%, alternatively from about 0.1% to about 2%. Hexanediol may be included.

Anti-Acne Active Substances The compositions of the present invention may contain one or more anti-acne active substances in a safe and effective amount. Examples of useful anti-acne actives include resorcinol, sulfur, salicylic acid, benzoyl peroxide, erythromycin, zinc and the like.

β-Hydroxy acids Non-limiting examples of oil-soluble β-hydroxy acids include salicylic acid and its derivatives, such as octanoyl derivatives. β-hydroxy acids are known to provide anti-acne and anti-aging effects.

Chelating agent As used herein, “chelating agent” or “chelating agent” refers to the formation of a complex so that metal ions do not readily participate in chemical reactions or catalyze chemical reactions. Means an active substance capable of removing metal ions from the system. Including a chelating agent is particularly useful to protect against excessive scales or UV radiation that may contribute to skin tissue changes and from other environmental chemicals that can cause skin damage. . Preferred oil-soluble chelating agents useful in the compositions of the subject invention are furyl dioxime, furyl monooxime, and derivatives thereof.

Flavonoids Flavonoid compounds are widely disclosed in US Pat. Nos. 5,686,082 and 5,686,367. Non-limiting examples of flavonoids useful herein include isoflavones; flavanones selected from the group consisting of unsubstituted flavanones, mono-substituted flavanones, and mixtures thereof; unsubstituted chalcones, mono-substituted chalcones, di- A chalcone selected from the group consisting of substituted chalcones, tri-substituted chalcones, and mixtures thereof; a flavone selected from the group consisting of unsubstituted flavones, mono-substituted flavones, di-substituted flavones, and mixtures thereof; A coumarin selected from the group consisting of the above isoflavones; unsubstituted coumarins, mono-substituted coumarins, di-substituted coumarins, and mixtures thereof; from unsubstituted chromones, mono-substituted chromones, di-substituted chromones, and mixtures thereof A chromone selected from the group consisting of; one or more dicoumarols; one or more Romanon; one or more chromanol; these isomers (e.g., cis / trans isomers); and mixtures thereof. As used herein, the term “substituted” flavonoids means that one or more hydrogen atoms of a flavonoid are independently replaced with hydroxyl, C1-C8 alkyl, or C1-C4 alkoxyl. To do. Mixtures of the above flavonoid compounds may also be used.

  Plant-derived isoflavones such as soy isoflavones are particularly useful herein. A particularly useful class of flavonoids herein is a glycoside flavonoid, preferably selected from the group consisting of glucosyl hesperidin, glucosyl rutin, glucosyl myristitrin, glucosyl isoquercitrin, glucosyl ercitrin, methyl hesperidin, and mixtures thereof. is there. Commercially available glycoside flavonoids include hesperidin, methyl hesperidin, and rutin available from Alps Pharmaceutical Industry Co. Ltd. (Japan), and Hayashibara Biochemical Laboratories, Inc. (Japan) Glucosyl hesperidin and glycosyl rutin available from

Anti-inflammatory agents Anti-inflammatory agents may be added to the compositions of the present invention in a safe and effective amount, preferably from about 0.1% to about 10%, more preferably from about 0.5% to about 0.5% of the composition. 5%. Anti-inflammatory agents improve the skin appearance effects of the present invention, for example, such agents contribute to a more uniform and more satisfactory skin tone or color. The exact amount of anti-inflammatory agent to be used in the composition will depend on the particular anti-inflammatory agent utilized as the efficacy of such agents is extensive.

  Steroidal anti-inflammatory agents are suitable for use herein and non-limiting examples include hydrocortisone. Non-steroidal anti-inflammatory agents are also suitable for use herein and include, but are not limited to, ibuprofen, naproxen, flufenamic acid, etofenamate, aspirin, mefenamic acid, meclofenamic acid, piroxicam, and felbinac Is mentioned. The various compounds encompassed by these groups are well known to those skilled in the art. Similar to the mixture of non-steroidal anti-inflammatory agents, dermatologically acceptable salts and esters of these agents may also be used.

