JP2005162249A - Package for sterilization - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a package for sterilization which has no special restriction for selecting a thermoplastic resin forming the innermost layer of a multi-layered package main body, can be selected by attaching importance to heat seal properties to a sheet for sterilization, can enough correspond to such a high temperature treatment as steam treatment, and has no fear of sticking and staining caused by an adhesive in the high temperature treatment. <P>SOLUTION: In the package prepared by heat sealing the multi-layered package main body 2 comprising the thermoplastic resin with the sheet 3 for sterilization, the packaging body 1 for sterilization is characterized by that the opening of the packaging body by releasing the sheet 3 for sterilization from the multi-layered package main body 2 requires the releasing by shifting a layer containing at least the innermost layer 25 of the multi-layered package main body 2 to the side of the sheet 3 for sterilization. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a sterilization package.

  Conventionally, when storing articles such as medical materials, medical instruments, foods, etc., it is possible to permeate sterilization gas without penetrating microorganisms such as bacteria and packaging bodies such as containers, films and sheets. A sterilization packaging body is used in which the above-described article is inserted and placed between a sterilization sheet having the performance of the above and the sterilization sheet is heat-sealed to the packaging body. This sterilization package is then treated with a sterilization gas such as ethylene oxide, hydrogen peroxide, steam or the like.

  In addition, the sterilization package that has been widely used conventionally is a package in which an adhesive layer is provided on the sealing surface of the sterilization sheet for heat sealability. In order to ensure gas permeability, it was necessary to partially coat the adhesive. On the other hand, since such a package has many restrictions from the surface of adhesive coating and sterilization gas permeation, there is a problem in practical use and improvement has been desired.

  On the other hand, when the sterilization sheet is heat-sealed via a heat-adhesive adhesive layer on the flange provided at the periphery of the main body of the cup-shaped container that is the package body, and opened, As the adhesive, a packaging structure using an adhesive having a property that remains in both the sterilization sheet and the package body has been proposed (for example, Patent Document 1). Specifically, such a packaging structure heat seals a sterilization sheet to a container having an adhesive as an innermost layer.

  FIG. 10 is a cross-sectional view illustrating a state when the packaging structure 100 of the conventional example is opened. As shown in FIG. 10, among the innermost layer 201 formed in the container 200 including the innermost layer 201, the next layer 202, and the next layer 203, the adhesive layer 201 a is on the sterilization sheet 300 side, and the adhesive layer 201b is opened by in-layer peeling of the adhesive layer 201 so as to be on the container 200 side. For this reason, as an adhesive agent, it will be limited to resin which peels in a layer. In general, the resin that peels in the layer maintains its characteristics by containing a resin having a weak strength or a resin having low heat resistance.

JP 2001-31146 A

  However, in the conventional packaging structure as described above, the adhesive layer formed on the container side needs to cohesively break when the adhesive layer is peeled off. There is a problem that a resin having low properties is required and the types of usable adhesives are greatly limited.

  Further, in recent years, in addition to the sterilization treatment of room temperature gas sterilization, sterilization treatment by an autoclave using high-temperature steam is also performed. The conventional packaging structure described above is not particularly problematic when sterilization is performed at room temperature using ethylene oxide or hydrogen peroxide sterilization gas, but sterilization by autoclave using high-temperature steam. In the case of treatment, there is also a problem that it cannot be applied from the viewpoint of heat resistance.

  In the conventional packaging structure, since the adhesive layer is an indispensable component, when the sterilization process is performed, the packaged object is treated even if the packaged article is sterilized. In some cases, it adheres to the main body or is contaminated by the adhesive. Furthermore, there is a problem that the unsealing feeling at the time of use is poor, and the actual situation is that a satisfactory one is not necessarily obtained.

  Accordingly, an object of the present invention is a sterilization package that can be selected with an emphasis on heat sealability with a sterilization sheet without any particular limitation on the selection of the thermoplastic resin that forms the innermost layer of the multilayer package body. In addition, the sterilization process is particularly compatible with high temperature processing such as steam processing, and there is no risk of adhesion of the object to be processed to the package body or contamination with adhesive during high temperature processing. It is to provide a sterilization package.

  In order to solve the above problems, the sterilization packaging body of the present invention is a multilayer packaging body body made of a thermoplastic resin and a sterilization sheet heat-sealed. When the film is peeled off and opened, the layer including at least the innermost layer of the multilayer package body moves to the sterilization sheet side and is peeled off.

As described above, the sterilization packaging body of the present invention has a multilayer packaging body as a multilayer structure, and an object to be packaged is inserted and arranged between the multilayer packaging body and the sterilization sheet, and the outer peripheral portion is heated in a circumferential shape. Seal (consent with thermal bonding; the same shall apply hereinafter) to form a sterilization package.
When the package is opened, at least the innermost thermal bonding portion of the multilayer package body moves to the sterilization sheet side and can be easily peeled open, and the sterilization sheet has a strong heat seal. It is intended to provide a sterilization package that can be used.

