JP2006008615A - Patch matrix and cosmetic composed thereof - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a matrix which hardly causes shrinkage and water release with time, excels in shape retention, and has good storage stability. <P>SOLUTION: The matrix patch comprises (1) 0.5-5 mass% hydrophilic thickener and/or hydrophilic gelling agent, (2) 40-50 mass% polyhydric alcohol, (3) 30-60 mass% water and (4) one or more kinds selected from the group (A) consisting of glycyrrhizic acid and its salt, an alkyl ester of glycyrrhetinic acid, ascorbic acid and its salt, and a glycoside of ascorbic acid and its salt, a phosphate of ascorbic acid and its salt, arbutin and its salt, ellagic acid and its salt, tranexamic acid and its salt, and 4-methoxysalicylic acid and its salt. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a cosmetic and a matrix for sticking which is a component thereof, and more particularly to a sheet-shaped pack cosmetic and a matrix for sticking which is a constituent thereof.

  Patches such as pack cosmetics are used by applying a viscous layer (hereinafter also referred to as a viscous composition layer) directly on the skin so that the active ingredients in the viscous composition layer are gradually added over time. It is used for percutaneous absorption (see, for example, Patent Document 1, Patent Document 2, and Patent Document 3). Such cosmetics in dosage form are often used as quasi drugs. By the way, in such a patch, for the purpose of maintaining the shape of the viscous composition layer, a support such as a nonwoven fabric is usually used, and a method of applying the viscous composition on the support is employed. However, the use of such a support is effective for maintaining the shape, but when it is applied to a curved face or the like, the rigidity of the support prevents the adhesion between the skin and the viscous composition layer. There was a problem that sufficient pasting was not possible. In addition, there is a limit to the thickness of the viscous composition layer that can be coated on the support, and there is a limit to the amount of active ingredient stored in the viscous composition. Furthermore, in the case of using a support, it is necessary to focus on the adhesion between the viscous composition and the support, and the patch, which is the final product, does not always have good skin affinity. It was. Therefore, a self-supporting patch that can be stuck only with a viscous composition layer without a support has been desired.

  By the way, a patch containing 25% by weight of a hydrophilic gelling agent and glycerin, which is a polyhydric alcohol, is known (see, for example, Patent Document 4). However, the patch described here is of the type in which a viscous composition is applied onto a support. The gel composition constituting this patch is intended to improve the adhesion to the skin and the storage performance of the active ingredient, but the gel composition layer shrinks or separates with time. Had problems such as.

JP 2004-26707 A JP 2004-51516 A Japanese Patent Laid-Open No. 2003-113036 JP 2002-255742 A

  The present invention has been made under such circumstances, and is a viscous composition layer (especially the viscous composition of the present invention) that hardly shrinks over time and does not release water, has excellent shape maintenance, and has good storage stability. It is an object to provide a layer) (hereinafter also referred to as a matrix). Furthermore, since shape maintenance stability is excellent, it aims at providing the viscous composition layer which can be used as a self-supporting type | mold patch which can be stuck only with a viscous composition layer even if there is no support body.

  In order to apply only the viscous composition layer without using a support, it is necessary to prevent the viscous composition layer from shrinking or water separation over time. As a result of intensive studies to obtain a viscous composition layer that hardly generates water or water separation, a viscous composition layer containing a specific component in a specific ratio exhibits such properties, and the viscous composition layer It has been found that even when an active ingredient shown in Group A described below is contained, the temporal stability of the viscous composition layer can be improved without impairing the transdermal absorbability of the active ingredient. It came to complete.

