JP2006130055A - Cryotherapy apparatus by peltier module/element and temperature control method for cryotherapy by peltier module/element - Google Patents

Cryotherapy apparatus by peltier module/element and temperature control method for cryotherapy by peltier module/element Download PDF

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JP2006130055A
JP2006130055A JP2004322309A JP2004322309A JP2006130055A JP 2006130055 A JP2006130055 A JP 2006130055A JP 2004322309 A JP2004322309 A JP 2004322309A JP 2004322309 A JP2004322309 A JP 2004322309A JP 2006130055 A JP2006130055 A JP 2006130055A
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cryotherapy
surface
temperature
temperature control
peltier
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JP4324673B2 (en
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Setsuya Aiba
Shigenao Maruyama
Tomoyuki Yamaya
圓山重直
山家智之
相場節也
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Tohoku Univ
国立大学法人東北大学
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Abstract

<P>PROBLEM TO BE SOLVED: To provide a cryotherapy apparatus necrotizing and ablating various types of skin tumors and a lesion part such as a pigmented lesion by controlling the temperature for rapidly cooling and heating an affected part using a Peltier module and to provide a temperature control method therefor. <P>SOLUTION: The cryotherapy apparatus uses a commercially available Peltier module 1 which is easily manufactured at a low cost compared with a Peltier element difficult to be manufactured. The cryotherapy apparatus manufactured easily and having a relatively large cooling area is thus attained to provide an effect of effectively perform the cryotherapy for the skin. The therapy for improving the necrosis rate of a skin affected part can be effectively performed by repeatedly thawing the frozen affected part and refreezing it. A heat sink 5 is cooled by liquid nitrogen 9 so as to improve the cooling speed of the Peltier module 1, and carbon dioxide filling a clearance part in a double container is sublimated to obtain a vacuum heat insulation effect and reduce the thickness for the heat insulation. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

本発明は、ペルチェモジュールを用いて患部を急速冷却および急速加熱の温度制御をすることによって皮膚癌または疣、痣、シミ等の病変部を壊死させ切除する凍結治療装置およびその温度制御方法に関する。 The present invention, skin cancer or warts by the temperature control of rapid cooling and rapid heating the affected area using a Peltier module, bruises, relates cryotherapy device and a temperature control method for excision is necrotic lesions of a stain.

冷凍療法は、皮膚の種々の良性、悪性腫瘍、色素性病変に対して皮膚科外来で日常的に行われている治療である。 Cryotherapy is a variety of benign, malignant tumor, treatment that is routinely performed in dermatology foreign to the pigmented lesions of the skin. 冷凍療法は、患者に与える苦痛が少ない、液体窒素があれば容易に行えるなどの利点があるが、その反面、現在行われている冷凍療法は、外科的切除、レーザー療法と異なり、凍結範囲を3次元的に制御することは不可能で、もっぱら術者の経験と感により調節されている。 Cryotherapy is less painful to the patient, there are advantages such as easily performed if there is liquid nitrogen, on the other hand, cryotherapy being currently performed, surgical resection, unlike laser therapy, freezing range 3-dimensionally controlled to impossible, it is regulated by experience and sense of solely surgeon. 従って、しばしば、不必要に周囲の正常組織を冷凍し結果的に水疱を形成して患者に苦痛を与えたり、また、治療が不十分で目的とする腫瘍の治療が不十分であったりする。 Therefore, often, or give pain to the patient to form a frozen resulting in blistering unnecessarily the surrounding normal tissue, also, the treatment of tumors and treatment is insufficient purpose or insufficient. そのため、この治療範囲を制御できる凍結療法の有用性は極めて大きい。 Therefore, the usefulness of cryotherapy that can control this therapeutic range is very large.

かかる問題を解決するために、p型とn型の単体のペルチェ半導体と電極で構成されるペルチェ素子を用いた微小温度制御装置が開発され、皮膚科治療に用いられようとしている。 To solve these problems, fine temperature control device using a configured Peltier element in a single Peltier semiconductor and the electrode of the p-type and n-type have been developed, it is about to be used in dermatology treatment. 例えば、特許文献1では、電極とヒートシンクを一体化することによりコンパクトな凍結治療装置が達成され、特許文献2では、ペルチェ素子を用いた凍結治療装置先端の形状を変えることによってより小さな領域の温度制御を可能としている。 For example, Patent Document 1, a compact cryotherapy device is achieved by integrating the electrode and the heat sink, in Patent Document 2, the temperature of the smaller areas by changing the shape of the cryotherapy device tip with Peltier elements thereby making it possible to control. さらに、非特許文献1では、冷媒に固形二酸化炭素つまりドライアイスを用いて、ペルチェ素子を用いた凍結治療装置のヒートシンクを冷却している。 Further, Non-Patent Document 1, by using a solid carbon dioxide, that dry ice refrigerant to cool the heat sink cryotherapy device using a Peltier element.

