JP2004528316A5 - - Google Patents

Info

Publication number

JP2004528316A5

JP2004528316A5 JP2002576888A JP2002576888A JP2004528316A5 JP 2004528316 A5 JP2004528316 A5 JP 2004528316A5 JP 2002576888 A JP2002576888 A JP 2002576888A JP 2002576888 A JP2002576888 A JP 2002576888A JP 2004528316 A5 JP2004528316 A5 JP 2004528316A5

Authority

JP

Japan

Prior art keywords

agent

cytotoxic agent

therapeutic agent

cancer therapeutic

rarα

Prior art date

2002-03-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
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• 229940127089 cytotoxic agent Drugs 0.000 claims 11
• 239000002254 cytotoxic agent Substances 0.000 claims 11
• 231100000599 cytotoxic agent Toxicity 0.000 claims 11
• 229940124597 therapeutic agent Drugs 0.000 claims 9
• 239000012830 cancer therapeutic Substances 0.000 claims 8
• 102100023606 Retinoic acid receptor alpha Human genes 0.000 claims 6
• 239000000556 agonist Substances 0.000 claims 6
• 108091008726 retinoic acid receptors α Proteins 0.000 claims 6
• 239000005557 antagonist Substances 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• 102000003702 retinoic acid receptors Human genes 0.000 claims 4
• 108090000064 retinoic acid receptors Proteins 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 3
• 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 claims 2
• 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 claims 2
• 229940123237 Taxane Drugs 0.000 claims 2
• 230000026731 phosphorylation Effects 0.000 claims 2
• 238000006366 phosphorylation reaction Methods 0.000 claims 2
• DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 2
• MQLACMBJVPINKE-UHFFFAOYSA-N 10-[(3-hydroxy-4-methoxyphenyl)methylidene]anthracen-9-one Chemical group C1=C(O)C(OC)=CC=C1C=C1C2=CC=CC=C2C(=O)C2=CC=CC=C21 MQLACMBJVPINKE-UHFFFAOYSA-N 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 229930012538 Paclitaxel Natural products 0.000 claims 1
• 102000004243 Tubulin Human genes 0.000 claims 1
• 108090000704 Tubulin Proteins 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 229960001592 paclitaxel Drugs 0.000 claims 1
• 239000012985 polymerization agent Substances 0.000 claims 1
• 230000000379 polymerizing effect Effects 0.000 claims 1
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1