  “Natural” anti-inflammatory agents are also useful in the present invention. Such anti-inflammatory agents can be suitably obtained as extracts from natural sources (eg plant, fungal, microbial by-products) by suitable physical and / or chemical isolation, or synthesized. Can be prepared. For example, candelilla wax, bisabolol (eg, α-bisabolol), aloe vera, plant sterol (eg, phytosterol), Manjistha (Rubia plant, especially Rubia Cordifolia) ), And Guggal (extracted from plants of the genus Commiphora, in particular Commiphora Mukul), cora extract, chamomile, purple clover extract, and whip coral extract may be used .

Anti-Cellulite Agent The composition of the present invention may contain an anti-cellulite agent in a safe and effective amount. Suitable agents can include, but are not limited to, xanthine compounds such as caffeine, theophylline, theobromine, and aminophylline.

Local anesthetic The composition of the present invention may contain a local anesthetic in a safe and effective amount. Examples of local anesthetics include benzocaine, lidocaine, bupivacaine, chlorprocaine, dibucaine, etidocaine, mepivacaine, tetracaine, dichronin, hexylcaine, procaine, cocaine, ketamine, pramoxine, phenol, and their pharmaceutically acceptable salts. Can be mentioned.

Desquamous actives The compositions of the present invention contain a safe and effective amount, preferably from about 0.1% to about 10%, more preferably from about 0.2% to about 5% by weight of the composition, More preferably from about 0.5% to about 4% by weight of the desquamating active may be added. The desquamating active substances enhance the effect on the appearance of the skin of the present invention. For example, desquamating actives tend to improve skin texture (eg, smoothness). One desquamation system suitable for use herein contains a sulfhydryl compound and a bipolar surfactant and is described in US Pat. No. 5,681,852 (Bissett); That patent is incorporated herein by reference. Other desquamation systems suitable for use herein include salicylic acid and zwitterionic surfactants and are described in US Pat. No. 5,652,228 (Bissett), which Patents are incorporated herein by reference. Bipolar surfactants as described in these patent applications are also useful herein as desquamating agents, with cetylbetaine being particularly preferred.

Antioxidant / Radical Scavenger The compositions of the present invention may comprise a safe and effective amount of an antioxidant / radical scavenger. Antioxidants / radical scavengers are particularly useful for protection from ultraviolet light, which can cause increased scale or texture changes in the stratum corneum, and from other environmental chemicals that can cause skin damage.

  A safe and effective amount of antioxidant / radical scavenger is preferably included in the compositions of the present invention from about 0.1% to about 10%, more preferably from about 0.1% to about 5% by weight of the composition. You may add by weight%.

  Antioxidants / radical scavengers include ascorbic acid (vitamin C) and salts thereof, ascorbyl esters of fatty acids, ascorbic acid derivatives (eg, magnesium ascorbyl phosphate, sodium ascorbyl phosphate, ascorbyl sorbate), tocopherol (vitamin E) , Tocopherol sorbate, tocopherol acetate, other tocopherol esters, butylated hydroxybenzoic acid and its salts, BHT, 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (trade name Trolox ( ), Gallic acid and its alkyl esters, especially propyl gallate, uric acid and its salts and alkyl esters, sorbic acid and its salts, lipoic acid, amines (for example N, N-diethylhydroxylamine, amino-guanidine), sulfhydryl compounds (eg glutathione), dihydroxyfumaric acid and its salts, lysine pidolate, arginine pyrolate, nordihydroguaiaretic acid, bioflavonoid, curcumin, lysine, Methionine, proline, superoxide dismutase, silymarin, tea extract, grape skin / seed extract, melanin, rosemary extract and the like may be used. Preferred antioxidants / radical scavengers are selected from tocopherol acetate and other esters of tocopherol, more preferably tocopherol acetate. For the use of tocopherol sorbate in topical compositions and those applicable to the present invention, see Donald L. Bissett, Rodney D. Bush, and Ranjit Chatterjee. In U.S. Pat. No. 4,847,071 issued on July 11, 1989.

