JP2005529125A - オボムチンを含有する口腔ケア組成物 - Google Patents
オボムチンを含有する口腔ケア組成物 Download PDFInfo
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- JP2005529125A JP2005529125A JP2003587342A JP2003587342A JP2005529125A JP 2005529125 A JP2005529125 A JP 2005529125A JP 2003587342 A JP2003587342 A JP 2003587342A JP 2003587342 A JP2003587342 A JP 2003587342A JP 2005529125 A JP2005529125 A JP 2005529125A
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- JP
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- Prior art keywords
- oral care
- care composition
- ovomucin
- saliva
- composition according
- Prior art date
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Abstract
Description
a)オボムチンを含有し、シアル酸含量が1.5〜2.5重量%である粘液剤、および
b)乳化剤
を含む口腔ケア組成物により達成される。
X軸:溶出容量(ml);
Y軸:溶出液の光学密度(280nmで測定)。
同定された化合物:1 オボムチン;2 オボアルブミン(43kDa)およびオボトランスフェリン(77kDa);3 リゾチーム(14kDa)。
図2は、37℃における種々の粘液剤のレオロジー的挙動を示す。
X軸:剪断速度(回転/秒);
Y軸:測定された粘度(パスカル×秒)。
下記のように表す。
a)実施例1で調製されたオボムチン含有粘液剤の乾燥サンプル、
b)ブタの胃由来のムチン(Sigmaから入手)、
c)およびd)ブタの胃由来のムチンの2つの異なるサンプル(ICNから入手)。
X軸:時間尺度(秒);
Y軸:粘度(パスカル×秒)。
a)は実施例1のオボムチン含有粘液剤、b)はブタの胃由来のムチン(Sigmaから入手)。
図4は、乳化剤として0.15重量%のCremophor(登録商標)RH 410を含有する唾液代替液(液体の重量に基づき、ちょうど2重量%(乾燥重量)未満のオボムチン含有粘液剤)の2つのサンプル(菱形または四角)の37℃におけるレオロジー的挙動を示す。
X軸:剪断速度(回転/秒);
Y軸:測定された粘度(パスカル×秒)。
図5は、0.15重量%のTween 20(登録商標)を含有する唾液代替液(液体の重量に基づき、ちょうど2重量%(乾燥重量)未満のオボムチン含有粘液剤)の3つのサンプル(三角、菱形、四角)の37℃におけるレオロジー的挙動を示す。
X軸:剪断速度(回転/秒);
Y軸:測定された粘度(パスカル×秒)。
鶏卵から除去したばかりの卵白を、3倍容量の蒸留水に溶解させ、クエン酸を用いて溶液のpHを6に調整した。得られた溶液を4℃で20時間攪拌した。次いでその溶液を4℃にて5500gで30分間遠心分離し、その遠心分離残留物を蒸留水で2回、2重量%のKCl水溶液で2回、蒸留水で2回洗浄し、洗浄溶液を4℃にて5500gで30分間遠心分離した。
既知の工程に従って分離を行った(Awad A.C., Moreau, S., Moll D., Brul G., Maubois, J.L., J. Chrom. A. 1994, 677, 279-288)。溶液は、調製実施例1の量のオボムチン含有粘液剤を溶解させることにより調製し(これは10mlの水中5mgの乾燥物に相当する)、この溶液を20℃にて20時間静置した。この溶液500μlをゲル透過クロマトグラフィー(分子量による分離)によってSuperose 6カラム(Amersham Pharmacia Biotech, 分離可能な分子量範囲5〜5000 kDa)を用いて分離した。移動層は水中50mMのイミダゾール、0.2容量%の2-メルカプトエタノール、0.5重量%のドデシル硫酸ナトリウム(SDS)pH7であり、溶出速度は0.45ml/分であった。溶出画分は、280nmにおけるUV吸収測定により検出した。図1に示したクロマトグラムが得られた。粘液剤中に含まれたオボムチンがデッドボリューム(ピーク1)中に溶出され、オボムチンの分子量は少なくとも5000kDaであると仮定される。
サンプル調製
実施例1から得られたオボムチン含有粘液剤サンプルを、Ultraturraxによって、ゆっくり攪拌しつつPBSバッファー(0.2g/lのKH2PO4,1.441g/lのNa2HPO4x2H2O,8.5g/lのNaCl,0.1g/のMgCl2x6H2O, 0.2g/lのKCl;pH7)に溶解させた。得られたオボムチンサンプルの最初の重量は2重量%(粘液剤の乾燥物重量に基づく)であった。測定する前に、最終溶液を4℃で一晩保存した。
