JP2008044887A - Extract of branch and/or leaf of acanthopanax senticosus harms, method for producing the same and use thereof - Google Patents

Extract of branch and/or leaf of acanthopanax senticosus harms, method for producing the same and use thereof Download PDF

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JP2008044887A
JP2008044887A JP2006221846A JP2006221846A JP2008044887A JP 2008044887 A JP2008044887 A JP 2008044887A JP 2006221846 A JP2006221846 A JP 2006221846A JP 2006221846 A JP2006221846 A JP 2006221846A JP 2008044887 A JP2008044887 A JP 2008044887A
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extract
acanthopanax
stems
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branch
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JP5044166B2 (en )
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Takahiko Fujikawa
Nobuo Sumida
澄田修生
藤川隆彦
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Redox:Kk
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<P>PROBLEM TO BE SOLVED: To obtain an extract prepared by extracting an active ingredient from stems and branches of Acanthopanax senticosus Harms expected not to have a pharmacodynamic effect. <P>SOLUTION: The extract of Acanthopanax senticosus Harms is obtained by extracting stems and/or branches of Acanthopanax senticosus Harms with alkali electrolytic water. Since the extract is expected to have a diet effect, the extract is useful as a supplement or food and beverage for diet. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

本発明は、あまり薬効の期待されないエゾウコギの茎や枝から有効成分を抽出した抽出物、その製造方法及びその用途に関するものである。 The present invention very extract obtained by extracting the active ingredient from the stems and branches of the expected non Acanthopanax efficacy, to a process for their preparation and their use.

エゾウコギ(学名:Acanthopanax senticosus harms)は、ウコギ科ウコギ属に属する植物である。 Siberian ginseng (scientific name: Acanthopanax senticosus harms) is a plant belonging to Araliaceae Eleutherococcus. エゾウコギには滋養強壮作用、鎮静作用、抗炎症作用、鎮痛作用、解熱作用等の薬理作用があることが公知である。 Nourishing effect on Acanthopanax, sedative, anti-inflammatory action, analgesic action, it is known to have pharmacological effects such as antipyretic.

特に、エゾウコギの根の抽出物は、薬効が高く薬事法で認可されている(非特許文献1)。 In particular, the roots of the extract of Acanthopanax may efficacy has been approved by the high Pharmaceutical Affairs Law (Non-Patent Document 1).

エゾウコギの根の抽出物には、エレウテロサイドB、イソフラキシジン、エレウテロサイドB1、エレウテロサイドE等の多糖類が含まれており、これらの作用により上述の薬理作用を奏するものと考えられているが詳細は不明である。 The root extract of Acanthopanax, Ereuterosaido B, Isofurakishijin, Ereuterosaido B1, includes polysaccharides such Ereuterosaido E, considered that by these effects exhibit the pharmacological effects described above it is but details are unclear.

エゾウコギの根以外の茎や枝から抽出した抽出物中の多糖類の組成は、根の抽出物の多糖類の組成と異なっており、茎や枝の抽出物は根の抽出物と比較すると薬効が劣っており、健康補助食品として使用されている。 Polysaccharide composition in the extract extracted from the stem and branches other than roots of Acanthopanax is different from the polysaccharide in the composition of the root extract, the extract of stems and branches are compared with the extract of the roots medicinal It is inferior, has been used as a health supplement.

本発明が解決しようとする課題は、薬効の期待されないエゾウコギの茎や枝から有効成分を抽出した抽出物、その製造方法及びその用途を提供することにある。 An object of the present invention is to provide an extract obtained by extracting the active ingredient from the stems and branches of the expected non Acanthopanax efficacy is to provide a manufacturing method thereof and use thereof.

上記課題を解決するため、鋭意研究を重ねたところ、本発明者は特定の抽出溶媒でエゾウコギの茎や枝を抽出することにより課題を解決できることを見出し、本発明を完成するに至った。 To solve the above problems, was diligent research, the present inventors have found that can solve the problem by extracting the stems and branches of Acanthopanax in particular the extraction solvent, thereby completing the present invention.

