JP2004041668A - Non-blood collecting type handy blood sugar meter (2) - Google Patents

Non-blood collecting type handy blood sugar meter (2) Download PDF

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Publication number
JP2004041668A
JP2004041668A JP2002249772A JP2002249772A JP2004041668A JP 2004041668 A JP2004041668 A JP 2004041668A JP 2002249772 A JP2002249772 A JP 2002249772A JP 2002249772 A JP2002249772 A JP 2002249772A JP 2004041668 A JP2004041668 A JP 2004041668A
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Prior art keywords
light
blood glucose
blood
amount
blood sugar
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JP2002249772A
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Japanese (ja)
Inventor
Kenji Ogaki
大垣 憲治
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Kenji Ogaki
大垣 憲治
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Abstract

<P>PROBLEM TO BE SOLVED: To provide a non-blood collecting type handy blood sugar meter detecting exactly a change in amount of a transmitted light and suppressing a spread by various factors of each specimen as a reading type by converting the detected amount of the transmitted light to a blood sugar level via "a correlation table" based on a correlation between the transmitted light amount of the light irradiated to an earlobe and the blood sugar level is adopted to calculate the blood sugar level from a trace amount of blood sugar in blood. <P>SOLUTION: A site, the earlobe with few individual differences and an always stable blood flow, hardly physiologically influenced, is chosen. The transmitted light amount is incarnated by irradiating with a light of a wavelength most absorbed by the blood sugar, and the blood sugar amount responding to the irradiated light is increased by extending exposure time. A detector with the maximum sensitivity and a high amplification rate is used for detecting the transmitted light to easily catch the responding result of the blood sugar to the irradiated light. Variations in measuring the light amount are classified and patternized for each definite range, and the mean values and the correlated blood sugar values are connected to prepare "a correlation table" for each pattern, and the error is reduced by selecting "a correlation table" with an optimum pattern for each individual. <P>COPYRIGHT: (C)2004,JPO