Tanning Agents The compositions of the present invention may contain a tanning active. When present, the composition comprises from about 0.1% to about 20%, more preferably from about 2% to about 7%, more preferably from about 3% to about 6% by weight of dihydroxy of the composition. Acetone is preferably included as an artificial tanning active.

Dihydroxyacetone, also known as DHA or 1,3-dihydroxy-2-propanone, is a white to off-white crystalline powder. This material can be represented by the chemical formula C ₃ H ₆ O ₃ .

Skin soothing and skin recovery actives The compositions of the present invention may comprise a skin soothing or skin recovery active. Skin soothing or skin recovery actives suitable for use herein include panthenolic acid derivatives (including panthenol, dexpanthenol, ethyl panthenol), aloe vera, allantoin, bisabolol, and dipotassium glycyrrhizinate. It is done. To the composition, a safe and effective amount of a skin soothing agent and skin rejuvenating agent is preferably from about 0.001% to about 30%, more preferably from about 0.01% to about 30% by weight of the resulting composition. 20% by weight, more preferably from about 0.01% to about 10% by weight can be added.

Antibacterial and antifungal actives The compositions of the present invention may contain antibacterial or antifungal actives. Such active substances can destroy microorganisms, prevent the development of microorganisms or prevent the pathogenic effects of microorganisms and are known to those skilled in the art. A safe and effective amount of an antimicrobial or antifungal active is preferably added to the composition of the present invention from about 0.001% to about 10%, more preferably from about 0.01% to about 5%, even more preferably. About 0.05% to about 2% may be added.

Solvent of oil-soluble active substance When an oil-soluble active substance is used for the purpose of sunscreen, whitening, antioxidant, etc., an ester may be used as a solvent in order to guarantee the effect of the oil-soluble active substance. A variety of suitable ester compounds are known and can be used herein. Numerous examples are described in the "International Cosmetic Ingredient Dictionary and Handbook, 11th Edition, 2004". Examples of suitable esters include esters of amino acids and C2-C8 alcohols such as isopropyl lauroyl sarcosinate (Eldew SL205 available from Ajinomoto), and phenethyl benzoate (International Specialty Products). Benzoic acid and esters of C2-C8 alcohols such as X-tend 226) available from Specialty Products. The concentration of the solvent used depends on the type and amount of the oil-soluble active substance contained, but can be easily determined by those skilled in the art.

Other Optional Ingredients Various additional ingredients can be incorporated into the compositions of the present invention. Non-limiting examples of these additional ingredients include colorants, dyes, pigments; essential oils, fragrances, skin sensates, opacifiers, aromatic compounds (eg clove oil, menthol, camphor, eucalyptus oil, and eugenol). Ingredients suitable for cosmetic purposes such as: preservatives (eg alkyl esters of parahydroxybenzoic acid, hydantoin derivatives (such as 1,3-bis (hydroxymethyl) -5,5-dimethylhydantoin), propionates, and various And quaternary ammonium compounds such as benzalkonium chloride, quaternium 15 [Dawisil 200], benzethonium chloride, and methylbenzethonium chloride). Particularly preferred preservatives are disodium EDTA, phenoxyethanol, ethyl paraben, methyl paraben, propyl paraben, imidazolidinyl urea (commercially available as Germall 1175), sodium dehydroacetate, benzyl alcohol, and sodium benzoate.

Composition Preparation Compositions useful in the methods of the present invention are generally prepared by conventional methods such as are known in the art when preparing topical compositions. Such methods usually involve mixing the components in one or more steps, with or without heating, cooling, application of vacuum, etc., to a relatively uniform state.

  The topical composition of the present invention comprises facial skin cosmetics, eye cosmetics, lip cosmetics, hair styling aids, facial hair styling aids, moisturizers, wrinkle-relieving serums, lotions, mascaras, facial skin masks. , Skin lotions, skin creams, skin gels, eye gels, eye creams, lip gels, lip balms, cosmetic foundations, or any other well-known skin product or treatment.

