JP2005186026A - Device and method of preparing emulsion - Google Patents

Device and method of preparing emulsion Download PDF

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JP2005186026A
JP2005186026A JP2003434007A JP2003434007A JP2005186026A JP 2005186026 A JP2005186026 A JP 2005186026A JP 2003434007 A JP2003434007 A JP 2003434007A JP 2003434007 A JP2003434007 A JP 2003434007A JP 2005186026 A JP2005186026 A JP 2005186026A
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emulsion
porous body
liquid
phase liquid
continuous phase
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JP4534123B2 (en
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Noboru Nakajima
昇 中島
Mitsuteru Fujiwara
光輝 藤原
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SPG TECHNO KK
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<P>PROBLEM TO BE SOLVED: To eliminate troublesome labor in preparation, handling and difficult operation of an emulsion device and to easily perform an emulsion preparation in a place where an emulsion device is not installed, for example, in a general household also. <P>SOLUTION: Connectors 2 connectable to a disposable syringe 6 or 7 are matched, a disk-like Shirasu-porous glass membrane porous body 1 is sandwiched between them to prepare the emulsion preparation device 3. When an emulsification working is performed, the syringe 6 or 7 in which a dispersed phase liquid or a continuous phase liquid is sampled is connected to each of the connectors 2 to alternately push a plunger 6a or 7a, thereby mixing the dispersed phase liquid and the continuous phase liquid while they are interacting with each other through the porous body, to produce the emulsified liquid of equal particle diameters. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

本発明は、乳化装置に関し、とくに少量でも粒子径の揃った乳化エマルションを手軽に調製することができるポンピング式の乳化用デバイスに関するものである。   The present invention relates to an emulsifying apparatus, and more particularly to a pumping type emulsifying device capable of easily preparing an emulsified emulsion having a uniform particle diameter even in a small amount.

従来、エマルション調製に使用される乳化装置として、連続相のあるエマルション形成室内に回転体を設け、この回転体により連続相液体を攪拌しながらその液体中に分散相液室の液体を、ピストンなどの機械的な加圧装置により圧入分散してエマルションを生成するものがある(例えば、特許文献1参照)。   Conventionally, as an emulsifying device used for emulsion preparation, a rotating body is provided in an emulsion forming chamber having a continuous phase, and the liquid in the dispersed phase liquid chamber is put into the liquid while stirring the continuous phase liquid by the rotating body, and the piston, etc. There are some which generate an emulsion by press-fitting and dispersing with a mechanical pressurizing apparatus (for example, see Patent Document 1).

特開平06−315617号公報Japanese Patent Laid-Open No. 06-315617

しかしながら、これらの乳化装置および乳化方法では、例えば、乳化量が1ml乃至100mlの僅かな分量であっても、分散相の圧入のために機械的な加圧手段が必要とされる。また、連続相の液体を攪拌させるための回転体の動力装置も必要で、ごく少量のエマルションの生成にも大掛かりな附帯装置が必要である。   However, in these emulsification apparatuses and emulsification methods, for example, even if the emulsification amount is a small amount of 1 ml to 100 ml, a mechanical pressurizing means is required for press-fitting the dispersed phase. Further, a rotating body power unit for stirring the liquid in the continuous phase is required, and a large incidental unit is also required for producing a very small amount of emulsion.

特に少量のエマルションの組成検証や粒子径検証のように、簡易な乳化で済むが頻繁な反復実験が要求されるもの、あるいは一回の乳化エマルションの使用量が極少量でよく、ロスボリュームを極力少なくしたい高価な組成物に対しては、実験の準備時間等も考慮に入れるまでもなく全く相応しない。   In particular, simple emulsification is required, such as composition verification and particle size verification of a small amount of emulsion, but frequent repeated experiments are required, or the amount of emulsified emulsion used at one time is extremely small, and loss volume is minimized. For expensive compositions to be reduced, it is not appropriate at all, without taking into account the experimental preparation time.