Description

【0001】 [0001]
【発明の属する技術分野】 BACKGROUND OF THE INVENTION
本発明は糖尿病治療における血糖管理に欠かせないハンディ血糖計の中の非採血式のものに関する。 The present invention relates to those of a non-blood type in the handy blood glucose meter indispensable to glycemic control in diabetes therapy.
【0002】 [0002]
【従来の技術】 BACKGROUND OF THE INVENTION
各種のハンディ血糖計は既に知られているが、そのすべては採血を必要とするものである。 Various handy blood glucose meter is already known, but all of those requiring blood sampling.
【0003】 [0003]
【発明が解決しようとする課題】 [Problems that the Invention is to Solve
1 患者に苦痛を与えず簡単に血糖値を適時適切に測定できるようにする。 Easy blood glucose without causing pain to 1 patient to allow timely and appropriate measurements.
2 耳朶の個体差を小さくする。 The individual differences of 2 earlobe reduced.
3 多様な物質よりなる耳朶から微量な血糖の増減のみを的確に読み取れるようにする。 3 to read accurately only increase or decrease a small amount of blood glucose from the earlobe consisting variety of materials.
4 すべての患者が使用できるよう一定の誤差を許容した有効な「相関表」を作成する。 4 all patients to create a valid "correlation table" that allows certain errors so that they can be used.
5 検体の持つさまざまな要因により血糖値と相関する透過光量の測定値にばらつきが生じ、そのままにしておくと大きな誤差になる。 Variations occur in the measured value of the transmitted light quantity that correlates with blood glucose level by a variety of factors with the 5 specimens, a big error and leave it.
6 透過光量の増減を的確に検出する方法(A)。 How to accurately detect an increase or decrease in 6 transmitted light amount (A).
7 透過光量の増減を的確に検出する方法(B)。 How to accurately detect the increase or decrease of 7 transmitted light amount (B).
8 透過光量の増減を的確に検出する方法(C)。 How to accurately detect the increase or decrease of 8 transmitted light amount (C).
【0004】 [0004]
【課題を解決するための手段】 In order to solve the problems]
1 ハンディ血糖計を在来の採血式から非採血式に転換する。 1 to convert the handy blood glucose meter from conventional blood type to the non-blood type.
2 光出力部の窓のレンズと受光部の窓のレンズの間隔を2〜4mmの範囲内で一定にし、又、レンズの直径を5〜10mmの範囲内で一定にする。 2 the light output of the window of the lens and the distance between the windows of the lens of the light receiving portion is constant in the range of 2-4 mm, also a constant diameter of the lens within the 5 to 10 mm.
3 血糖そのものを定量分析する方法によらず、耳朶の透過光量の変化のみを的確に検出し、「相関表」を介して血糖値に変換して読み取る方式を採用する。 3 glucose itself regardless of the method of quantitative analysis to detect accurately only the variation of the quantity of transmitted light earlobe, to adopt a method of reading is converted into the blood glucose level through the "correlation table".
4 「相関表」における血糖値は50〜400mg/dlの間を10mg/dl刻みの36段階に区分し、透過光量は、標準的「相関表」にあっては平均値L 〜L 36の36段階に区分する。 4 blood glucose level in the "correlation table" is divided between 50 to 400 mg / dl to 36 stages in increments of 10 mg / dl, the amount of transmitted light is, in the standard "correlation tables" mean L 1 ~L 36 divided into 36 stages. たとえば、血糖値50mg/dlと相関する透過光量はL で、血糖値100mg/dlと相関する透過光量はL 、血糖値400mg/dlと相関する透過光量はL 36である。 For example, in amount of transmitted light L 1 that correlate with blood glucose 50 mg / dl, the amount of transmitted light to correlate with blood glucose 100 mg / dl is the amount of transmitted light which correlates L 6, and the blood glucose level 400 mg / dl is L 36. 血糖値10mg/dl刻みの1段階における透過光量の測定値のばらつきは各血糖値の±5mg/dlの範囲とし、血糖値は10を単位にして読みとる。 Variations in the measured values ​​of the transmitted light quantity in the first stage of the tick blood glucose 10 mg / dl is in a range of ± 5 mg / dl of each blood glucose level, blood glucose level reading in the 10 units. 又、第2「相関表」にあっては、平均値L′ 〜L′ 36の36段階に区分し、血糖値10mg/dl刻みの1段階における透過光量の測定値のばらつきは各血糖値の±5mg/dl〜10mg/dlの範囲とする。 Further, in the second "correlation table", the average value L '1 ~L' is divided into 36 stages of 36, the variation of the measured values of the transmitted light quantity in the first stage of the tick blood glucose 10 mg / dl is the blood glucose level in the range of ± 5mg / dl~10mg / dl of. 又、第3「相関表」にあっては、平均値L″ 〜L″ 36の36段階に区分し、血糖値10mg/dl刻みの1段階における透過光量の測定値のばらつきは各血糖値の±10mg/dl〜±15mg/dlの範囲とする。 Further, in the third "correlation table", the average value L "1 ~L" is divided into 36 stages of 36, the variation of the measured values of the transmitted light quantity in the first stage of the tick blood glucose 10 mg / dl is the blood glucose level in the range of ± 10mg / dl~ ± 15mg / dl of.
