JP2006055218A - Utensil for transplanting reproductive material in fallopian tube for flexible uteroscope - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a utensil for transplantation which can transplant a reproductive material in the fallopian tube through the vagina by utilizing a lumen which is provided on a flexible uteroscope without using a laparoscope. <P>SOLUTION: This utensil 1 for transplanting reproductive material in the fallopian tube for the flexible uteroscope is a utensil for transplanting the reproductive material in the fallopian tube by being inserted in the lumen of the flexible uteroscope. The utensil 1 for transplantation is equipped with a connector 2, and a tube 3 for transplanting reproductive material which goes through the connector 2. The connector 2 has a connecting port 21 for the connection with the opening section of the lumen of the flexible uteroscope, a proximal end opening section 22, a passage 23 which communicates with the port 21 and the opening section 22, a port 24 for fluid injection which communicates with the passage 23, and a seal member 25 which can slide the tube 3 under a liquid-tight state. The tube 3 has a tube main body 31, a hub 33 having a fluid injection port 35, and a linear reinforcing body 32 which is housed in the lumen 31a of the tube main body 31, and extends to the distal end side by a predetermined length from the proximal end section of the lumen. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a transplantation device for transplanting reproductive material in the fallopian tube, and more particularly to a device for transplanting reproductive material in the fallopian tube for a flexible hysteroscope.

  Conventionally, gamete intrafallopian tranfer (abbreviated as GIFT method) has been performed. In the GIFT method, mature ovum and in vitro fertilized sperm are injected into the oviduct together, so the process of early development including fertilization is not different from that of natural pregnancy. However, the GIFT method is an oviduct transplantation method using a laparoscope and has a heavy load on a living body.

  An object of the present invention is for a flexible hysteroscope capable of transplanting a mixture of ovum and sperm, which are reproductive materials, into the fallopian tube using the lumen provided in the soft hysteroscope without using a laparoscope. An instrument for transplanting reproductive material in the fallopian tube is provided.

What achieves the above object is as follows.
(1) A device for transplanting reproductive material for a soft hysteroscope to be inserted into a lumen formed in a soft hysteroscope and transplanting reproductive material into the fallopian tube, the transplant device comprising: a connector; A tube for reproductive material transplantation disposed so as to penetrate through the connector, the connector having a connection port for connecting to the opening of the lumen of the flexible hysteroscope at one end, and a proximal end A proximal opening provided, a passage communicating between the connection port and the opening, a fluid injection port communicating with the passage, the proximal opening, and the reproductive material transplantation; The reproductive material transplanting tube includes a tube main body having a lumen penetrating from the distal end portion to the proximal end portion, and a base of the tube main body. Mounting on the edge A hub having a fluid inlet, and a linear reinforcement body that is accommodated in the lumen of the tube body so as not to move and does not close the lumen, and extends from the base end of the lumen to a distal end side by a predetermined length. A device for transplanting reproductive material in the fallopian tube for a flexible hysteroscope.
(2) The device for transplanting reproductive material in the fallopian tube for flexible hysteroscope according to (1), wherein the reproductive material is a mixture of an egg and a sperm.

The apparatus for transplanting reproductive material in the fallopian tube for soft hysteroscope of the present invention is a device for transplanting reproductive material in the fallopian tube for soft hysteroscope, which is inserted into the lumen formed in the soft hysteroscope and transplants the reproductive material in the fallopian tube The transplantation device includes a connector and a reproductive material transplantation tube disposed so as to penetrate through the connector, and the connector has an opening in the lumen of the flexible hysteroscope at one end. A connection port for connection to the base, a base end opening provided at the base end, a passage communicating between the connection port and the opening, a fluid injection port communicating with the passage, and the base end The reproductive material transplantation tube has a sealing member that seals the opening and can slide the reproductive material transplantation tube in a liquid-tight state. The reproductive material transplantation tube penetrates from the distal end portion to the proximal end portion. With a lumen A tube body, a hub attached to the proximal end of the tube body and having a fluid inlet, and housed in the lumen of the tube body so as not to move and not close the lumen, and the proximal end of the lumen And a linear reinforcing body extending to the tip side of a predetermined length.
For this reason, by using the lumen formed in the soft hysteroscope, the reproductive material can be easily and reliably transplanted into the fallopian tube. In addition, since the fluid can be injected into the lumen of the flexible hysteroscope using the port of the connector, the friction between the lumen inner wall and the tube can be reduced, the operability of the tube is good, and the connector Since the reproductive material transplantation tube has a seal member that can slide in a liquid-tight state, operations such as forward and backward movement of the tube can be performed while the liquid-tight state is maintained. Furthermore, since the tube for reproductive material transplantation has a linear reinforcement extending from the proximal end of the lumen of the tube to the distal end side by a predetermined length, the distal end of the linear reinforcement is less than the distal end of the connector within the normal operation range. Since the tube is positioned on the distal end side, tube kinking is hardly generated at the distal end and proximal end of the connector, and the operability is good.