かかる技術では、微小領域の冷却制御が可能となったが、温度制御部にペルチェ半導体を組み込んだペルチェ素子を使用しているために、装置の製作が難しく、製品の価格も高い欠点があった。 In such techniques, but enables cooling control of the minute region, due to the use of Peltier elements incorporating Peltier semiconductor temperature controller, fabrication of the device it is difficult, there is the price of the product is also high defect . また、冷媒にドライアイス等を用いる場合、皮膚科の医院でドライアイスを保存するための経費がかかる欠点があった。 In the case of using dry ice or the like in the refrigerant, there is a consuming drawback expenses for storing the dry ice in clinic dermatology.
特開2002−177296 公報 JP 2002-177296 Laid 特開2004−261210 公報 JP 2004-261210 Laid

これまでの凍結療法は、綿球にしみこませた液体窒素、液体窒素で冷やした金属、あるいは、液体窒素のスプレーなどの凍結範囲を制御できない治療方法であった。 Previously cryotherapy is liquid nitrogen soaked cotton balls, metal cooled with liquid nitrogen, or a method for treatment of uncontrolled freezing range such spray liquid nitrogen. そのため、過度な冷凍、また、不十分な冷凍による治療がしばしばなされている。 Therefore, excessive refrigeration, also treatment with inadequate refrigeration are often made. また、術者の毎の個人差、また、同一術者でも治療毎の凍結強度の変化が避けられない。 In addition, individual differences of each of the operator, also, can not be avoided change of frozen intensity for each treatment be the same surgeon. ペルチェ素子を用いた凍結装置は、電流の強さ、冷却時間を制御することにより凍結範囲を制御することが可能であり、また、この2つのパラメーターを一定にすることにより術者間の差、治療毎の差も生じない治療が可能となる。 Freeze device using a Peltier element, the current intensity, it is possible to control the freezing range by controlling the cooling time, also, the difference between the operator by the two parameters constant, treatment that does not occur the difference of each treatment is possible. また、ペルチェ素子を用いた凍結治療装置は微小領域の冷凍治療には適しているが、装置の構造と製作が困難で装置価格が高価になる問題があった。 Further, cryotherapy device using the Peltier element is suitable for freezing the treatment of small areas, there is a problem that the structure and fabrication of the device difficult and apparatus cost becomes expensive.

一方、皮膚科治療においては、直径5mm程度の領域以上の冷凍治療を行う必要があり、必ずしも、極微細領域の冷凍治療が必要でない。 On the other hand, in the dermatological treatment, it is necessary to perform a refrigeration treatment or region having a diameter of about 5 mm, not necessarily require refrigeration treatment of extremely fine region.

本発明は、従来のペルチェ素子を用いる凍結治療装置を簡便化し、市販のペルチェモジュールを使用した実用性の高い皮膚治療を目的とする凍結治療装置およびその温度制御方法を提供することを目的としている。 The present invention is to simplify the cryotherapy device using a conventional Peltier element, and its object is to provide a cryotherapy device and a temperature control method for the purpose of highly practical skin treatment using commercially available Peltier module .

本発明によれば、少なくとも2つの面である第11面と第12面を持ち前記第11面が凍結治療対象物に接触する先端チップと、少なくとも2つの面である第21面と第22面を持つペルチェモジュールと、前記ペルチェモジュールを低温に保つヒートシンクと、前記ペルチェモジュールの通電電流を逆転制御するパワーモジュールと、前記ペルチェモジュールの温度を制御する温度制御コンピュータ、とで構成され、前記第12面と前記第21面が接触し、前記第22面と前記ヒートシンクとが接触するよう配置されることを特徴とする凍結治療装置が得られる。 According to the present invention, the distal tip of the having the eleventh surface and the twelfth surface is at least two faces eleventh surface is in contact with cryotherapy object 21 surface and the surface 22 is at least two surfaces a Peltier module with a heat sink to keep the Peltier module to the cold, and the power module to reverse control energization current of the Peltier module, temperature control computer for controlling the temperature of the Peltier module is composed of city, the first 12 contacting the surface and the second 21 surface, cryotherapy device is obtained, wherein the first 22 surface and said heat sink is placed in contact.

本発明によれば、前記温度制御コンピュータが前記パワーモジュールの通電電流逆転制御を複数回可逆的に制御できるよう構成したことを特徴とする凍結治療装置が得られる。 According to the present invention, cryotherapy device is obtained, wherein the temperature control computer is configured to allow multiple reversibly control the energization current reversal control of the power module.

本発明によれば、少なくとも2つの面である第311面と第312面を持ち前記第311面が凍結治療対象物に接触する先端チップと、少なくとも2つの面である第321面と第322面を持つペルチェ素子と、前記ペルチェモジュールを低温に保つヒートシンク、と前記ペルチェ素子の通電電流を逆転制御するパワーモジュールと、前記ペルチェ素子の温度を制御する温度制御コンピュータ、とで構成され、前記第312面と前記第321面が接触し、前記第322面と前記ヒートシンクとが接触するよう配置されることを特徴とする凍結治療装置が得られる。 According to the present invention, the distal tip of the having a first 311 surface and a 312 plane which is at least two faces # 311 surface comes into contact with cryotherapy object # 321 surface and the surface No. 322 of at least two surfaces a Peltier element having a heat sink to keep the Peltier module to the low temperature, and the a power module to reverse controls energization current of the Peltier element, temperature control computer for controlling the temperature of the Peltier element, is composed of a city, the first 312 contacting the surface with the first 321 surface, cryotherapy device is obtained, wherein the first 322 surface and said heat sink is placed in contact.