5 透過光量の測定値のばらつきを一定の範囲毎に区分けしてパターン化し、それぞれの個体に最適のパターンを選択することにより誤差を小さくする。 5 the variation of the measured values ​​of the transmitted light quantity patterned divided to every predetermined range, to reduce the error by selecting an optimal pattern to each individual.
6 方法(A)として、血糖が最もよく吸収する波長の光を耳朶に照射して吸収光量を増やし、透過光量の増減を顕現する。 As 6 method (A), is irradiated with light of a wavelength that blood glucose is best absorbed earlobe increase the amount of light absorbed, manifests an increase or decrease in amount of transmitted light.
7 方法(B)として、照射時間を延長し、耳朶の毛細血管の血液の流動性を利用してより多くの血糖を照射光と反応させる。 As 7 method (B), extending the irradiation time, is reacted with irradiated light more blood glucose utilizing blood fluidity of capillaries earlobe.
8 方法(C)として、血糖と照射光の反応結果をより大きくするため、透過光の検出に極大感度を持ち且増幅機能の高い検出器を使用する。 As 8 method (C), in order to increase the reaction results in blood glucose and the irradiation light, using a high detector of 且増 width function has a maximum sensitivity in the detection of the transmitted light.
【0005】 [0005]
【実施例】 【Example】
光出力部には、血糖が最もよく吸収する波長の近赤外線を発する発光ダイオードを使用する。 The light output unit uses a light emitting diode that emits near-infrared wavelength blood sugar is best absorbed.
【0006】 [0006]
光出力部と受光部の窓のレンズの直径を10mmにし、照射面積を広げて光に反応する血糖量を増やすことで透過光量の減少幅を拡大する。 The diameter of the window of the lens between the light output unit receiving portion to 10 mm, expanding the reduced width of the transmitted light amount by increasing the blood sugar which reacts to light to expand the irradiation area.
【0007】 [0007]
レンズとレンズの間隔を3mmに一定する。 To constant intervals of the lens and the lens in 3 mm.
【0008】 [0008]
可動体の開閉は、本体と可動体の接続部が形成するちょうばんによって行われ程よい嵌合状態を保つ。 Opening and closing of the movable member is performed by a butterfly edition of connection of the main body and the movable body is formed keep the reasonable fit state.
【0009】 [0009]
ぶどう糖負荷試験は50gのぶどう糖を250mlの水に溶いて一気に飲み、飲む前と30分後、60分後、90分後、120分後の血糖値を測定する。 Glucose tolerance test drink once with beaten glucose of 50g of water 250 ml, drink before and 30 minutes after, after 60 minutes, after 90 minutes, measuring the blood sugar level after 120 minutes.
【0010】 [0010]
耳朶の毛細血管の血流速度が2mm/秒の場合、照射時間を1分間にすると、直径10mmのレンズで光に反応する血糖量は照射時間2秒のときの約10〜12倍になる。 When the blood flow velocity of capillary earlobe of 2 mm / sec, when the irradiation time to 1 minute, blood sugar which reacts to light in the lens diameter 10mm is approximately 10 to 12 times when the irradiation time 2 seconds.
【0011】 [0011]
【発明の効果】 【Effect of the invention】
本発明によって、糖尿病患者の血糖測定が必要に応じて手軽にできることから完全な血糖管理が可能となり、正常な血糖値を維持する有効な治療法を確立することができる。 The present invention, blood glucose in diabetic patients it is possible to complete glycemic control because it can be easily if necessary, can be established effective therapy to maintain normal blood glucose levels. その結果合併症はなくなり、本当の意味で糖尿病とのよい付き合いができるようになる。 Consequently complications longer, so that it is good relationship between diabetes truly. これは糖尿病治療の革命である。 This is a revolution in the treatment of diabetes.
【図面の簡単な説明】 BRIEF DESCRIPTION OF THE DRAWINGS
【図1】非採血式ハンディ血糖計の斜視図【図2】血糖計内部の各装置の配列を示す断面図【符号の説明】 Cross-sectional view showing the arrangement of Figure 1 the non-blood type handy blood glucose meter perspective view Figure 2 blood glucose meter within each unit [Description of symbols]
1 本体 2 可動体 3 ホールダー 4 光出力部窓のレンズ 5 受光部窓のレンズ 6 液晶ディスプレー 7 ちょうばん 8 発光ダイオード 9 フォトダイオード 10 相関表11 読み取り装置 12 表示装置 1 body 2 movable member 3 holder 4 of the lens 5 light receiving section window of the light output section window lens 6 LCD 7 Chouban 8 light-emitting diodes 9 photodiode 10 correlation table 11 reader 12 display