Here, the “innermost layer” in the multilayer package body refers to a layer existing on the innermost surface of the multilayer package body, which is heat-sealed with the sterilization sheet. The peeling mode is not particularly limited as long as at least the innermost layer of the package body moves together with the sterilization sheet to the sterilization sheet side when it is opened.
Therefore, for example, as an aspect of peeling, peeling between the innermost layer of the multilayer package body and the next layer in contact with the innermost layer, peeling within the layer of the next layer, or contacting the next layer with the next layer Examples include delamination that occurs one after another or some of these together. That is, in addition to the interlayer between the inner layer and the next layer, the next layer or the next layer may have a multilayer structure, and delamination may occur between the layers. That is, there is no problem as long as the sterilization sheet and the layer including the innermost layer to be heat-sealed are peeled off and moved integrally to the sterilization sheet side.

  Moreover, there is no restriction | limiting in particular as a shape of a multilayer package main body, For example, although it can be set as a sheet form and a film form, it is preferable to set it as the container shape which formed the flange part in the periphery of the opening part especially. preferable.

According to the sterilization packaging body of the present invention having such a configuration, since the layer including at least the innermost layer of the multilayer packaging body moves to the sterilization sheet side and is peeled, the innermost layer of the multilayer packaging body is formed. There is no restriction | limiting in the selection of the thermoplastic resin to perform, and it can select in consideration of the heat seal property (thermal adhesiveness) with the sheet | seat for sterilization. In addition, sterilization can be performed regardless of the type of sterilization gas, and in particular, it can sufficiently cope with high temperature processing such as steam processing.
Further, since it is not necessary to use an adhesive when adhering the multilayer package body and the sterilization sheet, there is no fear of adhesion or contamination due to the adhesive in high temperature processing such as steam processing.

  Furthermore, even if the heat seal between the multilayer package body and the sterilization sheet is bonded with a sufficiently high sealing strength, easy-openability can be imparted. Further, the opening strength of the sterilization package can be arbitrarily controlled without being limited to the innermost thermoplastic resin of the multilayer package body.

In the sterilization packaging body of the present invention, it is preferable that the above-described peeling occurs in any one of the innermost layer and the next layer of the multilayer packaging body, the inner layer of the next layer, and the next layer and the next layer.
According to this invention, the sterilization sheet and the multilayer package body are peeled at a specific position at which the layer including at least the innermost layer of the multilayer package body moves to the sterilization sheet side and is peeled off. Therefore, it is possible to make the easy-openability of the package even better, and to arbitrarily select the separation position by devising the configuration of each layer, such as the constituent material and thickness. Become.

In the sterilization package of the present invention, the innermost layer of the package body is preferably composed of a polyolefin resin having a melting point of 110 ° C. or higher.
According to this invention, since the innermost layer of the multilayer package body is composed of a polyolefin resin having a melting point in a specific range, it becomes a sterilization package excellent in heat resistance and chemical resistance, and steam treatment at a high temperature. Can be fully supported.

In the sterilization package of the present invention, the sterilization sheet is preferably composed of a nonwoven fabric made of a thermoplastic resin having a melting point of 110 ° C. or higher.
According to the present invention, since the sterilization sheet is composed of a thermoplastic resin having a melting point of 110 ° C. or higher, the sterilization package is excellent in heat resistance and chemical resistance.
In particular, by combining with the multilayer package body in which the innermost layer is made of a polyolefin resin having a melting point of 110 ° C. or higher, it is possible to more suitably cope with steam treatment at high temperatures.

In the sterilization packaging body of the present invention, it is preferable that the multilayer packaging body has a container shape.
According to the present invention, since the shape of the multilayer package body is a container shape, it is excellent in usability and storage property, and for example, in order to easily store articles to be packaged such as a syringe, There is also an advantage that it can easily correspond to the shape of the article to be packaged, such as a container shape in which one or a plurality of recesses or the like is arbitrarily formed in accordance with the shape of the article to be packaged with respect to the bottom surface portion. is there.

In the sterilization packaging body of the present invention, it is preferable that a circumferential cut is formed on the inner side of the heat seal portion of the multilayer packaging body.
According to this invention, since it is configured to have a circumferential cut inside the thermal bonding portion of the multilayer package body, when the innermost layer peels off and moves to the sterilization sheet, the innermost layer in the heat seal portion Since the cutting is reliable and easy, the opening is suitably performed, and the range of combinations of the multilayer package body and the sterilization sheet can be expanded.

The sterilization packaging body of the present invention is obtained by heat-sealing a sterilization sheet on the outer periphery of a multilayer packaging body body made of a thermoplastic resin. The multilayer package body constituting the sterilization package of the present invention is required to move at least the layer including the innermost layer to the sterilization sheet side when unsealing.
Therefore, for this purpose, for example, when the innermost layer moves together with a part of the next layer due to delamination between the innermost layer and the next layer of the multilayer package body and cohesive peeling in the next layer, When the next layer moves together with the innermost layer due to delamination, these may be combined delamination. By such peeling, even if the sealing strength between the innermost layer of the multilayer package body and the sterilization sheet is high, good easy-openability can be ensured.

