JP2005502657A5 - - Google Patents
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- Publication number
- JP2005502657A5 JP2005502657A5 JP2003521200A JP2003521200A JP2005502657A5 JP 2005502657 A5 JP2005502657 A5 JP 2005502657A5 JP 2003521200 A JP2003521200 A JP 2003521200A JP 2003521200 A JP2003521200 A JP 2003521200A JP 2005502657 A5 JP2005502657 A5 JP 2005502657A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- compound
- addition salt
- acid addition
- organic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 24
- 239000002253 acid Substances 0.000 claims description 23
- 150000003839 salts Chemical class 0.000 claims description 23
- 150000007522 mineralic acids Chemical class 0.000 claims description 17
- 150000007524 organic acids Chemical class 0.000 claims description 17
- 125000004432 carbon atom Chemical group C* 0.000 claims description 14
- -1 1-adamantylmethyl group Chemical group 0.000 claims description 7
- 125000004981 cycloalkylmethyl group Chemical group 0.000 claims description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 6
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims description 6
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims description 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 4
- IADUEWIQBXOCDZ-VKHMYHEASA-N (S)-azetidine-2-carboxylic acid Chemical group OC(=O)[C@@H]1CCN1 IADUEWIQBXOCDZ-VKHMYHEASA-N 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- IADUEWIQBXOCDZ-UHFFFAOYSA-N (2S)-azetidine-2-carboxylic acid Natural products OC(=O)C1CCN1 IADUEWIQBXOCDZ-UHFFFAOYSA-N 0.000 claims description 2
- 125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 claims description 2
- 230000023555 blood coagulation Effects 0.000 claims description 2
- 125000006622 cycloheptylmethyl group Chemical group 0.000 claims description 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 239000003085 diluting agent Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 239000003937 drug carrier Substances 0.000 claims 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims 5
- 150000004653 carbonic acids Chemical class 0.000 claims 2
- 150000003467 sulfuric acid derivatives Chemical class 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000005162 aryl oxy carbonyl amino group Chemical group 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000008298 dragée Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 239000011505 plaster Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- RLZHWBPDINBAJI-DLDKDUQYSA-N CN[C@H](C1CCCCC1)C(N(CC1)C1C(N[C@@H](CCCNC(N)=N)C=O)=O)=O Chemical compound CN[C@H](C1CCCCC1)C(N(CC1)C1C(N[C@@H](CCCNC(N)=N)C=O)=O)=O RLZHWBPDINBAJI-DLDKDUQYSA-N 0.000 description 3
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical group OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 3
- 125000005587 carbonate group Chemical class 0.000 description 3
- BFGQBANULUEMNL-PUFAWVJESA-N CCOC(N[C@H](CC1CCCCCC1)C(N(CCC1)[C@@H]1C(N[C@]1([C@H](CCNC(N)=N)C1)C=O)=O)=O)=O Chemical compound CCOC(N[C@H](CC1CCCCCC1)C(N(CCC1)[C@@H]1C(N[C@]1([C@H](CCNC(N)=N)C1)C=O)=O)=O)=O BFGQBANULUEMNL-PUFAWVJESA-N 0.000 description 2
- 0 CN[C@](*C1CCCCCC1)C(N(CCC1)[C@@]1C(NC1([C@@](CCNC(N)=N)C1)C=O)=O)=O Chemical compound CN[C@](*C1CCCCCC1)C(N(CCC1)[C@@]1C(NC1([C@@](CCNC(N)=N)C1)C=O)=O)=O 0.000 description 2
- DEQWKOHCECVDOK-YHHIVYBXSA-N NC(NCCC(C1)C1(C=O)NC([C@H](CCC1)N1C([C@@H](CC1CCCCCC1)O)=O)=O)=N Chemical compound NC(NCCC(C1)C1(C=O)NC([C@H](CCC1)N1C([C@@H](CC1CCCCCC1)O)=O)=O)=N DEQWKOHCECVDOK-YHHIVYBXSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 125000001151 peptidyl group Chemical group 0.000 description 2
- 229930182821 L-proline Natural products 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 208000009190 disseminated intravascular coagulation Diseases 0.000 description 1
- 229960002429 proline Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31385001P | 2001-08-21 | 2001-08-21 | |
| US31390101P | 2001-08-21 | 2001-08-21 | |