A device for transplanting a reproductive material in a fallopian tube for a flexible hysteroscope of the present invention will be described with reference to an embodiment shown in the drawings.
FIG. 1 is a front view of an embodiment of the device for transplanting the reproductive material in the fallopian tube for a flexible hysteroscope of the present invention. FIG. 2 is an enlarged cross-sectional view of a proximal end portion of the soft hysteroscope in-vitro reproductive material transplantation device shown in FIG. 1. FIG. 3 is an enlarged partial cross-sectional view of the distal end portion of the soft hysteroscope in-vitro reproductive material transplantation device shown in FIG. 1.
A soft hysteroscope in vitro reproductive material transplantation device 1 is a device for inserting a reproductive material into a fallopian tube inserted into a lumen (not shown) formed in a soft hysteroscope (not shown). . The transplant device 1 includes a connector 2 and a reproductive material transplant tube 3 arranged so as to penetrate the connector 2. The connector 2 includes a connection port 21 for connecting to an opening of a lumen of a flexible hysteroscope provided at one end, a proximal opening 22 provided at a proximal end, and a connection port 21 between the opening 22 A seal member 25 that seals the passage 23 that communicates with the fluid passage 23, the fluid injection port 24 that communicates with the passage 23, and the proximal end opening 22, and that can slide the reproductive material transplant tube 3 in a liquid-tight state. And have. The tube 3 for reproductive material transplantation includes a tube main body 31 having a lumen 31a penetrating from a distal end portion to a proximal end portion, a hub 33 attached to the proximal end of the tube main body and having a fluid inlet 35, and a lumen of the tube main body 31. The linear reinforcement body 32 is housed in the 31a so as not to move and does not block the lumen 31a, and extends from the base end portion of the lumen 31a to the distal end side by a predetermined length.

A soft hysteroscope in vitro reproductive material transplantation instrument 1 of this embodiment includes a connector 2 and a reproductive material transplantation tube 3 disposed so as to penetrate the connector 2.
The reproductive material transplanting tube 3 includes a tube main body 31 and a hub 33 fixed to the proximal end thereof.
The tube body 31 is a flexible tube body having substantially the same outer diameter and substantially the same inner diameter from the distal end to the proximal end. As a material for forming the tube body, a material having a certain degree of flexibility and a certain degree of stiffness is preferable. Polyolefin (for example, polyethylene, polypropylene, ethylene-propylene copolymer), polyamide (for example, 6 nylon, 66 nylon), polyester ( For example, polyethylene terephthalate), fluororesin (eg, PTFE, ETFE), urethane rubber, silicone rubber, natural rubber such as butadiene rubber, natural rubber such as latex rubber, polyolefin elastomer, polyamide elastomer, styrene elastomer (eg, Elastomers such as styrene-butadiene-styrene copolymers, styrene-isoprene-styrene copolymers, styrene-ethylenebutylene-styrene copolymers), in particular polyurethanes, Plastic polyurethane (thermoplastic polyether polyurethane, thermoplastic polyester polyurethane, particularly preferably a segmented thermoplastic polyether polyurethane having a soft segment portion and a hard segment portion, more specifically, as a main component of the soft segment, Polytetramethylene ether glycol, polyethylene glycol, polypropylene glycol and the like are preferable, and the main component of the hard segment is preferably 1,4-butanediol. Preferably, it is a fluororesin (for example, PTFE, ETFE).
The tube body 31 has a length of 400 to 650 mm, preferably 450 to 500 mm. The outer diameter is 0.5 to 1.2 mm, preferably 0.6 to 0.7 mm. Moreover, an internal diameter is 0.2-0.7 mm, Preferably, it is 0.4-0.5 mm.

Moreover, as shown in FIG. 3, it is preferable that the tube main body 31 is a curved surface without a corner | angular part or the taper surface which diameter-reduces toward a front-end | tip opening. By doing in this way, insertion to an oviduct becomes easy and it can prevent damaging an oviduct inner wall.
Furthermore, it is preferable to provide a marker 37 at the tip of the tube body 31 as shown in FIG. It is preferable to provide a plurality of markers as shown. In particular, when three or more are provided, they are preferably provided so as to be substantially equally spaced. In addition, at least the marker is preferably provided at the tip of the tube body 31 or at a position very close to the tip.