Methods of Use Applicants have found that the compositions of the present invention are useful in a variety of applications directed to enhancement of mammalian skin function. The methods of use of the compositions disclosed and claimed herein include 1) a method for increasing the permanence of cosmetics to the skin, 2) a method for moisturizing the skin, and 3) a natural appearance of the skin. 4) a method of applying colored cosmetics to the skin, 5) a method of preventing wrinkles, delaying its occurrence and / or treating it, 6) a method of providing UV protection to the skin, 7) oil A method for preventing and reducing the appearance and / or controlling its appearance, 8) a method for correcting skin feel and texture, 9) a method for providing a uniform skin tone, 10) spider blood vessels and How to prevent, delay and / or treat the appearance of dilated serpentine veins, 11) how to obscure the appearance of vellus hair on the skin, 12) acne, age spots, buckwheat, moles, scars, bears under the eyes, Nevus, hyperpigmentation after inflammation And a method of hiding the defects and / or imperfections and the like in human skin, including such as, but not limited thereto. Each method addressed herein includes applying the claimed composition topically to the skin.

  The following examples further describe and demonstrate embodiments within the scope of the present invention. These examples are presented for illustrative purposes only, and many modifications are possible without departing from the spirit and scope of the invention, and should be construed as limiting the invention. is not.

  A water-in-oil emulsion skin care product is prepared by conventional methods from the following components.

１． 例えば、ＫＦ９６Ａ（６ｃｓ）。シンエツ（Shin-Etsu）（日本、東京）から入手可能。
２． 例えば、トスパール（Tospearl）１４５Ａ、ＣＦ６００、または２０００。ＧＥアドバンスド・マテリアルズ（GE Advanced Materials）（コネティカット州ウィルトン）から入手可能。
３． １２．５％ジメチコンクロスポリマーのシクロペンタシロキサン溶液。ダウ・コーニング（Dow Corning）（ミシガン州ミッドランド）から入手可能。
４． １２．５％ジメチコンのシクロペンタシロキサン溶液。ダウ・コーニング（Dow Corning）（ミシガン州ミッドランド）から入手可能。
５． ５％ジメチコン／ビニルジメチコンクロスポリマーのジメチコン溶液。シンエツ（Shin-Etsu）（日本、東京）から入手可能。
６． 例えば、ＧＥアドバンスドマテリアルズ（GE Advanced Materials）（コネティカット州ウィルトン）から入手可能なＳＦ−１２０２、ダウ・コーニング（Dow Corning）（ミシガン州ミッドランド）から入手可能なＳＨ２４５。
７． ２５％ジメチコンＰＥＧ−１０／１５クロスポリマーのジメチコン溶液。シンエツ（Shin-Etsu）（日本、東京）から入手可能。
８． ＰＥＧ−９ポリジメチルシロキシエチルジメチコン。シンエツ（Shin-Etsu）（日本、東京）から入手可能。
９． ＰＥＧ−１０ジメチコン。シンエツ（Shin-Etsu）（日本、東京）から入手可能。
１０． ポリグリセリル−３ポリジメチルシロキシエチルジメチコン。シンエツ（Shin-Etsu）（日本、東京）から入手可能。
１１． ジメチコン／メチコンコポリマーの表面コーティングを有するシリカ、アルミナ、二酸化チタン、タルク。触媒化成工業株式会社（Catalysts & Chemicals Ind. Co. Ltd.）（日本、川崎）から入手可能。
１２． ２５％ジメチコン／ビニルジメチコンクロスポリマーのジメチコン溶液。シンエツ（Shin-Etsu）（日本、東京）から入手可能。
１３． ステアリルジメチコンワックス。ダウ・コーニング（Dow Corning）（ミシガン州ミッドランド）から入手可能。
１４． ポリエチレン。ジーン・インターナショナル社（Jeen Int'l Corp.）（ニュージャージー州フェアフィールド）から入手可能。
１５． 疎水変性ＴｉＯ₂分散液。コボ・プロダクツ社（Kobo Products, Inc.）（ニュージャージー州サウスプレーンフィールド）から入手可能。
１６． プロクター＆ギャンブル・ケミカルズ（Procter & Gamble Chemicals）（オハイオ州シンシナティ）から入手可能。
１７． ヘキサミジンジイセチオネート。ラボラトリーズ・セロバイオロジクス（Laboratoires Serobiologiques）（フランス、パリ）から入手可能。
１８． ０．０８５％パルミトイルペンタペプチド−３の水溶液。セダーマ（Sederma）（ニュージャージー州エジソン）から入手可能。
１９． ＤＭＤＭヒダントイン、ヨードプロピニルブチルカルバメート、１，３−ブチレングリコールの水溶液。ロンザ社（Lonza Inc.）（スイス、バーゼル）から入手可能。