That is, the present invention is as follows.
(1) 1) 0.5-5% by mass of hydrophilic thickener and / or hydrophilic gelling agent, 2) 40-50% by mass of polyhydric alcohol, 3) 30-60% by mass of water And 4) A matrix for sticking, comprising one or more components selected from the following group A.
(A) Glycyrrhizic acid and its salt, alkyl ester of glycyrrhetinic acid, ascorbic acid and its salt, glycoside of ascorbic acid and its salt, phosphate ester of ascorbic acid and its salt, arbutin and its salt, ellagic acid and its Salt, tranexamic acid and its salt, 4-methoxysalicylic acid and its salt (2) The hydrophilic thickener is selected from polyacrylic acid, polyglutamic acid, polyvinyl alcohol, carboxymethylcellulose, alginic acid, and salts thereof 1 The matrix for sticking according to (1), comprising a seed or two or more kinds.
(3) The hydrophilic gelling agent is cationized cellulose, hydroxyethyl cellulose, starch, ionized starch derivative, block polymer of starch and synthetic polymer, hyaluronic acid, carrageenan (copper, iota, lambda form), locust bean gum , Xanthan gum, guar gum, gellan gum, tamarindow, glucomannan, chitin, chitosan, pullulan, tuberose polysaccharide, collagen, alkyl-modified carboxyvinyl polymer, Ernest gum, gelatin, pectin, agarose, and these The matrix for pasting according to (1) or (2), comprising one or more selected from salts.
(4) The polyhydric alcohol contains 30% by mass or more of a polyhydric alcohol that is liquid under the conditions of 1 atm and 25 ° C. Any one of (1) to (3) The matrix for sticking described in 1.
(5) The matrix for pasting according to any one of (1) to (4), wherein the polyhydric alcohol contains 20% by mass or more of glycerin.
(6) A cosmetic comprising the matrix for application according to any one of (1) to (5).
(7) The cosmetic according to (6), which is applied around the eyes.
(8) The cosmetic according to (6) or (7), wherein the matrix is molded into a shape that matches an application site.
(9) The cosmetic according to any one of (6) to (8), wherein the matrix is formed by pouring the matrix into a transparent mold.
(10) The cosmetic according to any one of (6) to (9), which is a quasi-drug. (11) The cosmetic according to (10), characterized by appealing an anti-inflammatory effect and / or a melanin production inhibitory effect.
(12) The cosmetic according to (10) or (11), which is displayed as a quasi-drug for suppressing inflammation or suppressing melanin production.

  ADVANTAGE OF THE INVENTION According to this invention, the matrix which can maintain a shape stably for a long period of time which hardly produces shrinkage | temporality and water separation with time can be provided, maintaining the transdermal absorbability of an active ingredient favorably. In particular, since the matrix of the present invention is excellent in shape maintainability, it can be used as a self-supporting patch that can be pasted only with a viscous composition layer without a support.

Hereinafter, the present invention will be described in detail.
<1> A hydrophilic thickener and a hydrophilic gelling agent which are essential components of the matrix of the present invention

The matrix of the present invention contains a hydrophilic thickener and / or a hydrophilic gelling agent as an essential component, and is contained in an amount of 0.5 to 5% by mass, more preferably 1 to 3% by mass, based on the total amount of the matrix.
Here, the matrix in the present invention refers to a part of the patch that is necessary for administration of the active ingredient and cannot be easily divided. For example, in a patch in which a viscous composition containing a drug is applied to a support, the coated viscous composition layer corresponds to the matrix referred to in the present invention.

  The said hydrophilic thickener means the component mix | blended mainly in order to raise a viscosity in the aqueous | water-based formulation used in the field | area of skin external preparations, such as cosmetics and a skin external pharmaceutical. Specifically, polyacrylic acid, polyglutamic acid, polyvinyl alcohol, carboxymethyl cellulose, alginic acid, or a salt thereof can be preferably exemplified. Particularly preferred is carboxymethylcellulose and / or a salt thereof.

  The hydrophilic gelling agent refers to a component blended mainly for the purpose of gelation in aqueous preparations used in the field of skin external preparations such as cosmetics and skin external pharmaceuticals. Specifically, cationized cellulose, hydroxyethyl cellulose, starch, ionized starch derivatives, starch and synthetic polymer block polymers, hyaluronic acid, carrageenan (copper, iota, lambda form), locust bean gum, xanthan gum, guar gum, gellan gum , Tamarindough, glucomannan, chitin, chitosan, pullulan, tuberose polysaccharide, collagen, alkyl-modified carboxyvinyl polymer, Ernest gum, gelatin, pectin, agarose, or salts thereof can be preferably exemplified. Particularly preferred is carrageenan.

  The salt is not particularly limited as long as it is physiologically acceptable. For example, an alkali metal salt such as sodium salt or potassium salt, an alkaline earth metal salt such as calcium or magnesium, an ammonium salt, Preferred examples include organic amine salts such as ethanolamine salt and triethylamine salt, and basic amino acid salts such as lysine salt and arginine salt.