本発明によれば、前記温度制御コンピュータが前記パワーモジュールの通電電流逆転制御を複数回可逆的に制御できるよう構成したことを特徴とする請求項3記載の凍結治療装置が得られる。 According to the present invention, cryotherapy device according to claim 3, characterized in that the temperature control computer is configured to allow multiple reversibly control the energization current reversal control of the power module is obtained.

本発明によれば、前記ヒートシンクの冷却を液体窒素で行う事を特徴とする請求項1乃至4の内一に記載の凍結治療装置が得られる。 According to the present invention, cryotherapy device according to one of claims 1 to 4, characterized in that for cooling of the heat sink with liquid nitrogen can be obtained.

本発明によれば、前記焼却装置全体を、密封容器による2重容器構造とし、2重容器隙間部に乾燥二酸化炭素を充填したことを特徴とする凍結治療装置が得られる。 According to the present invention, the entire incinerator, a double container structure by a sealed container, cryotherapy device is obtained, characterized in that filled with dry carbon dioxide double container clearance.

本発明によれば、前記ペルチェモジュールによる凍結治療装置において、前記ペルチェモジュールを加熱状態に制御し、前記21面および前記12面を通して前記第11面を常温に保つ第1ステップと、前記ペルチェモジュールの通電電流の流れを前記第1ステップと逆転させる第2ステップと、前記ヒートシンクの熱を前記第22面と前記第21面ならびに前記第12面を介し前記第11面に伝え、前期凍結治療対象物を急速冷却することを特徴とする凍結治療温度制御方法が得られる。 According to the present invention, in the cryotherapy device according to the Peltier module, and controls the Peltier module in a heated state, a first step of keeping the eleventh surface to normal temperature through the 21 surface and the twelfth surface, the Peltier module a second step of reversing the flow of electric current between said first step, the heat of the heat sink through the first 21 surface and the twelfth surface and the second 22 surface communicated to the eleventh surface, year cryotherapy object cryotherapy temperature control method characterized by rapidly cooling the obtained.

本発明によれば、前記凍結治療対象物が人体の疾患であり、前記急速冷却は、人体の疾患の凍結であることを特徴とする凍結治療温度制御方法が得られる。 According to the present invention, the cryotherapy object is a disease of the human body, the rapid cooling, cryotherapy temperature control method which is a frozen human disease can be obtained.

本発明によれば、前記ペルチェモジュールによる凍結治療装置において、第11面を常温あるいは体温に保つ第1の状態と、次にヒートシンクの熱を第11面に伝え第11面をほぼヒートシンクの温度状態にする第2の状態、とを複数回繰り返すことを特徴とする凍結治療温度制御方法が得られる。 According to the present invention, in the cryotherapy device according to the Peltier module, the first state keeping the eleventh surface at room temperature or body temperature, then approximately the temperature condition of the heat sink 11 face convey a heat sink of heat eleventh surface a second state, cryotherapy temperature control method characterized by repeating several times the city to be obtained.

本発明によれば、前記ペルチェモジュールによる凍結治療装置において前記人体の疾患が凍結した後で、前記第11面の冷却時間と温度とを調節し、人体の凍結領域の大きさと深さを制御する事を特徴とする凍結治療温度制御方法が得られる。 According to the present invention, after the body of the disease has been frozen in the freezing treatment apparatus according to the Peltier module, to adjust the cooling time and temperature of the eleventh surface, to control the size and depth of the body of the freeze area cryotherapy temperature control method according to claim things are obtained.

本発明によれば、前記第11面を前記人体の疾患患部に接触させた状態で、前記第1の状態と前記第2の状態を複数回繰り返し患部細胞の壊死率を向上させることを特徴とする凍結治療温度制御方法が得られる。 According to the present invention, in a state where the eleventh surface is brought into contact with the human body disease affected area, and features to improve the necrosis factor of several times repeated diseased cells the first state and the second state cryotherapy temperature control method for obtain.

本発明によれば、前記ペルチェ素子による凍結治療装置において、前記ペルチェ素子を加熱状態に制御し、前記322面および前記312面を通して前記第311面を常温に保つ第31ステップと、前記ペルチェ素子の通電電流の流れを前記第31ステップと逆転させる第32ステップと、前記ヒートシンクの熱を前記第322面と前記第321面ならびに前記第312面を介し前記第311面に伝え、前期凍結治療対象物を急速冷却することを特徴とする凍結治療温度制御方法が得られる。 According to the present invention, in the cryotherapy device according to the Peltier device, and controls the Peltier element in a heated state, and the 31 steps to keep the first 311 plane to normal temperature through the 322 surface and the 312 plane, of the Peltier element a 32nd step of reversing the flow of the energizing current and the second 31 step, the heat of the heat sink through the first 321 surface and the second 312 surface and the second 322 surface communicated to the first 311 plane, year cryotherapy object cryotherapy temperature control method characterized by rapidly cooling the obtained.

