JP2005526070A - オキソ−アザ二環系化合物 - Google Patents
オキソ−アザ二環系化合物 Download PDFInfo
- Publication number
- JP2005526070A JP2005526070A JP2003574636A JP2003574636A JP2005526070A JP 2005526070 A JP2005526070 A JP 2005526070A JP 2003574636 A JP2003574636 A JP 2003574636A JP 2003574636 A JP2003574636 A JP 2003574636A JP 2005526070 A JP2005526070 A JP 2005526070A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- alkyl
- oxo
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 CC(C1=*C(C(N(*)C(*)(*)N2*)=O)=C2I=*1)=* Chemical compound CC(C1=*C(C(N(*)C(*)(*)N2*)=O)=C2I=*1)=* 0.000 description 8
- RHWQBDCMIUUGLN-UHFFFAOYSA-N COC(c1ccc(CN(C=Nc(cc2)c3cc2C#CCc2ccccc2)C3=O)cc1)=O Chemical compound COC(c1ccc(CN(C=Nc(cc2)c3cc2C#CCc2ccccc2)C3=O)cc1)=O RHWQBDCMIUUGLN-UHFFFAOYSA-N 0.000 description 1
- VWEMMOSCPQANBP-UHFFFAOYSA-N OC(c(cc1)cc2c1N=CN(Cc(cc1)ccc1F)C2=O)=O Chemical compound OC(c(cc1)cc2c1N=CN(Cc(cc1)ccc1F)C2=O)=O VWEMMOSCPQANBP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2002/003240 WO2003076416A1 (fr) | 2002-03-08 | 2002-03-08 | Composes oxo azabicycliques |
PCT/EP2003/002277 WO2003076417A2 (fr) | 2002-03-08 | 2003-03-06 | Composes oxo-azabicycliques |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2005526070A true JP2005526070A (ja) | 2005-09-02 |
Family
ID=27798761
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003574636A Withdrawn JP2005526070A (ja) | 2002-03-08 | 2003-03-06 | オキソ−アザ二環系化合物 |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP1492775A2 (fr) |
JP (1) | JP2005526070A (fr) |
KR (1) | KR20040095270A (fr) |
CN (1) | CN1738806A (fr) |
AP (1) | AP2004003125A0 (fr) |
AR (1) | AR039562A1 (fr) |
AU (2) | AU2002249275A1 (fr) |
BR (1) | BR0308280A (fr) |
CA (1) | CA2478706A1 (fr) |
CO (1) | CO5601020A2 (fr) |
EA (1) | EA200401053A1 (fr) |
EC (1) | ECSP045278A (fr) |
IL (1) | IL163818A0 (fr) |
IS (1) | IS7414A (fr) |
MA (1) | MA27183A1 (fr) |
MX (1) | MXPA04008681A (fr) |
NO (1) | NO20044041L (fr) |
OA (1) | OA12782A (fr) |
PA (1) | PA8568501A1 (fr) |
PE (1) | PE20031018A1 (fr) |
PL (1) | PL372622A1 (fr) |
SV (1) | SV2003001495A (fr) |
TN (1) | TNSN04169A1 (fr) |
UY (1) | UY27700A1 (fr) |
WO (2) | WO2003076416A1 (fr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PA8539501A1 (es) | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Compuestos triazolo como inhibidores de mmp |
US6962922B2 (en) | 2001-10-12 | 2005-11-08 | Warner-Lambert Company Llc | Alkynylated quinazoline compounds |
US6894057B2 (en) | 2002-03-08 | 2005-05-17 | Warner-Lambert Company | Oxo-azabicyclic compounds |
WO2004014923A1 (fr) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Inhibiteurs de metalloprotease bicycliques condenses avec la pyrimidinone |
WO2004014375A2 (fr) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Inhibiteurs de metalloprotease bicycliques condenses |
AU2003253186A1 (en) | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors |
PA8578101A1 (es) | 2002-08-13 | 2004-05-07 | Warner Lambert Co | Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz |
AU2003250471A1 (en) | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Pyrimidine-2,4-dione derivatives as matrix metalloproteinase inhibitors |
WO2004014378A1 (fr) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Derives de 3-isoquinolinone utilises comme inhibiteurs de metalloprotease de matrice |
WO2004014866A1 (fr) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Derives d'azaisoquinoline utilises comme inhibiteurs de metalloproteases matricielles |
WO2004014384A2 (fr) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Composes cycliques contenant des groupes liant le zinc en tant qu'inhibiteurs de metalloprotease de matrice |
JP2006501215A (ja) | 2002-08-13 | 2006-01-12 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | マトリックスメタロプロテイナーゼ阻害剤としての単環式誘導体 |
BR0313384A (pt) | 2002-08-13 | 2005-07-12 | Warner Lambert Co | Derivados de cromona como inibidores de metaloproteinases de matriz |
WO2005016926A1 (fr) * | 2003-08-19 | 2005-02-24 | Warner-Lambert Company Llc | Derives de pyrido[3,4-d]pyrimidine utiles comme inhibiteurs de la metalloproteinase-13 de matrice |
DE10360835A1 (de) * | 2003-12-23 | 2005-07-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclische Imidazolverbindungen, deren Herstellung und deren Verwendung als Arzneimittel |
RU2006142305A (ru) * | 2004-04-30 | 2008-06-10 | Такеда Фармасьютикал Компани Лимитед (Jp) | Гетероциклическое амидное соединение и его применение в качестве ингибитора ммр-3 |
US20080275022A1 (en) * | 2004-06-15 | 2008-11-06 | Astrazeneca Ab | Substituted Quinazolones as Anti-Cancer Agents |
BRPI0717502A2 (pt) | 2006-10-05 | 2015-06-16 | Cv Therapeutics Inc | Compostos heterocíclicos contendo nitrogênio bacíclico para uso como inibidores de estearoil-coa desaturase. |
WO2012052451A1 (fr) | 2010-10-18 | 2012-04-26 | Merz Pharma Gmbh & Co. Kgaa | Modulateurs des récepteurs métabotropes au glutamate |
CN103524431B (zh) * | 2013-09-24 | 2016-01-13 | 西安交通大学 | 3-苄基-4-喹唑啉酮类化合物及其合成方法和应用 |
JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
DK3353177T3 (da) | 2015-09-23 | 2020-08-24 | Janssen Pharmaceutica Nv | Tricykliske heterocykler til behandling af cancer |
RU2747644C2 (ru) | 2015-09-23 | 2021-05-11 | Янссен Фармацевтика Нв | Бигетероарил-замещенные 1,4-бензодиазепины и пути их применения для лечения рака |
FR3046793B1 (fr) * | 2016-01-14 | 2018-01-05 | Les Laboratoires Servier | Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998026664A1 (fr) * | 1996-12-17 | 1998-06-25 | E.I. Du Pont De Nemours And Company | Quinazolinones fongicides |
PA8539401A1 (es) * | 2001-02-14 | 2002-10-28 | Warner Lambert Co | Quinazolinas como inhibidores de mmp-13 |
PA8539301A1 (es) * | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Inhibidores de la metaloproteinasa de la matriz |
-
2002
- 2002-03-08 WO PCT/EP2002/003240 patent/WO2003076416A1/fr not_active Application Discontinuation
- 2002-03-08 AU AU2002249275A patent/AU2002249275A1/en not_active Abandoned
-
2003
- 2003-03-04 SV SV2003001495A patent/SV2003001495A/es not_active Application Discontinuation
- 2003-03-06 AR ARP030100749A patent/AR039562A1/es not_active Application Discontinuation
- 2003-03-06 CN CNA038048752A patent/CN1738806A/zh active Pending
- 2003-03-06 AU AU2003212307A patent/AU2003212307A1/en not_active Abandoned
- 2003-03-06 JP JP2003574636A patent/JP2005526070A/ja not_active Withdrawn
- 2003-03-06 PL PL03372622A patent/PL372622A1/xx not_active Application Discontinuation
- 2003-03-06 PE PE2003000218A patent/PE20031018A1/es not_active Application Discontinuation
- 2003-03-06 AP APAP/P/2004/003125A patent/AP2004003125A0/en unknown
- 2003-03-06 WO PCT/EP2003/002277 patent/WO2003076417A2/fr not_active Application Discontinuation
- 2003-03-06 IL IL16381803A patent/IL163818A0/xx unknown
- 2003-03-06 PA PA20038568501A patent/PA8568501A1/es unknown
- 2003-03-06 EA EA200401053A patent/EA200401053A1/ru unknown
- 2003-03-06 OA OA1200400234A patent/OA12782A/en unknown
- 2003-03-06 MX MXPA04008681A patent/MXPA04008681A/es unknown
- 2003-03-06 UY UY27700A patent/UY27700A1/es not_active Application Discontinuation
- 2003-03-06 CA CA002478706A patent/CA2478706A1/fr not_active Abandoned
- 2003-03-06 EP EP03708181A patent/EP1492775A2/fr not_active Withdrawn
- 2003-03-06 BR BR0308280-6A patent/BR0308280A/pt not_active IP Right Cessation
- 2003-03-06 KR KR10-2004-7013994A patent/KR20040095270A/ko not_active Application Discontinuation
-
2004
- 2004-08-19 IS IS7414A patent/IS7414A/is unknown
- 2004-08-25 CO CO04082792A patent/CO5601020A2/es not_active Application Discontinuation
- 2004-08-31 MA MA27842A patent/MA27183A1/fr unknown
- 2004-09-03 TN TNP2004000169A patent/TNSN04169A1/fr unknown
- 2004-09-03 EC EC2004005278A patent/ECSP045278A/es unknown
- 2004-09-24 NO NO20044041A patent/NO20044041L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1492775A2 (fr) | 2005-01-05 |
CA2478706A1 (fr) | 2003-09-18 |
MXPA04008681A (es) | 2004-12-06 |
EA200401053A1 (ru) | 2005-04-28 |
CN1738806A (zh) | 2006-02-22 |
IL163818A0 (en) | 2005-12-18 |
PE20031018A1 (es) | 2004-01-09 |
WO2003076417A2 (fr) | 2003-09-18 |
MA27183A1 (fr) | 2005-01-03 |
KR20040095270A (ko) | 2004-11-12 |
AP2004003125A0 (en) | 2004-09-30 |
AR039562A1 (es) | 2005-02-23 |
ECSP045278A (es) | 2004-10-26 |
SV2003001495A (es) | 2003-11-04 |
AU2003212307A1 (en) | 2003-09-22 |
IS7414A (is) | 2004-08-19 |
CO5601020A2 (es) | 2006-01-31 |
PL372622A1 (en) | 2005-07-25 |
WO2003076416A1 (fr) | 2003-09-18 |
UY27700A1 (es) | 2003-10-31 |
AU2002249275A1 (en) | 2003-09-22 |
TNSN04169A1 (fr) | 2007-03-12 |
PA8568501A1 (es) | 2003-12-19 |
OA12782A (en) | 2006-07-10 |
BR0308280A (pt) | 2004-12-28 |
WO2003076417A3 (fr) | 2003-11-13 |
NO20044041L (no) | 2004-10-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6894057B2 (en) | Oxo-azabicyclic compounds | |
JP2005526070A (ja) | オキソ−アザ二環系化合物 | |
US6747147B2 (en) | Oxo-azabicyclic compounds | |
EP2654422B1 (fr) | Dérivés d'amide bicyclo[3.2.1]octyl en tant que modulateurs allosteriques du récepteur 5 métabotropique du glutamate (mGlu5 ou GluR5) pour le traitement des troubles du système nerveux central (SNC) | |
US7312330B2 (en) | Bicycloheteroarylamine compounds as ion channel ligands and uses thereof | |
JP3927175B2 (ja) | N−置換ヒドロキシピリミジノンカルボキサミド系hivインテグラーゼ阻害薬 | |
AP1148A (en) | Novel 2,3 Disubstituted-4 (3H)- quinzolinones. | |
US6962922B2 (en) | Alkynylated quinazoline compounds | |
EP0471236B1 (fr) | Dérivés de l'imidazopyridine et leur application | |
MXPA04011557A (es) | Compuestos de quinazolinona sustituida. | |
US20050245548A1 (en) | Alkynylated fused ring pyrimidine compounds | |
JPH0794447B2 (ja) | キナゾリン誘導体 | |
JP2003500467A (ja) | 細胞接合分子としてのスクエア酸誘導体 | |
CA2523015A1 (fr) | Composes de quinazoline substitues par guanidino constituant des agonistes de mc4-r | |
JP2004529874A (ja) | マトリックスメタロプロテイナーゼ阻害剤 | |
US20040006077A1 (en) | Thiazine and oxazine derivatives as MMP-13 inhibitors | |
WO2004033435A1 (fr) | Derives de quinazolinone utilises comme agents anti-hyperalgesiques | |
JP2018516938A (ja) | RORガンマ(RORγ)モジュレーター | |
MXPA06005736A (es) | Compuestos de quinazolinona con bioacumulacion reducida. | |
US6649620B2 (en) | Quinoline and quinazoline compounds useful in therapy | |
JP2005538965A (ja) | 関節炎を治療するためのmmp−13阻害剤としてのチアジン及びオキサジン誘導体 | |
WO2003033477A1 (fr) | Composes alkynylates de pyrimidine a noyau condense sous forme d'inhibiteur de matrice de metalloprotease-13 | |
WO2004007469A1 (fr) | Nouveaux composes de quinazoline alcynyles utilises comme inhibiteurs de la mmp-13 | |
JPS61140568A (ja) | キナゾリン誘導体及びそれを有効成分とする血圧降下剤 | |
WO1994003439A1 (fr) | Composes tricycliques a activite antiproliferatrice |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A761 | Written withdrawal of application |
Free format text: JAPANESE INTERMEDIATE CODE: A761 Effective date: 20060322 |