JP2007522135A5 - - Google Patents
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- JP2007522135A5 JP2007522135A5 JP2006551595A JP2006551595A JP2007522135A5 JP 2007522135 A5 JP2007522135 A5 JP 2007522135A5 JP 2006551595 A JP2006551595 A JP 2006551595A JP 2006551595 A JP2006551595 A JP 2006551595A JP 2007522135 A5 JP2007522135 A5 JP 2007522135A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- independently
- subject
- electron withdrawing
- withdrawing group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54068804P | 2004-01-30 | 2004-01-30 | |
| US63245604P | 2004-12-02 | 2004-12-02 | |
| PCT/US2005/003183 WO2005074598A2 (en) | 2004-01-30 | 2005-01-28 | Nitroxyl progenitor compounds and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007522135A JP2007522135A (ja) | 2007-08-09 |
| JP2007522135A5 true JP2007522135A5 (US07981874-20110719-C00313.png) | 2008-11-27 |
Family
ID=34841107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006551595A Pending JP2007522135A (ja) | 2004-01-30 | 2005-01-28 | ニトロキシル前駆化合物および使用方法 |
Country Status (6)
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040038947A1 (en) | 2002-06-14 | 2004-02-26 | The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services | Method of treating ischemia/reperfusion injury with nitroxyl donors |
| US6936639B2 (en) | 2002-08-21 | 2005-08-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitroxyl progenitors in the treatment of heart failure |
| WO2005074598A2 (en) | 2004-01-30 | 2005-08-18 | Johns Hopkins University | Nitroxyl progenitor compounds and methods of use |
| EP1909779A1 (en) * | 2005-06-23 | 2008-04-16 | Johns Hopkins University | Thiol-sensitive positive inotropes |
| KR20150091427A (ko) | 2006-03-17 | 2015-08-10 | 더 존스 홉킨스 유니버시티 | 신규의 생리적으로 유용한 니트록실 도너로서 ｎ-히드록실술폰아미드 유도체 |
| RU2485097C2 (ru) | 2007-09-26 | 2013-06-20 | Джонс Хопкинс Юниверсити | Производные n-гидроксилсульфонамида как новые физиологически применимые доноры нитроксила |
| CA2711461A1 (en) * | 2008-02-08 | 2009-08-13 | Merck Sharp & Dohme Corp. | Angiotensin ii receptor antagonists |
| US20110160200A1 (en) * | 2009-11-23 | 2011-06-30 | Cardioxyl Pharmaceuticals, Inc. | Nitroxyl Progenitors for the Treatment of Pulmonary Hypertension |
| IN2012DN05025A (US07981874-20110719-C00313.png) * | 2009-12-07 | 2015-10-23 | Univ Johns Hopkins | |
| JP5832447B2 (ja) | 2009-12-07 | 2015-12-16 | ザ ジョンズ ホプキンス ユニバーシティ | ビスアシル化ヒドロキシルアミン誘導体 |
| KR20140003482A (ko) * | 2011-01-19 | 2014-01-09 | 머크 샤프 앤드 돔 코포레이션 | 디아제늄디올레이트 유도체 |
| MX363306B (es) | 2011-10-17 | 2019-03-20 | Univ Johns Hopkins | Derivados del acido de meldrum, acido barbiturico y pirazolona sustituidos con hidroxilamina como donadores de nitroxilo (hno). |
| AU2014207404B2 (en) | 2013-01-18 | 2017-10-19 | Cardioxyl Pharmaceuticals, Inc. | Nitroxyl donors with improved therapeutic index |
| EP3126329B1 (en) | 2014-01-17 | 2019-05-29 | Cardioxyl Pharmaceuticals Inc. | N-hydroxymethanesulfonamide nitroxyl donors |
| US9464061B2 (en) | 2014-05-27 | 2016-10-11 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives |
| WO2015183838A1 (en) | 2014-05-27 | 2015-12-03 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives as nitroxyl donors |
| ES2749682T3 (es) | 2014-05-27 | 2020-03-23 | Cardioxyl Pharmaceuticals Inc | Derivados de pirazolona como donadores de nitroxilo |
| WO2017070084A1 (en) | 2015-10-19 | 2017-04-27 | Cardioxyl Pharmaceuticals, Inc. | N-hydroxylsulfonamide derivatives as nitroxyl donors |
| KR20180063326A (ko) | 2015-10-19 | 2018-06-11 | 카르디옥실 파마슈티칼스 인코포레이티드 | 니트록실 공여자로서의 피라졸론 유도체 |
| EP3490975B1 (en) | 2016-07-28 | 2021-05-05 | The Johns Hopkins University | O-substituted hydroxamic acids |
| WO2018128999A1 (en) | 2017-01-03 | 2018-07-12 | Cardioxyl Pharmaceuticals, Inc. | Method of administering nitroxyl donating compounds |