本発明によれば、前記凍結治療対象物が人体の疾患であり、前記急速冷却は、人体の疾患の凍結であることを特徴とする請求項12記載の凍結治療温度制御方法が得られる。 According to the present invention, the cryotherapy object is a disease of the human body, the rapid cooling, cryotherapy temperature control method according to claim 12, wherein it is a freezing of human disease can be obtained.
本発明によれば、前記ペルチェ素子による凍結治療装置において、第311面を常温あるいは体温に保つ第31の状態と、次にヒートシンクの熱を第311面に伝える第311面をほぼヒートシンクの温度状態にする第32の状態とを複数回繰り返すことを特徴とする凍結治療温度制御方法が得られる。 According to the present invention, in the cryotherapy device according to the Peltier device, and the 31 state to keep the first 311 plane at room temperature or body temperature, then approximately the temperature condition of the heat sink to the 311 plane to convey a heat sink of the heat to the 311 plane 32 cryotherapy temperature control method and repeating state and a plurality of times to obtain.

本発明によれば、前記ペルチェ素子による凍結治療装置において、前記人体の疾患が凍結した後で、前記第311面の冷却時間と温度とを調節し、人体の凍結領域の大きさと深さを制御する事を特徴とする凍結治療温度制御方法が得られる。 According to the present invention, in the cryotherapy device according to the Peltier device, after the human body disease was frozen, to adjust the cooling time and temperature of the first 311 plane, controlling the size and depth of the body of the freeze area cryotherapy temperature control method characterized in that it is obtained.
本発明によれば、前記第311面を前記人体の疾患患部に接触させた状態で、前記第31の状態と前記第32の状態を複数回繰り返し患部細胞の壊死率を向上させることを特徴とする凍結治療温度制御方法が得られる。 According to the present invention, in the state in which the first 311 plane is brought into contact with the human body disease affected area, and characterized in that to improve the 31st state necrosis factor of claim 32 a plurality of times repeatedly diseased cells the state of the cryotherapy temperature control method for obtain.

本発明によれば、前記第11面あるいは第311面の近傍に温度センサーを設定し、当該面の温度をモニターしながら、前記温度制御コンピュータで前記パワーモジュールの制御を行う事を特徴とする凍結治療温度制御方法が得られる。 According to the present invention, freezing of the eleventh surface or to set the temperature sensor in the vicinity of the 311 plane, while monitoring the temperature of the surface, and wherein the performing control of the power module by the temperature control computer treatment temperature control method is obtained.

本発明によれば、製作の難しいペルチェ素子に比べて製作が容易で安価な市販のペルチェモジュールを使用するので製作が容易で冷却面積が比較的大きい凍結治療装置が達成され、有効に皮膚の凍結治療を行うことが出来るという効果が得られる。 According to the present invention, easy and cooling area manufacture is relatively large cryotherapy device is achieved since fabrication uses easy and inexpensive commercially available Peltier module compared to hard Peltier device fabrication, Effective skin frozen the effect is obtained that it is possible to perform the treatment. また、凍結患部を解凍したり、再凍結を繰り返したりすることにより、標的病変における細胞壊死率を向上させることが可能となる。 Also, or thawed frozen diseased part, by or repeatedly refreezing, it is possible to improve the cell necrosis factor in the target lesion.

また、ヒートシンクを液体窒素で冷却することによって、ペルチェモジュールの冷却速度を向上させるとともに、二重容器隙間部に充填させた二酸化炭素を昇華させ真空断熱効果を得ることが出来、断熱厚さを減少できる効果がある。 Further, by cooling the heat sink with liquid nitrogen, improves the cooling rate of the Peltier module, it is possible to obtain a vacuum heat insulation effect sublimed carbon dioxide was filled to double container gap portions, decreasing the insulation thickness there can be effectively.

以下、本発明の実施の形態について図面を参照しながら説明する。 It will be described below with reference to the drawings, embodiments of the present invention.
図1は本発明の実施の形態による、通常断熱材を用いた凍結治療装置の概略構成を示す図である。 1 according to an embodiment of the present invention, it is a diagram showing a schematic configuration of a cryotherapy device using a conventional insulation. 図1を参照すると、ペルチェモジュール1が熱伝導生の良いアルミニウムや銅などで製作される先端チップ2と熱伝導の良い金属で製作されたヒートシンク5に挟まれている。 Referring to FIG. 1, the Peltier module 1 is sandwiched between the heat sink 5 that is made of metal having excellent tip 2 and the heat conduction is made like a good aluminum or copper thermal conductivity production. ヒートシンク5は、液体窒素9を収納する内筒6にハンダ等で接着されている。 The heat sink 5 is adhered by soldering or the like to the inner cylinder 6 for housing the liquid nitrogen 9. ペルチェモジュール1と先端チップ2やヒートシンク5はシリコーンゴム接着剤や熱伝導性グリースなどで接着され、熱応力がかからない構造となっている。 Peltier module 1 and tip 2 and the heat sink 5 are bonded like a silicone rubber adhesive or thermally conductive grease has a structure in which thermal stress is not applied.