As shown in FIG. 2, the hub 33 includes a tube body proximal end housing portion at the distal end and a fluid injection port 35 at the proximal end. The liquid injection port 35 is a luer taper part to which a tip such as a syringe can be connected. The proximal end of the tube body 31 is housed in a housing portion provided at the distal end portion of the hub 33 and is fixed by a fixing tubular member 34 and a fixing material 36.
Further, as shown in FIG. 3, the tube 3 is accommodated in the lumen 31a of the tube body 31 so as not to move and not close the lumen 31a, and extends from the proximal end of the lumen 31a to the distal end side by a predetermined length. Shaped reinforcing body 32. The length of the linear reinforcement is such that the tip of the linear reinforcement is closer to the tip than the tip of the connector within the normal operating range of the tube. Specifically, the length of the linear reinforcing body 32 is 100 to 300 mm, preferably 150 mm.

The linear reinforcing body 32 is preferably a metal wire, and for example, an elastic metal wire such as stainless steel having a wire diameter of 0.02 to 2 mm, preferably 0.1 to 1 mm is suitable. Particularly preferred is a high-strength stainless steel wire for springs. Further, the linear reinforcing body 32 may be a synthetic resin wire. Forming materials include polyester, polyolefin (eg, polyethylene, polypropylene, ethylene-propylene copolymer), styrene resin (polystyrene, MS resin (methacrylate-styrene copolymer), MBS resin (methacrylate-butylene-styrene copolymer). Rigid or semi-rigid vinyl chloride, polyamide (for example, 6 nylon, 66 nylon), etc. may be used, and the tip of the linear reinforcing member 32 may be more flexible than the other portions. As a method for making the tip of the wire flexible, the tip of the linear reinforcing member 32 is made smaller in diameter than other portions by a method such as physical or chemical polishing, and is used for the linear reinforcing member 32. The tip of the metal wire is made flexible by annealing, and only the tip of the linear reinforcing body 32 is the outer surface. Grooves, for example, may be such that a plurality of annular grooves, a spiral groove.
The linear reinforcing body 32 is fixed to the tube 3 at least at the base end. The object to be fixed may be the tube main body 31 or the hub 33. In the embodiment shown in FIG. 2, the proximal end portion of the linear reinforcing body 32 is bent, and is sandwiched and fixed between the tube main body 31 and the fixing tubular member 34. Further, the bent proximal end portion of the linear reinforcing body 32 is also fixed to the hub 33 by the fixing material 36.

As shown in FIG. 2, the connector 2 is connected to a connection port 21 for connection to the opening of the lumen of the flexible hysteroscope provided at one end, and to a base end opening 22 provided at the base end. The passage 23 that communicates between the port 21 and the opening 22, the fluid injection port 24 that communicates with the passage 23, the proximal end opening 22, and the reproductive material transplanting tube 3 in a liquid-tight state And a slidable seal member 25.
In the connector 2 of this embodiment, as shown in FIG. 2, the connector 2 is connected to the distal end of the connector body 41 by a connector body 41 having a fluid injection port 24 and a proximal end opening 22 and a cylindrical connection member 43. A connection port member 42 that is fixed and includes the connection port 21 at the distal end and a seal member 25 that is attached to the proximal end opening 23 of the connector main body 41 are provided.

The connector main body 41 is a cylindrical member having a branch port (fluid injection port) 24 protruding from a side wall, and includes a passage 23 therein. The connection port member 42 includes a passage that is continuous with the passage 23, and further includes the connection port 21 that is a reduced diameter portion at the tip. Further, the connection port member 42 is provided with a cylindrical fixing member 44 for preventing separation after being attached to the opening of the lumen of the flexible hysteroscope. The cylindrical fixing member 44 is rotatably attached to the connection port member 42, and a helical rib that can be screwed onto the inner surface of the distal end portion with a protrusion that is normally formed in the opening of the lumen of the flexible hysteroscope It has.
As the connector 2, the length from the distal end (the distal end of the connection port 21) to the proximal end (the proximal end of the proximal end opening 23) is 340 to 630 mm, preferably 340 to 440 mm. Further, the tube body 31 of the tube 3 passes through the passage 23 of the connector 2. The passage 23 allows fluid to flow between the inner surface of the passage 23 and the outer surface of the tube body 31. For this reason, a certain gap is formed between the minimum inner diameter portion of the passage 23 and the tube body 31.