| US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4369172A (en) | 1981-12-18 | 1983-01-18 | Forest Laboratories Inc. | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose |
| DE3583799D1 (de) | 1985-01-11 | 1991-09-19 | Abbott Lab Ltd | Feste zubereitung mit langsamer freisetzung. |
| US4954526A (en) * | 1989-02-28 | 1990-09-04 | The United States Of America As Represented By The Department Of Health And Human Services | Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents |
| US5039705A (en) * | 1989-09-15 | 1991-08-13 | The United States Of America As Represented By The Department Of Health And Human Services | Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof |
| US5366997A (en) * | 1991-09-24 | 1994-11-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs |
| JP2773959B2 (ja) | 1990-07-10 | 1998-07-09 | 信越化学工業株式会社 | 大腸内放出性固形製剤 |
| US5632981A (en) * | 1992-08-24 | 1997-05-27 | The United States Of America As Represented By The Department Of Health And Human Services | Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
| US6200558B1 (en) * | 1993-09-14 | 2001-03-13 | The United States Of America As Represented By The Department Of Health And Human Services | Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
| US5700830A (en) * | 1994-11-22 | 1997-12-23 | The United States Of America As Represented By The Department Of Health And Human Services | Use of nitric oxide-releasing agents for reducing metastasis risk |
| CA2705474C (en) * | 1996-09-27 | 2013-07-16 | The Government Of The United States Of America, Represented By The Secre Tary, Department Of Health And Human Services | O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates |
| US5958427A (en) * | 1996-11-08 | 1999-09-28 | Salzman; Andrew L. | Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications |
| AU726861B2 (en) * | 1997-07-03 | 2000-11-23 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Novel nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same |
| UA73092C2 (uk) | 1998-07-17 | 2005-06-15 | Брістол-Майерс Сквібб Компані | Таблетка з ентеросолюбільним покриттям і спосіб її приготування |
| KR100501022B1 (ko) | 1998-07-28 | 2005-07-18 | 다나베 세이야꾸 가부시키가이샤 | 장내 적소 방출형 제제 |
| CA2448040A1 (en) * | 2001-06-05 | 2002-12-12 | Basf Aktiengesellschaft | Antimycotic agent |
| WO2003006427A1 (en) * | 2001-07-12 | 2003-01-23 | Johns Hopkins University | Compounds that release nitric oxide at controlled rates upon photolysis |
| US7074835B2 (en) * | 2002-03-15 | 2006-07-11 | Btg International Limited | Formulations of anthraquinone derivatives |
| AU2003230715A1 (en) * | 2002-03-21 | 2003-10-08 | The University Of Utah Research Foundation | In vivo use of glutathionone s-transferase activated nitric oxide donors |
| US20040038947A1 (en) * | 2002-06-14 | 2004-02-26 | The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services | Method of treating ischemia/reperfusion injury with nitroxyl donors |
| US6936639B2 (en) * | 2002-08-21 | 2005-08-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitroxyl progenitors in the treatment of heart failure |
| US20050009789A1 (en) | 2003-05-13 | 2005-01-13 | The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health And Human Service | Cyclooxygenase inhibition with nitroxyl |
| WO2005074598A2 (en) | 2004-01-30 | 2005-08-18 | Johns Hopkins University | Nitroxyl progenitor compounds and methods of use |
-
2005
- 2005-01-28 WO PCT/US2005/003183 patent/WO2005074598A2/en active Application Filing
- 2005-01-28 JP JP2006551595A patent/JP2007522135A/ja active Pending
- 2005-01-28 EP EP05726388A patent/EP1718621A4/en not_active Withdrawn
- 2005-01-28 CA CA002554771A patent/CA2554771A1/en not_active Abandoned
- 2005-01-28 US US10/587,644 patent/US20090281067A1/en not_active Abandoned
- 2005-01-28 AU AU2005209843A patent/AU2005209843B2/en not_active Ceased
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2014
- 2014-09-22 US US14/492,741 patent/US10273202B2/en active Active