ペルチェモジュール1は一辺が6mmから50mmの正方形または長方形であり、先端チップ2の皮膚と接触する被温度制御面3は直径3mmから50mmである。 Peltier module 1 side is 50mm square or rectangular from 6 mm, the temperature control surface 3 in contact with the skin of the tip 2 is 50mm in diameter 3 mm. 前記先端チップ2は少なくとも2面(第11面および第12面、不図示)を持ち、前記被温度制御面3は第11面に相当し、凍結治療対象物と接触する。 The tip 2 has at least two surfaces (eleventh surface and the twelfth surface, not shown), the target temperature control surface 3 corresponds to the eleventh surface, in contact with cryotherapy object. またペルチェモジュール1も少なくとも2面(第21面および第22面、不図示)を持ち、前記第12面と前記第21面が接触する。 The Peltier module 1 also at least two surfaces (21 side and a 22 surface, not shown) to control the first 21 surface and the twelfth surface is in contact. そして、前記22面と前記ヒートシンク5とが接触する構造となっている。 Then, the 22 surface and said heat sink 5 has a structure in contact.

これらの装置は金属またはプラスチック製の外筒7に覆われており、内筒6と外筒7の間を発泡ポリウレタンや発泡ポリスチレン等の断熱材10が充填されている。 These devices are covered with the outer cylinder 7 made of metal or plastic, between the inner tube 6 and the outer cylinder 7 is heat insulator 10 such as expanded polyurethane or expanded polystyrene have been filled. その断熱層厚さは、大略10mmから30mm程度である。 Its heat insulating layer thickness is 30mm order of approximately 10 mm.

先端チップ2の被温度制御面3近傍に温度センサー4が装着され、温度制御コンピュータ12ならびにパワーモジュール13を介してペルチェモジュール1の温度制御を行う。 The temperature control surface 3 temperature near the sensor 4 of the tip 2 is mounted, the temperature control of the Peltier module 1 via the temperature control computer 12 and the power module 13.

まず内筒6に液体窒素を入れてヒートシンク5を冷却するとき、ペルチェモジュール1は加熱モードで作動し、先端チップ2の温度を大略体温程度に保っている。 When cool the heat sink 5 by putting liquid nitrogen in the inner cylinder 6 First, the Peltier module 1 is operated in the heating mode, and maintaining the temperature of the tip 2 to approximately about body temperature. 凍結治療装置を皮膚腫瘍、色素性病変の患部に接触させてからペルチェモジュール1の電流を逆転させ急速冷却を行う。 The cryotherapy device skin tumors, performing rapid cooling to reverse the current of the Peltier module 1 from contacting the affected area of ​​the pigmented lesions. その時、温度センサー4の温度をモニターすることによって、皮膚組織の過冷却解除を関知し患部の組織の凍結開始をモニターし、冷却時間とペルチェモジュール1の通電電流を制御することにより、患部の凍結深さを制御し、皮下組織などの健康部位の凍結を防止する。 At that time, by monitoring the temperature of the temperature sensor 4, and concern the supercooling release of the skin tissue to monitor the freezing start of diseased tissue, by controlling the energizing current of the cooling time and the Peltier module 1, the affected area of ​​the freezing controlling the depth, to prevent freezing of the health sites such as subcutaneous tissue.

さらに、ペルチェモジュール1の電流を逆転することにより、凍結患部を解凍し、患部の細胞壊死率を高めることも可能である。 Furthermore, by reversing the current of the Peltier module 1, were thawed frozen diseased part, it is possible to increase cell necrosis factor affected areas. この制御を与えられたシークエンスに従って自動的に制御することも可能である。 It is also possible to automatically control in accordance with the sequence given this control. 温度制御コンピュータ12とパワーモジュール13は一体化して装置に組み込むことも可能である。 Temperature control computer 12 and the power module 13 can also be incorporated into the device and integrated.

また、本発明による温度制御法は、ペルチェモジュールを用いる本凍結治療装置に限定されるものではなく、ペルチェ素子を用いた温度制御法にも適用できる。 The temperature control method according to the present invention is not limited to the cryotherapy device using a Peltier module can also be applied to a temperature control method using a Peltier element. 本発明によるペルチェ素子を用いた凍結治療装置は図1あるいは図2においてペルチェモジュール4をペルチェ素子に置き代えたもので特に図示しない。 Cryotherapy device using the Peltier element according to the present invention is not specifically shown in that replaced the Peltier module 4 to the Peltier element 1 or 2. ペルチェ素子を用いた凍結治療装置においても前記先端チップ2は少なくとも2面(第311面および第312面、不図示)を持ち、前記被温度制御面3は第311面に相当し、凍結治療対象物と接触する。 At least two surfaces even the tip 2 in the cryotherapy device using a Peltier element (# 311 side and a 312 plane, not shown) to control the target temperature control surface 3 corresponds to a 311 plane, cryotherapy subject in contact with the object. またペルチェ素子1も少なくとも2面(第321面および第322面、不図示)を持ち、前記第312面と前記第321面が接触する。 The Peltier element 1 even at least two surfaces (# 321 side and a 322 plane, not shown) to control the first 321 surface and the second 312 surface contacts. そして、前記322面と前記ヒートシンク5とが接触する構造となっている。 Then, the 322 surface and said heat sink 5 has a structure in contact.

