JP2003171305A - Ameliorating therapeutic agent for diabetes - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a simply ingestible ameliorating therapeutic agent derived from a natural product without adverse effects. <P>SOLUTION: This ameliorating therapeutic agent is obtained by cutting a mixture of a leaf and a stem of Aspalathus linearis (a plant of the family Leguminosae) with a leaf of Echevaria glauca (a plant of the family Crassulaceae) in 2:1 (weight) to 5 mm length, then passing the resultant cut mixture through steps of rolling, enzyme fermentation and solar drying, affording dried leaves, subsequently heating 4 g of the dried leaves in 1.5 L of water from normal temperature and boiling the leaves for 15 min. The obtained extract solution is drunk. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a therapeutic agent for diabetes mellitus containing tea leaves of Aspalathus linearis belonging to the family Leguminaceae and stone of Lotus lotus belonging to the scenic family.

[0002]

2. Description of the Related Art In recent years, diabetes, which is an autoimmune disease, has been increasing in young people as well as middle-aged and elderly people. Also, diabetes is said to be one of the three major adult diseases, and it is difficult to cure it and it is difficult to completely cure it. Therefore, there is a demand for the development of an effective drug. Since a drug must be taken for a long period of time to treat diabetes, it is desirable to use a natural product with few side effects as a raw material, and it must be one that can be ingested easily on a daily basis.

[0003] Furthermore, diabetes includes insulin-dependent diabetes mellitus whose therapeutic effect is improved by insulin administration, and non-insulin-dependent diabetes mellitus which does not show a therapeutic effect by insulin administration. For non-insulin dependent diabetes mellitus, development of an improved therapeutic agent for stabilizing diabetes by oral ingestion without injection or the like has been demanded. It has been found that an Asparagus linealis extract of legumes has an improving effect on non-insulin dependent diabetes mellitus. (See Japanese Patent Laid-Open No. 5-246875)

In addition, new drugs for treating non-insulin-dependent diabetes mellitus and Chinese herbs have been developed. However, they have a large dose or have an anti-drug or side effect seen in long-term use. There are drawbacks such as easy blood sugar.

[0005]

[Problems to be Solved by the Invention] Asparasus linearias extract is a natural ingredient and has the advantage that it has no side effects and can be easily taken. It is an object of the present invention.

[0006]

The present invention has solved this problem by mixing the tea leaves of Aspalathus linealis with the tea leaves of the stone lotus belonging to the Jingten family. That is, rather than using Aspalathus linealis alone,
An excellent therapeutic effect on diabetes was found. Further, the mixed tea leaves can be extracted as they are from hot water and used, so that they can be easily ingested in daily life.

[0007] A mixture of Aspalathus linealis and Shirenbana tea leaves, or a mixture of these pulverized products is extracted with hot water or water in the same manner as ordinary Japanese tea, Chinese tea, black tea, etc. and is then drunk. .

In the case of extraction with water, it is preferable to add 50 to 1000 times as much water as the mixed tea leaves of Aspalathus linealis and Sekirenhana tea leaves, and carry out boiling extraction for about 5 to 30 minutes. Also, when extracting by the same method as green tea,
Using 100 degree hot water, the extract is obtained by immersing in 50 to 500 times hot water of mixed tea leaves of Aspalathus linealis and stone lotus for 1 to 30 minutes.

[0009] Also, Aspalathus linealis tea leaves and stone lotus tea leaves themselves are freeze-dried and crushed, powdered and dissolved in water or hot water, or in any form such as powder granules, tablets and jelly. Is.

The amount of intake varies depending on the degree of diabetes,
In the case of regular use, it is 1 for dried leaves obtained by mixing 2g of Aspalathus linealis tea leaves and 1g of stone lotus tea leaves per day.
It is preferable to drink a liquid extracted with 00 ml to 1500 ml of hot water or water.

The mixture of Aspalathus linealis and stone lotus showed no death in an acute toxicity test in rats, and no abnormality was observed in biochemical blood tests and histopathological tests.

[0012]

[Examples] Production example Aspalathus linealis leaves / stems and stone lotus leaves 2:
The 1 (weight) mixture is cut into a length of 5 mm, and then rolled, subjected to enzyme fermentation, and dried in the sun to be dried leaves. 4 g of dried leaves were heated from room temperature with 1.5 liters of water and boiled for 15 minutes to obtain an extract.

The extract obtained in the production example was administered to diabetic patients shown in Table 1 in an amount of 600 ml to 1200 ml per day to examine improvement of symptoms. Table 1 shows the results after drinking for 6 months. Male patients are 45-70 years old and female patients are 55-75 years old. A decrease in urinary glucose was confirmed regardless of sex or age.

[0014]

[Table 1]

[0015]

[Effects of the Invention] By ingesting Aspalathus linealis mixed with the tea leaves of stone lotus, it has a higher effect of improving diabetes compared with ingesting Aspalathus linealis alone. Further, since it can be used in the same manner as tea leaves such as green tea, it is convenient and easy to take daily. This makes it possible to surely improve and treat diabetic diseases, which have been difficult to treat until now, without causing side effects.

Claims (3)

[Claims] 1. A therapeutic agent for diabetes mellitus, which comprises a mixture of tea leaves of Aspalathus linealis and tea leaves of Lotus Lotus flower. 2. The therapeutic agent for diabetes mellitus according to claim 1, wherein the mixing ratio of the tea leaves of Aspalathus linealis and the tea leaves of stone lotus flower is 2 to 1 by weight. 3. The therapeutic agent for diabetes mellitus according to claim 1 or 2, wherein the tea leaves are ground.