そこで本発明のエマルション調製用デバイスは、ポンプ式容器が連通可能に形成された導管部に多孔体を設けたことを第1の特徴とする。また、一方に汲み上げ型のポンプ式容器が、他方に静置型の容器が連結可能に形成された導管部に多孔体を設けたことを第2の特徴とする。さらに、ポンプ式容器が注射用シリンジであることを第3の特徴とする。さらにまた、ノズルを有する押圧ヘッドと内部に液体汲み上げ用の導管が挿通されると共に、分散相液体と連続相液体との予備混合物が収納された液体収納容器とから成り、前記押圧ヘッドにポンピング式に圧力を加えることにより多孔体を介してノズルより乳化エマルションを生成吐出することを第4の特徴とする。すなわち、多孔体を介して区画された少なくとも二つの室の間を、分散相又は連続相あるいは分散相と連続相が予め混合された乳化物を往復移動させることによりエマルションを生成することを特徴とするエマルション調製方法を提供するものである。   Therefore, the emulsion preparation device of the present invention is characterized in that a porous body is provided in a conduit portion formed so that a pump-type container can communicate. The second feature is that a porous body is provided in a conduit portion formed so that a pump-type container can be connected to one side and a stationary container can be connected to the other side. Further, the third feature is that the pump-type container is a syringe for injection. Furthermore, a pressure head having a nozzle and a liquid storage container in which a conduit for pumping liquid is inserted and a premixed mixture of a dispersed phase liquid and a continuous phase liquid are stored. The fourth feature is that the emulsified emulsion is generated and discharged from the nozzle through the porous body by applying pressure to the nozzle. That is, an emulsion is generated by reciprocating a dispersed phase or a continuous phase or an emulsion in which a dispersed phase and a continuous phase are mixed in advance between at least two chambers partitioned through a porous body. An emulsion preparation method is provided.

例えば、本発明では、分散相室と連続相室を特段設けることなく、エマルションの調製量に合わせたシリンジ(例えば、入手が容易な市販の注射器等)を利用する事により、粒子径の揃ったエマルションの調製が可能となる。したがって、乳化作業に特段の機器類を要することなく、掌中で手軽にエマルションを調製することができる。   For example, in the present invention, particle diameters are uniformed by using a syringe (for example, a commercially available syringe that is easily available) that matches the preparation amount of the emulsion, without providing a dispersed phase chamber and a continuous phase chamber. An emulsion can be prepared. Therefore, the emulsion can be easily prepared in the palm without requiring special equipment for the emulsification operation.

また、薬液のように無菌状態で調製したい場合は、滅菌済のシリンジで分散相並びに連続相を滅菌済のシリンジで各々採取し、これら一対のシリンジを繋ぐ導管内に多孔体を設けた滅菌済みのデバイスの両端に接続し、連続相液体と分散相液体とを、多孔体を介して交互に行き来させることにより次第に粒子径の揃った乳化型エマルションを生成することができる。   In addition, if you want to prepare in a sterile condition like a chemical solution, collect the dispersed phase and continuous phase with a sterilized syringe, respectively, and collect the sterilized with a porous body in the conduit that connects the pair of syringes. By connecting the continuous phase liquid and the dispersed phase liquid alternately through the porous body, the emulsion emulsion having gradually uniform particle diameters can be generated.

また、予め分散相と連続相を混合したものを一方のシリンジで採取し、他方のシリンジ内に圧入していくか、直接容器内に圧入していくことにより粒子径の揃ったエマルションを生成する事も可能である。乳化エマルションの形態には、O/W系のエマルションと、W/O系のエマルションが存在するが、エマルションの形態に応じて多孔体の表面に親水性処理または疎水性処理を施せば、O/W系、W/O系のエマルションを生成することができる。これにより、W/O型、O/W型、O/W/O/W型、W/O/W/O型など複合型のエマルションも大掛かりな装置を全く要せず簡便に掌中で調製する事ができる   In addition, a mixture of a dispersed phase and a continuous phase is collected with one syringe in advance and press-fitted into the other syringe, or directly into a container to produce an emulsion having a uniform particle size. Things are also possible. There are O / W type emulsions and W / O type emulsions in the form of emulsified emulsions. If the surface of the porous body is subjected to a hydrophilic treatment or a hydrophobic treatment depending on the form of the emulsion, O / W type emulsions are provided. W-based and W / O-based emulsions can be produced. As a result, composite emulsions such as W / O, O / W, O / W / O / W, and W / O / W / O types can be easily prepared in the palm without requiring a large-scale apparatus. Can do