図2は、本発明の実施の形態による、二酸化炭素充填層を用いた凍結治療装置の概略構成を示す図である。 2, according to an embodiment of the present invention, is a diagram showing a schematic configuration of a cryotherapy device using the carbon dioxide-filled layer. 図2を参照すると、内筒17はベローズやフレキブルチューブで製作され、ヒートシンク5とハンダ等で接合されている。 Referring to FIG. 2, the inner cylinder 17 is made of bellows and flexible Bull tubes are joined with the heat sink 5 and solder. 装置1,2,5,17は気密性のある外筒18に収納され、その隙間に大略大気圧程度の二酸化炭素ガスが充填されている。 Device 1,2,5,17 is housed in the outer cylinder 18 an airtight, carbon dioxide gas of about atmospheric pressure generally is filled into the gap. 内筒17と外筒18はOリング20を介して接合され、内筒と外筒の隙間の気密を保っている。 The inner cylinder 17 and the outer cylinder 18 is joined via an O-ring 20 is hermetically the gap between the inner cylinder and the outer cylinder. 温度センサー4やペルチェモジュール1の導線は気密コネクタ21を介して接続されている。 Wires of the temperature sensor 4 and the Peltier module 1 is connected via a gas-tight connector 21. 本発明の形態によると、フレキシブルチューブの弾性で、ペルチェモジュール1と先端チップ2を圧着しているため、液体窒素を入れたときに容器が温度収縮してもペルチェモジュール1に適当な圧着力が作用する利点がある。 According to an embodiment of the present invention, an elastic flexible tube, because of the bonding the Peltier module 1 and tip 2, an appropriate crimping force to the Peltier module 1 even container to temperature shrinkage when filled with liquid nitrogen there is an advantage to act.

本装置が作動していないとき、二酸化炭素は単なるガス層として熱を伝えるが、装置動作時に液体窒素9を内筒17に充填すると内筒17が極低温になり二酸化炭素19がドライアイスとして内筒17外壁に昇華付着する。 When the apparatus is not operating, carbon dioxide transfer heat as a mere gas layer, but the inner carbon dioxide 19 becomes the inner tube 17 is extremely low temperature when during device operation to fill the liquid nitrogen 9 to the inner cylinder 17 as a dry-ice sublimes attached to cylinder 17 outer wall. この作用によって、隙間が真空状態となり、高性能断熱が達成される。 This action gap becomes a vacuum state, high-performance thermal insulation is achieved.

本発明の作用によって、薄い断熱層厚さで液体窒素の断熱が可能となるので、装置がコンパクトになり医師の治療がしやすくなる。 By the action of the present invention, since the insulation liquid nitrogen can be performed with a thin heat insulating layer thickness, it is easy to have medical treatment apparatus becomes compact. 従来の真空断熱を使った極低温プローブは、高度な真空容器にしたり、常に真空ポンプで吸引したりして使用していた。 Cryogenic probe using conventional vacuum thermal insulation, or a high vacuum vessel, was always used by or sucked by a vacuum pump. 本発明の断熱層によれば、装置を使用しないときは、この隙間は大気圧となっているので、高度な真空容器が必要とならない。 According to the heat insulating layer of the present invention, when not using the device, the gap is so has the atmospheric pressure, not required sophisticated vacuum container. この、真空断熱機構は、液体窒素等の極低温冷媒を使用する全ての真空断熱層に適用されるもので、本凍結治療装置に限定されるものではない。 The vacuum insulation mechanism, intended to be applied to all of the vacuum heat insulating layer using a cryogen such as liquid nitrogen, is not limited to the cryotherapy device.

本発明に係るペルチェモジュールによる凍結治療装置および温度制御方法は、各種皮膚腫瘍、色素性病変等冷凍凍結削除や、その他の人体部位の部分凍結や加熱を行う医療の様々な分野に広く適用できる。 Cryotherapy device and the temperature control method according to the Peltier module according to the present invention, various skin tumors, etc. and frozen freeze remove pigmented lesions, can be widely applied to various fields of medicine performing partial freezing or heating of other body part.

特に、皮膚の疾患部位を、健常部位を切除することなく正確に取り除くことが出来る。 In particular, the disease site of the skin, can be accurately removed without ablating healthy area. また、冷凍治療は治癒後の組織快復が良好なので医療および美容外科等に広く用いることが出来る。 Further, freezing treatment because the tissue recovery after healing good can be widely used in medical and cosmetic surgery and the like.

本発明の実施の形態による、通常断熱材を用いた凍結治療装置の断面図である。 According to embodiments of the present invention, it is a cross-sectional view of the freezing treatment apparatus using a conventional insulation. 本発明の実施の形態による、二酸化炭素充填層を用いた凍結治療装置の断面図である。 According to embodiments of the present invention, it is a cross-sectional view of the freezing treatment apparatus using carbon dioxide filling layer.

