JP2006510601A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006510601A5 JP2006510601A5 JP2004541625A JP2004541625A JP2006510601A5 JP 2006510601 A5 JP2006510601 A5 JP 2006510601A5 JP 2004541625 A JP2004541625 A JP 2004541625A JP 2004541625 A JP2004541625 A JP 2004541625A JP 2006510601 A5 JP2006510601 A5 JP 2006510601A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- group
- peg
- polyalkylene glycol
- kda
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41442402P | 2002-09-30 | 2002-09-30 | |
| US60/414,424 | 2002-09-30 | ||
| US10/317,092 US20040062748A1 (en) | 2002-09-30 | 2002-12-12 | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
| US10/317,092 | 2002-12-12 | ||
| PCT/US2003/029989 WO2004030617A2 (en) | 2002-09-30 | 2003-09-25 | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011082665A Division JP5603823B2 (ja) | 2002-09-30 | 2011-04-04 | 抗原性が低下したポリマー結合体、その調製方法および使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006510601A JP2006510601A (ja) | 2006-03-30 |
| JP2006510601A5 true JP2006510601A5 (https=) | 2006-12-07 |
| JP5366352B2 JP5366352B2 (ja) | 2013-12-11 |
Family
ID=32033300
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004541625A Expired - Fee Related JP5366352B2 (ja) | 2002-09-30 | 2003-09-25 | 抗原性が低下したポリマー結合体、その調製方法および使用方法 |
| JP2011082665A Expired - Fee Related JP5603823B2 (ja) | 2002-09-30 | 2011-04-04 | 抗原性が低下したポリマー結合体、その調製方法および使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011082665A Expired - Fee Related JP5603823B2 (ja) | 2002-09-30 | 2011-04-04 | 抗原性が低下したポリマー結合体、その調製方法および使用方法 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20040062748A1 (https=) |
| EP (2) | EP2535347A1 (https=) |
| JP (2) | JP5366352B2 (https=) |
| KR (1) | KR101022577B1 (https=) |
| CN (2) | CN1997661B (https=) |
| AU (1) | AU2003275176B8 (https=) |
| BR (1) | BRPI0314831B8 (https=) |
| CA (2) | CA2500389C (https=) |
| CR (1) | CR7776A (https=) |
| DK (1) | DK1572728T3 (https=) |
| EA (1) | EA009122B1 (https=) |
| EC (1) | ECSP055717A (https=) |
| ES (1) | ES2504165T3 (https=) |
| GE (1) | GEP20074016B (https=) |
| HR (1) | HRP20050353B1 (https=) |
| IL (1) | IL167723A (https=) |
| IS (1) | IS2944B (https=) |
| MA (1) | MA27521A1 (https=) |
| MX (1) | MXPA05003394A (https=) |
| NO (1) | NO20052089L (https=) |
| NZ (1) | NZ539133A (https=) |
| PT (1) | PT1572728E (https=) |
| RS (1) | RS20050263A (https=) |
| TW (1) | TWI362942B (https=) |
| WO (1) | WO2004030617A2 (https=) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| US20020065397A1 (en) * | 2000-10-12 | 2002-05-30 | Joseph Roberts | Protecting therapeutic compositions from host-mediated inactivation |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| WO2003103475A2 (en) | 2002-06-07 | 2003-12-18 | Dyax Corp. | Prevention and reduction of blood loss |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| US20060002935A1 (en) * | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
| US20040062748A1 (en) * | 2002-09-30 | 2004-04-01 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
| US8129330B2 (en) | 2002-09-30 | 2012-03-06 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
| EA008866B1 (ru) * | 2002-12-26 | 2007-08-31 | Маунтин Вью Фамэсьютикэлс, Инк. | ПОЛИМЕРНЫЙ КОНЪЮГАТ МОДИФИКАЦИЙ ИНТЕРФЕРОНА-β, ФАРМАЦЕВТИЧЕСКИЕ ПРОДУКТЫ НА ЕГО ОСНОВЕ И СПОСОБ ИХ ПОЛУЧЕНИЯ |
| NZ541122A (en) * | 2002-12-26 | 2008-09-26 | Mountain View Pharmaceuticals | Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity |
| KR20060003862A (ko) | 2003-03-14 | 2006-01-11 | 네오스 테크놀로지스, 인크. | 수용성분기폴리머 및 그 접합체 |