本発明は、滅菌済みのディスポーザブルデバイスとして無菌状態でエマルションを調製することが困難だった点、反復検証実験での乳化装置の洗浄、乾燥、組み立て及び滅菌などの煩わしさなど、乳化装置の準備や取り扱いの面倒な手間と操作の困難さを解消する点に着目したものであり、大掛かりな乳化装置や付帯装置が不要になるばかりでなく、これら装置の準備時間をも全く要せず、乳化装置が設備されていない場所、例えば、一般の家庭においても簡便にエマルション調製を行なうことができる。   The present invention relates to preparation of an emulsifying device, such as the difficulty of preparing an emulsion in a sterile state as a sterilized disposable device, and the troublesomeness of washing, drying, assembly and sterilization of the emulsifying device in repeated verification experiments. The emulsifier is not only the need for large-scale emulsifiers and incidental devices, but also the preparation time of these devices is not required at all. Can be easily prepared even in a place where is not installed, for example, in a general household.

以下、本発明の実施の形態を、図面に示す実施例に基づいて説明するが、本発明が、以下の例示及び説明の内容により何ら限定されるものではないことは言うまでもない。
図1は本発明に係るエマルション調製用デバイスの分解斜視図、図2は図1の本発明に係るエマルション調製用デバイスを組み立てた状態を示す斜視図、図3は円盤状の薄膜多孔体を示す斜視図、図4は管束状の多孔体を示す斜視図、図5は本発明に係るデバイスの両端に一対のシリンジ接続した状態を示す斜視図、図6は本発明に係るデバイスの一方にシリンジを、他方に静置型の容器を取付けた状態を示す斜視図、図7は本発明に係るデバイスの他の使用状態を示す斜視図である。
DESCRIPTION OF THE PREFERRED EMBODIMENTS Embodiments of the present invention will be described below based on examples shown in the drawings. Needless to say, the present invention is not limited to the contents of the following examples and descriptions.
FIG. 1 is an exploded perspective view of an emulsion preparation device according to the present invention, FIG. 2 is a perspective view showing a state where the emulsion preparation device according to the present invention of FIG. 1 is assembled, and FIG. 3 shows a disc-shaped thin film porous body. 4 is a perspective view showing a tube bundle-shaped porous body, FIG. 5 is a perspective view showing a state in which a pair of syringes are connected to both ends of the device according to the present invention, and FIG. 6 is a syringe in one of the devices according to the present invention. And FIG. 7 is a perspective view showing another use state of the device according to the present invention.

図1乃至図5に示すように、本実施例に係るエマルション調製用デバイス3は、後述するディスポーザブルシリンジ6又は7と接続可能なコネクター2同士を突き合わせ、その間に円盤状のシラス多孔質ガラス膜製多孔体1を挟んだものである。すなわち、乳化作業を行なう際には、各々のコネクター2の端部に各々、分散相液体あるいは連続相液体を採取したシリンジ6又は7を接続してプランジャ6a又は7aを交互に押動させることにより、分散相液体と連続相液体が多孔体を介して交流しながら混合し、粒子径の揃った乳化エマルションを生成することができる。   As shown in FIG. 1 to FIG. 5, the emulsion preparation device 3 according to the present example is made by connecting connectors 2 that can be connected to a disposable syringe 6 or 7 described later, with a disc-shaped shirasu porous glass film therebetween. The porous body 1 is sandwiched between them. That is, when emulsifying work is performed, the syringe 6 or 7 that collects the dispersed phase liquid or the continuous phase liquid is connected to the end of each connector 2 and the plungers 6a or 7a are alternately pushed. The dispersed phase liquid and the continuous phase liquid can be mixed while being exchanged through the porous body to produce an emulsion having a uniform particle size.

尚、本発明における、多孔体としては、例えば、金属製多孔体、ガラス製多孔体、木質製多孔体、メッキ製多孔体などが挙げられるが、本発明においては、均一な細孔径を有し、且つ気孔率の高い無機多孔体が好適である。   In addition, examples of the porous body in the present invention include a metal porous body, a glass porous body, a wooden porous body, and a plated porous body. In the present invention, the porous body has a uniform pore diameter. An inorganic porous body having a high porosity is preferable.

