JP2003533468A -
Protein matrix materials, production and their production and use
- Google Patents
Protein matrix materials, production and their production and use
Info
Publication number
JP2003533468A
JP2003533468A
JP2001583736A
JP2001583736A
JP2003533468A
JP 2003533468 A
JP2003533468 A
JP 2003533468A
JP 2001583736 A
JP2001583736 A
JP 2001583736A
JP 2001583736 A
JP2001583736 A
JP 2001583736A
JP 2003533468 A
JP2003533468 A
JP 2003533468A
Authority
JP
Japan
Prior art keywords
protein
biocompatible
protein matrix
drug
matrix material
Prior art date
2000-02-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001583736A
Other languages
Japanese (ja )
Other versions
JP2003533468A5
(en
Inventor
ビー. マスターズ,デイビッド
Original Assignee
ゲル−デル テクノロジーズ,インコーポレイティド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
2000-02-28
Filing date
2001-02-28
Publication date
2003-11-11
2001-02-28
Application filed by ゲル−デル テクノロジーズ,インコーポレイティド
filed
Critical
ゲル−デル テクノロジーズ,インコーポレイティド
2003-11-11
Publication of JP2003533468A
publication
Critical
patent/JP2003533468A/en
2008-04-24
Publication of JP2003533468A5
publication
Critical
patent/JP2003533468A5/ja
Status
Pending
legal-status
Critical
Current
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p-Hydroxyampicillin
Natural products
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papaverine
Chemical compound
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phenothiazine
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phentermine
Chemical compound
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phenylephrine
Chemical compound
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phenylpropanolamine
Chemical compound
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propranolol
Chemical compound
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pseudoephedrine
Chemical compound
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quinidine
Chemical compound
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salsalate
Chemical compound
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scopolamine
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scopolamine hydrobromide trihydrate
Chemical compound
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terbutaline
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tetracycline
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tetracyclines
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triacetin
Chemical compound
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triamcinolone
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triamcinolone
Chemical compound
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tricalcium bis(phosphate)
Chemical compound
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vaccine
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vasopressin
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vitamin E
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wetting
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(+)-Casbol
Chemical compound
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(+)-Fenfluramine
Chemical compound
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(+)-estrone
Natural products
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(+-)-Fenfluramine
Chemical compound
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(-)-(11S,2'R)-erythro-mefloquine
Chemical compound
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(-)-Nicotine
Chemical compound
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(13-methyl-3-oxo-2,6,7,8,14,15,16,17-octahydro-1h-cyclopenta[a]phenanthren-17-yl) acetate
Chemical compound
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(1S,2R)-2-phenylcyclopropan-1-amine (1R,2S)-2-phenylcyclopropan-1-amine
Chemical compound
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(1s)-1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol
Chemical compound
C([C@](O)(C1CCCCC1)C=1C=CC=CC=1)CN1CCCC1
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(2R,4S)-ketoconazole
Chemical compound
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(2R,6S)-2,6-dimethyl-4-[(2S)-2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine
Chemical compound
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(2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
Chemical compound
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CEMAWMOMDPGJMB-CYBMUJFWSA-N
(2r)-1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)propan-2-ol
Chemical compound
CC(C)NC[C@@H](O)COC1=CC=CC=C1OCC=C
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0.000
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RDJGLLICXDHJDY-NSHDSACASA-N
(2s)-2-(3-phenoxyphenyl)propanoic acid
Chemical compound
OC(=O)[C@@H](C)C1=CC=CC(OC=2C=CC=CC=2)=C1
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(2s)-2-[2-[[(2s)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol;dihydrobromide
Chemical compound
Br.Br.CC[C@@H](CO)NCCN[C@@H](CC)CO
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0.000
description
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(2s)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;trihydrate
Chemical compound
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0.000
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(2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(2r,3s,4r,5s)-5-[(1r,2r,3s,5r,6s)-3,5-diamino-2-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric ac
Chemical compound
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DNXIKVLOVZVMQF-UHFFFAOYSA-N
(3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester
Natural products
C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1
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0.000
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FELGMEQIXOGIFQ-CYBMUJFWSA-N
(3r)-9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1h-carbazol-4-one
Chemical compound
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(3r,4s,5s,6r,7r,9r,11r,12r,13s,14r)-6-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione;(2r,3
Chemical compound
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DIWRORZWFLOCLC-HNNXBMFYSA-N
(3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
Chemical compound
N([C@H](C(NC1=CC=C(Cl)C=C11)=O)O)=C1C1=CC=CC=C1Cl
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0.000
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(4-chlorophenyl)-[3-(2h-tetrazol-5-ylmethyl)indol-1-yl]methanone
Chemical compound
C1=CC(Cl)=CC=C1C(=O)N1C2=CC=CC=C2C(CC2=NNN=N2)=C1
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0.000
description
1
LGFMXOTUSSVQJV-NEYUFSEYSA-N
(4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;(4r,4ar,7s,7ar,12bs)-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol;1-[(3,4-dimethoxyphenyl)methyl]-6
Chemical compound
Cl.Cl.Cl.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC.C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12
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0.000
description
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DEQANNDTNATYII-OULOTJBUSA-N
(4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa
Chemical compound
C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1
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0.000
description
1
XIYOPDCBBDCGOE-IWVLMIASSA-N
(4s,4ar,5s,5ar,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methylidene-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide
Chemical compound
C=C1C2=CC=CC(O)=C2C(O)=C2[C@@H]1[C@H](O)[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O
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0.000
description
1
SGKRLCUYIXIAHR-AKNGSSGZSA-N
(4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide
Chemical compound
C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O
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0.000
description
1
FFTVPQUHLQBXQZ-KVUCHLLUSA-N
(4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide
Chemical compound
C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O
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0.000
description
1
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(4s,4as,5as,6s,12ar)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide
Chemical compound
C1([C@H]2O)=C(Cl)C=CC(O)=C1C(O)=C1[C@@H]2C[C@H]2[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]2(O)C1=O
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0.000
description
1
JFTOCKFCHJCDDX-UVTDQMKNSA-N
(4z)-4-benzylidene-5,6,7,8-tetrahydroisoquinoline-1,3-dione
Chemical compound
C1CCCC2=C1C(=O)NC(=O)\C2=C/C1=CC=CC=C1
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0.000
description
1
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(6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide
Chemical compound
