JP2006522761A5 - - Google Patents
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- Publication number
- JP2006522761A5 JP2006522761A5 JP2006505027A JP2006505027A JP2006522761A5 JP 2006522761 A5 JP2006522761 A5 JP 2006522761A5 JP 2006505027 A JP2006505027 A JP 2006505027A JP 2006505027 A JP2006505027 A JP 2006505027A JP 2006522761 A5 JP2006522761 A5 JP 2006522761A5
- Authority
- JP
- Japan
- Prior art keywords
- iii
- paramagnetic
- use according
- substrate molecule
- bulk water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000005298 paramagnetic effect Effects 0.000 claims 9
- 239000000758 substrate Substances 0.000 claims 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 239000013522 chelant Substances 0.000 claims 3
- 150000004697 chelate complex Chemical class 0.000 claims 3
- 229910021645 metal ion Inorganic materials 0.000 claims 3
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 claims 2
- 229910052692 Dysprosium Inorganic materials 0.000 claims 2
- 229910052691 Erbium Inorganic materials 0.000 claims 2
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 claims 2
- 229910052689 Holmium Inorganic materials 0.000 claims 2
- VEQPNABPJHWNSG-UHFFFAOYSA-N Nickel(2+) Chemical compound [Ni+2] VEQPNABPJHWNSG-UHFFFAOYSA-N 0.000 claims 2
- 229910052777 Praseodymium Inorganic materials 0.000 claims 2
- 229910052771 Terbium Inorganic materials 0.000 claims 2
- 229910052775 Thulium Inorganic materials 0.000 claims 2
- XQTIWNLDFPPCIU-UHFFFAOYSA-N cerium(3+) Chemical compound [Ce+3] XQTIWNLDFPPCIU-UHFFFAOYSA-N 0.000 claims 2
- XLJKHNWPARRRJB-UHFFFAOYSA-N cobalt(2+) Chemical compound [Co+2] XLJKHNWPARRRJB-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- KBQHZAAAGSGFKK-UHFFFAOYSA-N dysprosium atom Chemical compound [Dy] KBQHZAAAGSGFKK-UHFFFAOYSA-N 0.000 claims 2
- UYAHIZSMUZPPFV-UHFFFAOYSA-N erbium Chemical compound [Er] UYAHIZSMUZPPFV-UHFFFAOYSA-N 0.000 claims 2
- LNBHUCHAFZUEGJ-UHFFFAOYSA-N europium(3+) Chemical compound [Eu+3] LNBHUCHAFZUEGJ-UHFFFAOYSA-N 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- KJZYNXUDTRRSPN-UHFFFAOYSA-N holmium atom Chemical compound [Ho] KJZYNXUDTRRSPN-UHFFFAOYSA-N 0.000 claims 2
- 229910052742 iron Inorganic materials 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- QEFYFXOXNSNQGX-UHFFFAOYSA-N neodymium atom Chemical compound [Nd] QEFYFXOXNSNQGX-UHFFFAOYSA-N 0.000 claims 2
- 229920001308 poly(aminoacid) Polymers 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- PUDIUYLPXJFUGB-UHFFFAOYSA-N praseodymium atom Chemical compound [Pr] PUDIUYLPXJFUGB-UHFFFAOYSA-N 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 229910052703 rhodium Inorganic materials 0.000 claims 2
- 239000010948 rhodium Substances 0.000 claims 2
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 claims 2
- 238000000926 separation method Methods 0.000 claims 2
- GZCRRIHWUXGPOV-UHFFFAOYSA-N terbium atom Chemical compound [Tb] GZCRRIHWUXGPOV-UHFFFAOYSA-N 0.000 claims 2
- FRNOGLGSGLTDKL-UHFFFAOYSA-N thulium atom Chemical compound [Tm] FRNOGLGSGLTDKL-UHFFFAOYSA-N 0.000 claims 2
- AWSFICBXMUKWSK-UHFFFAOYSA-N ytterbium(3+) Chemical compound [Yb+3] AWSFICBXMUKWSK-UHFFFAOYSA-N 0.000 claims 2
- QBPPRVHXOZRESW-UHFFFAOYSA-N 1,4,7,10-tetraazacyclododecane Chemical compound C1CNCCNCCNCCN1 QBPPRVHXOZRESW-UHFFFAOYSA-N 0.000 claims 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 239000000412 dendrimer Substances 0.000 claims 1
- 229920000736 dendritic polymer Polymers 0.000 claims 1
- 230000005292 diamagnetic effect Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 239000004530 micro-emulsion Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920000724 poly(L-arginine) polymer Polymers 0.000 claims 1
- 229920000962 poly(amidoamine) Polymers 0.000 claims 1
- 229920000768 polyamine Polymers 0.000 claims 1
- 108010011110 polyarginine Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03008456.0 | 2003-04-11 | ||
| EP03008456A EP1466629A1 (en) | 2003-04-11 | 2003-04-11 | Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications |
| PCT/EP2004/003684 WO2004089424A1 (en) | 2003-04-11 | 2004-04-06 | Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for “cest” applications |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006522761A JP2006522761A (ja) | 2006-10-05 |
| JP2006522761A5 true JP2006522761A5 (https=) | 2007-05-24 |
| JP4891763B2 JP4891763B2 (ja) | 2012-03-07 |
Family