すなわち本発明は下記に関するものである。 That is, the present invention relates to the following.
(1) エゾウコギの茎及び/または枝をアルカリ電解水で抽出して得られるエゾウコギ抽出物。 (1) Acanthopanax stems and / or branches Eleutherococcus senticosus extract obtained by extraction with alkaline electrolyzed water.
(2) エゾウコギの茎及び/又は枝をアルカリ電解水で抽出することを特徴とする(1)に記載のエゾウコギ抽出物の製造方法。 (2) Acanthopanax manufacturing method of stems and / or branches and extracting with alkaline electrolyzed water (1) Acanthopanax senticosus extract according to.
(3) エゾウコギの茎及び/又は枝をアルカリ電解水で抽出した抽出物を含むことを特徴とするサプリメント。 (3) Supplement, characterized in that the stems and / or branch of Acanthopanax comprising an extract extracted by the alkaline electrolyzed water.
(4) エゾウコギの茎及び/又は枝をアルカリ電解水で抽出した抽出物を含むことを特徴とする飲食品。 (4) A food or drink stems and / or branch of Acanthopanax, characterized in that it comprises an extract obtained by extracting with alkaline electrolyzed water.

本発明のエゾウコギの茎及び/又は枝からアルカリ電解水で抽出した抽出物は、薬効が高く、ダイエット用のサプリメントや飲食品として好適である。 It stems and / or extract extracted by alkaline electrolyzed water from the branch of Acanthopanax of the present invention, drug efficacy is high, is suitable as a supplement or food products for dietary.

本発明のエゾウコギの茎及び/又は枝からアルカリ電解水で抽出した抽出物が、ダイエット効果を奏することの詳細な理由は不明である。 It stems and / or extract extracted by alkaline electrolyzed water from the branch of Acanthopanax of the present invention, a detailed reason for achieving the diet effect is unknown.

本発明の原料となるエゾウコギの茎や枝は、エゾウコギの茎や枝を乾燥し、裁断したものを用いればよい。 It stems and branches of Acanthopanax as a raw material of the present invention is to dry the stems and branches of Acanthopanax, may be used that cut.

本発明の抽出溶媒は、アルカリ電解水である。 Extraction solvent of the present invention is an alkaline electrolyzed water. 本発明におけるアルカリ電解水とは、 The electrolyzed alkaline water of the present invention,
隔膜でアノード室とカソ−ド室に仕切られた隔膜電解槽に水を供給してカソ−ド電解により生成したアルカリ性の電解水のことである。 The anode chamber with a diaphragm and cathode - to supply water to membrane electrolytic cell which is partitioned into de chamber cathode - is that of alkaline electrolyzed water produced by de electrolysis.

アルカリ電解水で抽出するための条件は、例えば、逆浸透膜処理水をカソ−ド電解して生成したアルカリ性電解水に細断したエゾウコギの茎及び枝を浸漬した後、アルカリ性電解水を加熱して抽出すればよい。 Condition for extracting with alkaline electrolyzed water, for example, a reverse osmosis membrane treated water catholyte - after soaking the stems and branches of shredded Acanthopanax alkaline electrolyzed water generated by de electrolyte, heating the alkaline electrolyzed water it may be extracted Te.

アルカリ電解水でエゾウコギの茎や枝を抽出した抽出物中のエレウテロサイドB、イソフラキシジン、エレウテロサイドB1、エレウテロサイドEの組成は、従来法で抽出したエゾウコギの茎や枝の抽出物の組成と異なり、むしろ根の抽出物の組成と近いものである(図1参照)。 Ereuterosaido B in the extract obtained by extracting the stem and branches of Acanthopanax alkaline electrolyzed water, Isofurakishijin, Ereuterosaido B1, the composition of Ereuterosaido E, extraction of the stems and branches of Acanthopanax extracted by the conventional method Unlike the composition of the object, but rather close to the composition of the extract of the roots (see Figure 1). エゾウコギの茎及び/又は枝のアルカリ電解水抽出物のエレウテロサイドB、イソフラキシジン、エレウテロサイドB1、エレウテロサイドEの組成は、各々0.01〜0.3、0.01〜0.2、0.01〜0.3、0.1〜0.5の範囲にある。 Ereuterosaido B stems and / or branch of alkaline electrolyzed water extract of Acanthopanax, Isofurakishijin, the composition of Ereuterosaido B1, Ereuterosaido E, respectively 0.01~0.3,0.01~0 It is in the range of .2,0.01~0.3,0.1~0.5.