| EP2055189A1 (en) | 2003-04-09 | 2009-05-06 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
| SI1625156T1 (sl) | 2003-05-12 | 2013-02-28 | Affymax, Inc. | Peptidi, ki se veĹľejo k eritropoetinskemu receptorju |
| WO2004100997A2 (en) | 2003-05-12 | 2004-11-25 | Affymax, Inc. | Spacer moiety for poly(ethylene glycol) -modified peptides |
| WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
| PT1663281E (pt) * | 2003-08-29 | 2014-03-17 | Dyax Corp | Inibidores de proteases poli-peguilados |
| US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| US7338933B2 (en) | 2004-01-08 | 2008-03-04 | Neose Technologies, Inc. | O-linked glycosylation of peptides |
| WO2006010143A2 (en) | 2004-07-13 | 2006-01-26 | Neose Technologies, Inc. | Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1] |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| US20080176790A1 (en) | 2004-10-29 | 2008-07-24 | Defrees Shawn | Remodeling and Glycopegylation of Fibroblast Growth Factor (Fgf) |
| US9029331B2 (en) | 2005-01-10 | 2015-05-12 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
| US7365127B2 (en) * | 2005-02-04 | 2008-04-29 | Enzon Pharmaceuticals, Inc. | Process for the preparation of polymer conjugates |
| US20070154992A1 (en) | 2005-04-08 | 2007-07-05 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
| US7858080B2 (en) * | 2005-05-20 | 2010-12-28 | Agency For Science, Technology And Research | Aldehyde conjugated flavonoid preparations |
| EP1891231A4 (en) | 2005-05-25 | 2011-06-22 | Novo Nordisk As | GLYCOPEGYLATED FACTOR IX |
| US7550433B2 (en) | 2005-06-03 | 2009-06-23 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
| EP1996237B1 (en) * | 2006-02-28 | 2010-07-28 | Dr. Reddy's Laboratories (EU) Limited | Method for making polyethylene glycol carbonates |
| WO2007102562A1 (ja) * | 2006-03-01 | 2007-09-13 | Keio University | 新規抗血栓薬 |
| US20080096819A1 (en) * | 2006-05-02 | 2008-04-24 | Allozyne, Inc. | Amino acid substituted molecules |
| EP2444499A3 (en) * | 2006-05-02 | 2012-05-09 | Allozyne, Inc. | Amino acid substituted molecules |
| ES2516694T3 (es) | 2006-07-21 | 2014-10-31 | Ratiopharm Gmbh | Glicosilación de péptidos a través de secuencias de glicosilación con unión en O |
| US8969532B2 (en) | 2006-10-03 | 2015-03-03 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography |
| CA2670618C (en) | 2006-12-15 | 2016-10-04 | Baxter International Inc. | Factor viia- (poly) sialic acid conjugate having prolonged in vivo half-life |
| KR20100016160A (ko) | 2007-04-03 | 2010-02-12 | 바이오제너릭스 에이지 | 글리코페길화 g―csf를 이용하는 치료 방법 |
| WO2008154639A2 (en) | 2007-06-12 | 2008-12-18 | Neose Technologies, Inc. | Improved process for the production of nucleotide sugars |
| CA2707840A1 (en) * | 2007-08-20 | 2009-02-26 | Allozyne, Inc. | Amino acid substituted molecules |
| CA2696208A1 (en) * | 2007-08-21 | 2009-02-26 | Genzyme Corporation | Treatment with kallikrein inhibitors |
| KR101582841B1 (ko) | 2008-02-27 | 2016-01-11 | 노보 노르디스크 에이/에스 | 콘쥬게이트된 인자 viii 분자 |
| CA2744235A1 (en) | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
| CN102497884A (zh) | 2009-07-27 | 2012-06-13 | 巴克斯特国际公司 | 凝血蛋白缀合物 |
| KR101912335B1 (ko) | 2009-07-27 | 2018-10-26 | 리폭센 테크놀로지즈 리미티드 | 비혈액 응고 단백질의 글리코폴리시알화 |
| CN106110311A (zh) | 2009-07-27 | 2016-11-16 | 百深公司 | 凝血蛋白缀合物 |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| EP3459564B1 (en) | 2010-01-06 | 2021-10-27 | Takeda Pharmaceutical Company Limited | Plasma kallikrein binding proteins |