These hydrophilic thickeners and hydrophilic gelling agents can be used alone or in combination of two or more. In the matrix of the present invention, such a hydrophilic thickener and / or hydrophilic gelling agent is particularly preferably a form containing both a hydrophilic thickener and a hydrophilic gelling agent. The content ratio of the hydrophilic thickener to the hydrophilic thickener is preferably 3: 1 to 1: 3, and more preferably 2: 1 to 1: 2. This is because the matrix has the highest shape stability in such a composition.
<2> Polyhydric alcohol that is an essential component of the matrix of the present invention

  The matrix of the present invention contains polyhydric alcohol as an essential component and 40 to 50% by mass, more preferably 35 to 45% by mass with respect to the total amount of the matrix.

  Such polyhydric alcohol can be used without particular limitation as long as it is usually used in cosmetics and pharmaceutical compositions for external use on the skin. For example, propylene glycol, 1,3-butanediol, glycerin, polyethylene Preferred examples include glycol, sorbitol, maltitol and the like.

  These polyhydric alcohols can be contained alone or in combination of two or more. When two or more kinds are contained, the total amount is within the range of 40 to 50% by mass.

In the present invention, it is more preferable that the polyhydric alcohol contains 30% by mass or more of the polyhydric alcohol that is liquid under the conditions of 1 atm and 25 ° C. Here, examples of the polyhydric alcohol that is liquid under the conditions of 1 atm and 25 ° C. include propylene glycol, 1,3-butanediol, glycerin, and polyethylene glycol. To do.

Furthermore, in the present invention, it is particularly preferable that glycerin is contained in the polyhydric alcohol in an amount of 20% by mass, and further 30% by mass. Glycerin has a large moisturizing effect on the skin, and can suppress the cooling sensation when applied.
<3> Water which is an essential component of the matrix of the present invention

The matrix of the present invention contains 30 to 60% by mass, more preferably 40 to 60% by mass, based on the total amount of the matrix, with water as an essential component.
By adopting such a form, it is excellent in the action of transferring moisturizing ingredients to the skin, unlike the sticking matrix consisting of only the adhesive layer, and it is possible to suppress itching and inflammation due to sticking even if applied for a long time. . Moreover, even if it contains the above-mentioned amount of moisture, a stable gel is formed due to the balance with other essential components, so that the shape can be maintained for a long time without breaking the matrix.
<4> An active ingredient which is an essential ingredient of the matrix of the present invention

The matrix of the present invention contains, as an essential component, one or more selected from the following group A compounds as an essential component.
All of these ingredients are ingredients contained as active ingredients in cosmetics, particularly quasi-drugs, glycyrrhizic acid and its salts, alkyl esters of glycyrrhetinic acid are known for their anti-inflammatory action, ascorbic acid and its Salts, glycosides of ascorbic acid and salts thereof, phosphate esters and salts of ascorbic acid, arbutin and salts thereof, ellagic acid and salts thereof, 4-methoxysalicylic acid and salts thereof are known to inhibit melanin production Tranexamic acid and its salts are known to have an anti-inflammatory action and a melanin production-suppressing action.

These salts can be used without any particular limitation as long as they are physiologically acceptable. For example, alkali metal salts such as sodium salt and potassium salt, alkaline earth metal salts such as calcium and magnesium, and the like. Preferred examples include organic amine salts such as ammonium salt, triethanolamine salt and triethylamine salt, and basic amino acid salts such as lysine salt and arginine salt.
These components of Group A can contain only one species, or can contain two or more species in combination. The preferred content of such active ingredients in the matrix of the present invention is somewhat different depending on the type and the combination thereof, but the total amount is 0.01 to 10% by mass, more preferably 0.02 to the total amount of the matrix. 5% by mass.
<5> Matrix and patch of the present invention

  The matrix of the present invention contains the above essential components. The matrix of the present invention is in a gel state, and once the matrix is formed, the formed layer hardly shrinks or separates with time, has excellent shape maintenance, and has good storage stability. It will be a thing.

  Therefore, the matrix of the present invention can be used as a self-supporting patch of a type that is stuck only with a matrix without a support (in this case, matrix = (equal) patch). However, the matrix of the present invention may be used for a patch of the type in which the matrix is coated on a support (in this case, a combination of the support and the matrix is called a patch).