また、図6に示すように、デバイス3の一方に、分散相液体と連続相液体との予備混合物を採取したディスポーザブルシリンジ8を、他方に静置型の抽出容器9を取付けるものでも良く、さらに、図7に示すように、ノズル13を有する押圧ヘッド11と内部に液体汲み上げ用の導管12が挿通された液体収納容器10とからなるポンプ式容器内に、分散相液体と連続相液体との予備混合物を入れておき、ポンピング式に圧力を加えることにより多孔体14を介してノズル13より乳化エマルションを生成注出させるものでもよい。   In addition, as shown in FIG. 6, a disposable syringe 8 obtained by collecting a premix of a dispersed phase liquid and a continuous phase liquid may be attached to one of the devices 3, and a stationary extraction container 9 may be attached to the other. As shown in FIG. 7, in a pump-type container composed of a pressure head 11 having a nozzle 13 and a liquid storage container 10 having a liquid pumping pipe 12 inserted therein, a preliminary dispersion of a dispersed phase liquid and a continuous phase liquid is provided. An emulsion may be produced and poured out from the nozzle 13 through the porous body 14 by putting a mixture and applying pressure in a pumping manner.

(実験例1)
多孔体に無機多孔質膜として、細孔径が均一で、気孔率の高い0.05μm乃至20μmの範囲で細孔径が選定できるシラス多孔質ガラス(以下、SPGと言う)を用いた。SPGは本発明で使用する多孔体として好適なものの一つである。O/W系のエマルション調製用デバイスに使用する多孔体1には、連続相の水中に濡れやすい親水化溶液で親水化表面処理を施し、また、W/O系のエマルション調製用デバイスに使用する多孔体1には、連続相の油中に濡れやすい疎水化溶液で疎水化表面処理を施すことができる。
(Experimental example 1)
Shirasu porous glass (hereinafter referred to as SPG) having a uniform pore diameter and a high porosity in a range of 0.05 μm to 20 μm was used as the inorganic porous membrane for the porous body. SPG is one of the preferred porous bodies used in the present invention. The porous body 1 used for the device for preparing an O / W emulsion is subjected to a hydrophilization surface treatment with a hydrophilizing solution that easily wets in continuous phase water, and is used for a device for preparing a W / O emulsion. The porous body 1 can be subjected to a hydrophobized surface treatment with a hydrophobizing solution that easily wets in continuous phase oil.

図5に示すように、多孔体1としてのSPG膜には外径6.5mm、厚み0.8mmの円盤形状のものを用い、コネクター3には、一般医療用具としての量産を前提として、優れた成形性と溶剤接着性を有し、耐薬品性のある安価な塩化ビニル樹脂の成形パーツを使用してディスポーザブルポンピングデバイス(図1参照)を製作した。シリンジ6に分散相液体を、シリンジ7に連続相液体を採取して、ポンピングデバイス3の両端に各々接続し、シリンジプランジャ6a、7aを交互に押し込むポンピング操作によりO/W系の乳化エマルションを生成した。表2に、SPG膜孔径とポンピング回数、乳化エマルション粒子径の関係を示し、図8にその関係図を示す。

Figure 2005186026
As shown in FIG. 5, the SPG film as the porous body 1 is a disk-shaped one having an outer diameter of 6.5 mm and a thickness of 0.8 mm, and the connector 3 is excellent on the premise of mass production as a general medical device. Disposable pumping devices (see Fig. 1) were manufactured using inexpensive vinyl chloride resin molded parts that had excellent moldability and solvent adhesion. The dispersed phase liquid is collected in the syringe 6 and the continuous phase liquid is collected in the syringe 7, connected to both ends of the pumping device 3, and an O / W emulsion emulsion is generated by a pumping operation in which the syringe plungers 6 a and 7 a are alternately pushed. did. Table 2 shows the relationship between the SPG membrane pore size, the number of pumping times, and the emulsion emulsion particle size, and FIG. 8 shows the relationship diagram.
Figure 2005186026