| US9981017B2 (en) | 2010-04-02 | 2018-05-29 | Hanmi Science Co., Ltd. | Insulin conjugate using an immunoglobulin fragment |
| AR081066A1 (es) | 2010-04-02 | 2012-06-06 | Hanmi Holdings Co Ltd | Conjugado de insulina donde se usa un fragmento de inmunoglobulina |
| GB201007356D0 (en) | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIIa |
| CA2821411C (en) | 2010-12-13 | 2020-02-25 | Quiapeg Pharmaceuticals Ab | Functionalized polymers |
| HUE049352T2 (hu) | 2010-12-22 | 2020-09-28 | Baxalta GmbH | Anyagok és módszerek egy vízoldható zsírsavszármazéknak egy fehérjéhez való konjugálására |
| CA2823776A1 (en) | 2011-01-06 | 2012-07-12 | Dyax Corp. | Plasma kallikrein binding proteins |
| JP5949037B2 (ja) | 2011-03-30 | 2016-07-06 | 日油株式会社 | 末端に複数の水酸基を有するポリオキシエチレン誘導体 |
| CA3114356C (en) | 2012-06-12 | 2023-08-22 | Quiapeg Pharmaceuticals Ab | Conjugates of biologically active molecules to functionalized polymers |
| WO2014137161A1 (ko) * | 2013-03-05 | 2014-09-12 | 한미약품 주식회사 | 생리활성 폴리펩타이드 결합체의 고수율 생산을 위한 개선된 제조 방법 |
| IL295414B2 (en) | 2014-03-27 | 2026-02-01 | Takeda Pharmaceuticals Co | Compositions and methods for treating macular edema due to diabetes |
| EP3151796A4 (en) * | 2014-06-04 | 2018-01-10 | Zim Biosciences, Inc. | Compositions and methods for improving skin quality |
| EP3240579B1 (en) | 2014-12-31 | 2022-07-27 | Lantheus Medical Imaging, Inc. | Lipid-encapsulated gas microsphere compositions and related methods |
| AU2016366557B2 (en) | 2015-12-11 | 2024-01-25 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
| MX2018013409A (es) | 2016-05-04 | 2019-07-08 | Lantheus Medical Imaging Inc | Métodos y dispositivos para la preparación de agentes de contraste de ultrasonido. |
| US9789210B1 (en) | 2016-07-06 | 2017-10-17 | Lantheus Medical Imaging, Inc. | Methods for making ultrasound contrast agents |
| EP4011396A1 (en) | 2017-03-10 | 2022-06-15 | QuiaPEG Pharmaceuticals AB | Releasable conjugates |
| AU2019340472A1 (en) | 2018-09-12 | 2021-04-01 | Quiapeg Pharmaceuticals Ab | Releasable GLP-1 conjugates |
| WO2020210750A1 (en) * | 2019-04-10 | 2020-10-15 | University Of Utah Research Foundation | Macromolecular and nonparticulate agrochemicals to reduce vapor drift |
| CN110376369B (zh) * | 2019-07-30 | 2022-02-15 | 重庆派金生物科技有限公司 | 一种抗聚乙二醇抗体的抗原区免疫原性分析方法 |
| US12508251B2 (en) | 2019-10-29 | 2025-12-30 | National University Corporation Kumamoto University; | CD4 mimic compound with anti-HIV activity |
| US12528880B2 (en) | 2020-01-13 | 2026-01-20 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack |
| BR112023005246A2 (pt) * | 2020-09-23 | 2023-04-25 | Ablevia Biotech Gmbh | Composto para o sequestro de anticorpos anti-peg indesejáveis em um paciente |
| CN114392237B (zh) * | 2021-12-28 | 2024-02-02 | 上海允英生物医药科技有限公司 | 一种冻干病毒制剂及其制备方法 |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2433883C2 (de) * | 1973-07-20 | 1986-03-27 | Research Corp., New York, N.Y. | Verwendung von physiologisch aktiven Polypeptiden |
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4002531A (en) * | 1976-01-22 | 1977-01-11 | Pierce Chemical Company | Modifying enzymes with polyethylene glycol and product produced thereby |
| GB1578348A (en) * | 1976-08-17 | 1980-11-05 | Pharmacia Ab | Products and a method for the therapeutic suppression of reaginic antibodies responsible for common allergic |
| JPS5599189A (en) | 1979-01-22 | 1980-07-28 | Mihama Hisaharu | Modified uricase free from antigenicity and its preparation |
| US4399282A (en) * | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
