JP2009023947A5

JP2009023947A5 -

Info

Publication number: JP2009023947A5
Application number: JP2007188625A
Authority: JP
Filing date: 2007-07-19
Publication date: 2010-05-27
Anticipated expiration: 2027-07-19

Description

＜試験例１＞
ローション１、比較例１、比較例２、比較例３の凍結切片を作成し、これの１５０００倍の拡大写真より、ミセルに相当する凸部の粒径を実測し、平均を求め、これを平均粒径とした。具体的な測定方法は、前述したとおりである。同様に、４０℃で１ヶ月保存したもの、５℃で１ヶ月保存したものについても、平均粒子径を求めた。結果を表２に示す。これより、本発明のローションは、ミセルの合一・会合が著しく抑制されていることが分かる。
<Test Example 1>
Frozen sections of Lotion 1, Comparative Example 1, Comparative Example 2 and Comparative Example 3 were prepared, and from the enlarged photo of 15000 times, the particle diameter of the convex portion corresponding to the micelle was measured, and the average was obtained. The particle size was taken. The specific measurement method is as described above. Similarly, the average particle size was determined for those stored at 40 ° C. for 1 month and those stored at 5 ° C. for 1 month. The results are shown in Table 2. From this, it can be seen that the lotion of the present invention has remarkably suppressed micelle coalescence and association.

実施例１と同様の操作で、本発明の皮膚外用剤である、水中油乳化剤形の乳液１（医薬部外品）を作成した。「プロモイスＥＦＬＳ」を水に置換した比較例４、ＰＯＥ（８０）硬化ヒマシ油に置換した比較例５、「プロモイスシルク−１０００」に置換した比較例６も同様に作成した。乳液１、比較例４、比較例５、及び比較例６を、試験例１、試験例２と同様に評価した。この結果を表５及び表６に示す。乳化剤形でも、可溶化剤形同様、アシル化された蛋白加水分解物である、「プロモイスＥＦＬＳ」によってミセルの合一・会合が抑制されていることが分かる。また、乳液１の美白効果は、比較例４、比較例５及び比較例６に比して顕著であった。 In the same manner as in Example 1, an oil-in-water emulsifier type emulsion 1 (quasi-drug), which is an external preparation for skin of the present invention, was prepared. Comparative Example 4 in which “Promois EFLS” was replaced with water, Comparative Example 5 in which POE (80) hydrogenated castor oil was replaced, and Comparative Example 6 in which “Promois Silk-1000” was replaced were also prepared. Emulsion 1, Comparative Example 4, Comparative Example 5, and Comparative Example 6 were evaluated in the same manner as Test Example 1 and Test Example 2. The results are shown in Tables 5 and 6. In the emulsifier form as well as the solubilizer form, it is understood that the coalescence / association of micelles is suppressed by “Promois EFLS” which is an acylated protein hydrolyzate. Further, the whitening effect of the emulsion 1 was remarkable as compared with Comparative Example 4 , Comparative Example 5 and Comparative Example 6 .