1. For example, KF96A (6cs). Available from Shin-Etsu (Tokyo, Japan).
2. For example, Tospearl 145A, CF600, or 2000. Available from GE Advanced Materials (Wilton, Conn.).
3. A cyclopentasiloxane solution of 12.5% dimethicone crosspolymer. Available from Dow Corning (Midland, MI).
4). A cyclopentasiloxane solution of 12.5% dimethicone. Available from Dow Corning (Midland, MI).
5. Dimethicone solution of 5% dimethicone / vinyl dimethicone crosspolymer. Available from Shin-Etsu (Tokyo, Japan).
6). For example, SF-1202 available from GE Advanced Materials (Wilton, Conn.), SH245 available from Dow Corning (Midland, MI).
7). Dimethicone solution of 25% dimethicone PEG-10 / 15 crosspolymer. Available from Shin-Etsu (Tokyo, Japan).
8). PEG-9 polydimethylsiloxyethyl dimethicone. Available from Shin-Etsu (Tokyo, Japan).
9. PEG-10 dimethicone. Available from Shin-Etsu (Tokyo, Japan).
10. Polyglyceryl-3 polydimethylsiloxyethyl dimethicone. Available from Shin-Etsu (Tokyo, Japan).
11. Silica, alumina, titanium dioxide, talc with a surface coating of dimethicone / methicone copolymer. Available from Catalysts & Chemicals Ind. Co. Ltd. (Kawasaki, Japan).
12 Dimethicone solution of 25% dimethicone / vinyl dimethicone crosspolymer. Available from Shin-Etsu (Tokyo, Japan).
13. Stearyl dimethicone wax. Available from Dow Corning (Midland, MI).
14 polyethylene. Available from Jeen Int'l Corp. (Fairfield, NJ).
15. Hydrophobic modified TiO ₂ dispersion. Available from Kobo Products, Inc. (South Plainfield, NJ).
16. Available from Procter & Gamble Chemicals (Cincinnati, Ohio).
17. Hexamidine diisethionate. Available from Laboratoires Serobiologiques (Paris, France).
18. An aqueous solution of 0.085% palmitoyl pentapeptide-3. Available from Sederma (Edison, NJ).
19. An aqueous solution of DMDM hydantoin, iodopropynyl butyl carbamate, and 1,3-butylene glycol. Available from Lonza Inc. (Basel, Switzerland).

  Add Phase A and Phase B ingredients to separate suitable containers and mix each phase using a suitable mixer (eg, anchor blade, propeller blade, IKA T25). When each phase is uniform, slowly add Phase B to Phase A while milling Phase A with a suitable mixer (eg, anchor blade, propeller blade, IKA T25). Continue milling until the batch is uniform. Transfer the product to a suitable container.