(実験例2)
本発明に係るポンピング式膜乳化と、従来の直接膜乳化で乳化エマルション粒子径約2μmを生成するのに要する時間を表2に示す。表2からも分かるように、直接膜乳化では、乳化エマルション粒子径が、SPG膜孔径の約3倍乃至3.5倍に膨れて生成されるため、目的とする大きさの粒子径を得るために使用する乳化膜には乳化エマルション粒子径より小さな孔径のものが必要になる。このため均一な粒子径の乳化エマルションを得るために要する加圧量も少さくする必要がある。したがって、乳化速度が非常に遅くエマルションの生成時間が長大になる傾向にある。しかしながら、本発明のデバイスによるポンピング式膜乳化によれば、ポンピングを数回繰り返すことのみにより乳化エマルション粒子径を小さくできるために、目的とする大きさの乳化エマルション粒子径より大きいSPG膜孔径を使用することができ、また、直接膜乳化よりも極めて短時間で乳化エマルションを生成することができる。
(Experimental example 2)
Table 2 shows the time required to produce an emulsion particle size of about 2 μm by the pumping membrane emulsification according to the present invention and the conventional direct membrane emulsification. As can be seen from Table 2, in direct membrane emulsification, the emulsified emulsion particle size swells to about 3 to 3.5 times the SPG membrane pore size, so that the desired particle size can be obtained. The emulsified membrane used in the invention needs to have a pore size smaller than the particle size of the emulsified emulsion. For this reason, it is necessary to reduce the amount of pressurization required to obtain an emulsion having a uniform particle size. Therefore, the emulsification rate is very slow and the emulsion generation time tends to be long. However, according to the pumping membrane emulsification by the device of the present invention, since the emulsion emulsion particle size can be reduced only by repeating the pumping several times, the SPG membrane pore size larger than the emulsion emulsion particle size of the desired size is used. In addition, an emulsified emulsion can be produced in a much shorter time than direct membrane emulsification.

Figure 2005186026
Figure 2005186026

(実験例3)
図7に示すように、ノズル13を有する押圧ヘッド11と内部に液体汲み上げ用の導管12が挿通された液体収納容器10とからなるポンプ式容器内に、分散相液体と連続相液体との予備混合物を入れておき、ポンピング式に圧力を加えることにより多孔体14を介してノズル13より乳化エマルションを生成注出させるポンプ式のハンドスプレーで乳化エマルションを生成した。
このときの多孔体14には、外径10mm、内径8.5mm、長さ20mmの円筒管状のSPG膜で細孔径は3μmのものを使用した。液体収納容器10内に分散相液体と、連続相液体を投入し、容器10を振とうして予備乳化した。その後、押圧ヘッド11を数回ポンピングして多孔体14を介してろ過乳化することにより、ノズル13出口より粒子径の揃った乳化エマルションを生成注出した。
(Experimental example 3)
As shown in FIG. 7, in a pump-type container composed of a pressure head 11 having a nozzle 13 and a liquid storage container 10 having a liquid pumping pipe 12 inserted therein, a preliminary dispersion of a dispersed phase liquid and a continuous phase liquid is provided. An emulsified emulsion was produced by a pump-type hand spray in which the mixture was placed and pressure was applied in a pumping manner to produce and dispense the emulsified emulsion from the nozzle 13 through the porous body 14.
As the porous body 14 at this time, a cylindrical tubular SPG film having an outer diameter of 10 mm, an inner diameter of 8.5 mm, and a length of 20 mm and having a pore diameter of 3 μm was used. The dispersed phase liquid and the continuous phase liquid were put into the liquid storage container 10, and the container 10 was shaken to pre-emulsify. Thereafter, the pressing head 11 was pumped several times and filtered and emulsified through the porous body 14 to produce and dispense an emulsified emulsion having a uniform particle diameter from the nozzle 13 outlet.

図9は、上記ポンプ式のハンドスプレーで最終的に得られた乳化エマルション粒子径と、液体収納容器10内で予備乳化されたエマルション粒子径と、汲み上げ用導管部12に多孔体14を具備しないスプレーを使用してノズル13から吐出されるエマルション粒子径の分布図である。ここで、分布L1が、液体収納容器10に分散相液体と連続相液体を投入し、人手で振とうさせて予備乳化したときの粗いエマルション粒子径分布を示している。分布L2は、汲み上げ用導管部12に多孔体14を設けずにチューブのみで予備乳化エマルションを汲み上げてノズル13から吐出されたエマルション粒子径分布を示している。分布L3は、汲み上げ用導管部12の先端に多孔体14(SPG膜)を設け、予備乳化した粗いエマルションをさらに多孔体14を介してノズル13より吐出されたエマルション粒子径分布を示している。   FIG. 9 shows the emulsion particle diameter finally obtained by the pump-type hand spray, the emulsion particle diameter preliminarily emulsified in the liquid storage container 10, and the pumping conduit portion 12 does not include the porous body 14. It is a distribution map of the emulsion particle diameter discharged from the nozzle 13 using a spray. Here, the distribution L1 indicates a coarse emulsion particle size distribution when the dispersed phase liquid and the continuous phase liquid are put into the liquid storage container 10 and shaken manually to pre-emulsify. The distribution L2 indicates the emulsion particle size distribution in which the pre-emulsified emulsion is pumped only by a tube without providing the porous body 14 in the pumping conduit section 12 and is discharged from the nozzle 13. The distribution L3 shows the emulsion particle size distribution in which a porous body 14 (SPG film) is provided at the tip of the pumping conduit section 12 and a coarse emulsion preliminarily emulsified is further discharged from the nozzle 13 through the porous body 14.