本発明の抽出物は、エゾウコギの茎や枝を抽出したままの液状でも良く、抽出液を濃縮したコンク品でもよく、抽出液を乾燥した粉末品でもよい。 Extract of the present invention may be in a liquid state which was extracted stems and branches of Acanthopanax senticosus, extract may be concentrated product was concentrated, extract may be a dried powder product.

本発明の抽出物は、凍結乾燥して、粉末化し、リン酸カルシウム、セルロース、アルギン酸、ステアリン酸カルシウム、ショ糖等と配合してサプリメントとすることができる。 Extract of the present invention, and freeze-dried, powdered, calcium phosphate, may be cellulose, alginic acid, calcium stearate, and supplements formulated with sucrose and the like.

本発明のサプリメントは後述の実施例から分かるように、ダイエット用のサプリメントとして好適である。 Supplements of the present invention, as seen from the examples described below, is suitable as a supplement for diet.

本発明の抽出物は、飲料水、ドリンク、茶の飲料やビスケットのような食品に配合することにより、ダイエット効果が期待できる。 Extract of the present invention, drinking water, beverages, by blending in food products such as tea drinks, biscuits, can be expected diet effect.
参考例1 Reference Example 1
実施例で使用したアルカリ電解水は、以下のように調製した。 Electrolyzed alkaline water used in the examples was prepared as follows. まず、図1に示す電解槽を用いて、逆浸透膜処理水をアノード室1とカソ−ド室6に供給して、pHが〜10の水を生成した。 First, using the electrolytic cell shown in FIG. 1, a reverse osmosis membrane treated water anode chamber 1 and the cathode - is supplied to the de-chamber 6, pH generated a 10 water.

(1)抽出 乾燥エゾウコギ原木(茎主体)を針状に切断し、25gに対して溶媒250gを加え、80〜100℃にて溶媒抽出を行った。 (1) extracting dried Acanthopanax wood (the stems mainly) was cut into needle shape, a solvent 250g added to 25 g, were solvent extracted at 80 to 100 ° C.. それぞれ室温まで冷却後、濾紙にてろ過し、抽出液量、エキス濃度、比重、pHを測定した。 Each After cooling to room temperature, filtered through filter paper, and the extract amount was measured extract concentration, specific gravity, and pH. 抽出液量とエキス濃度より抽出率(100gより抽出された乾燥エキスのg数)を求めた。 Extract amount and calculated extraction rate than extract concentration (g number of dry extract which is extracted from 100 g). 抽出条件と測定結果を表1に示す。 Criteria and measurement results are shown in Table 1.

(2)成分分析 抽出物を液体クロマトグラフ法によりエゾウコギの特徴5成分を測定した。 (2) a component analysis extracts were measured features five components of Acanthopanax by liquid chromatography. 測定結果を表2に示す。 The measurement results are shown in Table 2.

表2中、「通常水抽出1」とは電解無処理の水を80〜100℃に加熱して抽出した例を示す。 In Table 2, the "normal water extract 1" shows an example of extracted by heating the water electrolysis untreated to 80 to 100 ° C..
意味し、「通常水抽出2」とは熱水抽出1と同様な条件で抽出した別の例を意味する。 Refers to refers to another example extracted under the same conditions as in hot water extracted from the "normal water extraction 2".

表2の測定結果を、クロロゲン酸を1とした場合のエレウテロサイドB、イソフラキシジン、エレウテロサイドB1、エレウテロサイドEの重量比をグラフ化した(図2)。 The measurement results in Table 2, Ereuterosaido B in the case of a 1 chlorogenic acid, Isofurakishijin, Ereuterosaido B1, graph of the weight ratio of Ereuterosaido E (FIG. 2). グラフ中「根」とあるのは、エゾウコギの根を熱水抽出した抽出物を測定したものである。 In the graph the term "roots" is one in which the roots of Acanthopanax was measured extract extracted with hot water.

表2及び図2の結果から明らかなように、本発明のエゾウコギの茎のアルカリ電解水抽出物の有効成分の組成は、従来の熱水抽出物の組成と異なり、むしろ根の熱水抽出物の組成に近いものであった。 Table 2 and As is clear from the results shown in FIG. 2, the composition of the active ingredient in the alkaline electrolyzed water extract of stems of Acanthopanax of the present invention is different from the composition of a conventional hot water extract, rather hot water extract of the roots It was close to the composition.