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(6r,8s,9r,10s,11s,13s,14s,17r)-2-bromo-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Chemical compound
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description
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(8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid
Natural products
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description
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(E)-dacarbazine
Chemical compound
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description
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(E)-roxithromycin
Chemical compound
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description
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(E,E)-sorbate
Chemical compound
C\C=C\C=C\C([O-])=O
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0.000
description
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(E,Z)-(1R,2R,3R,5S)-7-(3,5-Dihydroxy-2-((3S)-(3-hydroxy-1-octenyl))cyclopentyl)-5-heptenoic acid
Chemical compound
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(R)-atenolol
Chemical compound
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(R)-citalopram
Chemical compound
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(R)-fluoxetine
Chemical compound
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(R)-isoconazole
Chemical compound
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(R,R)-tramadol
Chemical compound
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(S)-atropine
Chemical compound
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(S)-chloroquine
Chemical compound
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(S)-nitrendipine
Chemical compound
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(S)-timolol hemihydrate
Chemical compound
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(S)-timolol maleate
Chemical compound
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1-(4-pentylphenyl)ethanone
Chemical compound
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Chemical compound
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1-[(z)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]imidazolidine-2,4-dione
Chemical compound
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1-[biphenyl-4-yl(phenyl)methyl]imidazole
Chemical compound
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1-benzyl-3-(2-pyridin-4-ylethyl)indole;hydrochloride
Chemical compound
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description
1
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1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
Chemical compound
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0.000
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1
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1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole
Chemical compound
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0.000
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10,10-dioxo-2-[4-(N-phenylanilino)phenyl]thioxanthen-9-one
Chemical compound
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11-dehydrocorticosterone
Natural products
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16beta-hydroxyestradiol
Chemical compound
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17alpha-ethynyl estradiol
Natural products
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17alpha-methyltestosterone
Natural products
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17β-estradiol
Chemical compound
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1h-1,2-benzodiazepine
Chemical compound
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2,3-bis(4-methoxyphenyl)-1h-indole
Chemical compound
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2,6-dimethoxybenzenecarbothioamide
Chemical compound
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2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
Chemical compound
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2-[4-(3-fluorophenyl)phenyl]propanoic acid
Chemical compound
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2-[4-[3-(11-benzo[b][1]benzazepinyl)propyl]-1-piperazinyl]ethanol
Chemical compound
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2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
Chemical compound
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2-acetyloxy-5-(4-fluorophenyl)benzoic acid
Chemical compound
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2-chloro-5-[(1r)-1-hydroxy-3-oxo-2h-isoindol-1-yl]benzenesulfonamide
Chemical compound
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2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide
Chemical compound
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3-(4-methoxyphenyl)-4-methyl-1h-imidazol-2-one
Chemical compound
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3-pyridinemethanol
Chemical compound
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4-(3-methoxyphenyl)aniline
Chemical compound
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4-[1-hydroxy-2-(1-phenoxypropan-2-ylamino)propyl]phenol
Chemical compound
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5'-deoxyadenosine deaminase
Proteins
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5,7-Dihydroxyisoflavone
Chemical compound
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5-HT3 receptors
Human genes
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108091005477
5-HT3 receptors
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239000002677
5-alpha reductase inhibitor
Substances
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5-azaniumylpentan-2-yl-(6-methoxyquinolin-8-yl)azanium;dihydrogen phosphate
Chemical compound
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5-bromo-2-(trifluoromethoxy)pyridine
Chemical compound
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5-methyl-N'-(phenylmethyl)-3-isoxazolecarbohydrazide
Chemical compound
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5-o-ethyl 3-o-methyl (4s)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Chemical compound
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6-(dimethylamino)-4,4-diphenylheptan-3-one
Chemical compound
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6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
Chemical compound
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6alpha-Fluoroprednisolone
Chemical compound
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6alpha-methylprednisolone
Chemical compound
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7-[2-hydroxy-3-[2-hydroxyethyl(methyl)amino]propyl]-1,3-dimethylpurine-2,6-dione
Chemical compound
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7553-56-2
Chemical compound
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8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one
Chemical class
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229930008281
A03AD01 - Papaverine
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Aldoclor
Chemical class
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Allylestrenol
Chemical compound
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Alzheimer's drug
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Natural products
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Amiodarone hydrochloride
Chemical compound
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Natural products
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Amphotericin A
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Antibiotic SQ 26917
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Antisense RNA
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Aromasine
Chemical compound
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Atracurium Dibesylate
Chemical compound
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Chemical compound
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Chemical compound
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Chemical compound
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Chemical compound
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Chemical compound
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Chemical compound
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Chemical compound
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Chemical compound
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Chemical compound
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Natural products
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Chemical compound
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Chemical compound
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Chemical compound
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Chemical compound