Test Method Microscopy—A method of visually analyzing the presence and size of an aqueous region in a sample composition using a microscope. This method uses a standard optical microscope with differential interference contrast and cross-polarization functions and with an optical shear stage. Optionally, cross-polarized light may be used for low-projection sample compositions or to characterize aqueous regions. When cross-polarization techniques are used, the aqueous region will appear dark in the resulting image. A preferred configuration is a Zeiss Axioplan 2 microscope (Carl Zeiss, Inc.) (Thorn, NY) with an MTI 3CCD camera (available from DAGE-MTI (Michigan City, Ind.)). Available from Wood). Images were acquired using Metamorph Software 6.1 version (available from Molecular Devices Corporation (Sunnyvale, Calif.)), Measuring droplet diameter, and resulting images Save. The microscope is equipped with a CSS450 optical shear stage (available from Linkam Scientific Instruments, Surrey, UK). The microscope is configured to give a magnification of 500 times. About 1.5 g of the emulsion (“sample”) is carefully placed on the shear stage to minimize shear. The shearing system is set to a fixed mode with a gap width of 1 mm and a constant shear rate of 16 s- ¹ . The temperature is maintained at a constant temperature of about 25 ° C. First take a photomicrograph of the sample before starting shearing at the shear stage. The average aqueous droplet diameter of the sample should be about 3 μm or less. If the average aqueous droplet diameter of the sample is greater than 3 μm, the microscope may not adequately characterize the sample, but the milling or rheological methods can characterize the sample. The sample is sheared for 15 seconds, the shear is interrupted and a photomicrograph is obtained. This is repeated 3 times (eg, the sample is sheared cumulatively for 60 seconds) and 5 micrographs are obtained (eg, at 0, 15, 30, 45, and 60 seconds). Analyze the visible aqueous region of the sample and examine the maximum linear dimension of each visible aqueous region. Compositions that do not release upon dermal application do not show a significant change in aqueous droplet diameter when exposed to such conditions. Three samples are tested for each emulsion.

  Photomicrographs of selected examples tested according to microscopy are shown in FIGS. 1A-B, 2A-C, and 3A-C. The value shown in the photomicrograph is the approximate maximum dimension (in μm) of the aqueous region. 1A-B are photomicrographs of Example 13 taken at 0 seconds and 15 seconds, respectively. FIG. 1B shows an aqueous region of about 74.05 μm after 15 seconds of shear. 2A-C are photomicrographs of Example 12 taken at 0 seconds, 15 seconds, and 60 seconds, respectively. FIG. 2C shows an aqueous region of about 56.04 μm after 60 seconds of shear. FIGS. 3A-C show comparative examples taken at 0, 15 and 60 seconds, respectively (Regenerist Daily Regenerating Serum, commercially available from Procter & Gamble Company). Serum)). FIG. 3C shows a silicone elastomer region that is readily judged by a skilled user of the microscope, but there is no aqueous region greater than 10 μm.

Milling method—bulk milling a sample emulsion (“sample”) to produce a visible phase separation (with the naked eye). The milling method uses an Ultra Turrax T25 mixer with S25KR-18G dispersion available from IKA Works (Wilmington, NC) and bulk milled 30 g of sample in a 50 mL beaker. To do. The process is carried out at a temperature of about 25 ° C. The sample is milled for about 1 minute at either about 13500 rpm (corresponding to a shear rate of about 30000 s ⁻¹ ) or about 24000 rpm (corresponding to a shear rate of about 53000 s ⁻¹ ). During a 1 minute mill, the beaker may be slowly moved by hand parallel to the axis of rotation of the mixer (ie, reciprocating less than about 1 Hz). Optionally, the sample may be milled at a speed of 8000 rpm (corresponding to a shear rate of about 18000 s ⁻¹ ). Visually observe phase separation within 5 minutes after milling. The aqueous phase is removed from the beaker using standard separation techniques. The weight of the separated aqueous phase is measured. The method is repeated with two more samples to obtain an average weight value.

  Selected examples tested according to the milling method showed the following water release:

＊ 比較例はプロクター＆ギャンブル社（Procter & Gamble Company）から入手可能な市販のリジェネリスト・デイリー・リジェネレイティング・セラム（Regenerist Daily Regenerating Serum）である。

* A comparative example is the commercially available Regenerist Daily Regenerating Serum available from Procter & Gamble Company.