  In the case of using a support, examples of the support are preferably polypropylene, polyethylene terephthalate, a nonwoven fabric lined with a polyethylene sheet, and the like. Coating may be performed according to a normal method, and for example, the coating may be performed to a predetermined thickness using a coating tool such as a doctor blade (manufactured by MDC).

In addition to the above components, the matrix of the present invention can contain optional components that are usually used in cosmetics and external pharmaceuticals for skin. Such optional ingredients include, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hydrogenated coconut oil Oils, waxes, oils, waxes, liquid oil paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petroleum jelly, beeswax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax , Hydrocarbons such as microcrystalline wax; higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid; cetyl alcohol, stearyl alcohol, isostear Higher alcohols such as alcohol, behenyl alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol; cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, apple Diisostearyl acid, ethylene glycol di-2-ethylhexanoate, neopentyl glycol dicaprate, glycerin di-2-heptylundecanoate, glycerin tri-2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, Synthetic ester oils such as trimethylolpropane triisostearate and pentane erythritol tetra-2-ethylhexanoate; dimethylpolysiloxane, Linear polysiloxanes such as siloxane, diphenylpolysiloxane, cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexanesiloxane, amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane , Oil agents such as silicone oils such as modified polysiloxanes such as fluorine-modified polysiloxanes; anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, alkyl sulfate triethanolamine ether; Cationic surfactants such as stearyltrimethylammonium chloride, benzalkonium chloride, laurylamine oxide; imidazoline-based amphoteric surfactants (2-cocoyl-2- Amphoteric surfactants such as midazolinium hydroxide-1-carboxyethyloxy disodium salt), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), acylmethyl taurine; sorbitan fatty acid esters ( Sorbitan monostearate, sorbitan sesquioleate, etc.); glycerin fatty acids (glyceryl monostearate, etc.), propylene glycol fatty acid esters (propylene glycol monostearate, etc.), hardened castor oil derivatives, glycerin alkyl ether, POE sorbitan fatty acid ester (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbitol monolaurate, etc.), POE glycerin fat Fatty acid esters (POE-glycerin monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkyl phenyl ethers (POE) Nonylphenyl ether, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.) ), Nonionic surfactants such as sucrose fatty acid esters and alkyl glucosides; moisturizing ingredients such as sodium pyrrolidonecarboxylate, lactic acid, sodium lactate and trimethylglycine; mica whose surface may be treated, Powders such as luc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, silicic anhydride (silica), aluminum oxide, barium sulfate; surface treated, bengara, yellow iron oxide, black iron oxide, Cobalt oxide, ultramarine, bituminous, titanium oxide, zinc oxide inorganic pigments; surface treated pearlescent agents such as titanium mica, fish phosphorus foil, bismuth oxychloride; red raked 202, Red 228, Red 226, Yellow 4, Blue 404, Yellow 5, Red 505, Red 230,
Organic dyes such as Red No. 223, Orange No. 201, Red No. 213, Yellow No. 204, Yellow No. 203, Blue No. 1, Green No. 201, Purple No. 201, Red No. 204; polyethylene powder, polymethyl methacrylate, nylon Organic powders such as powders and organopolysiloxane elastomers; paraaminobenzoic acid UV absorbers, anthranilic acid UV absorbers, salicylic acid UV absorbers, cinnamic acid UV absorbers, benzophenone UV absorbers, sugar UV UV absorbers such as absorbers, 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole, 4-methoxy-4′-t-butyldibenzoylmethane; lower alcohols such as ethanol and isopropanol , Vitamin A or its derivatives, Vitamin B6 hydrochloride, Vitamin B6 tripalmitate, Vita Min B6 dioctanoate, vitamin B2 or derivatives thereof, vitamin B such as vitamin B12, vitamin B15 or derivatives thereof, α-tocopherol, β-tocopherol, γ-tocopherol, vitamin E such as vitamin E acetate, vitamin D, vitamin Preferred examples include vitamins such as H, pantothenic acid, panthetin, and pyrroloquinoline quinone; viscosity modifiers such as potassium chloride; and preservatives such as parabens such as methylparaben. The matrix of this invention can be manufactured by processing the said essential component and arbitrary components in accordance with a conventional method.

  The matrix of the present invention thus obtained has good adhesion to the skin, has an excellent storage capacity for active ingredients, and maintains a good transdermal absorbability of active ingredients while shrinking over time. And almost no water separation.