  Here, when the layer structure of the multilayer package body is a laminate of the innermost layer / next layer / next layer, the innermost layer is a layer heat-sealed with a sterilization sheet to be described later. It is preferably a material having a sealing property, (poly) olefin resin, for example, polypropylene resin such as homopolypropylene (HPP), random polypropylene (RPP), block polypropylene, high density polyethylene (HDPE), low density It is preferable to use a polyethylene-based resin such as polyethylene (LDPE) or a linear ethylene-α-olefin copolymer.

  Further, as the next layer or the next layer, for example, it is preferable to use a polyolefin resin such as a polypropylene (PP) resin or a polyethylene (PE) resin. For example, homopolypropylene (HPP), random polypropylene (RPP) Polypropylene resins such as block polypropylene and polyethylene resins such as high density polyethylene (HDPE) and low density polyethylene (LDPE) can be applied. Furthermore, depending on the mode of use, a polystyrene resin, a polystyrene resin in which a reinforcing rubber component is blended, or the like can be used. Further, an inorganic filler such as talc may be added to these materials.

  As a specific example of the innermost layer / subsequent layer / subsequent layer laminate, in the case of delamination between the innermost layer and the next layer, polypropylene / high density polyethylene (HDPE) / polyolefin And a layer structure of a high molecular weight resin (HDPE) / polypropylene + low density polyethylene (LDPE) / polyolefin resin. Here, the peel strength between the innermost layer and the next layer is set to be smaller than the peel strength between the next layer and the next layer.

  In order to cause cohesive peeling in the next layer, the layer structure of polypropylene / polypropylene + ethylene-acrylic ester-maleic anhydride copolymer / polyolefin resin, high density polyethylene (HDPE) / polypropylene Examples include a layer configuration of + ethylene-acrylic acid ester-maleic anhydride copolymer / polyolefin resin.

  As the shape of the multilayer package body, the optimum shape is selected depending on the shape, type, size, etc. of the packaged articles to be stored. For example, the shape of the multilayer package body is a sheet shape, a film shape, a container shape, or the like. It can be. Among these, the multilayer package body constituting the sterilization package of the present invention is a container, and a storage section such as a recess in accordance with the shape of the package can be formed from the multilayer sheet by thermoforming. Therefore, it is preferable. Moreover, the said storage part is good also as a thing from one thing to several things from the kind and aspect of a to-be-packaged item.

  Moreover, as a multilayer package body, air permeability is not necessarily required, and it is required that bacteria do not enter. As described above, as described above, a film shape, a sheet shape, and a container shape can be considered. From the viewpoint of the shape and the arrangement of the packaged object, for example, when considering use in medical applications, the flange It is preferable to make it a container shape with a mark.

  Next, the sterilization sheet constituting the sterilization packaging body of the present invention is heat-sealed with respect to the multilayer packaging body described above, and does not permeate microorganisms such as bacteria and sterilization gas. It is a sheet that also has the performance of being able to permeate the gas.

  As this sterilization sheet, if it has micropores and Gurley type air permeability is preferably 0.1 to 2000 seconds / 100 cc, more preferably about 0.5 to 1000 seconds / 100 cc, Good. In addition, what is necessary is just to measure this air permeability based on JISP8117, for example.

  As a material for the sterilization sheet, sterilized paper, a microporous film made of a synthetic resin, a nonwoven fabric, or the like can be used, or a multilayered sheet made of a combination of these may be used. Further, as a commercial product, a high-density polyethylene sheet material known as a trade name “Tyvek 1073B” manufactured by DuPont can be used. Among these, it is preferable to use a nonwoven fabric as the sterilization sheet constituting the sterilization package of the present invention, and it is particularly preferable to use a nonwoven fabric composed of a thermoplastic resin.

In the case of adopting a nonwoven fabric composed of a thermoplastic resin as a sterilization sheet, the thermoplastic resin may be high density polyethylene (HDPE), low density polyethylene (LDPE), linear low density ethylene-α-olefin copolymer Polyolefin resins such as random copolymerized polypropylene (LLDPE), homopolypropylene, ethylene, etc., polyester resins such as polyethylene terephthalate (PET), polyamide (nylon) resins, or a combination of these materials can do.
The non-woven fabric may be a multi-layer non-woven fabric using a heat-resistant resin for the core layer such as the center layer and a resin having good thermal adhesiveness for the surface layer.
Moreover, you may use the composite nonwoven fabric which consists of the fiber which consists of these thermoplastic resins, and a rayon fiber.

  The nonwoven fabric made of thermoplastic resin is preferably a nonwoven fabric having a melting point of 110 ° C. or higher, particularly 120 ° C. or higher. In particular, it is preferable to employ a nonwoven fabric made of polyolefin resin having these melting points. By setting the nonwoven fabric to such a configuration, a sterilization sheet excellent in heat resistance and chemical resistance can be obtained, and such performance can be imparted to the sterilization package.

