JP2003534836A - 可撓性連結末端部分を有する粘着性組織シーラント用ディスペンサ - Google Patents

可撓性連結末端部分を有する粘着性組織シーラント用ディスペンサ

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Publication number
JP2003534836A
JP2003534836A JP2001572001A JP2001572001A JP2003534836A JP 2003534836 A JP2003534836 A JP 2003534836A JP 2001572001 A JP2001572001 A JP 2001572001A JP 2001572001 A JP2001572001 A JP 2001572001A JP 2003534836 A JP2003534836 A JP 2003534836A
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rigid
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JP2003534836A5 (ja
JP4686651B2 (ja
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エイチ. ドッジ,ラリー
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3M Innovative Properties Co
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491Surgical glue applicators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491Surgical glue applicators
    • A61B2017/00495Surgical glue applicators for two-component glue

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)
  • Materials For Medical Uses (AREA)
  • Coating Apparatus (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

(57)【要約】 たとえば、粘着性組織シーラントを投与するシリンジ用の可撓性部分(18)によって互いに接続された2つの剛性部分(14、20)を有する投与先端部(10)である。好ましくは、屈曲可能であるが、可撓性部(18)は、外力が無い時に2つの剛性部分(14、20)が互いに対して予測可能な角度で保持されるために十分な弾性を有する。このように、手術中に届きにくい場所に手で投与することが容易になる。また、この柔軟性により、カニューレと共に投与先端部(10)を使用することも容易になる。