  As described above, the matrix of the present invention can be used as it is as a patch, or can be used as a patch having a support coated on a support. The patch of the present invention is preferably used as a cosmetic. It is particularly preferable to apply it to sheet-shaped pack cosmetics. Here, the sheet-shaped pack cosmetic refers to a type of cosmetic in which a sheet made of the matrix of the present invention is applied to the skin, the active ingredient is absorbed into the skin, and then the sheet is peeled off.

Especially as a part to which cosmetics are applied, the circumference | surroundings of eyes are preferable. This is because the skin is easily dried and wrinkles are easily formed, and the pack cosmetic treatment is effective.
Also, since the area around the eyes is small and three-dimensionally recessed, ordinary pack cosmetics have problems such as poor adhesion to the skin and poor moisture retention performance. Use of the inventive matrix can eliminate such problems. In particular, it is preferable to apply only the matrix of the present invention without using a support because the adhesion with the skin can be further improved and the application effect can be sufficiently exhibited.

  When applying the matrix of the present invention, the matrix of the present invention may be formed into a shape suitable for the application site and then applied to the application site. For example, when a support is used, the matrix of the present invention can be coated on a support having a desired shape. Or when not using a support body, a matrix can be poured into a transparent formwork and it can shape | mold into a desired shape. More specifically, the matrix of the present invention can be formed as follows.

It can be poured into a mold made of polypropylene, polyethylene terephthalate or the like in advance while the matrix has fluidity, and then solidified to form the matrix into a desired shape.
As the mold into which the matrix is poured, it is preferable to use a transparent material as described above in view of the beauty after production. Moreover, it is good to process this type | mold beforehand in the shape suitable for the location stuck. For example, when affixing around the eyes, it may be shaped like a curved ball according to the shape around the eyes.

  The active ingredient shown by the group A contained in the matrix of the present invention exhibits an anti-inflammatory effect and a melanin production inhibitory effect. Cosmetics containing a certain concentration of active ingredients that have been recognized for their specific purposes as described above are generally called medicated cosmetics and can be approved as quasi drugs. The cosmetics of the present invention can also be manufactured and sold as quasi drugs. And in that case, the anti-inflammatory effect and / or melanin production inhibitory effect can be appealed for the cosmetic of the present invention.

  Moreover, the indication that it is a quasi-drug for suppressing inflammation or suppressing melanin production can be given with respect to the final product form of the cosmetics of the present invention. More specifically, in the final product form, regarding the indication that the product is a quasi-drug for suppressing inflammation or suppressing melanin production, and how to use the product, the cosmetic product is anxious about spots and pigmentation. By applying to a site, or a site with mild inflammation, to the effect that it is possible to improve spots and pigmentation by the application, or to reduce inflammation, and by the operation, If you feel a tingling sensation or a burning sensation, you can immediately indicate that you want to stop using it.

EXAMPLES Hereinafter, although an Example demonstrates this invention further more concretely, this invention is not limited to this.
Example 1

  The matrix of the present invention was produced according to the formulation shown below. That is, the components of (a) and (b) are weighed, heated to 80 ° C., and gradually added to the mixture under stirring to produce a uniform system, which is poured into a polypropylene mold shown in FIG. After sealing with a seal, it was solidified to obtain the matrix = gel sheet pack cosmetic 1 of the present invention (a quasi-drug that promoted anti-inflammatory action).

I)
52% by mass of water
Potassium chloride 0.3% by mass
1% trimethylglycine aqueous solution 0.5% by mass
1% dipotassium glycyrrhizinate aqueous solution 5% by mass
B)
Glycerin 30% by mass
Sorbitol 10% by mass
Carrageenan 0.8% by mass
Carboxymethylcellulose 0.7% by mass
Glucomannan 0.3% by mass
1,3-butanediol 0.2% by mass
Methylparaben 0.2% by mass

Comparative Example 1 was prepared in the same manner as in Example 1, except that 30% by mass of glycerin in Example 1 was changed to 15% by mass and the remaining 15% by mass was replaced with water.
Gel sheet-shaped pack cosmetic 1 and Comparative Example 1 were stored at 40 ° C. for 1 month, and the shape was observed while the temperature was returned to 20 ° C. As a shape index, the contraction length in the width was measured. They also showed these samples to 10 randomly selected panelists and asked if they noticed any shrinkage. Panelists who noticed the shrinkage also asked whether the shrinkage would be a quality problem.
The results are shown in Table 1.