ダイナミックストレスレオメーターSR-200(Rheometric Scientific Inc., Piscataway, USA)を用いて、37℃にてレオロジー測定を行った。容量16mlのクロムめっきしたCouetteセルを使用した。実際の測定の前に、サンプルに約100s-1の剪断応力を1分間かけ、次いで3分間回復させる前処理を行った。
以下の実施例4a〜4jのための一般的な調製手順は以下のとおりである:
これらの実施例の口腔ケア組成物(各100g)は、6種類までの異なる水溶液A、B、C、D、EおよびFから調製した。
唾液代替液の調製
乾燥物4gを含んだオボムチン含有粘液剤のサンプル(実施例1で調製)を200mlのPBSバッファー(1.102g/lのKH2PO4、0.262g/lのNa2HPO4x2H2O、0.585g/lのNaCl、0.1g/のMgCl2x6H2O、0.2g/lのKCl;pH6.5)に懸濁させた。この懸濁液を最初に固定子−ローター原理によって動く攪拌子(Ultraturrax T25ベーシック, ロッド直径1.8cm)を用いて20秒ごとに3回、11,500rpmで氷冷槽中で冷却しながら攪拌し、2回の攪拌操作の間に15秒間、攪拌を休止させた。次いでこの懸濁液を超音波プローブ(Branson Sonifier 450, ロッド直径1.2cm)を用いて、6にセットして各5秒を20回、氷冷槽中で冷却しながら超音波処理し、各超音波処理の間に15秒間、攪拌を休止させた。次いで乳化剤0.3g(Cremophor(登録商標)RH 410またはTween(登録商標)20)を加え、この最終唾液代替液を室温で2時間攪拌した。この溶液の上清のみを測定に使用した;シアル酸含量の定量によれば、使用したオボムチン含有粘液剤の少なくとも約80重量%が溶解していた。
ダイナミックストレスレオメーターSR-200 (Rheometric Scientific Inc., Piscataway, USA)を用いて、37℃にてレオロジー測定を行った。クロムめっきした、分離が0.200mmのパラレルプレートを有する40mmのセルを使用した。実際の測定の前に、唾液代替液サンプルに約100s-1の剪断応力を1分間かけ、次いで3分間回復させる前処理を行った。実際の測定に関しては、試験は測定装置が生じさせ得る最も低い応力で開始し、その応力を50Paまで増加させた。
Claims (22)
- a)オボムチンを含有し、シアル酸含量が1.5〜2.5重量%である粘液剤、および
b)乳化剤
を含む口腔ケア組成物。 - a)オボムチンを含有する粘液剤、および
b)マンノプロテイン
を含む口腔ケア組成物。 - 粘液剤のマンノプロテインに対する重量比が1:1000〜10:1、好ましくは1:100〜 2:1であることを特徴とする、請求項2に記載の口腔ケア組成物。
- カルボキシメチルセルロース、ヒドロキシアルキルセルロース、ポリアクリル酸の水溶性かつ膨潤可能な塩、アルギン酸塩、カラギーナン、グアーガム、高分子量ポリエチレンオキシドおよび動物性ムチンならびにその混合物からなる群から選択されるさらなる粘液剤を含む、請求項1に記載の口腔ケア組成物。
- 乳化剤を含む、請求項2〜4のいずれか一項に記載の口腔ケア組成物。
- 乳化剤が合成乳化剤であることを特徴とする、請求項1または5に記載の口腔ケア組成物。
- 該乳化剤が、部分的にエステル化された(C3-C6)糖アルコールのポリ(オキシエチレン)誘導体であり、その糖アルコールをエステル化する酸が(C10-C20)脂肪酸、あるいは炭化水素鎖がヒドロキシル化されているものであることを特徴とする、請求項6に記載の口腔ケア組成物。
- 該ポリ(オキシエチレン)誘導体が、5〜50のオキシエチレンユニット、好ましくは20〜40のオキシエチレンユニットを含むことを特徴とする、請求項7に記載の口腔ケア組成物。
- 該乳化剤が両性イオンであることを特徴とする、請求項6に記載の口腔ケア組成物。
- それが唾液代替液であることを特徴とする、請求項1〜9のいずれか一項に記載の口腔ケア組成物。
- NaCl、CaCl2、MgCl2、KCl、ナトリウムまたはカリウムの二水素リン酸塩およびリン酸水素塩、ならびにナトリウムまたはカリウムの炭酸塩および炭酸水素塩から選択される添加剤を含有することを特徴とする、請求項10に記載の唾液代替液。
- 該添加剤が0.05〜0.15重量%のKCl;0.05〜0.1重量%のNaCl;0.002〜0.008重量%のMgCl2および0.01〜0.02重量%のCaCl2であり、それが二水素リン酸塩/リン酸水素塩および/または炭酸塩/炭酸水素塩緩衝液を用いてヒト唾液に相当するpHおよび緩衝能に緩衝化されていることを特徴とする、請求項11に記載の唾液代替液。
- 約0.12重量%のKCl、約0.086重量%のNaCl、約0.005重量%のMgCl2および約0.015重量%のCaCl2を含有することを特徴とする、請求項12に記載の唾液代替液。
- ヒト唾液に類似したチキソトロピーを有する、請求項10〜13のいずれか一項に記載の唾液代替液。
- 保湿剤を添加剤として含有することを特徴とする、請求項1〜14のいずれか一項に記載の口腔ケア組成物。
