JP2006518996A5 - - Google Patents

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Publication number
JP2006518996A5
JP2006518996A5 JP2006500911A JP2006500911A JP2006518996A5 JP 2006518996 A5 JP2006518996 A5 JP 2006518996A5 JP 2006500911 A JP2006500911 A JP 2006500911A JP 2006500911 A JP2006500911 A JP 2006500911A JP 2006518996 A5 JP2006518996 A5 JP 2006518996A5
Authority
JP
Japan
Prior art keywords
aav
serca2
host
aav vector
vector according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006500911A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006518996A (ja
Filing date
Publication date
Priority claimed from US10/342,120 external-priority patent/US7745416B2/en
Application filed filed Critical
Publication of JP2006518996A publication Critical patent/JP2006518996A/ja
Publication of JP2006518996A5 publication Critical patent/JP2006518996A5/ja
Pending legal-status Critical Current

Links

JP2006500911A 2003-01-13 2004-01-12 心筋収縮性をｉｎｖｉｖｏで調節するための方法 Pending JP2006518996A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/342,120 US7745416B2 (en) 1995-04-11 2003-01-13 Method for in vivo regulation of cardiac muscle contractility
PCT/US2004/000719 WO2004062618A2 (en) 2003-01-13 2004-01-12 Method for in vivo regulation of cardiac muscle contractility

Publications (2)

Publication Number Publication Date
JP2006518996A JP2006518996A (ja) 2006-08-24
JP2006518996A5 true JP2006518996A5 (https=) 2007-03-01

Family

ID=32711653

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006500911A Pending JP2006518996A (ja) 2003-01-13 2004-01-12 心筋収縮性をｉｎｖｉｖｏで調節するための方法

Country Status (10)

Country Link
US (1) US7745416B2 (https=)
EP (1) EP1590001B1 (https=)
JP (1) JP2006518996A (https=)
AT (1) ATE416792T1 (https=)
AU (2) AU2004204815B2 (https=)
CA (1) CA2513249A1 (https=)
DE (1) DE602004018269D1 (https=)
ES (1) ES2318264T3 (https=)
IL (1) IL169663A (https=)
WO (1) WO2004062618A2 (https=)

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WO2005023292A1 (en) 2003-09-03 2005-03-17 The General Hospital Corporation Methods of treating restenosis
CN101056539B (zh) * 2004-09-09 2012-12-12 综合医院公司 调节心脏细胞中的磷酸酶活性
WO2006089340A2 (en) * 2005-02-23 2006-08-31 V-Kardia Pty Ltd Polynucleotide delivery to cardiac tissue
KR20090035711A (ko) * 2006-07-25 2009-04-10 셀라돈 코포레이션 유전자 치료를 위한 아데노-관련 바이러스 벡터의 전방 심외막 관상에의 연장 주입
EP2164330A4 (en) * 2007-06-18 2011-12-28 Celladon Corp SERCA2-BASED THERAPEUTIC COMPOSITIONS AND METHODS OF USE
DK2205618T3 (en) * 2007-09-26 2017-02-20 Intrexon Corp SYNTHETIC 5 'NON-TRANSLATED REGIONS, EXPRESSION VECTORS AND PROCEDURES FOR INCREASING TRANSGENIC EXPRESSION
KR20100129295A (ko) 2008-02-19 2010-12-08 셀라돈 코포레이션 심근 내 바이러스 벡터의 흡수를 개선시키기 위한 조성물
US20180099029A9 (en) * 2010-04-15 2018-04-12 Mount Sinai School Of Medicine Serca2 therapeutic compositions and methods of use
EP2931899A1 (en) 2012-12-12 2015-10-21 The Broad Institute, Inc. Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
WO2014093709A1 (en) 2012-12-12 2014-06-19 The Broad Institute, Inc. Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
DK2931897T3 (en) 2012-12-12 2018-02-05 Broad Inst Inc CONSTRUCTION, MODIFICATION AND OPTIMIZATION OF SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTICAL APPLICATIONS
EP3725885A1 (en) 2013-06-17 2020-10-21 The Broad Institute, Inc. Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
MX2015017312A (es) * 2013-06-17 2017-04-10 Broad Inst Inc Suministro y uso de composiciones, vectores y sistemas crispr-cas para la modificación dirigida y terapia hepáticas.
WO2014204724A1 (en) 2013-06-17 2014-12-24 The Broad Institute Inc. Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
KR20250012194A (ko) 2013-06-17 2025-01-23 더 브로드 인스티튜트, 인코퍼레이티드 바이러스 구성성분을 사용하여 장애 및 질환을 표적화하기 위한 crispr-cas 시스템 및 조성물의 전달, 용도 및 치료 적용
EP3011030B1 (en) 2013-06-17 2023-11-08 The Broad Institute, Inc. Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
KR20160019553A (ko) * 2013-06-17 2016-02-19 더 브로드 인스티튜트, 인코퍼레이티드 유사분열 후 세포의 질병 및 장애를 표적화하고 모델링하기 위한 시스템, 방법 및 조성물의 전달, 유전자 조작 및 최적화
JP6793547B2 (ja) 2013-12-12 2020-12-02 ザ・ブロード・インスティテュート・インコーポレイテッド 最適化機能ＣＲＩＳＰＲ−Ｃａｓ系による配列操作のための系、方法および組成物
BR112016013207A2 (pt) * 2013-12-12 2017-09-26 Massachusetts Inst Technology administração, uso e aplicações terapêuticas dos sistemas crispr-cas e composições para o hbv e distúrbios e doenças virais
MX2016007325A (es) 2013-12-12 2017-07-19 Broad Inst Inc Composiciones y metodos de uso de sistemas crispr-cas en desordenes debidos a repeticion de nucleotidos.
EP3080259B1 (en) 2013-12-12 2023-02-01 The Broad Institute, Inc. Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
AU2014361781B2 (en) 2013-12-12 2021-04-01 Massachusetts Institute Of Technology Delivery, use and therapeutic applications of the CRISPR -Cas systems and compositions for genome editing
WO2015089364A1 (en) 2013-12-12 2015-06-18 The Broad Institute Inc. Crystal structure of a crispr-cas system, and uses thereof
EP3889260A1 (en) 2014-12-12 2021-10-06 The Broad Institute, Inc. Protected guide rnas (pgrnas)
WO2016106244A1 (en) 2014-12-24 2016-06-30 The Broad Institute Inc. Crispr having or associated with destabilization domains
WO2016205759A1 (en) 2015-06-18 2016-12-22 The Broad Institute Inc. Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
TWI813532B (zh) 2015-06-18 2023-09-01 美商博得學院股份有限公司 降低脱靶效應的ｃｒｉｓｐｒ酶突變
WO2021158982A2 (en) * 2020-02-07 2021-08-12 University Of Rochester Targeted translation of rna with crispr-cas13 to enhance protein synthesis

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