Furthermore, in the case of the sterile sheet and a nonwoven fabric having the air permeability characteristics, the basis weight is preferably of the order of ^{20~200g / m 2, 30~150g / m} 2 about Those are more preferably used.

The nonwoven fabric used as the sterilization sheet should have hydrophilicity to prevent clogging due to water droplets in the autoclave sterilization process using high-temperature steam gas and moisture remaining inside the package. It is preferable.
Therefore, for example, when using a polyolefin resin nonwoven fabric, various hydrophilic treatment agents such as corona treatment, plasma treatment, sulfonic acid-based or carboxylic acid-based hydrophilic group introduction treatment, known sorbitan-based, etc. It is effective to perform introduction processing.

These multi-layer package body and sterilization sheet form a sterilization package body by packaging the article to be packaged and then heat-sealing and sealing it in a circumferential shape.
Here, when heat-sealing the multilayer packaging body and the sterilization sheet, if the multilayer packaging body is in the form of a film or sheet, the multilayer packaging body and the sterilization sheet are overlapped,
What is necessary is just to heat-seal a peripheral part with a well-known heat-seal machine.
On the other hand, when the multilayer package body has a container shape, a sterilization sheet is placed on the upper surface of the flange formed on the periphery of the opening of the container, and the surface of the flange upper surface is sterilized. What is necessary is just to heat-seal the sheet | seat with a well-known heat sealing machine etc.

  The sterilization package obtained in this way is sterilized by the treatment with the sterilization gas for the articles to be packaged in the sterilization package. Examples of the sterilization gas include ethylene oxide gas, hydrogen peroxide gas, and high-temperature steam gas. These sterilizing gases pass through the inside of the package from the entire surface except the heat-sealed portion of the sterilizing sheet.

Next, an embodiment of a sterilization package when a multilayer container is used as the multilayer package body will be described with reference to the drawings.
FIG. 1 is an example of an embodiment of a sterilization packaging body 1 according to the present invention, and is a perspective view showing an example in which a multilayer container 2 is used as a multilayer packaging body. In FIG. 1, 1 is a sterilization package, 2 is a multilayer container, and 3 is a sterilization sheet.

The sterilization sheet 3 is heat-sealed by providing a circumferential heat seal portion 23 with respect to the flange portion 22 formed at the periphery of the opening 21 of the multilayer container 2.
Then, as shown in FIG. 1, for example, by pulling up the sterilization sheet 3 at the corner of the sterilization package 1, the heat seal portion 23 of the innermost layer 25 of the multilayer container 2 causes an edge break. The layer including the innermost layer 25 moves to the sterilization sheet 3 to be peeled off and can be opened.

In addition, the multilayer container 2 in the present embodiment is a substantially rectangular tray-shaped container having a predetermined depth, and has the substantially rectangular opening 21 as described above. A flange portion 22 is formed on the periphery so as to project outward.
The multilayer container 2 having such a shape is obtained by thermoforming a predetermined multilayer sheet having a layer configuration described later. As a thermoforming method for forming the multi-layer container 2, for example, a multi-layer sheet is pre-stretched with a plug in a mold cavity formed in the outer shape of the multi-layer container 2, and then the shape of the container is formed by pressure forming or vacuum forming. Various thermoforming methods such as a plug assist molding method can be employed.

  2 is a cross-sectional view taken along the line II-II before the sterilization packaging body 1 of FIG. 1 is opened. As shown in FIG. 2, the multilayer container 2 includes an innermost layer 25, a next layer 26, and a layer (base layer) 27 one after another.

  In the present embodiment, examples of the resin material constituting the innermost layer 25 include homopolypropylene (HPP), random polypropylene (RPP), block polypropylene, high-density polyethylene (HDPE), and linear ethylene-α-olefin copolymer. Olefin resins such as coalescence can be exemplified.

  In the present embodiment, the next layer 26 that is in contact with the innermost layer 25 and the next layer 27 (base layer) that is in contact with the next layer 26 are, for example, polypropylene (PP) resin, polyethylene (PE) A polyolefin resin such as a resin or a resin material blended with the polyolefin resin can be used, and these resin materials may be appropriately selected according to the state of the opened state.

  In the present embodiment, the sterilization sheet 3 to be heat-sealed with the flange portion 22 of the multilayer container 2 can use, for example, sterilized paper, a microporous film made of a synthetic resin, a nonwoven fabric, and the like. It is preferable to use a nonwoven fabric composed of a plastic resin. The nonwoven fabric is preferably composed of a polyolefin resin having a melting point of 110 ° C. or higher, particularly 120 ° C. or higher, and particularly preferably subjected to hydrophilic treatment such as corona treatment.

Hereinafter, the opened state of the sterilization packaging body 1 of the present invention will be described with reference to FIGS.
FIG. 3 is a partial sectional view showing a state (state before opening) in which the innermost layer 25 of the multilayer container 2 and the sterilization sheet 3 are heat-sealed in the sterilization package 1 of the present embodiment. As shown in FIG. 3, the heat seal portion 23 is formed between the innermost layer 25 existing on the upper surface of the flange portion 22 formed in the multilayer container 2 and the sterilization sheet 3, and the heat seal portion 23 is provided over the entire circumference of the flange portion 22 formed on the periphery of the opening 21 of the multilayer container 2.