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Chemical compound
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Natural products
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Chemical compound
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Chemical compound
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Proteins
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D-alpha-tocopherylacetate
Chemical compound
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Chemical compound
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Dapsone
Chemical compound
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Deamino Arginine Vasopressin
Proteins
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Demethylchlortetracyclin
Natural products
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Desimpramine
Chemical compound
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Didanosine
Chemical compound
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Difluprednate
Chemical compound
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Natural products
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Dihydrogriseofulvin
Natural products
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Chemical compound
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Diseases
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Emetamine
Natural products
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Proteins
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Human genes
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Epitiostanol
Chemical compound
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Estrone
Chemical compound
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Ethinyl estradiol
Chemical compound
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Chemical compound
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Ethylmorphine
Natural products
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Etidocaine
Chemical compound
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Chemical compound
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Chemical compound
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Fluorouracil
Chemical compound
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Fusicsaeure
Natural products
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Halcinonide
Chemical compound
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Human genes
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Chemical compound
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Hyosciamin-hydrochlorid
Natural products
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Chemical compound
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Ibuprofen
Chemical compound
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Diseases
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Iophendylate
Chemical compound
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Islet Cell Adenoma
Diseases
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Isocaffeine
Natural products
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L-DOPA
Chemical compound
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L-Dopa
Natural products
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L-glutamine
Chemical compound
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LSM-2525
Chemical compound
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Laminin
Human genes
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108010085895
Laminin
Proteins
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Lewis A pentasaccharide
Natural products
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Lincomycin
Natural products
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Lithium
Chemical compound
[Li]
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Meclizine
Chemical compound
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Meclofenamic Acid
Chemical compound
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Meperidine
Chemical compound
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Meprobamate
Chemical compound
NC(=O)OCC(C)(CCC)COC(N)=O
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Methicillin
Chemical compound
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Methyltestosterone
Chemical compound
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Mianserin
Chemical compound
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Miconazole
Chemical compound
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Minoxidil
Chemical compound
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Molybdenum
Chemical compound
[Mo]
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229940123685
Monoamine oxidase inhibitor
Drugs
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208000000112
Myalgia
Diseases
0.000
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1
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N,N-dimethyl-3-phenyl-3-(2-pyridinyl)-1-propanamine
Chemical compound
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IDBPHNDTYPBSNI-UHFFFAOYSA-N
N-(1-(2-(4-Ethyl-5-oxo-2-tetrazolin-1-yl)ethyl)-4-(methoxymethyl)-4-piperidyl)propionanilide
Chemical compound
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Chemical compound
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Chemical compound
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Chemical compound
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Chemical compound
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clavulanic acid
Chemical compound
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clemastine
Chemical compound
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clindamycin
Chemical compound
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clobazam
Chemical compound
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clofazimine
Chemical compound
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clomifene
Chemical compound
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clonazepam
Chemical compound
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clonixin
Chemical compound
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clorazepic acid
Chemical compound
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clotrimazole
Chemical compound
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cloxacillin
Chemical compound
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Chemical compound
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colistin A
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Chemical compound
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Chemical compound
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Chemical compound
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Chemical compound
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Chemical compound
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danazol
Chemical compound
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Chemical compound
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Chemical compound
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Chemical compound
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Chemical compound
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Chemical compound
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dicoumarol
Chemical compound
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didanosine
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dienestrol
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dienestrol
Chemical compound
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diethylcarbamazine
Chemical compound
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diethylpropion
Chemical compound
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diethylstilbestrol
Chemical compound
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diflunisal
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Chemical compound
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difluprednate
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digoxin
Chemical compound
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Chemical compound
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dihydrocodeine
Natural products
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dihydroergotamine
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Chemical compound
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Chemical compound
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Chemical compound
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Chemical compound
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Chemical compound
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