本実施例では、アルカリ電解水抽出エゾウコギエキスの抗肥満効果を様々なパラメータから検証を行い、既存の水抽出エゾウコギエキスの抗肥満効果との違いを明らかにする。 In this embodiment, to validate the anti-obesity effect of alkaline electrolytic water extract Siberian ginseng extract from a variety of parameters, it reveals the difference between the anti-obesity effect of existing water extraction Acanthopanax extract.

効果確認試験には以下の動物を用いた。 The effect confirmation test using the following animal.

a.使用動物 a. use animal
SD雄性ラット4週令を購入後、1週間の予備飼育を行い、実験に使用した。 After purchasing an SD male rats 4 weeks old, conducted a preliminary breeding for one week, were used in the experiment.

b.グループ・H2O,ND:普通食(360 kcal/100g)自由摂取ラット 6匹(図中、「普通食」と表示) . B Group · H2O, ND: normal diet (360 kcal / 100g) ad libitum rat 6 animals (in the figure, display a "normal diet")
・H2O,HFD35%:βカゼイン5%入り35%ラード入り高脂肪(630 kcal/100g)食自由摂取ラット 6匹(図中、「高脂肪食」と表示) · H2O, HFD35%: β-casein 35% 5% containing lard containing high fat (630 kcal / 100g) diet ad libitum rat 6 animals (in the figure, display a "high fat diet")
・AlkaliASH5%,HFD:アルカリ電解水抽出エゾウコギエキス5%入り高脂肪食(630 kcal/100g)自由摂取ラット 6匹(図中、「電解水抽出」と表示) · AlkaliASH5%, HFD: alkaline electrolyzed water extraction Siberian ginseng extract 5% containing high-fat diet (630 kcal / 100g) ad libitum rat 6 animals (in the figure, indicated as "electrolytic water extraction")
・ASH5%,HFD:普通の水抽出エゾウコギエキス0.5%入り高脂肪食(630 kcal/100g)自由摂取ラット 6匹(図中、「通常水抽出」と表示) · ASH5%, HFD: plain water extraction Siberian ginseng extract 0.5% containing high-fat diet (630 kcal / 100g) ad libitum rat 6 animals (in the figure, display a "normal water extraction")

これらのラットを予備飼育後、5週間、それぞれの処置を行った。 After preliminary breeding these rats, 5 weeks, were each treatment.

試験結果は以下のとおりまとめられる。 The test results are summarized as follows.

(1)アルカリ電解水抽出エゾウコギエキスの体重増加率への影響(図3) (1) Effect on body weight gain of the electrolyzed alkaline water extracts Acanthopanax extract (Fig. 3)
高脂肪食投与ラットは、普通食投与ラットに比べ1日あたり平均約1.9倍の体重増加が認められた。 High-fat diet administration rats, an average of about 1.9 times the weight gain per day was observed compared to the normal diet rats. 高脂肪食条件下、通常の水抽出ASHエキスは、高脂肪食単独投与ラットに比べ1日あたり平均約27%の体重抑制を示した。 High fat diet conditions, conventional water extraction ASH extract, showed an average of about 27 percent of body weight suppression per day compared to the high fat diet alone rats. 一方、アルカリ電解水抽出エキスは、高脂肪食単独投与ラットに比べ1日あたり平均約42-49%の体重抑制を示し、アルカリ電解水抽出エキスによる作用の増強効果が明らかとなった。 On the other hand, the alkaline electrolyzed water extract showed an average of about 42-49% of the body weight suppression per day compared to the high fat diet alone rats revealed enhancement effect of action by the alkaline electrolyzed water extract.

(2)アルカリ電解水抽出エゾウコギエキスの内臓脂肪への影響(図4) (2) Effect on visceral fat of electrolyzed alkaline water extracts Acanthopanax extract (FIG. 4)
高脂肪食投与ラットは、普通食投与ラットに比べ約2.7内臓脂肪組織重量の増加が認められた。 High-fat diet rats, an increase of about 2.7 visceral adipose tissue weight compared with the normal diet rats were observed. 高脂肪食条件下、通常の水抽出ASHエキスは、高脂肪食単独投与ラットに比べ約26%脂肪重量の低下を示した。 High fat diet conditions, conventional water extraction ASH extract showed a reduction of approximately 26% fat by weight as compared to the high fat diet alone rats. 一方、アルカリ電解水抽出エキスは、高脂肪食単独投与ラットに比べ約52%の低下作用を示した。 On the other hand, the alkaline electrolyzed water extract showed a lowering effect of about 52% compared to high-fat diet alone rats. アルカリ電解水抽出エキスによる作用の増強効果が明らかとなった。 Enhancing effect of action by the alkaline electrolyzed water extract revealed.