Description

【発明の詳細な説明】
【0001】 技術分野 本発明は、概して、使用直前に混合する必要のあるものを含む粘着性組織シー
ラントおよび他の液体製剤の投与に関する。
【0002】 発明の背景 生きている組織を接着またはシールするために、種々の技術が使用されてきた
。たとえば、異なる種類の組織が、縫合、ステープル、テープおよび包帯を含む
複数の処置、材料および方法を用いて機械的に接着またはシールされてきた。用
途によっては、これらの材料は、治癒する時の組織を接着および/またはシール
し、その後ある期間に亙って吸収されるように意図された、吸収性材料からなる
【0003】 最近加えられた使用可能な技術は、組織を接着および/またはシールするため
の吸収性粘着シーラント組成物を塗布するというものである。粘着剤配合物は、
架橋剤からなる第1部と、蛋白質、好ましくはアルブミン等の血清蛋白質からな
る第2部と、を含む2成分混合物から容易に形成される。混合物の2つの部分が
結合される時、その混合物は最初は液体である。その後、結合された混合物は、
生体内において組織の表面上で硬化することにより、確実に組織に接着する実質
的な組成物を形成する。より完全な論考は、Barrows等に不要され、本願
と同一の譲受人に譲渡された米国特許第5,583,114号、「ADHESI
VE SEALANT COMPOSITION」において見いだすことができ
、その内容はすべて引用をもって本明細書内に包含されたものとする。
【0004】 この材料は、最も都合のよいことには、完成したシーラントの形成に対する反
応時間が極めて短時間であるため、2つの部分を組織上に投与される直前まで厳
密に分離したままにするデュアルシリンジから投与される。内容がすべて引用を
もって本明細書内に包含されたものとする、同時係属でありかつ本願と同一の譲
受人に譲渡されたWirt等による2000年3月10日に出願された米国特許
出願第09/524,141号は、ツインカープル(carpule)を使用し
て液体成分を収容する特に適当なデュアルシリンジを開示する。使用者がピスト
ンを押圧すると、液体成分が加圧されて流路と投与先端部とに入る。デュアルシ
リンジのノズルと投与先端部の構造とは、適当な混合の時間まで2つの成分を分
離したままにする。
【0005】 このシーラントとそのディスペンサとの使用に対して残っている制限は、短く
直線状の投与先端部が時に、手術部位の制限された空間で作動するためには不適
当である、ということである。角度付先端部は、しばしばより適当であるが、今
日しばしば最小限の切開で人体器官に接触するために使用される長く細いカニュ
ーレに挿入することができない。
【0006】 発明の概要 本発明は、可撓性部分によって互いに接続された2つの剛性部分を有する投与
先端部を提供する。好ましくは、屈曲可能であるが、可撓性部分は、外力の無い
時に2つの剛性部分が互いに対して予測可能な角度で保持されるために十分な弾
性を有する。このように、手術中に届きにくい場所に手で投与することが容易に
なる。しかしながら、急に、カニューレによる大部分閉じた体腔への投与が望ま
しいと判断された場合、手首を動かすことにより、末端剛性部分が、投与先端部
を直線状のカニューレに挿入することができるほど十分にまっすぐになる。末端
剛性部分は、患者の人体内部でカニューレの遠端から現れると、その都合のよい
角度の付いた方向に弾力的に戻る。
【0007】 より詳細には、投与先端部は、少なくとも1つの内腔が貫通している第1剛性
部分を有する。特に米国特許第5,583,114号の組成物に対する好ましい
実施形態は、第1剛性部分の長さの実質的にすべてを通して組成物の成分を分離
したままにする2つの内腔を有する。投与先端部はまた、第1剛性部分に取付け
られた可撓性部分も有する。可撓性部分の末端は、可撓性部分に取付けられてい
る第2剛性部分である。この第2剛性部分は、内腔内を導かれる投与材料に対す
る開口を有する。好ましい実施形態は、第2剛性部分の少なくとも一部内に、成
分が開口に到達する前に経由するスタティックミキサを有する。スタティックミ
キシングエレメントは、第2剛性部分に対して選択された長さにより、および投
与されている溶剤をどれくらい混合する必要があるかにより、可撓性部分内に任
意に設けられてよい。
【0008】 好ましい実施形態では、可撓性部分が第1および第2剛性部分を互いに事前設
定された角度に強制的に向けるような事前設定された屈曲を粘着性組成物が有す
る。多くの手術の目的のために、約20度と45度との間の角度が、外科医の要
求を最も満足させる。特に、約30度の角度が特に望ましいと考えられる。しか
しながら、いくつかの特殊な目的のために、特に気胸を治療する手術においては
、非常に鋭い屈曲、180度ほどもが、時には、たとえば肺の裏側の届きにくい
部分に粘着性シーラントを噴霧するために有用となる。
【0009】 本発明の他の特徴および利点は、以下の説明および図面から、および特許請求
の範囲から明らかとなろう。
【0010】 詳細な説明 ここで図1を参照すると、本発明の投与先端部10の好ましい実施形態の平面
図が示されている。その完全な機能を理解する便宜上、それは、典型的なデュア
ルシリンジ12に取付けられて示されている。例示の目的のために、概して、上
の引用によって包含された、Wirt等の2000年3月10に出願された同時
係属であり本願と同一の譲受人に譲渡された米国特許出願第09/524,14
1号において述べられているようなデュアルシリンジが示されているが、投与先
端部が他の同様のディスペンサに対してより一般的な適用性を有するということ
が理解されよう。
【0011】 投与先端部10は、第1剛性部分14を有する。最も好ましい実施形態では、
第1剛性部分14は、投与先端部をシリンジが共に動作するよう意図された他の
流体投与装置に対するシリンジのノズルに係合させるように適合された取付部分
16を有する。第1剛性部分14には可撓性部分18が取付けられており、この
可撓性部分はさらに第2剛性部分20に取付けられている。第2剛性部分20は
、シリンジ12内の成分、たとえば粘着性手術用シーラントが噴出される開口2
2を有する。
【0012】 ここで図2を参照すると、図1の投与先端部10の平断面図が分離して示され
ている。この図では、取付部分16が、都合のよいことには、投与先端部10の
共に使用されるシリンジへの取付けを容易にするためにフランジ24および26
を有することが、より容易にわかる。第1剛性部分14は、2つの通路28およ
び30を有する。これらの通路が、シリンジから開口22に向かって搬送する成
分を、少なくとも可撓性部分18に達するまで分離したままにする、ということ
が観察されよう。これは、本発明の必要条件ではないが、周知の組織シーラント
およびグルーの多くに対してしばしば好ましい。液体を、シリンジのノズルの出
口穴と通路との間でシールするために、通路28および30と連絡する通し穴3
4および36を有するシール要素32が使用される。
【0013】 可撓性部分18は、好都合には、第1および第2剛性部分14および20にそ
れぞれバーブ38および40によって取付けられている。単純なバーブ接続が作
製される場合、ディスペンサの使用者は、第2剛性部分20を第1剛性部分14
の軸を中心に、最も好都合なあらゆる向きに回転させることができる。材料の選
択と抵抗する必要のある力とによっては、接着接合、溶剤溶接、音波溶接または
クリンチリングの使用もまた適当である。当業者には、他の機械的手段が浮かぶ
であろう。
【0014】 シリンジから噴出されている成分に必要である場合は、第2剛性部分20内に
スタティックミキシングエレメント42が好都合に配置される。さらなる混合が
望ましい場合は、部分的に混合された成分が、ブレークアップ部(break−
up piece)44のそばを通路内に亙ってたとえば開口22に隣接する渦
流室46に向かって導かれてよい。
【0015】 シール部材32と可撓性部分18とは、好都合には、メディカルグレードシリ
コンから作製されるが、生物学的に許容可能な任意のゴム状材料から製作するこ
とができる。第1および第2剛性部分14および20は、好都合には、重合体の
射出成形によって製作される。メディカルグレードポリカーボネートが目下好ま
しいと考えられている。第1剛性部分14と第2剛性部分20と可撓性部分18
との細長い部分の外径は、挿入するために可撓性部分が屈曲された後に全体が8
mmカニューレに入ることができるように、約7mm以下のサイズであることが
目下好ましいと考えられる。
【図面の簡単な説明】
【図1】 典型的なデュアルシリンジに取付けられて示されている、本発明の投与先端部
の好ましい実施形態の平面図である。
【図2】 図1の投与先端部の分離した断面図である。
───────────────────────────────────────────────────── フロントページの続き (81)指定国 EP(AT,BE,CH,CY, DE,DK,ES,FI,FR,GB,GR,IE,I T,LU,MC,NL,PT,SE),OA(BF,BJ ,CF,CG,CI,CM,GA,GN,GW,ML, MR,NE,SN,TD,TG),AP(GH,GM,K E,LS,MW,MZ,SD,SL,SZ,TZ,UG ,ZW),EA(AM,AZ,BY,KG,KZ,MD, RU,TJ,TM),AE,AG,AL,AM,AT, AU,AZ,BA,BB,BG,BR,BY,BZ,C A,CH,CN,CR,CU,CZ,DE,DK,DM ,DZ,EE,ES,FI,GB,GD,GE,GH, GM,HR,HU,ID,IL,IN,IS,JP,K E,KG,KP,KR,KZ,LC,LK,LR,LS ,LT,LU,LV,MA,MD,MG,MK,MN, MW,MX,MZ,NO,NZ,PL,PT,RO,R U,SD,SE,SG,SI,SK,SL,TJ,TM ,TR,TT,TZ,UA,UG,UZ,VN,YU, ZA,ZW