| US4902506A (en) * | 1983-07-05 | 1990-02-20 | The University Of Rochester | Immunogenic conjugates |
| US4434228A (en) * | 1982-04-20 | 1984-02-28 | Genex Corporation | Immobilization of biological materials in condensed polyalkyleneimine polymers |
| EP0098110B1 (en) * | 1982-06-24 | 1989-10-18 | NIHON CHEMICAL RESEARCH KABUSHIKI KAISHA also known as JAPAN CHEMICAL RESEARCH CO., LTD | Long-acting composition |
| US4917888A (en) * | 1985-06-26 | 1990-04-17 | Cetus Corporation | Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation |
| US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US4904582A (en) * | 1987-06-11 | 1990-02-27 | Synthetic Genetics | Novel amphiphilic nucleic acid conjugates |
| IE64284B1 (en) | 1987-08-03 | 1995-07-26 | Ddi Pharmaceuticals | Conjugates of superoxide dismutase |
| US5006333A (en) * | 1987-08-03 | 1991-04-09 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
| US5080891A (en) * | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
| US4943579A (en) * | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
| US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
| JP2958019B2 (ja) * | 1988-05-06 | 1999-10-06 | 住友製薬株式会社 | ポリエチレングリコール誘導体、修飾ペプチドおよびその製造方法 |
| US6132763A (en) * | 1988-10-20 | 2000-10-17 | Polymasc Pharmaceuticals Plc | Liposomes |
| US5324844A (en) * | 1989-04-19 | 1994-06-28 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| US5286637A (en) * | 1989-08-07 | 1994-02-15 | Debiopharm, S.A. | Biologically active drug polymer derivatives and method for preparing same |
| US5013556A (en) * | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US6552170B1 (en) * | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| US5766897A (en) * | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| US5252714A (en) * | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
| US5364612A (en) * | 1991-05-06 | 1994-11-15 | Immunomedics, Inc. | Detection of cardiovascular lesions |
| ZA933926B (en) * | 1992-06-17 | 1994-01-03 | Amgen Inc | Polyoxymethylene-oxyethylene copolymers in conjuction with blomolecules |
| US5395619A (en) * | 1993-03-03 | 1995-03-07 | Liposome Technology, Inc. | Lipid-polymer conjugates and liposomes |
| US6326353B1 (en) * | 1993-03-23 | 2001-12-04 | Sequus Pharmaceuticals, Inc. | Enhanced circulation effector composition and method |
| US6180134B1 (en) * | 1993-03-23 | 2001-01-30 | Sequus Pharmaceuticals, Inc. | Enhanced ciruclation effector composition and method |
| CA2163232A1 (en) * | 1993-05-20 | 1994-12-08 | Robert C. Brasch | Macromolecular contrast media for mr imaging |
| US5621039A (en) * | 1993-06-08 | 1997-04-15 | Hallahan; Terrence W. | Factor IX- polymeric conjugates |
| WO1995000162A1 (en) * | 1993-06-21 | 1995-01-05 | Enzon, Inc. | Site specific synthesis of conjugated peptides |
| AU8052194A (en) * | 1993-10-20 | 1995-05-08 | Enzon, Inc. | 2'- and/or 7- substituted taxoids |
| US5880131A (en) * | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5965566A (en) * | 1993-10-20 | 1999-10-12 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5824701A (en) * | 1993-10-20 | 1998-10-20 | Enzon, Inc. | Taxane-based prodrugs |
| US5840900A (en) * | 1993-10-20 | 1998-11-24 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5919455A (en) * | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5643575A (en) * | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| KR960705579A (ko) | 1993-11-10 | 1996-11-08 | 에릭에스. 딕커 | 개선된 인터페론 중합체 결합체(Improved interferon polymer conjugates) |
