JP2003034629A - Breaching agent for discolored tooth and breaching system - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a breaching agent for a discolored tooth and its manufacturing method and breaching system. SOLUTION: The breaching agent for a discolored tooth is characterized by that by sticking the surface of discolored tooth, based on a photo activation effect produced by emitted the light to the area to breach the discolored tooth and compound of phosphate and calcium that produces the photo activation effect by emitting the light is mixed as an active ingredient.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to bleaching and removing pigments (coloring, discoloration) and bacteria deposited on teeth by the action of phosphorus and calcium compounds. More specifically, the present invention is characterized in that a bleaching material having a specific composition having photoactivity is adhered to the surface of a discolored tooth and the tooth is bleached based on the photoactive action generated by irradiating the portion with light. Bleaching method for discolored teeth, containing phosphorus and calcium compounds that produce photoactive action by light irradiation, useful in the bleaching method, and 4% or less hydrogen peroxide solution and / or acids such as phosphoric acid or pyrophosphoric acid The present invention relates to a novel bleaching material, a method for producing the same, and a bleaching system formed by combining the above bleaching materials.

[0002]

2. Description of the Related Art In recent years, there has been a strong demand in dentistry for improving the aesthetics, such as improving the morphology, arrangement and harmony of teeth. Among these, recently, young women are increasingly demanding dental treatment because of the desire to whiten their teeth as an important factor for beauty. Tooth discoloration or coloring (p
cause, for example, deposition of colored substances (tobacco, tea astringency, etc.), pigment-producing bacteria, discoloration of restorations (mainly composite resin), metal salts (mainly amalgam, silver nitrate, silver ammonia) So-called extrinsic ones and, for example, so-called endogenous ones due to ageing, chemical substances and drugs (fluorine, tetracycline, etc.), metabolic disorders, genetic diseases, tooth damage, etc. Separately, in the dental health care, the latter intrinsically discolored tooth is mainly an indication of the bleaching method.

As a method of improving the aesthetics of discolored teeth,
Although several methods have been proposed in the past, among them, the bleaching method (bleaching) may show some relapse if a method suitable for each case is selected and appropriately performed. Even if there is a problem of, it can be said that it is an excellent treatment method with high preservation of tooth structure. This bleaching method is basically a method of making a colored substance colorless by a chemical reaction, and is conventionally a bleaching method for vital teeth (vitalbl).
and bleaching of dead teeth (non-vital bl)
Various bleaching materials composed of various chemical agents and bleaching methods using the same have been reported.

Examples of these methods include the following. Using 30% H ₂ O ₂ as a drug,
A bleaching method that uses light and heat together with hydrogen peroxide. This is 30
Put a small piece of gauze soaked with% H ₂ O ₂ on the labyrinth, 500W
It is a method of irradiating from the left and right for 30 minutes with the two photography lamps. This method requires the lamps to be as close together as possible and refilled with H ₂ O ₂ about every 5 minutes to prevent the gauze from drying out.

In addition, a tooth bleaching material prepared by mixing hydrogen peroxide solution and orthophosphoric acid, and a bleaching method (Japanese Patent Laid-Open No. 8-1
43436/1996), a bleaching material obtained by mixing silicic acid anhydride with a hydrogen peroxide solution, and a method for bleaching vital teeth, which comprises applying the bleaching material (Japanese Patent Laid-Open No. 5-320033).
/ 1993), a dental bleaching composition comprising a dental bleaching material (urea hydrogen peroxide, carbamide hydrogen peroxide, carbamide peroxide, etc.) and a matrix material (carboxymethylene, etc.), and a method for bleaching teeth using them (special Many have been reported, such as Kaihei 8-113520 / 1996).

By the way, upon bleaching teeth, the bleaching method and the bleaching material have the following conditions: (a) the bleaching effect is remarkable, (b) the chemicals used are not toxic, and (c) the work is easy. That (d) does not cause deterioration of the physical properties of the tooth substance after the operation, (e) is effective for both vital teeth and inactive teeth, and (f) shows a bleaching effect in a short period of time. Required. With the bleaching method having the above conditions, it is possible to improve the aesthetics while maintaining the shape of the teeth, and it can be said that the improving effect is remarkable. However, the conventional bleaching method is based on 30-35% hydrogen peroxide water, which has a strong tissue corrosive property, as a main chemical, and performs bleaching by its oxidizing action. It can be said that various bleaching methods currently practiced in Japan are combinations of 30 to 35% hydrogen peroxide solution, various instruments and other chemicals, as described above. As one of the bleaching methods used in the United States, there is an example in which 30% to 35% hydrogen peroxide solution is not used and 10% peracid urea is used. There is currently a problem with
It is in dispute and has not been approved in Japan. In addition, there is also a method of applying fluorapatite to teeth after bleaching with hydrogen peroxide as described above to remineralize the rough enamel and restore it. However, even with this method, it is impossible to completely repair the once modified enamel.