(3)血中中性脂肪値に対するアルカリ電解水抽出エゾウコギエキスの効果(図5) (3) alkaline electrolyzed water extraction Acanthopanax extract effect on blood triglyceride level (Fig. 5)
ラットへの高脂肪食投与は、血中中性脂肪値が、普通食に比較して上昇傾向を示した。 High-fat diet administration to rats, blood triglyceride levels, showed an upward trend compared to the normal diet. アルカリ電解水抽出エキスは、高脂肪食による血中中性脂肪値の上昇を顕著に抑制し、さらに、通常水抽出エキスに比較しても抑制した。 Alkaline electrolyzed water extract is elevated blood triglyceride level by a high fat diet significantly suppressed, further suppressed as compared to a normal water extract.

(4)血糖値に対するアルカリ電解水抽出エゾウコギエキスの効果(図6) (4) alkaline electrolyzed water extraction Acanthopanax extract effect on blood glucose (FIG. 6)
高脂肪食による血糖値の上昇は、アルカリ電解水抽出エキスや水抽出ASH5%エキスにより顕著に抑制された。 Elevated blood sugar level by high fat diet was markedly inhibited by the alkaline electrolyzed water extract or water extract ASH5% extract. また、アルカリ電解水抽出エキスは、ASH5%エキスの効果をさらに増強していることも明らかとなった。 Further, the alkaline electrolyzed water extract became also clear that further enhance the effect of ASH5% extract.

本発明のエゾウコギの茎や枝の抽出物は、ダイエット効果が期待できるので、ダイエット用のサプリメントや飲食品として有用である。 It stems and branches of the extract of Acanthopanax of the present invention, because the diet effect can be expected, it is useful as supplements and food and drink for the diet.

アルカリ電解水を生成する電解装置。 Electrolytic apparatus for producing electrolyzed alkaline water. エゾウコギ抽出物中の有効成分の構成比を示したグラフ。 Graph showing the composition ratio of the active ingredient of Acanthopanax senticosus extract. 体重増加量を示すグラフ。 Graph showing the weight gain. 脂肪細胞面積率を示すグラフ。 Graph showing the adipocyte area ratio. 血中中性脂肪値を示すグラフ。 Graph showing the blood triglyceride level. 血糖値を示すグラフ。 Graph showing the blood glucose level.

Claims (4)

  1. エゾウコギの茎及び/または枝をアルカリ電解水で抽出して得られるエゾウコギ抽出物。 It stems and / or branches Eleutherococcus senticosus extract obtained by extraction with alkaline electrolyzed water of Acanthopanax.
  2. エゾウコギの茎及び/又は枝をアルカリ電解水で抽出することを特徴とする請求項1に記載のエゾウコギ抽出物の製造方法。 Manufacturing method of Acanthopanax extract according to claim 1, the stems and / or branch of Acanthopanax and extracting with alkaline electrolyzed water.
  3. エゾウコギの茎及び/又は枝をアルカリ電解水で抽出した抽出物を含むことを特徴とするサプリメント。 Supplements, characterized in that the stems and / or branch of Acanthopanax comprising an extract extracted by the alkaline electrolyzed water.
  4. エゾウコギの茎及び/又は枝をアルカリ電解水で抽出した抽出物を含むことを特徴とする飲食品。 Food products, characterized in that the stems and / or branch of Acanthopanax comprising an extract extracted by the alkaline electrolyzed water.
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KR101150309B1 (en) 2012-01-09 2012-06-08 주식회사 경희매니지먼트컴퍼니 Manufacturing method of herbal extract/powder for preventing periodontal disease and dental calculus, and dentifrice composition using the same
JP2012514634A (en) * 2009-01-09 2012-06-28 ソウル大学校産学協力団 Inflammatory diseases for improving compositions utilizing Abh antigen
CN103893345A (en) * 2009-08-14 2014-07-02 株式会社爱茉莉太平洋 Composition containing a natural extract

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