- 該保湿剤が、グリセロール、プロピレングリコール、ソルビトール、マンニトール、グルコースシロップおよびポリエチレングリコールまたはポリプロピレングリコールからなる群から選択されることを特徴とする、請求項15に記載の口腔ケア組成物。
- 合成香料を添加剤として含有することを特徴とする、請求項1〜16のいずれか一項に記載の口腔ケア組成物。
- フッ化物イオン源を添加剤として含有することを特徴とする、請求項1〜17のいずれか一項に記載の口腔ケア組成物。
- マンノプロテイン、カルボキシメチルセルロース、ヒドロキシアルキルセルロース、ポリアクリル酸の水溶性かつ膨潤可能な塩、アルギン酸塩、カラギーナン、グアーガム、動物性ムチンおよびその混合物からなる群から選択される1以上のさらなる粘液剤とオボムチン含有粘液剤の組み合わせの、口腔ケア組成物の調製における添加剤としての使用。
- マンノプロテイン、カルボキシメチルセルロース、ヒドロキシアルキルセルロース、ポリアクリル酸の水溶性かつ膨潤可能な塩、アルギン酸塩、カラギーナン、グアーガム、動物性ムチンおよびその混合物からなる群から選択される1以上のさらなる粘液剤とオボムチン含有粘液剤の組み合わせ、およびあるいは該製剤が水または水とエタノールの混合物に溶解する際に口腔ケア組成物を形成するようなさらなる添加剤を含む、固体製剤。
- シアル酸含量1.5〜2.5重量%(乾燥重量)のオボムチン含有粘液剤と、乳化剤を含む水溶液の混合を含む、口腔ケア組成物調製のための工程。
- その混合が以下のステップ:
a)乳化剤を含む水溶液に、シアル酸含量が1.5〜2.5重量%(乾燥重量)であるオボムチン含有粘液剤を懸濁させること、
b)a)で得られた懸濁液を高い剪断力下で攪拌すること、
c)所望により、b)の後に、まだ懸濁液状である場合は、この懸濁液を超音波で処理すること、
d)所望により、c)の後に、まだ懸濁液状である場合は、この懸濁液を攪拌すること
を含むことを特徴とする、請求項21に記載の工程。
Applications Claiming Priority (2)
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CH7072002 | 2002-04-25 | ||
PCT/CH2003/000271 WO2003090703A1 (de) | 2002-04-25 | 2003-04-25 | Mundpflegemittel enthaltend ovomucin |
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JP2005529125A true JP2005529125A (ja) | 2005-09-29 |
JP4307269B2 JP4307269B2 (ja) | 2009-08-05 |
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US (1) | US20050226822A1 (ja) |
EP (2) | EP2319489A2 (ja) |
JP (1) | JP4307269B2 (ja) |
AU (1) | AU2003218853A1 (ja) |
CA (2) | CA2483000C (ja) |
HR (1) | HRP20041100A2 (ja) |
IL (2) | IL164694A (ja) |
NO (1) | NO20044992L (ja) |
PL (2) | PL371950A1 (ja) |
WO (1) | WO2003090703A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010501640A (ja) * | 2006-09-01 | 2010-01-21 | ユニゼル デヴェロップメント | 唾液代替剤 |
JP2011519896A (ja) * | 2008-05-08 | 2011-07-14 | ネステク ソシエテ アノニム | 唾液分泌を補助するシアル酸 |
JP2014513723A (ja) * | 2011-05-16 | 2014-06-05 | コルゲート・パーモリブ・カンパニー | オーラルケア組成物 |
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US20100030100A1 (en) * | 2007-02-06 | 2010-02-04 | Hisamitsu Pharmaceutical Co., Inc. | Microneedle Device For Diagnosis Of Allergy |
FR2921260B1 (fr) * | 2007-09-25 | 2012-08-24 | Lesaffre & Cie | Utilisation d'un nouvel agent naturel dans des compositions cosmetiques |
CN103439459A (zh) * | 2013-08-16 | 2013-12-11 | 云南烟草科学研究院 | 一种用于新型烟草制品中烟碱及香味成分提取测定的溶媒 |
WO2015177288A1 (en) * | 2014-05-22 | 2015-11-26 | University Of Copenhagen | Aqueous gel composition and its use |