  The heat sealing between the flange portion 22 formed on the periphery of the opening 21 of the multilayer container 2 and the sterilization sheet 3 places the sterilization sheet 3 on the innermost layer 25 existing on the upper surface of the flange portion 22. Then, if necessary, it can be performed using an annular heat seal ring having a crow-mouth shaped protrusion. The heat sealing temperature can be appropriately determined depending on the material configuration of the innermost layer 25 of the multilayer container 2 and the sterilization sheet 3, and may be about 170 to 230 ° C., preferably about 180 to 210 ° C. .

  When the sterilization packaging body 1 of the present embodiment shown in FIG. 3 is opened, as shown in FIGS. 4 to 6, the layer including at least the innermost layer 25 of the sterilization packaging body 1 is In addition, the inner seal layer 25 and the innermost layer 25 are integrally moved to the sterilization sheet 3 side without requiring the inner layer separation in the innermost layer 25.

  First, FIG. 4 is a partial cross-sectional view showing an aspect in which the innermost layer 25 moves to the sterilization sheet 3 side and is opened by delamination between the innermost layer 25 and the next layer 26. In this case, the innermost layer 25 and the next layer 26 are essentially the basis. In the case of a three-layer structure, the thickness of the next layer 26 is not particularly limited, and may be set to about 5 to 200 μm, for example, and this next layer 26 adjusts the peel strength with the innermost 25 layers. Become a layer.

  Next, FIG. 5 is a partial cross-sectional view showing a mode in which the innermost layer 25 moves to the sterilization sheet 3 side and is opened by delamination between the next layer 26 and the next layer 27. In this case, the innermost layer 25 and the next layer 26 are integrally moved to the sterilization sheet 3 side, whereby the sterilization package 1 is opened. It is better not to make the thickness of the next layer 26 too large. For example, it is preferable to set the thickness to about 5 to 30 μm.

  6 shows that the next layer 26 is peeled off due to cohesive failure in the next layer 26, and the innermost layer 25 and a part 26a of the next layer 26 are integrally moved to the sterilization sheet 3 side. It is the fragmentary sectional view which showed the aspect by which opening is performed. Therefore, a part 26 b of the next layer remains on the flange portion 22 of the multilayer container 2. In addition, there is no restriction | limiting in particular as the thickness of the next layer 26 in which the intra-layer cohesive fracture peeling is performed, but it can be set to about 5-100 micrometers.

Here, the thickness of the innermost layer 25 in the above-described embodiment can be appropriately determined depending on the opening mode and type, and can be, for example, about 3 to 100 μm.
In addition, in this embodiment, although the aspect which makes the edge cut | disconnection of the heat seal part 23 of the innermost layer 25 arise in heat sealing is shown, for example, as mentioned later, in the innermost layer 25 of the multilayer container 2, In addition, a cut may be formed on the inner side of the heat seal portion 23, and the thickness of the innermost layer 25 can be appropriately determined according to other opening modes. Therefore, the thickness of the innermost layer 25 is generally 5 to 40 μm in consideration of the type of resin of the innermost layer 25 and the size of the multilayer container 2 when the edge of the innermost layer 25 is cut during heat sealing. Preferably, it may be 5 to 20 μm.

Further, in order to enable delamination between the innermost layer 25 and the next layer 26 and between the next layer 26 and the next layer 27, each layer is formed so that the delamination strength between the respective layers is about 2 to 20 N / 15 mm. What is necessary is just to make it combine the resin material or resin composition to comprise.
Many combinations of such resin materials have already been proposed. For example, the innermost layer 25 / next layer 26, or the next layer 26 / second layer 27, and polypropylene / polypropylene with 10 to 50 masses of polyethylene. %, Polypropylene / high density polyethylene (HDPE) and the like.

  Next, many known means are already known as means for making the next layer 26 cohesive fracture within the layer and imparting easy peelability. For example, polypropylene with low density polyethylene, ethylene- (meth) acrylic acid copolymer, ethylene- (meth) acrylic acid ester copolymer, ethylene- (meth) acrylic acid-maleic anhydride copolymer, ethylene-vinyl acetate The layer which consists of a resin composition containing 5-50 mass% of a copolymer, a thermoplastic elastomer, etc. is mentioned. Even in this case, it is preferable to select a resin having an in-layer peel strength of about 2 to 20 N / 15 mm.