| PCT/US2002/026564 WO2003016273A2 (en) | 2001-08-21 | 2002-08-21 | Peptide arginals and methods for treating disseminated intravascular coagulation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005502657A JP2005502657A (ja) | 2005-01-27 |
| JP2005502657A5 true JP2005502657A5 (https=) | 2007-10-18 |
| JP4230908B2 JP4230908B2 (ja) | 2009-02-25 |
Family
ID=26979079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003521200A Expired - Fee Related JP4230908B2 (ja) | 2001-08-21 | 2002-08-21 | ペプチド・アルギナル類および播種性血管内血液凝固の治療方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20050070480A1 (https=) |
| EP (1) | EP1425009A4 (https=) |
| JP (1) | JP4230908B2 (https=) |
| KR (1) | KR20040062942A (https=) |
| CN (1) | CN1302776C (https=) |
| AU (1) | AU2002331654B2 (https=) |
| BR (1) | BR0212122A (https=) |
| CA (1) | CA2457436A1 (https=) |
| CZ (1) | CZ2004265A3 (https=) |
| HU (1) | HUP0401312A3 (https=) |
| IL (1) | IL160488A0 (https=) |
| MX (1) | MXPA04001534A (https=) |
| NO (1) | NO20040820L (https=) |
| NZ (1) | NZ531315A (https=) |
| PL (1) | PL368464A1 (https=) |
| RU (1) | RU2312856C2 (https=) |
| SK (1) | SK1112004A3 (https=) |
| WO (1) | WO2003016273A2 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2062909A1 (en) * | 2007-11-21 | 2009-05-27 | SOLVAY (Société Anonyme) | Peptide production and purification process |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU192646B (en) * | 1984-12-21 | 1987-06-29 | Gyogyszerkutato Intezet | Process for preparing new n-alkyl-peptide aldehydes |
| GB8929070D0 (en) * | 1989-12-22 | 1990-02-28 | Fujisawa Pharmaceutical Co | Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same |
| IL99527A (en) * | 1990-09-28 | 1997-08-14 | Lilly Co Eli | Tripeptide antithrombotic agents |
| US5252566A (en) * | 1991-11-12 | 1993-10-12 | Eli Lilly And Company | Antithrombotic agents |
| WO1995014788A1 (en) * | 1993-11-24 | 1995-06-01 | University Of Washington | Blood coagulation retardants and devices |
| US5484772A (en) * | 1994-03-04 | 1996-01-16 | Eli Lilly And Company | Antithrombotic agents |
| ZA951618B (en) * | 1994-03-04 | 1996-08-27 | Lilly Co Eli | Antithrombotic agents |
| US5436229A (en) * | 1994-03-04 | 1995-07-25 | Eli Lilly And Company | Bisulfite adducts of arginine aldehydes |
| AU1884395A (en) * | 1994-03-04 | 1995-09-18 | Eli Lilly And Company | Antithrombotic agents |
| HU222199B1 (hu) * | 1996-06-05 | 2003-05-28 | Gyógyszerkutató Intézet Kft. | Véralvadásgátló hatású peptid-aldehid-származékok és a vegyületeket tartalmazó gyógyszerkészítmények |
-
2002
- 2002-08-21 AU AU2002331654A patent/AU2002331654B2/en not_active Ceased
- 2002-08-21 CZ CZ2004265A patent/CZ2004265A3/cs unknown
- 2002-08-21 BR BR0212122-0A patent/BR0212122A/pt not_active IP Right Cessation
- 2002-08-21 MX MXPA04001534A patent/MXPA04001534A/es active IP Right Grant
- 2002-08-21 WO PCT/US2002/026564 patent/WO2003016273A2/en not_active Ceased
- 2002-08-21 IL IL16048802A patent/IL160488A0/xx unknown
- 2002-08-21 EP EP02768632A patent/EP1425009A4/en not_active Withdrawn
- 2002-08-21 US US10/487,465 patent/US20050070480A1/en not_active Abandoned
- 2002-08-21 RU RU2004108117/04A patent/RU2312856C2/ru not_active IP Right Cessation
- 2002-08-21 JP JP2003521200A patent/JP4230908B2/ja not_active Expired - Fee Related
- 2002-08-21 CN CNB028200314A patent/CN1302776C/zh not_active Expired - Fee Related
- 2002-08-21 PL PL02368464A patent/PL368464A1/xx not_active Application Discontinuation
- 2002-08-21 NZ NZ531315A patent/NZ531315A/en not_active IP Right Cessation
- 2002-08-21 KR KR10-2004-7002553A patent/KR20040062942A/ko not_active Ceased
- 2002-08-21 CA CA002457436A patent/CA2457436A1/en not_active Abandoned
- 2002-08-21 HU HU0401312A patent/HUP0401312A3/hu unknown
- 2002-08-21 SK SK111-2004A patent/SK1112004A3/sk unknown
-
2004
- 2004-02-20 NO NO20040820A patent/NO20040820L/no not_active Application Discontinuation
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