Claims (3)

  1. 本発明は、受光部を持つ本体と光出力部を持つ開閉式の可動体よりなり、本体と可動体の間が検体の耳朶を挟むホールダーになっていて、両部の窓のレンズの直径を一定にし、向き合うレンズの間隔を一定にしたハンディタイプの血糖計で、受光部は標準的「相関表」・窓のレンズ・透過光を検出するフォトダイオード・「相関表」の読み取り装置・液晶ディスプレーを持つ表示装置とによって構成され、又、光出力部は窓のレンズと発光ダイオードによって構成され、回路に接続される。 The present invention is made of a retractable movable body having a main body and a light output section having a light-receiving portion, between the body and the movable body have become a holder sandwiching the earlobe of the specimen, the diameter of the window of the lens of both parts constant and, in the blood glucose meter handheld in which the distance to a certain face lens, the light receiving unit photodiode reader and LCD display of the "correlation table" for detecting a standard lens transmitted light "correlation table" and windows is constituted by a display device having, also, the light output section is constituted by the lens and the light emitting diodes of the window, is connected to a circuit.
    標準的「相関表」は、正常血糖から高血糖までのさまざまな状態にある多数の検体において、それぞれの検体で同時に、一方でぶどう糖負荷試験による血糖値の精密検査をし、もう一方でその都度耳朶に血糖が最もよく吸収する波長の光を一定時間照射してその透過光量を極大感度のフォトダイオードで測定し、それぞれの血糖値と相関する透過光量の測定値を線で結び、その線を低血糖から高血糖までを一定に区分した各段階に拡張して、血糖値を各段階に区分した幅の±50%の範囲内にばらつく透過光量の測定値を集めて平均値(L)を出し、各段階の血糖値と相関関係を結んで作成し、電子化する。 Standard "correlation table" in many specimens in a variety of states from normoglycemia to hyperglycemia, simultaneously in each sample, and the workup of the blood glucose level by glucose tolerance test on the other hand, each time on the other hand the amount of transmitted light was measured by a photodiode maximum sensitivity wavelengths of light glycemic best absorbed in the earlobe is irradiated a certain time, signed a measure of the amount of transmitted light which correlates with the respective blood glucose levels in a line, the line extended to each stage of partitioning constant from hypoglycemia to hyperglycemia, average blood glucose level collected measurements of transmission light varies within a range of ± 50% of the width obtained by dividing each stage (L) out, it creates signed correlation between blood glucose level of each stage, digitization.
    本発明は、耳朶という個体差が少なくて生理的影響を受けにくく常に血流の安定している部位を選んで透過光量の増減を検出し、「相関表」を介して血液中の微量の血糖の増減を血糖値に変換して読み取れることを特徴とする非採血式ハンディ血糖計(2)。 The present invention detects the increase or decrease of the transmitted light amount to choose site less individual difference is stable always bloodstream less susceptible to physiological effects of earlobe blood glucose traces through the "correlation table" in the blood non blood type handy blood glucose meter to increase or decrease, characterized in that read and converted into blood glucose level (2).
  2. 血糖値を各段階に区分した幅の±50%〜±100%の範囲内にばらつく透過光量の測定値を集め平均値(L′)を出して、各段階の血糖値と相関関係を結んで作成した第2「相関表」を持つ請求項1に記載の非採血式ハンディ血糖計(2)。 Out average value collected measurements of the transmitted light intensity varies blood glucose levels within a range of ± 50% ~ ± 100% of the width obtained by dividing each stage (L '), connects the correlation between blood glucose level at each stage non blood type handy blood glucose meter according to claim 1 having a second "correlation table" created (2).
  3. 血糖値を各段階に区分した幅の±100%〜±150%の範囲内にばらつく透過光量の測定値を集め平均値(L″)を出して、各段階の血糖値と相関関係を結んで作成した第3「相関表」を持つ請求項1に記載の非採血式ハンディ血糖計(2)。 Out average value collected blood glucose measurement value of the transmission light amount varies within a range of ± 100% ~ ± 150% of the width obtained by dividing each stage (L "), by connecting a correlation between blood glucose values ​​at each stage non blood type handy blood glucose meter according to claim 1 having a third "correlation table" created (2).
JP2002249772A 2002-07-15 2002-07-15 Non-blood collecting type handy blood sugar meter (2) Pending JP2004041668A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013078674A (en) * 2004-10-23 2013-05-02 Josh Hogan Correlation of concurrent non-invasively acquired signals

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013078674A (en) * 2004-10-23 2013-05-02 Josh Hogan Correlation of concurrent non-invasively acquired signals

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