According to the sterilization packaging body 1 of the present invention having the above-described aspect, the following effects can be obtained.
(1) In the sterilization package 1, the layer including at least the innermost layer 25 of the multilayer container 2 that is a multilayer package is moved to the sterilization sheet 3 side so as to be peeled off. There is no restriction | limiting in the selection of the thermoplastic resin which forms the inner layer 25, and it can select, attaching importance to the heat sealing property with the sheet | seat 3 for sterilization. Further, sterilization can be performed regardless of the type of sterilization gas, and in particular, it can sufficiently cope with high-temperature processing such as steam processing.
Further, since no adhesive is used when the multilayer container 2 and the sterilization sheet 3 are bonded, there is no concern about adhesion or contamination due to the adhesive in high temperature processing such as steam processing.
Furthermore, even if the heat seal between the multilayer container 2 and the sterilization sheet 3 is bonded with a sufficiently high adhesive strength, easy-openability can be imparted. Further, the opening strength of the sterilization package 1 can be arbitrarily controlled without being limited to the thermoplastic resin constituting the innermost layer 25 of the multilayer container 2.

(2) Further, if the above-described peeling occurs between the innermost layer 25 and the next layer 26 of the multilayer container 2, within the layer of the next layer 26, or between the layers of the next layer 26 and the next layer 27, The easy-openability of the sterilization package 1 can be further improved, and the delamination position in the multilayer container 2 can be arbitrarily selected by devising the configuration of each layer such as the constituent material and thickness. Become.

(3) If the innermost layer 25 of the multilayer container 2 is made of a polyolefin resin having a melting point of 110 ° C. or higher, the sterilization packaging body 1 having excellent heat resistance and chemical resistance is obtained, and steam treatment at a high temperature is performed. Can be fully supported.
Furthermore, if the innermost layer 25 is combined with a multilayer container 2 made of a polyolefin resin having a melting point of 110 ° C. or higher and a sterilization sheet 3 made of a thermoplastic resin having a melting point of 110 ° C. or higher, It is possible to provide the sterilization packaging body 1 that is excellent in performance and chemical resistance and that can more suitably cope with steam treatment at high temperatures.

(4) Since the shape of the multilayer package body is a container shape, it is excellent in usability and storage properties, and can easily correspond to the shape of the article to be packaged.
For example, when the article to be packaged is a syringe or the like, the multilayer container 2 can be arbitrarily selected in accordance with the shape of the article to be packaged with respect to the bottom surface portion in order to easily accommodate the article to be packaged such as the syringe. One or a plurality of recesses or the like can be formed on the substrate.

In addition, this invention is not limited to the said aspect, The deformation | transformation in the range which achieves the objective of this invention, improvement, etc. are included in this invention.
For example, in the above-described embodiment, only the inner side of the heat seal portion 23 is cut off at the edge. However, the present invention is not limited to this, and the heat seal portion 23 does not reach the end of the flange portion 22. As shown in FIG. 7, the inner and outer positions of the heat seal portion 23 may be cut off at the edges.
In the above-described embodiment, the form of peeling at the time of opening has been specifically described with three examples, but the sterilization packaging body 1 of the present invention is used for sterilization of the multilayer container 2 at the time of opening the packaging body 1 for use. It is sufficient that at least the innermost layer 25 including the heat seal portion 23 with the sheet 3 can move to the sterilization sheet 3 side. Therefore, depending on the selection of the resin constituting the multilayer container 2 and the layer thickness, a release form in which these release forms are combined may be used.

In the embodiment described above, the heat seal portion 23 of the innermost layer 25 of the multilayer container 2 is broken so that the layer including the innermost layer 25 moves to the sterilization sheet 3 and is peeled off and opened. However, the present invention is not limited to this. For example, as shown in FIGS. 8 and 9, the innermost layer 25 of the multilayer container 2 has a circumferential shape with respect to the inside of the heat seal portion 23. The cut 30 may be formed.
In the following description, parts and members that are the same as the parts and members that have already been described are assigned the same reference numerals and description thereof is omitted.

FIG. 8 is a view showing another embodiment of the sterilization packaging body 1 of the present invention, in which the heat of the innermost layer 25 is obtained for the multilayer container 2 that is the multilayer packaging body constituting the sterilization packaging body 1. FIG. 6 is a perspective view showing an aspect in which a circumferential cut 30 is formed on the inner side of the seal portion 23.
In addition, this aspect shows as an example an aspect in which peeling occurs between the innermost layer 25 and the next layer 26, and the innermost layer 25 moves to the sterilization sheet 3 side and is opened.

9 shows a cross-sectional view taken along the line IX-IX in FIG. 8, wherein (A) shows a state before opening, and (B) shows a cross-sectional view showing a state after opening. .
In the present embodiment, the notch 30 has a V-shaped cross section. In addition, the notch 30 can be formed in various other shapes such as a U shape and a rectangular shape.
In addition, in FIG. 9, the depth of the notch 30 shows a mode in which the depth reaches the next layer 26 and does not reach the next layer 26. For example, if the depth reaches the next layer 26, the peeling can be reliably performed. it can.
When opening the sterilization sheet 3, when the sterilization sheet 3 is pulled up, peeling occurs between the innermost layer 25 and the next layer 26 of the multilayer container 2, and when the peeling reaches the cut portion 30, The layer including the innermost layer 25 moves to the sterilization sheet 3 and is opened.