この粒子分布の状態から明らかなように、液体収納容器内で予備乳化されたエマルション粒子径の分布L1は約2μm乃至500μmの粒子径分布の広がりを持ち、エマルション粒子径が不均一である。また、分布L2は、ノズル13のスプレー作用により小さくはなるが、エマルション粒子径の分布約1μm乃至100μmという広がりから均一とはいい難い。すなわち、導管部にSPG膜14を設けることにより、分布L3のように約1μm乃至9μmというエマルション粒子径の揃った乳化エマルションを生成することができる。   As is apparent from this particle distribution state, the emulsion particle size distribution L1 pre-emulsified in the liquid container has a particle size distribution spread of about 2 μm to 500 μm, and the emulsion particle size is not uniform. The distribution L2 is reduced by the spray action of the nozzle 13, but it is difficult to say that it is uniform due to the emulsion particle size distribution of about 1 μm to 100 μm. That is, by providing the SPG film 14 in the conduit portion, an emulsified emulsion having a uniform emulsion particle diameter of about 1 μm to 9 μm can be generated as in the distribution L3.

本発明は、滅菌済みのディスポーザブルデバイスとして無菌的にエマルションを調製することが可能で、医療分野でDDS療法などエマルション製剤の新薬の開発を行う際、動物実験など種々の薬液のエマルションカプセル化を容易に用事調製し試作することが可能で繰り返し実験も簡単に行うことができる。また、一般家庭でも粒の揃った食品用エマルションカプセルフレーバーなど簡単に調製することができ、ベーカリー店などフレーバー入りベーカリー食品について、例えば1日販売量1kg生地に対して10ml程度で済むものなど、オリジナル性に富んだカプセルフレーバー入りベーカリー食品を容易に作ることができる。また揮発性に富む薬液や肥料を散布する過程で有効成分をカプセル化しながら農薬や養殖で散布したり撒いたりすることが可能である。このように本発明は短時間に簡単に粒子径の揃ったエマルション調製が可能であるため、エマルション化技術開発に大いに役立つもので、実用的で画期的なエマルション調製用デバイスである。また、図7に示すような、ポンプ式デバイスに関しては、水のクラスターを小さく改質する電解水生成装置などあるが、このような大掛りで高価な装置を必要とせずに、ハンディータイプのポンピング式デバイスで小さな細孔を持つ多孔体を介することにより、安価で水のクラスターを小さくした改質水を生成することなども可能である。   The present invention makes it possible to prepare an emulsion aseptically as a sterilized disposable device. When developing new drugs for emulsion formulations such as DDS therapy in the medical field, it is easy to encapsulate various chemical solutions such as animal experiments. In addition, it is possible to prepare a prototype and make a prototype, and it is possible to easily carry out repeated experiments. In addition, it is easy to prepare emulsion capsule flavors for foods with regular grains even in general households. For bakery foods with flavors such as bakery stores, originals such as those that only need about 10 ml per 1 kg of dough per day are sold. A bakery food with capsule flavor that is rich in properties can be easily produced. In addition, it is possible to spray and spread by agrochemicals or aquaculture while encapsulating active ingredients in the process of spraying volatile chemicals and fertilizers. Thus, since the present invention can easily prepare emulsions with uniform particle diameters in a short time, it is very useful for developing emulsion technology, and is a practical and innovative device for preparing emulsions. As for the pump-type device as shown in FIG. 7, there is an electrolyzed water generating device that modifies the water cluster to a small size, but without requiring such a large and expensive device, a handy type pumping is possible. By using a porous body having small pores in an expression device, it is possible to produce reformed water that is inexpensive and has a small water cluster.