| US5951974A (en) * | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
| US5730990A (en) * | 1994-06-24 | 1998-03-24 | Enzon, Inc. | Non-antigenic amine derived polymers and polymer conjugates |
| US5738846A (en) * | 1994-11-10 | 1998-04-14 | Enzon, Inc. | Interferon polymer conjugates and process for preparing the same |
| US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US5672662A (en) * | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| US5728560A (en) * | 1996-06-14 | 1998-03-17 | Enzon, Inc. | Method of treating CD4+ T cell lymphopenia in immuno-compromised patients |
| US5804183A (en) * | 1997-01-31 | 1998-09-08 | Enzon, Inc. | Arginine deminase derived from mycoplasma arthritidis and polymer conjugates containing the same |
| WO1998035026A1 (en) * | 1997-02-06 | 1998-08-13 | Novo Nordisk A/S | Polypeptide-polymer conjugates having added and/or removed attachment groups |
| EP0981548A4 (en) * | 1997-04-30 | 2005-11-23 | Enzon Inc | GLYCOSYLATABLE SINGLE CHAIN ANTIGEN-BINDING PROTEINS, MANUFACTURE AND USE THEREOF |
| US5990237A (en) * | 1997-05-21 | 1999-11-23 | Shearwater Polymers, Inc. | Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines |
| US5900402A (en) * | 1997-05-29 | 1999-05-04 | Enzon, Inc. | Method of reducing side effects associated with administration of oxygen-carrying proteins |
| US6011042A (en) * | 1997-10-10 | 2000-01-04 | Enzon, Inc. | Acyl polymeric derivatives of aromatic hydroxyl-containing compounds |
| US6448369B1 (en) * | 1997-11-06 | 2002-09-10 | Shearwater Corporation | Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation |
| US6180095B1 (en) * | 1997-12-17 | 2001-01-30 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| US5981709A (en) * | 1997-12-19 | 1999-11-09 | Enzon, Inc. | α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same |
| US5965119A (en) * | 1997-12-30 | 1999-10-12 | Enzon, Inc. | Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents |
| US6239262B1 (en) * | 1998-01-07 | 2001-05-29 | Rensselaer Polytechnic Institute | Low molecular weight displacers for protein purification in hydrophobic interaction and reversed phase chromatographic systems |
| US5880225A (en) * | 1998-02-18 | 1999-03-09 | Arco Chemical Technology, L.P. | Process for making polyetherester resins having high aromatic diester |
| US6783965B1 (en) | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
| ES2245114T3 (es) | 1998-08-06 | 2005-12-16 | Mountain View Pharmaceuticals, Inc. | Conjugados de peg-oxidasa de urato y su uso. |
| PL202799B1 (pl) | 1998-08-06 | 2009-07-31 | Mountain View Pharmaceuticals | Sposób izolowania urykazy w postaci tetramerycznej oraz wyizolowana tetrameryczna urykaza |
| US6552167B1 (en) | 1998-08-28 | 2003-04-22 | Gryphon Therapeutics, Inc. | Polyamide chains of precise length |
| DK1656952T3 (da) * | 1998-10-16 | 2014-01-20 | Biogen Idec Inc | Polyalkylenglycolkonjugater af interferon beta-1A og anvendelser deraf |
| GB9822963D0 (en) | 1998-10-20 | 1998-12-16 | Agner Erik | Improvements in or relating to chromatography |
| US6596849B1 (en) | 1999-05-28 | 2003-07-22 | Academia Sinica | Monoclonal-antibody for analysis and clearance of polyethylene glycol and polyethylene glycol-modified molecules |
| CN1284603C (zh) | 1999-10-08 | 2006-11-15 | 内科塔治疗亚拉巴马公司 | 杂双官能聚乙二醇衍生物和它们的制备方法 |
| US6638906B1 (en) * | 1999-12-13 | 2003-10-28 | Nobex Corporation | Amphiphilic polymers and polypeptide conjugates comprising same |