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WO1981002977A1 (en) * | 1980-04-25 | 1981-10-29 | Orthana Kemisk Fab As | Sterilized,preserved,stable mucine-containing solutions and sterilization method |
NL8402786A (nl) * | 1984-09-12 | 1986-04-01 | Stichting Biomaterials Science | Preparaat voor het beschermen van gebitselementen tegen ontkalking. |
US5496558A (en) * | 1993-03-02 | 1996-03-05 | Block Drug Company Inc. | Solid form xerostomia product |
NL9400160A (nl) * | 1994-02-02 | 1995-09-01 | Stichting Tech Wetenschapp | Therapeutische samenstelling voor het vervangen en/of aanvullen van lichaamsvloeistoffen. |
DK0944579T3 (da) | 1996-11-18 | 2002-01-07 | Gaba Internat | Aminhydrofluorider og deres anvendelse som mundhygiejnemidler |
IE970541A1 (en) | 1997-07-25 | 1999-01-27 | Michael Anthony Folan | Maternal immune secretions and their use in the treatment and/or prophylaxis of the buccal cavity |
GB2361870A (en) * | 2000-05-03 | 2001-11-07 | Zia Hashmi | Treating xerostomia |
US7025992B2 (en) * | 2001-02-14 | 2006-04-11 | Gw Pharma Limited | Pharmaceutical formulations |
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2003
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010501640A (ja) * | 2006-09-01 | 2010-01-21 | ユニゼル デヴェロップメント | 唾液代替剤 |
JP2011519896A (ja) * | 2008-05-08 | 2011-07-14 | ネステク ソシエテ アノニム | 唾液分泌を補助するシアル酸 |
JP2014513723A (ja) * | 2011-05-16 | 2014-06-05 | コルゲート・パーモリブ・カンパニー | オーラルケア組成物 |
US9675542B2 (en) | 2011-05-16 | 2017-06-13 | Colgate-Palmolive Company | Oral care compositions |
Also Published As
Publication number | Publication date |
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WO2003090703A1 (de) | 2003-11-06 |
IL206752A0 (en) | 2011-07-31 |
IL164694A0 (en) | 2005-12-18 |
EP2319489A2 (de) | 2011-05-11 |
IL206752A (en) | 2012-12-31 |
CA2711709C (en) | 2013-03-12 |
NO20044992L (no) | 2004-11-17 |
EP1496851A1 (de) | 2005-01-19 |
CA2483000A1 (en) | 2003-11-06 |
CA2483000C (en) | 2011-10-11 |
HRP20041100A2 (en) | 2004-12-31 |
AU2003218853A1 (en) | 2003-11-10 |
IL164694A (en) | 2012-10-31 |
US20050226822A1 (en) | 2005-10-13 |
PL371950A1 (en) | 2005-07-11 |
CA2711709A1 (en) | 2003-11-06 |
PL393878A1 (pl) | 2011-05-09 |
JP4307269B2 (ja) | 2009-08-05 |
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