ID=32865006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006505027A Expired - Fee Related JP4891763B2 (ja) | 2003-04-11 | 2004-04-06 | 「ｃｅｓｔ」用途のための、磁気共鳴シフト試薬と交換性プロトンを含有する基質との付加物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8945512B2 (https=) |
| EP (3) | EP1466629A1 (https=) |
| JP (1) | JP4891763B2 (https=) |
| CN (1) | CN100579583C (https=) |
| AT (1) | ATE444763T1 (https=) |
| AU (1) | AU2004228932B2 (https=) |
| DE (1) | DE602004023492D1 (https=) |
| WO (1) | WO2004089424A1 (https=) |
| ZA (1) | ZA200508155B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008513533A (ja) * | 2004-09-23 | 2008-05-01 | ゲルベ | Ｃｅｓｔイメージング用の造影剤封入システム |
| WO2006086343A2 (en) * | 2005-02-07 | 2006-08-17 | The Johns Hopkins University | Chemical exchange saturation transfer based mri using reporter genes and mri methods related thereto |
| JP5638752B2 (ja) * | 2005-04-26 | 2014-12-10 | コーニンクレッカ フィリップス エヌ ヴェ | Ｃｅｓｔ活性な常磁性の錯体を含むｍｒｉ造影剤 |
| EP1716870A1 (en) * | 2005-04-29 | 2006-11-02 | Bracco Imaging S.p.A. | MRI contrast agents endowed with concentration independent responsiveness |
| EP1907873B1 (en) * | 2005-07-21 | 2015-02-25 | Johns Hopkins University | Non-invasive mri measurement of tissue glycogen |
| DE102007039899B3 (de) * | 2007-08-23 | 2009-04-09 | Siemens Ag | Sensor zum Ermöglichen des Nachweises einer Substanz im Körper eines Lebewesens |
| WO2011075476A1 (en) * | 2009-12-14 | 2011-06-23 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University | Methods and compositions relating to reporter gels for use in mri techniques |
| EP2457594A1 (en) * | 2010-11-05 | 2012-05-30 | Bracco Imaging S.p.A | Cest systems exhibiting a concentration independent responsiveness |
| CN109963839A (zh) * | 2016-09-19 | 2019-07-02 | 香港理工大学 | 手性轮环藤宁化合物及其用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5672334A (en) * | 1991-01-16 | 1997-09-30 | Access Pharmaceuticals, Inc. | Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans |
| US5050609B1 (en) | 1987-10-04 | 1999-11-02 | Us Health | Magnetization transfer contrast and proton relaxation and use thereof in magnetic resonance imaging |
| JPH04501723A (ja) * | 1988-11-09 | 1992-03-26 | アンガー，エヴァン，シー． | リポソーム性放射線造影剤 |
| JP2774378B2 (ja) * | 1991-02-08 | 1998-07-09 | ダイアテク，インコーポレイテッド | 映像用テクネチウム−９９ｍ標識化ポリペプチド |
| JP2894879B2 (ja) * | 1991-10-04 | 1999-05-24 | 日本メジフィジックス株式会社 | 診断用造影剤 |
| GB9420390D0 (en) * | 1994-10-10 | 1994-11-23 | Nycomed Salutar Inc | Liposomal agents |
| US5707605A (en) * | 1995-06-02 | 1998-01-13 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
| JP2002512942A (ja) * | 1998-04-28 | 2002-05-08 | ヤーゴウテック アーゲー | ヒアルロナン系像形成剤 |
| EP1178837A2 (en) * | 1999-04-21 | 2002-02-13 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Method for enhancing contrast produced by mri |
| CA2322344A1 (en) * | 1999-12-08 | 2001-06-08 | Mallinckrodt Inc. | Non-covalent bioconjugates useful for magnetic resonance imaging |
| EP1406669A2 (en) * | 2000-10-31 | 2004-04-14 | Bracco International B.V. | Conjugates of an antioxidants with metal chelating ligands |
| WO2002043775A2 (en) * | 2000-11-20 | 2002-06-06 | GODFREY, Cullen, M. | Paramagnetic metal ion-based macrocyclic contrast agents |
| DE10135355C1 (de) * | 2001-07-20 | 2003-04-17 | Schering Ag | Konjugate makrocyclischer Metallkomplexe mit Biomolekülen und deren Verwendung zur Herstellung von Mitteln für die NMR- und Radiodiagnostik sowie die Radiotherapie |
| EP1331012A1 (en) * | 2002-01-29 | 2003-07-30 | BRACCO IMAGING S.p.A. | Responsive paramagnetic MRI contrast agents |
-
2003
- 2003-04-11 EP EP03008456A patent/EP1466629A1/en not_active Withdrawn
-
2004
- 2004-04-06 AT AT04725938T patent/ATE444763T1/de not_active IP Right Cessation
- 2004-04-06 DE DE602004023492T patent/DE602004023492D1/de not_active Expired - Lifetime
- 2004-04-06 EP EP09155670A patent/EP2116267A1/en not_active Withdrawn
- 2004-04-06 WO PCT/EP2004/003684 patent/WO2004089424A1/en not_active Ceased
- 2004-04-06 EP EP04725938A patent/EP1613358B1/en not_active Expired - Lifetime
- 2004-04-06 JP JP2006505027A patent/JP4891763B2/ja not_active Expired - Fee Related
- 2004-04-06 US US10/552,851 patent/US8945512B2/en not_active Expired - Fee Related
- 2004-04-06 AU AU2004228932A patent/AU2004228932B2/en not_active Ceased
- 2004-04-06 ZA ZA200508155A patent/ZA200508155B/en unknown
- 2004-04-06 CN CN200480009565.0A patent/CN100579583C/zh not_active Expired - Fee Related
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