JP2006500022A - 誘導可能な局所接着キナーゼ細胞アッセイ - Google Patents

誘導可能な局所接着キナーゼ細胞アッセイ Download PDF

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Publication number
JP2006500022A
JP2006500022A JP2004537413A JP2004537413A JP2006500022A JP 2006500022 A JP2006500022 A JP 2006500022A JP 2004537413 A JP2004537413 A JP 2004537413A JP 2004537413 A JP2004537413 A JP 2004537413A JP 2006500022 A JP2006500022 A JP 2006500022A
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Prior art keywords
fak
cell
cells
protein
phosphorylation
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JP2004537413A
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English (en)
Japanese (ja)
Inventor
ロバーツ，ウォルター・グレゴリー
ホエーレン，パメラ・マシューズ
アング，イーサン・ジェームズ・テクリー
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ファイザー・プロダクツ・インク
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Publication of JP2006500022A publication Critical patent/JP2006500022A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2004537413A 2002-09-19 2003-09-08 誘導可能な局所接着キナーゼ細胞アッセイ Pending JP2006500022A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41207802P 2002-09-19 2002-09-19
PCT/IB2003/003968 WO2004027018A2 (en) 2002-09-19 2003-09-08 Inducible focal adhesion kinase cell assay

Publications (1)

Publication Number Publication Date
JP2006500022A true JP2006500022A (ja) 2006-01-05

Family

ID=32030798

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004537413A Pending JP2006500022A (ja) 2002-09-19 2003-09-08 誘導可能な局所接着キナーゼ細胞アッセイ

Country Status (9)

Country Link
EP (1) EP1546372A4 (no)
JP (1) JP2006500022A (no)
KR (1) KR20050052663A (no)
CN (1) CN1681939A (no)
AU (1) AU2003259498A1 (no)
CA (1) CA2497434A1 (no)
NO (1) NO20051869L (no)
RU (1) RU2005107701A (no)
WO (1) WO2004027018A2 (no)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010511892A (ja) * 2006-12-07 2010-04-15 ソウル ナショナル ユニバーシティ インダストリー ファウンデーション Ｔｍ４ｓｆ５の機能を阻害する抗がん物質のスクリーニング方法及びカルコン系の化合物を含有する抗がん用組成物

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009046129A2 (en) * 2007-10-01 2009-04-09 Columbia University Methods for treating adult respiratory distress syndrome
CN109112213B (zh) * 2017-06-22 2021-01-12 中国科学院动物研究所 检测黏着斑激酶结构变异体的pcr引物及其检测方法与应用
KR102007450B1 (ko) 2018-05-31 2019-08-05 한국과학기술연구원 대장암 치료제 발굴을 위한 신규 표적 치료 작용점의 스크리닝 방법 및 이를 이용하여 선별한 대장암 치료 예후 바이오마커
KR102408538B1 (ko) * 2020-10-29 2022-06-15 한국과학기술연구원 Fak 활성 억제제를 스크리닝하기 위한 조성물, 키트 및 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395506B1 (en) * 1991-04-18 2002-05-28 Becton, Dickinson And Company Device for monitoring cells
JP2001505779A (ja) * 1996-12-11 2001-05-08 スージェン・インコーポレーテッド Ｐｙｋ２関連産物および方法
US20010055585A1 (en) * 1997-12-03 2001-12-27 William G. Cance Frnk proteins in the treatment of tumor cells
US6133031A (en) * 1999-08-19 2000-10-17 Isis Pharmaceuticals Inc. Antisense inhibition of focal adhesion kinase expression

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010511892A (ja) * 2006-12-07 2010-04-15 ソウル ナショナル ユニバーシティ インダストリー ファウンデーション Ｔｍ４ｓｆ５の機能を阻害する抗がん物質のスクリーニング方法及びカルコン系の化合物を含有する抗がん用組成物
JP4932005B2 (ja) * 2006-12-07 2012-05-16 ソウル ナショナル ユニバーシティ インダストリー ファウンデーション Ｔｍ４ｓｆ５の機能を阻害する抗がん物質のスクリーニング方法及びカルコン系の化合物を含有する抗がん用組成物

Also Published As

Publication number Publication date
CN1681939A (zh) 2005-10-12
NO20051869L (no) 2005-06-16
EP1546372A4 (en) 2006-08-23
KR20050052663A (ko) 2005-06-03
EP1546372A2 (en) 2005-06-29
RU2005107701A (ru) 2005-08-27
CA2497434A1 (en) 2004-04-01
NO20051869D0 (no) 2005-04-18
WO2004027018A3 (en) 2004-09-16
AU2003259498A1 (en) 2004-04-08
WO2004027018A2 (en) 2004-04-01

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