本発明に係るエマルション調製用デバイスの分解斜視である。It is a disassembled perspective view of the device for emulsion preparation which concerns on this invention. 本発明に係るエマルション調製用デバイスを組み立てた状態を示す斜視図である。It is a perspective view which shows the state which assembled the device for emulsion preparation which concerns on this invention. 円盤状の薄膜多孔体を示す斜視図である。It is a perspective view which shows a disk shaped thin film porous body. 管束状の多孔体を示す斜視図である。It is a perspective view which shows a tube bundle-shaped porous body. 本発明に係るデバイスの両端に一対のシリンジ接続した状態を示す斜視図である。It is a perspective view which shows the state which connected a pair of syringe to the both ends of the device which concerns on this invention. 本発明に係るデバイスの一方にシリンジを、他方に静置型の容器を取付けた状態を示す斜視図である。It is a perspective view which shows the state which attached the syringe to one side of the device which concerns on this invention, and the stationary container to the other. 本発明に係るデバイスの他の使用状態を示す斜視図である。It is a perspective view which shows the other use condition of the device which concerns on this invention. ハンドポンプ式デバイスのポンピング回数と乳化エマルション粒子径を示すグラフである。It is a graph which shows the frequency | count of pumping of a hand pump type device, and an emulsion emulsion particle diameter. エマルション粒子径を比較した分布図である。It is the distribution map which compared the emulsion particle diameter.

符号の説明Explanation of symbols

1 多孔体
2 コネクター
3 エマルション調製用デバイス
4 薄膜状多孔体
5 管束体
6 液体入りシリンジ
6a プランジャー
7 液体入りシリンジ
7a プランジャー
8 液体入りシリンジ
8a プランジャー
9 乳化エマルション抽出用容器(静置型容器)
10 液体収納用容器
11 押圧ヘッド
12 液体汲み上げ導管
13 ノズル
14 円筒状多孔体
DESCRIPTION OF SYMBOLS 1 Porous body 2 Connector 3 Emulsion preparation device 4 Thin-film porous body 5 Tube bundle body 6 Liquid-filled syringe 6a Plunger 7 Liquid-filled syringe 7a Plunger 8 Liquid-filled syringe 8a Plunger 9 Emulsion emulsion extraction container (stationary container)
DESCRIPTION OF SYMBOLS 10 Liquid container 11 Press head 12 Liquid pumping conduit 13 Nozzle 14 Cylindrical porous

Claims (5)

ポンプ式容器が連通可能に形成された導管部に多孔体を設けたことを特徴とするエマルション調製用デバイス。 A device for preparing an emulsion, characterized in that a porous body is provided in a conduit portion formed so that a pump-type container can communicate therewith. 一方に汲み上げ型のポンプ式容器が、他方に静置型の容器が連結可能に形成された導管部に多孔体を設けたことを特徴とするエマルション調製用デバイス。 A device for preparing an emulsion, characterized in that a porous body is provided in a conduit portion formed so that a pump-type container on one side and a stationary container on the other side can be connected. ポンプ式容器が注射用シリンジであることを特徴とする請求項1又は請求項2記載のエマルション調製用デバイス。 The emulsion preparation device according to claim 1 or 2, wherein the pump-type container is a syringe for injection. ノズルを有する押圧ヘッドと内部に液体汲み上げ用の導管が挿通されると共に、分散相液体と連続相液体との予備混合物が収納された液体収納容器とから成り、前記押圧ヘッドにポンピング式に圧力を加えることにより多孔体を介してノズルより乳化エマルションを生成吐出することを特徴とするエマルション調製用デバイス。 A pressure head having a nozzle, and a liquid storage container in which a pre-mixture of a dispersed phase liquid and a continuous phase liquid is stored, and a pressure pumping type pressure is applied to the pressure head. An emulsion preparation device characterized in that an emulsion emulsion is generated and discharged from a nozzle through a porous body by addition. 多孔体を介して区画された少なくとも二つの室の間を、分散相又は連続相あるいは分散相と連続相が予め混合された乳化物を往復移動させることによりエマルションを生成することを特徴とするエマルション調製方法。 An emulsion characterized in that an emulsion is produced by reciprocating a dispersed phase or a continuous phase or an emulsion in which a dispersed phase and a continuous phase are preliminarily mixed between at least two chambers partitioned through a porous body. Preparation method.
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