The seal member 25 has a through-hole that seals the proximal end opening 22 in a liquid-tight manner and allows the reproductive material transplantation tube 3 (specifically, the tube main body 31) to slide in a liquid-tight state. . Specifically, as shown in FIG. 2, the seal member 25 is fitted in close contact with the inner cylindrical portion that enters the proximal end opening 22 of the connector body 41 and the outer surface of the proximal end opening 22. And an outer cylindrical portion, and a seal portion that connects the inner cylindrical portion and the outer cylindrical portion. And the through-hole is formed in the approximate center of this seal part.
As a forming material of the seal member 25, synthetic rubber such as urethane rubber, silicone rubber, butadiene rubber, natural rubber such as latex rubber, polyolefin elastomer, polyamide elastomer, styrene elastomer (for example, styrene-butadiene-styrene copolymer, Elastomers such as styrene-isoprene-styrene copolymer, styrene-ethylenebutylene-styrene copolymer), polyurethane and the like can be used.
The forming material of the hub 33, the connector main body 41, the connection port member 42, the cylindrical connection member 43 and the cylindrical fixing member 44 may be polycarbonate, polyamide, polysulfone, polyarylate, methacrylate-butylene-styrene copolymer, etc. A thermoplastic resin can be suitably used.
The reproductive material to be transplanted in the soft hysteroscope oviduct reproductive material transplantation device of the present invention is preferably a mixture of an egg and a sperm. The mixture of ovum and sperm may be a mixture immediately after mixing, that is, a so-called “medium”, or may be a mixture that has been mixed for a certain period of time after so-called “measuring”.

Next, a method of using the device for transplanting reproductive material in the fallopian tube for the flexible hysteroscope of the present invention will be described.
A device for transplanting a reproductive material for a flexible hysteroscope as shown in FIG. 1 is prepared, and suction means (for example, a syringe) is attached to the proximal end of the tube for reproductive material transplantation.
First, eggs and semen to be transplanted are collected. Then, the collected plurality of eggs are placed in a culture solution and cultured. Moreover, a culture solution is added to the collected semen and centrifuged to prepare a sperm suspension. Then, add the sperm suspension to the egg-containing culture solution (measles), and after about 1 hour, operate the syringe to remove the ovum with a high degree of disappearance of the cumulus and sperm in the vicinity. Collect in the tip of the tube for reproductive material transplantation. Then, the tube body of the transplantation device from which the reproductive material is collected is inserted into the lumen of the flexible hysteroscope, and the connection port of the connector is connected to the opening of the lumen of the flexible hysteroscope. Then, the soft hysteroscope is inserted into the living body vaginally, and the tip is passed through the uterus and inserted into the fallopian tube opening. Then, the tube for transplantation is pushed, and the tip of the tube is inserted into the fallopian tube. After confirming the insertion into the fallopian tube, the plunger of the syringe is pushed, and the transplant material collected in the tip of the graft tube is pushed into the fallopian tube. Then, the transplantation device is removed from the living body together with the soft hysteroscope.

FIG. 1 is a front view of an embodiment of the device for transplanting a reproductive material in a fallopian tube for a flexible hysteroscope of the present invention. 2 is an enlarged cross-sectional view of a proximal end portion of the soft hysteroscope oviduct reproductive material transplantation device shown in FIG. FIG. 3 is an enlarged partial cross-sectional view of the distal end portion of the soft hysteroscope in-vitro reproductive material transplantation device shown in FIG. 1.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Reproductive material transplantation instrument 2 for flexible hysteroscope 2 Connector 3 Reproductive material transplantation tube 21 Connection port 22 Base end opening 23 Passage 24 Fluid injection port 25 Seal member 31 Tube body 32 Linear reinforcement 33 Hub

Claims (2)

A soft hysteroscope in-vitro reproductive material transplantation device for inserting a reproductive material into a fallopian tube inserted into a lumen formed in the soft hysteroscope, the transplantation device comprising: a connector; A tube for reproductive material transplantation disposed so as to penetrate the connector, and the connector is provided at one end with a connection port for connecting to the opening of the lumen of the flexible hysteroscope, and at the proximal end A proximal end opening, a passage communicating between the connection port and the opening, a fluid injection port communicating with the passage, the proximal opening, and the reproductive material transplanting tube; The reproductive material transplanting tube is attached to the proximal end of the tube main body having a lumen penetrating from the distal end portion to the proximal end portion. Is A hub having a fluid inlet, and a linear reinforcement body that is housed in the lumen of the tube body so as not to move and does not block the lumen, and extends from the base end of the lumen to the distal end side by a predetermined length. A device for transplanting reproductive material in the fallopian tube for a flexible hysteroscope, The device for transplanting a reproductive material in a fallopian tube for a flexible hysteroscope according to claim 1, wherein the reproductive material is a mixture of an egg and a sperm.

Images