符号の説明 DESCRIPTION OF SYMBOLS

1 ペルチェモジュール 2 先端チップ 3 被温度制御面 1 Peltier module 2 tip 3 the temperature control surface
4 温度センサー 5 ヒートシンク 6 内筒 7 外筒 8 スペーサー 9 液体窒素 10 断熱材 11 ふた 12 温度制御コンピュータ 13 パワーモジュール 14 表皮 15 真皮 16 皮下組織 17 フレキシブルチューブ製内筒 18 気密外筒 20 Oリング 21 気密コネクタ 4 Temperature sensor 5 heat sink 6 inner cylinder 7 the outer tube 8 spacer 9 Liquid nitrogen 10 heat insulating material 11 lid 12 Temperature control computer 13 power module 14 epidermis 15 dermis 16 hypodermis 17 made flexible tube inner cylinder 18 airtight outer cylinder 20 O-ring 21 hermetically connector

Claims (17)

  1. 少なくとも2つの面である第11面と第12面を持ち前記第11面が凍結治療対象物に接触する先端チップと、少なくとも2つの面である第21面と第22面を持つペルチェモジュールと、前記ペルチェモジュールを低温に保つヒートシンクと、前記ペルチェモジュールの通電電流を逆転制御するパワーモジュールと、前記ペルチェモジュールの温度を制御する温度制御コンピュータ、とで構成され、前記第22面と前記第21面が接触し、前記第22面と前記ヒートシンクとが接触するよう配置されることを特徴とする凍結治療装置。 A distal tip of the eleventh surface and the eleventh surface has a twelfth surface is at least two surfaces in contact with cryotherapy object, a Peltier module having a first 21 surface and surface 22 is at least two surfaces, a heat sink to keep the Peltier module to the cold, and the power module to reverse control energization current of the Peltier module, temperature control computer for controlling the temperature of the Peltier module is composed of city, the first 21 surface and the second 22 surface cryotherapy device but in contact, wherein the first 22 surface and said heat sink is placed in contact.
  2. 前記温度制御コンピュータが前記パワーモジュールの通電電流逆転制御を複数回可逆的に制御できるよう構成したことを特徴とする請求項1記載の凍結治療装置。 Cryotherapy device according to claim 1, characterized in that said temperature control computer is configured to allow multiple reversibly control the energization current reversal control of the power module.
  3. 少なくとも2つの面である第311面と第312面を持ち前記第311面が凍結治療対象物に接触する先端チップと、少なくとも2つの面である第321面と第322面を持つペルチェ素子と、前記ペルチェモジュールを低温に保つヒートシンクと、前記ペルチェ素子の通電電流を逆転制御するパワーモジュールと、前記ペルチェ素子の温度を制御する温度制御コンピュータ、とで構成され、前記第312面と前記第321面が接触し、前記第322面と前記ヒートシンクとが接触するよう配置されることを特徴とする凍結治療装置。 A distal tip of the 311 plane and the first 311 plane has a second 312 side is at least two surfaces in contact with cryotherapy object, a Peltier element having a first 321 surface and a 322 plane which is at least two surfaces, a heat sink to keep the Peltier module to the cold, and the power module to reverse control energization current of the Peltier element, temperature control computer for controlling the temperature of the Peltier element, it is composed of a city, the first 321 surface and the second 312 surface cryotherapy device but in contact, wherein the first 322 surface and said heat sink is placed in contact.
  4. 前記温度制御コンピュータが前記パワーモジュールの通電電流逆転制御を複数回可逆的に制御できるよう構成したことを特徴とする請求項3記載の凍結治療装置。 Cryotherapy device according to claim 3, characterized in that the temperature control computer is configured to allow multiple reversibly control the energization current reversal control of the power module.
  5. 前記ヒートシンクの冷却を液体窒素で行う事を特徴とする請求項1乃至4の内一に記載の凍結治療装置。 Cryotherapy device according to one of claims 1 to 4, characterized in that for cooling of the heat sink with liquid nitrogen.
  6. 前記焼却装置全体を、密封容器による2重容器構造とし、2重容器隙間部に乾燥二酸化炭素を充填したことを特徴とする請求項1乃至5の内一に記載の凍結治療装置。 Wherein the entire incinerator, a double container structure by a sealed container, cryotherapy device according to one of claims 1 to 5, characterized in that filled with dry carbon dioxide double container clearance.
  7. 前記ペルチェモジュールによる凍結治療装置において、前記ペルチェモジュールを加熱状態に制御し、前記21面および前記12面を通して前記第11面を常温に保つ第1ステップと、前記ペルチェモジュールの通電電流の流れを前記第1ステップと逆転させる第2ステップと、前記ヒートシンクの熱を前記第22面と前記第21面ならびに前記第12面を介し前記第11面に伝え、前期凍結治療対象物を急速冷却することを特徴とする凍結治療温度制御方法。 In the cryotherapy device according to the Peltier module, and controls the Peltier module in a heated state, a first step of keeping the eleventh surface to normal temperature through the 21 surface and the twelfth surface, the flow of electric current of the Peltier module the a second step of reversing the first step, the convey heat sink heat to the eleventh surface through the first 21 surface and the second 22 surface and the twelfth surface, that rapidly cooling the year cryotherapy object cryotherapy temperature control method according to claim.
  8. 前記凍結治療対象物が人体の疾患であり、前記急速冷却は、人体の疾患の凍結であることを特徴とする請求項7記載の凍結治療温度制御方法。 The cryotherapy object is the human disease, the rapid cooling, cryotherapy temperature control method according to claim 7, characterized in that the freezing of the human disease.