| US6639493B2 (en) | 2001-03-30 | 2003-10-28 | Arizona State University | Micro machined RF switches and methods of operating the same |
| AU2002345938A1 (en) * | 2001-06-28 | 2003-03-03 | Mountain View Pharmaceuticals, Inc. | Polymer stabilized proteinases |
| US6913915B2 (en) * | 2001-08-02 | 2005-07-05 | Phoenix Pharmacologics, Inc. | PEG-modified uricase |
| EP1498420B1 (en) * | 2002-03-29 | 2017-02-01 | Nof Corporation | Phospholipid derivative |
| US20040062748A1 (en) * | 2002-09-30 | 2004-04-01 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
-
2002
- 2002-12-12 US US10/317,092 patent/US20040062748A1/en not_active Abandoned
-
2003
- 2003-09-25 CA CA2500389A patent/CA2500389C/en not_active Expired - Lifetime
- 2003-09-25 NZ NZ539133A patent/NZ539133A/en not_active IP Right Cessation
- 2003-09-25 BR BRPI0314831A patent/BRPI0314831B8/pt not_active IP Right Cessation
- 2003-09-25 RS YUP-2005/0263A patent/RS20050263A/sr unknown
- 2003-09-25 CN CN038248565A patent/CN1997661B/zh not_active Expired - Lifetime
- 2003-09-25 GE GEAP20038766A patent/GEP20074016B/en unknown
- 2003-09-25 HR HRP20050353AA patent/HRP20050353B1/hr not_active IP Right Cessation
- 2003-09-25 CN CNA038248565A patent/CN1997661A/zh active Granted
- 2003-09-25 CA CA2836959A patent/CA2836959C/en not_active Expired - Lifetime
- 2003-09-25 EP EP12183751A patent/EP2535347A1/en not_active Withdrawn
- 2003-09-25 AU AU2003275176A patent/AU2003275176B8/en not_active Ceased
- 2003-09-25 KR KR1020057005504A patent/KR101022577B1/ko not_active Expired - Fee Related
- 2003-09-25 DK DK03759445.4T patent/DK1572728T3/da active
- 2003-09-25 WO PCT/US2003/029989 patent/WO2004030617A2/en not_active Ceased
- 2003-09-25 MX MXPA05003394A patent/MXPA05003394A/es active IP Right Grant
- 2003-09-25 PT PT37594454T patent/PT1572728E/pt unknown
- 2003-09-25 JP JP2004541625A patent/JP5366352B2/ja not_active Expired - Fee Related
- 2003-09-25 EA EA200500519A patent/EA009122B1/ru not_active IP Right Cessation
- 2003-09-25 EP EP03759445.4A patent/EP1572728B1/en not_active Expired - Lifetime
- 2003-09-25 ES ES03759445.4T patent/ES2504165T3/es not_active Expired - Lifetime
- 2003-09-30 TW TW092127073A patent/TWI362942B/zh not_active IP Right Cessation
-
2005
- 2005-03-29 IL IL167723A patent/IL167723A/en active IP Right Grant
- 2005-03-29 CR CR7776A patent/CR7776A/es unknown
- 2005-03-30 IS IS7778A patent/IS2944B/is unknown
- 2005-04-05 EC EC2005005717A patent/ECSP055717A/es unknown
- 2005-04-28 NO NO20052089A patent/NO20052089L/no not_active Application Discontinuation
- 2005-04-29 MA MA28243A patent/MA27521A1/fr unknown
-
2011
- 2011-04-04 JP JP2011082665A patent/JP5603823B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5366352B2 (ja) | 抗原性が低下したポリマー結合体、その調製方法および使用方法 | |
| JP2006510601A5 (https=) | ||
| US8129330B2 (en) | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof | |
| EP3313527B1 (en) | Anticancer drug-containing plant virus particles | |
| US20040092449A1 (en) | Amphiphilic polymers and polypeptide conjugates comprising same | |
| JP2002508400A (ja) | アミノ及びヒドロキシル含有生物活性剤のポリマープロドラッグ | |
| EA008866B1 (ru) | ПОЛИМЕРНЫЙ КОНЪЮГАТ МОДИФИКАЦИЙ ИНТЕРФЕРОНА-β, ФАРМАЦЕВТИЧЕСКИЕ ПРОДУКТЫ НА ЕГО ОСНОВЕ И СПОСОБ ИХ ПОЛУЧЕНИЯ | |
| JP2022058911A (ja) | 非血液凝固タンパク質の糖ポリシアル酸化 | |
| JP6876618B2 (ja) | 治療目的のための抗体−ウレアーゼコンジュゲート | |
| JP2022502392A (ja) | 経口剤形の製造方法 | |
| JP2006521372A (ja) | 生物学的活性物質と生体適合性高分子の1:1接合体、この製造方法とこれを含む薬学組成物 | |
| HK1083190B (en) | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof | |
| ZA200502707B (en) | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |