JP2005518907A - Medical connector assembly for fluid transfer - Google Patents

Abstract

The invention relates to a connector assembly (10) for the transfer of fluids, particularly fluids comprising an active agent from a reservoir to a medical device for dosage, comprising: a first connector element (20), pertaining to the reservoir with first fixing means (23), a second connector element (10), pertaining to the medical dosage device with second fixing means (12), cooperating with the first fixing means to give an irreversible connection between the two elements. The first and second elements are embodied such as to cooperate with other by clipping on a single translational movement of a connector element relative to the other to produce the irreversible connection, characterized in that at least one of the connection elements is embodied with means to render the same breakable.

Description

  The present invention relates to a medical coupling system configured to transfer fluid, in particular pharmaceutical products, from a reservoir to a medical delivery device.

  As used herein, the term “fluid” refers to chemical synthesis or to be designed to provide care or treatment for an infection or injury, or to modify or alter a biological function, or to make a diagnosis. It relates to various pharmaceuticals or active products obtained by natural extract compounds. For example, anti-inflammatory agents, antibiotics, antibacterial agents, antifungal agents, anticancer agents, antiangiogenic agents, antiglaucoma agents, neuroprotective agents, neuromodulators, anaesthetics, oligonucleotides, etc. Examples include gene therapy products, plasmids, nutrients, vitamins, salts, minerals, and hormonal agents. The fluid includes bodily fluids such as blood and gastric juice and urine which are one of its components.

  Additional information on the definition of pharmaceuticals is defined in the European Directive 65/65 / CEE dated January 26, 1965, which deals with legal requirements regarding pharmaceuticals as follows:

“The following definitions are applicable to the use of this directive.
1. Characteristics of medicines Medicines are prepared in advance and sold in special packages with special names.
2. Drug Any substance or compound that has the property of alleviating or preventing human and animal diseases.
Any substance or formulation that is administered to a human or animal in order to make a medical diagnosis or to restore, correct or change the biological function of a human or animal.
3. Substance Any material not related to origin.
The origin is
-Human blood and products obtained from human blood,
-Animal microorganisms, all animals, tissue fragments, animal secretions, toxins, substances obtained by extraction, products obtained from blood, etc.
-Plant microorganisms, plants, plant fragments, plant secretions, substances obtained by extraction, etc.
-There are chemicals such as elements, natural chemicals, and chemical transfer and synthetic products.
4). Special prescription Any drug prepared at a pharmacy using a prescription for a specific patient.
5. Pharmacopoeia prescription Any drug prepared at the pharmacy according to the instructions of the pharmacopoeia. This is delivered directly to the patient and supplied through this pharmacy. 』

  This is supplemented by a directive dated July 22, 1993.

“Drugs from one of the following biotechnology processes.
-Recombination of deoxyribonucleic acid technology,
Control of the expression of the genetic code for prokaryotic and eukaryotic biologically effective proteins, including transformed mammalian cells,
-Methods based on hybrid and monoclonal antibodies.
Veterinary drugs that have come to be used primarily to enhance performance, to promote growth, or to increase the productivity of treated animals, including drugs not obtained through biotechnology

  Because of the risk of cross-contamination between various patients or between patients and caregivers, it is currently being marketed as a sanitary product that is discarded after a single use. As warranted by development, it is customary and sometimes mandatory to use a medical delivery device only once for a particular patient. Similarly, pharmaceuticals are increasingly being sold in vials containing single doses. This makes it impossible to use the drug for several patients and limits the risk of incorrect doses. However, despite the fact that the medical delivery device has a “disposable” indication, no measures have been taken to ensure that these are not actually reused for several patients. Thus, for example, an intravenous infusion needle can be connected to a syringe containing a single dose of a medicament and thus can be used to administer the dose to several patients. First, many solutions have been proposed to address the problem of reuse of these hypodermic needles and syringes, and second, to accidental contamination caused by injection. And always resulted in a single use of the syringe and / or needle.

  However, some drugs need to be prepared by dilution, for example in the form of lyophilized powder. In the preparation of such a pharmaceutical, the form to be diluted is mixed with a solvent in a specific ratio, and the obtained solution is transferred to a medical delivery device. In general, the solvent is first drawn into a syringe and then poured into a container containing the lyophilized powder. After mixing, the mixture is again sucked up with a syringe. The syringe is then connected to a medical delivery device so that the mixture can be administered. Therefore, the syringe and various containers must be connected and disconnected as many times as necessary to form a mixture. The final connection that is made is the connection between the syringe and the medical delivery device.

  US Pat. No. 6,231,552 describes a coupling assembly between a reservoir (in this case a syringe) and a medical delivery device (in this case a hypodermic needle). This coupling assembly uses a standard male luer cone. A cone with a thread on the inner surface is surrounded by a coaxial cylinder, and a notch is formed at the free end of the thread. The needle has a standard female luer cone with a thread formed on the outer surface of the hypodermic needle base that is complementary to the thread provided on the syringe that is compatible with the male luer cone provided on the syringe. Furthermore, a pin projects from the outer surface at the tip of a thread provided on the needle. Thus, when the syringe is connected to the needle, after the two threads described above have been brought together by screwing, the pin provided on the hypodermic needle is irreversibly in the notch provided on the syringe for this pin. Clipped. The resulting system prevents the reservoir and medical delivery device from disconnecting, while at the same time standard male and female “locked” luer connectors (with similar threads as described above). It can be irreversibly linked. This system is irreversible only when connecting between luer cones provided with either a protruding pin or a notch into which the pin fits.

  The disadvantage of this type of device is that the user must perform a translational movement combined with a rotational movement (spiral movement) in order to irreversibly connect such a system and to form a connection. That's what it means. At this time, in order to engage the irreversible holding means between the two elements, an additional force is applied at the end of the screwing. At this time, the male and female luer cones are already cooperating by contact so as to make the connecting part liquid-tight.

  One object of the present invention is to provide an irreversible coupling assembly between a reservoir assembled during a single coupling movement and a medical delivery device.

  To this end, according to the present invention, a coupling assembly for transferring a fluid, in particular a fluid containing an active product, from a reservoir to a medical delivery device, the first holding associated with the reservoir. A first connecting element including means and a second connecting element associated with the medical delivery device, wherein the second holding means cooperates with the first holding means to form an irreversible connecting portion between the two connecting elements. The first holding means and the second holding means cooperate with each other by clipping when the one connecting element is translated with respect to the other to form an irreversible connecting portion. A coupling assembly is provided.

  Thus, this particular configuration of retaining means allows the user to connect the medical delivery device to the reservoir. Both the medical delivery device and the reservoir are designed to irreversibly connect them to each other by performing a single translational movement as is normally done with standard connection elements such as male and female luer cones. A connecting element is provided.

Advantageously, all connecting elements comprise at least one of the additional features listed below. That is,
Either one of the first holding means or the second holding means comprises at least one elastically deformable tab and the other holding means comprises at least one lip capable of cooperating with the tab;
-Either the first holding means or the second holding means comprises two tabs arranged on both sides of the connecting element;
-Either the first holding means or the second holding means has at least one recess, the other holding means comprising at least one lip capable of cooperating with the recess;
The lip is elastically deformable,
-Either the first coupling element or the second coupling element comprises a male part and the other coupling element is complementary to the male part and cooperates with the male part so as to make the coupling part liquid-tight Including a female part that can
The male and female parts are luer cones with a taper of about 6%;
The male part is essentially a tube-shaped piercer, and at least one of the connecting elements is provided with means allowing it to break.

  The present invention further includes a connecting element including a holding means for transferring fluid, in particular a fluid containing the active product, from the reservoir to the medical delivery device, the holding means between the two connecting elements. During one translation, these holding means cooperate with the holding means of the other connecting element by clipping to form an irreversible connection between the two connecting elements.

  Other features and advantages of the present invention will become more apparent after reading the following description of one embodiment and variations.

  The following definitions can apply to the rest of this document.

[Medical delivery device]
To contact a body tissue (skin, mucous membrane, muscle, etc.) in order to administer a therapeutically effective product systemically or locally or to collect a body fluid, ie a fluid as defined above, Or a device designed to penetrate one of the holes in the human body (mouth, nostril, bladder, genital organs, eyes, lungs, etc.) or into the circulatory system (veins, arteries). Examples include the following devices that are considered to be medical delivery devices. Transdermal patches, intramuscular vaccination systems, transdermal vaccination systems, intravenous catheters, urethral probes, gastric probes, hypodermic needles, pharmaceuticals delivered by iontophoresis, electroporation, or other energy sources A system for doing so, a bronchial sampling catheter and the like.

[Pharmaceutical reservoir or fluid reservoir]
A reservoir that contains medicinal products ready for administration. A flexible or rigid vial containing a single dose, administered in either continuous (eg flexible perfusion pack) or discontinuous (eg antibiotic treatment) over several days It may be a vial containing a therapeutic agent, a syringe containing a prepared pharmaceutical product, an aerosol vial, etc. The drug reservoir is always provided with an end piece that can be connected to a medical device such as a standard luer cone for syringes, or a puncturable rubber stopper for rigid glass vials.

[Ruel]
Standard male or female connecting element, including a cone with a taper of about 6%, inlet diameter of about 4 mm (for male) or about 4.3 mm (for female), used for medical purposes Defined by ISO international standards and used in all perfusion and infusion lines (such as intravenous catheters, syringes and hypodermic needles).

〔spike〕
A metal or plastic hollow needle used to puncture a rubber stopper (scepter) of a pharmaceutical container (vial) to access the contents. There is no detailed standard for these spikes, only the vial.

BEST MODE FOR CARRYING OUT THE INVENTION

  A first embodiment of the present invention will be described with reference to FIGS. 1a to 1c. The coupling assembly 1 includes two coupling elements 10, 20 that can cooperate with each other to form a coupling that is first irreversible and second liquid-tight.

  The connecting element 10, also called a female connector, has an elongated rotating body shape as a whole. An internal duct 17 passes through from one side to the other side coaxially with a rotation axis (not shown). The female connector 10 includes three functional parts. The first portion 14 is preferably an interface area with the medical delivery device. This portion allows the female connector to be attached to a medical delivery device (not shown). For example, in the case shown in FIG. 1, this region is essentially tubular and can accept a needle or tube. This is preferably assembled by gluing or insert molding. The entire interface area 14 may be part of the medical delivery device. In this case, the female connector 10 forms part of the medical delivery device and is integrated therewith.

  The second functional part of the female connector is a liquid-tight region 13 having an overall tubular shape and an inner surface 15. The inner surface 15 in this case has a contact portion that is substantially equivalent to the female luer cone described above and that defines part of the inner duct 17.

  The third part of the female connector is a region 11 designed to cooperate with other connecting elements to form an irreversible connection.

  Region 11 of female connector 10 includes a series of tabs 12 derived from the material used for the ring. These tabs 12 have free ends 16 extending in the internal duct 17 along the direction indicated by the arrow F for inserting the male connector 20 into the female connector 10. These tabs 12 are elastically deformable.

  The connecting element 20, i.e. the male connector, has a generally elongated rotor shape. An internal duct 25 penetrates coaxially with a rotation axis (not shown) from one side to the other side. Similarly, the male connector 20 includes the following three functional parts. Portion 21 is preferably the interface area with the reservoir containing the medicinal product. As described above, this interface region 21 preferably forms part of a pharmaceutical reservoir. In this case, the interface region 21 is in the form of any essentially tubular region. Preferably, the entire interface area 21 may be part of the drug reservoir. The male connector 20 forms part of the reservoir and is therefore integrated therewith. For example, as can be seen in the description below, such a male connector may be provided in a flexible pharmaceutical vial containing a single dose.

  The second part 23 is designed to cooperate with the region 11 of the female connector so as to form an irreversible connection. The part 23 consists of a lip 23 protruding from the outer surface of the male connector. The lip 23 is preferably continuous over the entire circumference of the male connector 20 as shown in FIG. 1b. The lip 23 has a first surface 26 inclined at a predetermined angle of preferably about 10 ° to 45 ° with respect to the rotation axis of the male connector, and the second surface 27 is substantially perpendicular to the rotation axis. The intersection of these surfaces 26, 27 forms the top of the lip 23. The surface 26 is along the introduction direction indicated by the arrow F, and the surface 27 is on the opposite side.

  Finally, the third part forming the male connector is a liquid-tight region 22 having an outer surface 24 substantially equivalent to the male luer cone described above.

  Female connector 10 is assembled with male connector 20 using a single translation along the direction of arrow F. When the male connector is inserted into the female connector, the lip 23 elastically deforms the tabs 12, the face 26 pushes back their ends 16, and then the ends 16 of the tab 12 return to their original position after the top of the lip 23 has passed. Return to the position so that the two connecting elements do not come off. When trying to translate in the direction opposite to the direction of arrow F, the end 16 of the tab 12 contacts the lip 23, specifically contacts the surface 27 and stops, thus preventing movement. When the male connector 20 is inserted into the female connector 10, the liquid-tight region 22 cooperates with the liquid-tight region 13 by contact between the female luer cone 15 and the male luer cone 24. Make it liquid-tight. Thus, fluid passing through the internal duct 25 of the male connector can circulate through the internal duct 17 of the female connector toward the medical delivery device without loss of fluid outward at the coupling assembly. The resulting assembly is shown in FIG.

  The portion 22 forming the liquid tight region of the male connector 20 is approximately equivalent to a female luer cone that connects the drug reservoir to any other device having a standard luer female connector. Thereby, a solution can be formed from the lyophilized product and the solvent. This requires connecting to a device containing the solvent, then connecting to the device containing the lyophilized product, and forming a solution before connecting to the medical delivery device.

  Next, a modification of the above-described embodiment will be described with reference to FIGS. 2a, 2b, and 2c. The coupling assembly 100 includes a coupling element 110 or female connector and a coupling element 120 or male connector. As described above, the connector has an elongated rotating body shape. The connector has internal ducts 117, 125 that are coaxial with a rotational axis (not shown). The connector has three functional parts. The female connector 110 has a functional portion 114 that forms an interface with the drug delivery device, here shown in the form of a conical beam that forms an end piece. This is forcibly fitted into a flexible tube connected to the drug delivery device. Preferably, as described above, the entire interface region 114 forms part of the medical delivery device, and thus the medical connector 110 forms an integral part of the medical delivery device. The female connector 110 has a second portion 113 that forms a liquid-tight region. This portion has an essentially tubular inner contact surface 115 which can cooperate with a complementary shaped male connector 120 as will be described below. Finally, the female connector 110 has a third part 111 that is very similar to the part 11 of the embodiment described above. The third portion includes two opposite tabs 112 provided on each side of the ring 111 and the internal duct 117. As described above, the tab 112 is formed of the same material as the ring of the connector 110 and has the free end 116 facing the insertion direction indicated by the arrow F and facing the inside of the duct 117.

  The male connector 120 is provided with an internal duct 125 that is used to transfer fluid from a drug reservoir (not shown) to the opposite end 126. The male connector 120 has three functional parts. Portion 121 is designed to form an interface with a pharmaceutical reservoir. This interface is formed in exactly the same way as the embodiment described above. This interface may include a female luer cone 127. The female luer cone is designed to work with a standard syringe that forms a reservoir with a complementary male luer cone. In this case, the male connector 120 has a portion that forms a liquid tight region 122 with an essentially tubular outer surface 124 that can cooperate with the surface 115 of the female connector 110 to make the connection liquid tight. . Finally, the male connector 120 has a cooperating region 123 that includes an outwardly projecting lip 123. This region is designed to cooperate with the tab 112 of the female connector 110 to make the connection irreversible. The embodiment shown in FIG. 2c is manufactured and assembled in the same way as the assembly of the embodiment shown in FIG. 1c and described above.

  Turning to FIGS. 2a, 2b and 2c, the region 122 of the male connector 120 is advantageously in the form of a spike that can pierce the rubber stopper of the pharmaceutical vial. Consider, for example, that this type of connector can be installed or can form an integral part of a syringe to collect sterile water or any other injectable solvent in a vial with a stopper Can do. This sterile water can then be transferred to a second vial with a stopper containing the lyophilized active product to dilute the lyophilized active product to obtain a solution, after which the female described above Irreversibly and permanently connected to a medical delivery device having a connector 110.

  The minimum number of tabs 12 or 112 is one. However, it is advantageous to provide an even number of tabs distributed evenly around the circumference of the female connector ring. One modification is shown in FIG. In this variation, female connector 210 differs from female connector 110 in that it has eight tabs 212 evenly distributed across the ring of connector 210. Industrially, it is preferable to use two tabs as shown in FIGS. 1a to 2c. This is to facilitate the production of a female connector by plastic injection molding.

  A second modification of the female connector is shown in FIG. This includes forming a continuous recess in the form of a ring 312. In this case, the coupling assembly 300 includes a male connector 20 similar to that described above and a female connector 310 associated with the needle 314 and having the same structure as the connector 10 described above. This connector 310 is not provided with a tab in the region 311, but instead is provided with a recess in the form of a ring 312, so that the lip 23 of the male connector 20 fits into this recess during assembly. Different from 10. In this type of embodiment, the connector 310 is formed of an elastic material so that a conical portion 316 disposed between the recess and the connector inlet can pass the lip 23 until it reaches the recess. It needs to be able to be deformed by the lip 23 so that it can.

  Next, a modification of the male connector 120 will be described with reference to FIGS. The male connector 420 is the same as the male connector 120 except that a continuous notch 426 is provided over the entire outer periphery of the connector between the lip 123 and the portion 121 that forms the interface region between the drug reservoir. This notch 426 weakens the male connector 420 at this location so that when a small shear force is applied, the connector breaks at this location. This so-called breakable area means that after transferring fluid between the drug reservoir and the medical delivery device, this area is broken to separate the reservoir from the device and leave a portion of the male connector on the female connector. . This means that after the drug is transferred, the portion of the drug reservoir can be separated from the medical delivery device, so that the size of the drug delivery device is not increased unnecessarily during use. To do. Furthermore, the portion of the male connector remains in the female connector, making it more difficult to later use the female connector and thus the medical delivery device. This situation is shown in FIG. In FIG. 10, the female connector 110 is connected to the medical delivery device 64 through a check valve 65 or anti-reflux valve, thereby preventing fluid from flowing out after injection and preventing the male connector from rupturing. In this case, the male connector 420 is shown broken apart at the notch 426 and forms an integral part of the syringe forming the drug reservoir 54.

  Preferably, the male connector described above, which generally forms the coupling assembly, is fully integrated with the medical reservoir, and the complementary female connector is fully integrated with the medical delivery device. Please pay attention to it.

  FIG. 5 shows a first use of the coupling assembly shown in FIGS. 1a to 1c. In this case, the female connector 10 is installed in a state of being fixed to a hypodermic needle 60 that may be a catheter or a probe. Further, the male connector 10 is fixedly installed in a single-dose or multi-dose syringe containing a medicine. It is important to note that in this type of configuration, the syringe may be removably connected to a standard female luer. Thus, for example, a drug or bodily fluid is collected from a source with a standard female luer connector, removed from the source after the drug or fluid has been collected, and then this fluid is needled without having to remove the medical delivery device 60 again. Or it can inject into the catheter mentioned above.

  FIG. 6 shows a second use of the coupling assembly shown in FIGS. 1a to 1c. In this case, the medical delivery device is a perfusion pack 61 pre-filled with a solute (for example, water containing glucose), and the solute in the pack 61 is mixed with a single dose of a medicine, such as an antibiotic. Therefore, the female connector 10 is provided integrally. A medicine reservoir is formed, and a vial 51 containing a single dose with a male connector 20 integrated therein is irreversibly installed on the female connector 10. Placing this type of connector in the access path to the perfusion pack makes it impossible to reuse it, which makes it easy to completely eliminate the risk of accidental injection of overdose medication. Means.

  FIG. 7 shows a third method of using the coupling assembly shown in FIGS. 1a to 1c. In this example, the medical delivery device is a device for transporting pharmaceuticals into the eye, percutaneously, or transmucosally, and the female connector 10 forms an integral part of the device. An intraocular drug delivery device is described in further detail in French Patent Application No. 2 773 320. Therefore, the connector 20 is attached to the flexible vial 52 containing a single dose. With this vial containing a single dose, the assembly cannot be used a second time after connecting the vial to the medical delivery device and after transferring the drug product from the vial to the medical delivery device.

  FIG. 8 shows the method of use of the present invention shown in FIGS. 2a, 2b and 2c.

  This figure shows the procedure to be performed following the preparation of a lyophilized form of the medicament. A male connector 120 in the form of a spike is placed and secured in a syringe or any other pharmaceutical reservoir equipped with a suction device. In the first step A, a necessary amount of the solution is sucked up by puncturing the diaphragm of the vial 70 containing the solution. In step B, the pre-aspirated solution is injected into the vial 71 containing the lyophilized product by puncturing the septum of the vial 71 in the same manner. The solution is then sucked back into this vial. In step C, the syringe 53 is irreversibly connected to the female connector 110 connected to the medical delivery device 63, which is simply indicated by a supply cable in the drawing.

  The material used to form this type of connector is preferably a polymer material commonly used in the manufacture of connectors for medical devices, this material being clipped by deformation of the connector tabs Therefore, it has good mechanical strength and is suitable for injection molding or molding with a molding die. For example, materials such as polystyrene, polycarbonate, polyvinyl chloride, polyethylene, polypropylene, polyurethane, polyamide, and polysulfonate can be used. The material is not limited to these. In addition, several alloys are suitable for this application, and the criterion for selecting such alloys is that they reversibly elastically deform.

  It should also be noted that the female connector of the preferred embodiment shown in the accompanying drawings cannot be used with a standard male luer connector.

  Obviously, many modifications can be made to the present invention without departing from the scope of the invention.

  For example, the male connector may be provided with a deformable tab having a deformable free end facing the insertion direction on the outside instead of the lip 23. The female connector may include a lip protruding toward the inside of the duct 17 instead of the tab 12. The lip cooperates with a tab provided on the male connector to form an irreversible connection and deforms the tab during insertion. The tab returns to its initial position after insertion. Reverse movement to remove the assembly is completely impossible because the tab stops in contact with the lip.

1a and 1b are a cross-sectional view and a perspective view at a removal position according to the first embodiment of the present invention, and FIG. 1c is a cross-sectional view at a connection position. 2a and 2b are a cross-sectional view and a perspective view at a removal position of a modification of the embodiment of FIG. 1, and FIG. 2c is a cross-sectional view at a connection position. It is a perspective view of the 2nd modification of the connection element of FIG. It is sectional drawing of the 3rd modification of the connection assembly of FIG. It is a figure which shows the 1st usage method of invention of FIG. It is a figure which shows the 2nd usage method of invention of FIG. It is a figure which shows the 3rd usage method of invention of FIG. FIG. 3 shows a method of using the invention of FIG. 2 for a lyophilized product. It is sectional drawing of the 2nd Embodiment of this invention. It is a figure which shows the usage method of invention of FIG.

Claims (12)

A coupling assembly (10; 100; 300) for transferring fluid, in particular fluid containing an active product, from a reservoir to a medical delivery device,
A first coupling element (20; 120) comprising first retaining means (23; 123) associated with the reservoir;
A second connecting element (10; 110; 210; 310) associated with the medical delivery device, which cooperates with the first holding means to form an irreversible connection between the two elements. A second coupling element comprising means (12; 112; 212; 312),
In the coupling assembly, the first retaining means and the second retaining means are configured to cooperate with each other by clipping when translating one coupling element relative to the other to form an irreversible coupling,
A coupling assembly, characterized in that at least one of the coupling elements is provided with means allowing the element to be broken.   Either the first holding means or the second holding means may include at least one elastically deformable tab (12; 112; 212), and the other holding means may cooperate with the tab. 2. A coupling assembly according to claim 1, characterized in that it comprises at least one lip (23; 123).   The connection assembly according to claim 2, wherein either one of the first holding means or the second holding means includes two tabs arranged on both sides of the connecting element.   Either the first holding means or the second holding means has at least one recess (312), and the other holding means has at least one lip capable of cooperating with the recess. The coupling assembly of claim 1, comprising:   The connection assembly according to claim 1, wherein the lip is elastically deformable.   Either the first connecting element or the second connecting element includes a male part (22; 122), and the other connecting element is complementary to the male part and makes the connecting part liquid-tight. 6. Coupling assembly according to any one of the preceding claims, characterized in that it comprises a female part (13; 113) capable of cooperating with the male part.   7. A coupling assembly according to claim 6, characterized in that the male part and the female part are luer cones (15, 24) having a taper of about 6%.   7. A coupling assembly according to claim 6, characterized in that the male part is essentially a tubular piercer.   9. A check means according to claim 1, further comprising a check means capable of preventing the fluid from exiting after injection, the means being able to make the connecting element fragile. A coupling assembly according to any one of the preceding claims.   8. The method of claim 7, wherein one of the first connection element and the second connection element can be irreversibly connected to a standard connector before irreversibly connecting to the other element. A coupling assembly as described.   9. The coupling assembly according to claim 8, wherein the second coupling element uses the piercer to reversibly couple to a reservoir before irreversibly coupling to the first coupling element.   A connecting element comprising holding means for transferring a fluid, in particular a fluid containing an active product, from a reservoir to a medical delivery device, said holding means being in one translational movement between the two connecting elements The connecting element is configured to cooperate with the holding means of the other connecting element by clipping to form an irreversible connecting portion between the two connecting elements.

Images