Thus, in the sterilization packaging body 1 according to the present invention, if the circumferential cuts 30 are provided inside the heat seal portion 23 of the multilayer container 2, the effects (1) to (4) described above can be achieved. In addition, when the innermost layer 25 peels off and moves to the sterilization sheet 3, opening by cutting at the heat seal portion 23 is suitably performed, and the multilayer container 2 that is the multilayer package body and the sterilization container The effect that the range of the wider combination of the sheet | seat 3 can be expanded can be show | played.
FIG. 9 shows a mode in which peeling occurs between the innermost layer 25 and the next layer 26, and the innermost layer 25 moves to the sterilization sheet 3 side to open the seal. The same effect can be obtained even when peeling within the layer 26 or peeling between the next layer 26 and the next layer 27 in contact with the next layer 26.

  In addition, the specific structure, shape, and the like in the implementation of the present invention may be other structures as long as the object of the present invention can be achieved.

  EXAMPLES Next, although an Example and a comparative example are given and this invention is demonstrated in more detail, this invention is not restrict | limited at all to description content, such as these Examples.

[Example 1]
A laminate (multilayer sheet) composed of the following innermost layer (A) / next layer (B) / next layer (C) was formed by coextrusion molding.
In this specification, the density is a value measured according to JIS K6922, the MFR is measured according to JIS K7210, and the melting point is measured according to JIS K7122.

Innermost layer (A): propylene-ethylene random copolymer [IDEMITSU PP F
744NP (manufactured by Idemitsu Petrochemical Co., Ltd.), melting point 135 ° C., MFR (abbreviation of melt flow rate, hereinafter the same) 6.4 g / 10 min] layer thickness 10 μm
Next layer (B): 50% by mass of homopolypropylene [IDEMITSU PP E304GP (manufactured by Idemitsu Petrochemical Co., Ltd.), melting point: 162 ° C., MFR: 3.0 g / 10 min]
Low density polyethylene [Novatech HE30 (manufactured by Nippon Polyethylene Co., Ltd.), melting point:
108 ° C., MFR: 0.3 g / 10 min], a resin composition comprising 50% by mass. Layer thickness: 100 μm
Next layer (C): 90% by mass of homopolypropylene [IDEMI SUPP E304GP (made by Idemitsu Petrochemical Co., Ltd.), melting point: 162 ° C.], low density polyethylene [Novatech LD HE30 (made by Nippon Polyethylene Co., Ltd.), melting point: 108 ° C., MFR: 0.3 g / 10 minutes] 10% by mass of resin composition Layer thickness 240 μm

  Then, using this multilayer sheet, a flanged multilayer container having a flange portion of 100 mm × 200 mm × 20 mmH and a width of 8 mm was obtained by employing a thermoforming method.

After arranging and arranging glass syringes against the flange part of this flanged multilayer container,
A sterilization sheet of polypropylene non-woven fabric (having a hydrophilic treatment) [basis weight 100 g / m ² , Gurley type air permeability 15 seconds / 100 cc] is heat-sealed using the following heat seal conditions, and used for sterilization of the present invention. A package was obtained.

(Heat seal condition)
Sealing temperature 170 ° C
Sealing pressure 40kg / cm ²
Time 3.5 seconds
Number of heat seals 2 times

[Example 2]
According to the same method as in Example 1 except that a laminate (multilayer sheet) formed by coextrusion molding and comprising the innermost layer (A) / next layer (B) / next layer (C) having the following configuration was used. The sterilization packaging body of the present invention was obtained.

Innermost layer (A): propylene-ethylene random copolymer [IDEMITSU PP F744NP (manufactured by Idemitsu Petrochemical Co., Ltd.), melting point 135 ° C., MFR 6.4 g / 10 min] layer thickness 10 μm
Next layer (B): homopolypropylene [IDEMITSU PP E304GP (manufactured by Idemitsu Petrochemical Co., Ltd.), melting point 162 ° C., MFR 3.0 g / 10 min] 70% by mass, ethylene-acrylic acid ester-maleic anhydride copolymer Combined [Lex Pearl ET182 (manufactured by Nippon Polyethylene Co., Ltd.), density 937 kg / m ³ , melting point: 99 ° C., MFR: 8 g / 10 min] 30% by mass blend layer thickness 30 μm
Next layer (C): Homopolypropylene [IDEMITSU PP E304GP (manufactured by Idemitsu Petrochemical Co., Ltd.), melting point: 162 ° C., MFR: 3.0 g / 10 min] Layer thickness 360 μm

[Comparative Example 1]
According to the same method as in Example 1 except that a laminate (multilayer sheet) formed by coextrusion molding and comprising the innermost layer (A) / next layer (B) / next layer (C) having the following configuration was used. A sterilization package was obtained.