From the above results, it was confirmed that the matrix = gel sheet-shaped pack cosmetic of the present invention was excellent in shape maintainability (no shrinkage or water separation).
(Example 2)

In the same manner as in Example 1, the matrix of the present invention was prepared according to the formulation shown below, and this was used as a gel sheet pack (cosmetics; quasi-drug that promoted anti-inflammatory action).
A storage test at 40 ° C. for 1 month was also conducted in the same manner as in Example 1.
It can be seen that this cosmetic also has the same effect as in Example 1.

I)
47% by mass of water
Potassium chloride 0.3% by mass
1% trimethylglycine aqueous solution 0.5% by mass
1% dipotassium glycyrrhizinate aqueous solution 5% by mass
B)
Glycerin 35% by mass
Sorbitol 10% by mass
Carrageenan 0.8% by mass
Carboxymethylcellulose 0.7% by mass
Glucomannan 0.3% by mass
1,3-butanediol 0.2% by mass
Methylparaben 0.2% by mass

Example 3

In the same manner as in Example 1, the matrix of the present invention was prepared according to the formulation shown below, and this was used as a gel sheet pack (cosmetics; quasi-drug that promoted anti-inflammatory action).
A storage test at 40 ° C. for 1 month was also conducted in the same manner as in Example 1.
It can be seen that this cosmetic also has the same effect as in Example 1.

I)
52% by mass of water
Potassium chloride 0.3% by mass
1% trimethylglycine aqueous solution 0.5% by mass
1% dipotassium glycyrrhizinate aqueous solution 5% by mass
B)
Glycerin 20% by mass
Sorbitol 10% by mass
Carrageenan 0.8% by mass
Carboxymethylcellulose 0.7% by mass
Glucomannan 0.3% by mass
1,3-butanediol 10.2% by mass
Methylparaben 0.2% by mass

Example 4

For Example 1 and Comparative Example 1, the influence of the support in the presence of the support was examined. That is, in the manufacture of Example 1 and Comparative Example 1, after pouring into a plastic mold, a non-woven fabric having a similar shape (thickness 0.3 mm), which is slightly smaller than the mold, was placed and hermetically sealed with an aluminum seal. Thereafter, it was solidified (Example 4 and Comparative Example 2).
These were similarly subjected to a storage test at 40 ° C. for one month.
The results are shown in Table 4.
Moreover, although each panelist actually used cosmetics, peeling of the support from the gel sheet was observed when the cosmetics of Comparative Example 2 were taken out of the mold for use.

(Example 5)

In the same manner as in Example 1, a matrix of the present invention was prepared according to the formulation shown below, and this was used as a gel sheet pack (cosmetics; quasi-drugs that promoted melanin production inhibitory action).
A storage test at 40 ° C. for 1 month was also conducted in the same manner as in Example 1.
It can be seen that this cosmetic also has the same effect as in Example 1.

I)
55% by mass of water
Potassium chloride 0.3% by mass
1% trimethylglycine aqueous solution 0.5% by mass
Ascorbic acid-2-glucoside 2% by mass
B)
Glycerin 30% by mass
Sorbitol 10% by mass
Carrageenan 0.8% by mass
Carboxymethylcellulose 0.7% by mass
Glucomannan 0.3% by mass
1,3-butanediol 0.2% by mass
Methylparaben 0.2% by mass

(Example 6)

In the same manner as in Example 1, a matrix of the present invention was prepared according to the formulation shown below, and this was used as a gel sheet pack (cosmetics; quasi-drugs that promoted melanin production inhibitory action).
A storage test at 40 ° C. for 1 month was also conducted in the same manner as in Example 1.
It can be seen that this cosmetic also has the same effect as in Example 1.

I)
55% by mass of water
Potassium chloride 0.3% by mass
1% trimethylglycine aqueous solution 0.5% by mass
Ascorbic acid disodium phosphate 2% by mass
B)
Glycerin 30% by mass
Sorbitol 10% by mass
Carrageenan 0.8% by mass
Carboxymethylcellulose 0.7% by mass
Glucomannan 0.3% by mass
1,3-butanediol 0.2% by mass
Methylparaben 0.2% by mass

(Example 7)

In the same manner as in Example 1, a matrix of the present invention was prepared according to the formulation shown below, and this was used as a gel sheet pack (cosmetics; quasi-drugs that promoted melanin production inhibitory action).
A storage test at 40 ° C. for 1 month was also conducted in the same manner as in Example 1.
It can be seen that this cosmetic also has the same effect as in Example 1.