Rheological Method—Provides the rheological properties of an emulsion (“sample”). Sample evaluation uses an AR2000 rheometer available from TA Instruments (Newcastle, Del.) Connected to a computer with software that provides data recording and analysis. The rheometer is configured to use a flat plate with a gap setting of 1000 μm, a temperature of 25 ° C. and a controlled stress mode of 4 cm. In addition, the rheometer is configured to increase the stress from 1 Pa to 1000 Pa with a duration of 3 minutes and to sample at a rate of 10 points per decimal. Rheological properties are plotted using log ₁₀ shear stress (Pa) on the x-axis and log ₁₀ viscosity (Pa · s) on the y-axis. Moisture-releasing samples show a sharp drop in viscosity at critical shear stress. This decrease in viscosity can be measured as the slope of the plot between a region with a substantially constant high viscosity and a region with a substantially constant low viscosity. The slope is calculated according to the formula: [(log viscosity (t2) −log viscosity (t1)] / [(log shear stress (t2) −log shear stress (t1)], where viscosity (t1) and viscosity. (T2) is the viscosity reading before and after the viscosity value decreases 10 times between the two regions (change of 1.0 on the logarithmic scale), and the shear stress (t1) and shear stress (t2) Any representative reading on the plot for the slope calculation when the viscosity drops slowly and does not cause a sharp drop in viscosity of more than 10 times between the two readings. A sharp drop in viscosity is believed to indicate the release of moisture from the sample.

  Graphs obtained from data of selected examples tested according to the rheological method are shown in FIGS. FIG. 4 is a graph obtained from Example 12. FIG. 4 shows an abrupt viscosity drop (eg, a slope of about −106) between data points with a shear stress of about 1.8 (log). FIG. 5 is a graph obtained from Example 11. FIG. 5 shows a decrease in viscosity (eg, a slope of about −14.7) between data points with a shear stress of about 0.8 (log). FIG. 6 is a graph obtained from Example 10. FIG. 6 shows a decrease in viscosity (eg, a slope of about −12) between data points with a shear stress of about 1.7 (log). FIG. 7 is a graph obtained from a test of a comparative example (commercially available Regenerist Daily Regenerating Serum available from Procter & Gamble Company). The maximum drop between the viscosity points of the comparative example is about -3.4.

  The foregoing detailed description of the examples and embodiments of the present invention is provided for purposes of illustration only and numerous modifications and changes will become apparent to those skilled in the art without departing from the spirit and scope of the invention. Such obvious modifications and changes are intended to be included within the scope of the appended claims.

  The dimensions and values disclosed herein are not to be understood as being strictly limited to the exact numerical values recited. Instead, unless otherwise specified, each such dimension is intended to mean both the recited value and a functionally equivalent range surrounding that value. For example, a dimension disclosed as “40 mm” is intended to mean “about 40 mm”.

  All documents cited in “Best Mode for Carrying Out the Invention” are incorporated herein by reference in the relevant part, and any citation of any document shall be regarded as prior art to the present invention. It should not be construed as acceptable. To the extent that any meaning or definition of a term in this document conflicts with any meaning or definition of a term in a document incorporated by reference, the meaning or definition given to that term in this document applies And

  While particular embodiments of the present invention have been illustrated and described, it would be obvious to those skilled in the art that various other changes and modifications can be made without departing from the spirit of the invention. Accordingly, all such modifications and variations that are within the scope of this invention are intended to be covered by the appended claims.

The photomicrograph of suitable embodiment of the present invention. The photomicrograph of suitable embodiment of the present invention. The photomicrograph of suitable embodiment of the present invention. The photomicrograph of suitable embodiment of the present invention. The photomicrograph of suitable embodiment of the present invention. The micrograph of a comparative example. The micrograph of a comparative example. The micrograph of a comparative example. 3 is a plot of log shear stress (x-axis) versus log viscosity (y-axis) for three preferred embodiments of the present invention. 3 is a plot of log shear stress (x-axis) versus log viscosity (y-axis) for three preferred embodiments of the present invention. 3 is a plot of log shear stress (x-axis) versus log viscosity (y-axis) for three preferred embodiments of the present invention. Plot of log shear stress (x-axis) versus log viscosity (y-axis) for the comparative example.