Claims (6)

    【特許請求の範囲】
  1. 【請求項1】 (a)少なくとも1つの内腔が貫通している第1剛性部分と
    、 (b)該第1剛性部分に取付けられた可撓性部分と、 (c)該可撓性部分に取付けられ、該内腔を通って導かれる材料を投与するた
    めの開口を有する第2剛性部分と、 を具備する投与先端部。
  2. 【請求項2】 前記可撓性部分が、前記第1および第2剛性部分を互いに事
    前設定された角度に強制的に向けるように、事前設定された屈曲を有する、請求
    項1記載の投与先端部。
  3. 【請求項3】 前記事前設定された角度が、約20度と45度の間である、
    請求項2記載の投与先端部。
  4. 【請求項4】 前記事前設定された角度が約30度である、請求項3記載の
    投与先端部。
  5. 【請求項5】 前記第1剛性部分を少なくとも2つの内腔が貫通しており、
    前記第2剛性要素がさらに、前記開口に達する前に該内腔を通って導かれる材料
    を混合する少なくとも1つのスタティックミキシングエレメントを備える、請求
    項1記載の投与先端部。
  6. 【請求項6】 前記第1剛性部分が、少なくとも2つの出口ポートを有する
    デュアルシリンジに係合するようになっており、それにより該出口ポートから投
    与される液体の各々が、前記内腔のうちの異なる1つに入って該第1剛性部分内
    に別々に維持される、請求項5記載の投与先端部。
JP2001572001A 2000-03-31 2000-10-12 粘着性組織シーラント用ディスペンサの投与先端部 Expired - Lifetime JP4686651B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/540,592 2000-03-31
US09/540,592 US6802822B1 (en) 2000-03-31 2000-03-31 Dispenser for an adhesive tissue sealant having a flexible link
PCT/US2000/028190 WO2001074253A1 (en) 2000-03-31 2000-10-12 Dispenser for an adhesive tissue sealant having a flexible link distal section

Publications (3)

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JP2003534836A true JP2003534836A (ja) 2003-11-25
JP2003534836A5 JP2003534836A5 (ja) 2007-11-29
JP4686651B2 JP4686651B2 (ja) 2011-05-25

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US (1) US6802822B1 (ja)
EP (1) EP1267726B8 (ja)
JP (1) JP4686651B2 (ja)
AT (1) ATE418916T1 (ja)
AU (1) AU2001213319A1 (ja)
DE (1) DE60041279D1 (ja)
DK (1) DK1267726T3 (ja)
ES (1) ES2319855T3 (ja)
WO (1) WO2001074253A1 (ja)

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DK1267726T3 (da) 2009-03-30
EP1267726B1 (en) 2008-12-31
DE60041279D1 (de) 2009-02-12
AU2001213319A1 (en) 2001-10-15
EP1267726A1 (en) 2003-01-02
ES2319855T3 (es) 2009-05-14
WO2001074253A1 (en) 2001-10-11
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