  9. 前記ペルチェモジュールによる凍結治療装置において、第11面を常温あるいは体温に保つ第1の状態と、次にヒートシンクの熱を第11面に伝え第11面をほぼヒートシンクの温度状態にする第2の状態、とを複数回繰り返すことを特徴とする請求項7あるいは8記載の凍結治療温度制御方法。 In the cryotherapy device according to the Peltier module, the first state and, then the second state to approximately the temperature condition of the heat sink 11 face convey a heat sink of heat eleventh surface to keep the eleventh surface at room temperature or body temperature , cryotherapy temperature control method according to claim 7 or 8, wherein a plurality of times and.
  10. 前記ペルチェモジュールによる凍結治療装置において前記人体の疾患が凍結した後で、前記第11面の冷却時間と温度とを調節し、人体の凍結領域の大きさと深さを制御する事を特徴とする請求項8記載の凍結治療温度制御方法。 After freezing the human disease in cryotherapy device according to the Peltier module, according to the eleventh surface cooled by adjusting the time and temperature, and controlling the size and depth of the body of the freeze area cryotherapy temperature control method of claim 8, wherein.
  11. 前記第11面を前記人体の疾患患部に接触させた状態で、前記第1の状態と前記第2の状態を複数回繰り返し患部細胞の壊死率を向上させることを特徴とする請求項9記載の凍結治療温度制御方法。 In a state where the eleventh surface is brought into contact with the human body disease affected area, according to claim 9, wherein the improving the necrosis factor of said first state and said second state is repeated a plurality of times diseased cells freezing treatment temperature control method.
  12. 前記ペルチェ素子による凍結治療装置において、前記ペルチェ素子を加熱状態に制御し、前記322面および前記312面を通して前記第311面を常温に保つ第31ステップと、前記ペルチェ素子の通電電流の流れを前記第31ステップと逆転させる第32ステップと、前記ヒートシンクの熱を前記第322面と前記第321面ならびに前記第312面を介し前記第311面に伝え、前期凍結治療対象物を急速冷却することを特徴とする凍結治療温度制御方法。 In the cryotherapy device according to the Peltier device, and controls the Peltier element in a heated state, and the 31 steps to keep the first 311 plane to normal temperature through the 322 surface and the 312 plane, the flow of electric current of the Peltier element and the a 32nd step of reversing the first 31 steps, the heat of the heat sink through the first 322 surface and the second 321 surface and the second 312 surface communicated to the first 311 plane, to rapidly cool the year cryotherapy object cryotherapy temperature control method according to claim.
  13. 前記凍結治療対象物が人体の疾患であり、前記急速冷却は、人体の疾患の凍結であることを特徴とする請求項12記載の凍結治療温度制御方法。 The cryotherapy object is a disease of the human body, the rapid cooling, cryotherapy temperature control method according to claim 12, wherein it is a freezing of human disease.
  14. 前記ペルチェ素子による凍結治療装置において、第311面を常温あるいは体温に保つ第31の状態と、次にヒートシンクの熱を第311面に伝える第311面をほぼヒートシンクの温度状態にする第32の状態とを複数回繰り返すことを特徴とする請求項12あるいは13記載の凍結治療温度制御方法。 In the cryotherapy device according to the Peltier element 32 the state of which the first 31 states to keep the 311 plane at room temperature or body temperature, then the first 311 plane to convey a heat sink of the heat to the 311 plane substantially temperature condition of the heat sink cryotherapy temperature control method according to claim 12 or 13, wherein a plurality of times and.
  15. 前記ペルチェ素子による凍結治療装置において、前記人体の疾患が凍結した後で、前記第311面の冷却時間と温度とを調節し、人体の凍結領域の大きさと深さを制御する事を特徴とする請求項13記載の凍結治療温度制御方法。 In the cryotherapy device according to the Peltier device, after the human body disease was frozen, to adjust the cooling time and temperature of the first 311 plane, and wherein the controlling the size and depth of the body of the freeze area cryotherapy temperature control method of claim 13, wherein.
  16. 前記第311面を前記人体の疾患患部に接触させた状態で、前記第31の状態と前記第32の状態を複数回繰り返し患部細胞の壊死率を向上させることを特徴とする請求項14記載の凍結治療温度制御方法。 In a state where the second 311 surface is brought into contact with the human body disease affected area of ​​claim 14, wherein the improving the necrosis factor of claim 31 with said first 32 states a plurality of times diseased cells freezing treatment temperature control method.
  17. 前記第11面あるいは第311面の近傍に温度センサーを設定し、当該面の温度をモニターしながら、前記温度制御コンピュータで前記パワーモジュールの制御を行う事を特徴とする請求項7乃至16の内一に記載の凍結治療温度制御方法。 Set temperature sensor in the vicinity of the eleventh surface or the 311 plane, while monitoring the temperature of the surface, of the claims 7 to 16, characterized in that for controlling the power module by the temperature control computer cryotherapy temperature control method according to an.
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