Innermost layer (A): Adhesive polyolefin resin [CMPS V70 (Mitsui, manufactured by DuPont Polychemical), density 920 kg / m ³ , MFR: 8 g / 10 min] Layer thickness 60 μm
Next layer (B): Homopolypropylene [IDEMITSU PP E304GP (manufactured by Idemitsu Petrochemical Co., Ltd.), melting point 162 ° C., MFR: 3.0 g / 10 min] Layer thickness 100 μm
Next layer (C): homopolypropylene [IDEMITSU PP E304GP (manufactured by Idemitsu Petrochemical Co., Ltd.), melting point: 162 ° C., MFR: 3.0 g / 10 min] Layer thickness 240 μm

[Test Example 1]
The container-shaped sterilization packaging bodies obtained in Examples 1 and 2 and Comparative Example 1 were subjected to steam sterilization treatment (temperature 110 ° C., time 30 minutes) for comparison and evaluation. The results are shown in Table 1.
In addition, as the content of evaluation, the state of the sterilization package after sterilization was confirmed visually. Moreover, after cooling the said sterilization packaging body at room temperature, the flange part is cut out to a width of 15 mm, and the opening strength is measured by the following measuring method, and the peeling mode (position of peeled layer, peeling mode) and opening feeling are confirmed. did.

(Measurement method of opening strength)
Using a commercially available tensile tester, measurement was performed under the following conditions, and the measured peak value was defined as the opening strength.
Peel angle: 130 °
Peeling speed: 300mm / min

(Result)

(State of sterilization package after sterilization)
As shown in Table 1, the packages for sterilization of Examples 1 and 2 were good with no change in the appearance after sterilization. On the other hand, in the sterilization package of Comparative Example 1, peeling was observed at a part of the seal portion. In any of the sterilization packaging bodies, substantially no water remained inside.

Next, as for the opening strength and the peeling mode, the packaging for sterilization of Examples 1 and 2 was 8.4 N / 15 mm (delamination between the innermost layer and the next layer) in Example 1, and 7.5 N / in Example 2. It was 15 mm (cohesive peeling of the next layer). Moreover, both showed smooth openability, and from these results, it was confirmed that they were optimal as sterilization packages.
On the other hand, the opening strength of the sterilization package of Comparative Example 1 is as large as 18.2 N / 15 mm, and the innermost adhesive resin causes cohesive failure at the time of opening to both the flange portion and the sterilization sheet. It was an existing peeling mode. Moreover, it shows a somewhat hard opening feeling, and it can be seen from these results that it is not preferable as a sterilization package.

  The sterilization packaging body of the present invention can be expected to be used in the medical and food fields in which the contents are sterilized using a gas after packaging. In particular, it is difficult to use a sterilizing gas such as ethylene oxide or hydrogen peroxide. In addition, it can be suitably used as a sterilization package that can be used for autoclave treatment using high-temperature steam.

It is the perspective view which showed one Embodiment of the packaging body for sterilization based on this invention. It is II-II sectional drawing of FIG. It is an important section of Drawing 1, and is an expanded sectional view showing the state after heat sealing (before opening). It is an expanded sectional view showing one mode of an opened state. It is an expanded sectional view showing other modes of an opened state. It is an expanded sectional view showing another mode of an opened state. It is the figure which showed the other aspect of the opened state of the sterilization packaging body, Comprising: It is the fragmentary sectional view in which the position near the inner side and the outer side of a heat seal part showed the edge cutting | disconnection aspect. It is the figure which showed other embodiment of the packaging body for sterilization based on this invention, Comprising: It is a perspective view which shows the aspect which put the circumferential cut | incision in the flange part of the multilayer container. It is IX-IX sectional drawing of FIG. 8, Comprising: (A) is the state before opening, (B) is a figure which shows the state after opening. It is the expanded sectional view which showed the unsealed state of the prior art example.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 ... Sterile packaging body, 2 ... Multilayer container (multilayer packaging body), 3 ... Sterilization sheet, 21 ... Opening part, 22 ... Flange part, 23 ... Heat seal part, 25 ... Innermost layer, 26 ... Subsequent layer, 27 ... one after another, 30 ... notches

Claims (6)

In the package formed by heat-sealing the multilayer package body made of thermoplastic resin and the sterilization sheet,
When peeling and opening the sterilization sheet from the multilayer package body,
A sterilization packaging body, wherein a layer including at least the innermost layer of the multilayer packaging body moves to the sterilization sheet side and is peeled off. In the sterilization package according to claim 1,
The peeling occurs in any of the innermost layer of the multilayer package body and the next layer in contact with the innermost layer, the inner layer of the next layer, and the subsequent layer in contact with the next layer and the next layer. A package for sterilization. In the sterilization packaging body according to claim 1 or 2,
A sterilization packaging body, wherein the innermost layer of the packaging body is made of a polyolefin resin having a melting point of 110 ° C or higher. In the sterilization packaging body according to any one of claims 1 to 3,
A sterilization packaging body, wherein the sterilization sheet is made of a nonwoven fabric made of a thermoplastic resin having a melting point of 110 ° C or higher. In the sterilization packaging body according to any one of claims 1 to 4,
The sterilization packaging body, wherein the multilayer packaging body has a container shape. In the sterilization packaging body according to any one of claims 1 to 5,
A package for sterilization, characterized in that a circumferential cut is formed on the inside of the heat seal part of the multilayer package body.

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