I)
55% by mass of water
Potassium chloride 0.3% by mass
1% trimethylglycine aqueous solution 0.5% by mass
Arbutin 2% by mass
B)
Glycerin 30% by mass
Sorbitol 10% by mass
Carrageenan 0.8% by mass
Carboxymethylcellulose 0.7% by mass
Glucomannan 0.3% by mass
1,3-butanediol 0.2% by mass
Methylparaben 0.2% by mass

(Example 8)

In the same manner as in Example 1, the matrix of the present invention was prepared according to the formulation shown below, and this was used as a gel sheet pack (cosmetics; quasi-drug that promoted anti-inflammatory action and melanin production inhibitory action).
A storage test at 40 ° C. for 1 month was also conducted in the same manner as in Example 1.
It can be seen that this cosmetic also has the same effect as in Example 1.

I)
55% by mass of water
Potassium chloride 0.3% by mass
1% trimethylglycine aqueous solution 0.5% by mass
Sodium tranexamate 2% by mass
B)
Glycerin 30% by mass
Sorbitol 10% by mass
Carrageenan 0.8% by mass
Carboxymethylcellulose 0.7% by mass
Glucomannan 0.3% by mass
1,3-butanediol 0.2% by mass
Methylparaben 0.2% by mass

  INDUSTRIAL APPLICABILITY The present invention can be applied to sheet-shaped pack cosmetics that are quasi-drugs that have promoted anti-inflammatory action and melanin production-suppressing action.

1 is a schematic diagram showing a polypropylene mold used in Example 1. FIG.

Claims (12)

1) 0.5-5% by mass of hydrophilic thickener and / or hydrophilic gelling agent, 2) 40-50% by mass of polyhydric alcohol, 3) 30-60% by mass of water, 4 ) A matrix for sticking, comprising one or more components selected from the following group A.
(A) Glycyrrhizic acid and its salt, alkyl ester of glycyrrhetinic acid, ascorbic acid and its salt, glycoside of ascorbic acid and its salt, phosphate ester of ascorbic acid and its salt, arbutin and its salt, ellagic acid and its Salt, tranexamic acid and its salt, 4-methoxysalicylic acid and its salt   The said hydrophilic thickener consists of 1 type (s) or 2 or more types selected from polyacrylic acid, polyglutamic acid, polyvinyl alcohol, carboxymethylcellulose, alginic acid, and these salts, It is characterized by the above-mentioned. Matrix for pasting.   The hydrophilic gelling agent is cationized cellulose, hydroxyethyl cellulose, starch, ionized starch derivative, starch and synthetic polymer block polymer, hyaluronic acid, carrageenan (kappa, iota, lambda form), locust bean gum, xanthan gum, Guar gum, gellan gum, tamarindow, glucomannan, chitin, chitosan, pullulan, tuberose polysaccharide, collagen, alkyl-modified carboxyvinyl polymer, Ernest gum, gelatin, pectin, agarose, and salts thereof The matrix for sticking according to claim 1 or 2, characterized in that it comprises one or more of the above.   The polyhydric alcohol contains 30% by mass or more of a polyhydric alcohol that is liquid under the conditions of 1 atm and 25 ° C, according to any one of claims 1 to 3. Matrix for application.   The matrix for sticking according to any one of claims 1 to 4, wherein 20% by mass or more of glycerin is contained in the polyhydric alcohol.   Cosmetics containing the matrix for sticking of any one of Claims 1-5.   The cosmetic according to claim 6, wherein the cosmetic is applied around the eyes.   The cosmetic according to claim 6 or 7, wherein the matrix is formed in a shape suitable for an application site.   The cosmetic according to any one of claims 6 to 8, wherein the matrix is formed by pouring the matrix into a transparent mold.   The cosmetic according to any one of claims 6 to 9, wherein the cosmetic is a quasi-drug.   The cosmetic according to claim 10, characterized by appealing an anti-inflammatory effect and / or a melanin production inhibitory effect.   The cosmetic according to claim 10 or 11, wherein the cosmetic is indicated to be a quasi-drug for suppressing inflammation or suppressing melanin production.