Claims (13)

A water-in-oil emulsion composition comprising:
a) 0.1% to 15% non-emulsifying crosslinked siloxane elastomer,
b) 0.1% to 15% of an emulsifying crosslinked siloxane elastomer,
c) 1% to 40% of the non-emulsifiable and emulsifiable crosslinked siloxane elastomer solvent,
d) optionally 0% to 5% additional emulsifier,
e) contains 50% to 99% aqueous phase;
A composition in which an aqueous phase is released from the emulsion when shear stress is applied to the composition during spreading on the skin.   The composition of claim 1, further comprising a skin care active selected from the group consisting of niacinamide, hexamidine compounds, whitening agents, peptides, sugar amines, and mixtures thereof.   The composition of claim 1 further comprising a skin conditioning agent.   The skin conditioning agent is propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol, sorbitol, hydroxypropyl sorbitol, trehalose, hexylene glycol, 1,3-butylene glycol, 1,2,6-hexanetriol, glycerin, 1 The composition of claim 3 selected from the group consisting of 1,2-hexanediol, pentylene glycol, ethoxylated glycerin, propoxylated glycerin, and mixtures thereof.   The composition of claim 1 further comprising a particulate material.   The composition of claim 1 wherein the emulsifying crosslinked siloxane elastomer is a dimethicone copolyol crosspolymer and dimethicone.   The composition of claim 1, wherein the non-emulsifying crosslinked siloxane elastomer is selected from the group consisting of dimethicone / vinyl dimethicone crosspolymers, and mixtures thereof.   The elastomer solvent is from the group consisting of volatile non-polar oils, non-volatile polar oils, non-volatile non-polar oils, non-volatile paraffinic hydrocarbon oils, and mixtures thereof. The composition according to claim 1, which is selected.   0.1% to 50% of an additional skin care active, wherein the additional skin care active is a sunscreen active, oil soluble terpene alcohol, phytosterol, oil soluble vitamin compound, emollient and occlusive agent, dehydro Acetic acid, hexanediol, anti-acne active substance, beta hydroxy acid, chelating agent, flavonoid, anti-inflammatory agent, anti-cellulite agent, local anesthetic agent, desquamating active substance, antioxidant / free radical scavenger, tanning agent, skin soothing and The composition of claim 1 selected from the group consisting of a recovery agent, an antimicrobial active substance, an antifungal active substance, and mixtures thereof.   A method for regulating skin condition comprising applying a safe and effective amount of a composition according to claim 1 to human skin in need of treatment. A water-in-oil emulsion composition comprising:
a) 0.1% to 15% non-emulsifying crosslinked siloxane elastomer,
b) 0.1% to 15% of an emulsifying crosslinked siloxane elastomer,
c) 1% to 40% of the non-emulsifiable and emulsifiable crosslinked siloxane elastomer solvent,
d) optionally 0% to 5% additional emulsifier,
e) contains 50% to 99% aqueous phase;
The composition releases an amorphous portion of the aqueous phase having a maximum linear dimension of at least 10 μm within 1 minute of shear by microscopy as described herein. A water-in-oil emulsion composition comprising:
a) 0.1% to 15% non-emulsifying crosslinked siloxane elastomer,
b) 0.1% to 15% of an emulsifying crosslinked siloxane elastomer,
c) 1% to 40% of the non-emulsifiable and emulsifiable crosslinked siloxane elastomer solvent,
d) optionally 0% to 5% additional emulsifier,
e) contains 50% to 99% aqueous phase;
A composition that releases a portion of an aqueous phase weighing at least 0.25 g after 1 minute of milling at a rate of 13500 rpm by the stirring method described herein. A water-in-oil emulsion composition comprising:
a) 0.1% to 15% non-emulsifying crosslinked siloxane elastomer,
b) 0.1% to 15% of an emulsifying crosslinked siloxane elastomer,
c) 1% to 40% of the non-emulsifiable and emulsifiable crosslinked siloxane elastomer solvent,
d) 0% to 5% additional emulsifier, if desired,
e) contains 50% to 99% aqueous phase;
A composition that yields a plot of log shear stress versus log viscosity having a slope of less than -5 as measured by the rheological method described herein.

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