Further, in Japanese Patent No. 3030380, a tooth dioxide powder and a solution / paste of hydrogen peroxide solution are adhered to the surface of a discolored tooth, and the tooth is irradiated with light to cause this photoactive action to cause the tooth to be removed. A bleaching method for discolored teeth characterized by bleaching has been reported. This method does not use dangerous high-concentration hydrogen peroxide as in the conventional method, but it uses a bleaching material that combines low-concentration hydrogen peroxide of 3% or less and titanium dioxide that is harmless to the body, and exposes it to light. It is bleaching. It is safe, easy and has remarkable effects. But,
There is a need for a bleaching material that has a good affinity with enamel and that allows more efficient bleaching. The present inventors have proposed a method of bleaching teeth with titanium dioxide coated with apatite on the surface and hydrogen peroxide (Japanese Patent Application No. 2000-34464).
0). The biocompatibility of apatite improves the compatibility with enamel and allows good bleaching. However, even with this, the proportion of apatite is extremely small, so that it is not sufficiently compatible with enamel, and therefore a more effective bleaching method is required.

The bleaching effect is weak with commercially available apatite produced by a conventional wet method or the like. Currently, the bleaching method accepted in insurance medical treatment is limited to unmyelinated teeth, and in some cases, non-carious teeth are extracted for bleaching. In addition, in various bleaching methods, the use of highly toxic 30-35% hydrogen peroxide solution or titanium dioxide causes various restrictions on work, and in particular, the limit of the bleaching effect on myelinated teeth has been pointed out. There is. Therefore, as a tooth bleaching method, it is currently possible to develop a new bleaching material that is excellent in safety, simplicity, and biocompatibility and is effective for both myelinated and unmyelinated teeth in a short period of time and does not damage enamel. There is a strong demand.

[0009]

Under such circumstances, the present inventors have found that the compound of phosphorus and calcium deposited in the simulated body fluid is excellent in photoactivity and biocompatibility, and has a remarkable bleaching effect and sterilization effect. It was discovered that it showed an effect, and this invention was reached. That is, the present inventor, as a result of extensive research with the goal of establishing a new bleaching method which is excellent in safety and convenience and has a remarkable bleaching effect, has photoactivity, and has in vivo The inventors have found that the intended purpose can be achieved by using a compound of phosphorus and calcium such as apatite, which is an existing component and is excellent in biocompatibility, as an active ingredient, and completed the present invention. That is, an object of the present invention is to provide a new bleaching material which is excellent in safety and convenience and is effective for both myelinated teeth and unmyelinated teeth in a short period of time. Another object of the present invention is to provide a method for producing the bleaching material, and a tooth bleaching system using the bleaching material.

[0010]

The present invention for solving the above-mentioned problems comprises the following technical means. (1) A bleaching material for discolored teeth, which is used by being applied to the surface of a tooth and which contains a compound of phosphorus and calcium. (2) A bleaching material for discolored teeth, which is used by being applied to the surface of teeth, and which contains a compound of phosphorus and calcium, hydrogen peroxide solution and / or acid. (3) The bleaching material for discolored teeth according to (1) or (3) above, which contains a photoactive phosphorus and calcium compound. (4) A bleaching material that is attached to the surface of a discolored tooth and bleaches the discolored tooth on the basis of the photoactive action produced by irradiating the portion with light, and phosphorus and calcium that produce the photoactive action by light irradiation. A bleaching material for discolored teeth, which comprises a combination of the compounds of 1. (5) A bleaching material for bleaching a discolored tooth on the basis of a photoactive action caused by irradiating light to the surface of the discolored tooth and irradiating the portion with phosphor and calcium which produce a photoactive action by light irradiation. A bleaching material for discolored teeth, characterized in that it comprises a combination of the above compound and hydrogen peroxide and / or acid as an active ingredient. (6) The above (5), which contains phosphorus and calcium compounds having a particle size of about 1 nm to 10 μm and 4% or less of hydrogen peroxide solution.
Bleaching material for discolored teeth described in. (7) In any one of (1) to (6), the compound of phosphorus and calcium is one or more of calcium phosphate represented by hydroxyapatite, fluorapatite, octacalcium phosphate, and tricalcium phosphate. Bleaching material for the discolored tooth described. (8) The compound of phosphorus and calcium is A ₉ (BO ₄ ) ₆
X, where A is Ca, Co, Ni, Cu, Al, La,
A metal atom typified by Cr, Fe, Mg, B is a P or S atom, and X is a hydroxyl group or one or more of a halogen atom. ) To bleaching material for discolored teeth according to any one of (7). (9) A method for producing a bleaching material for bleaching a discolored tooth on the basis of a photoactive action which is caused by irradiating light to the surface of the discolored tooth and irradiating the portion with light, wherein
A method for producing a bleaching material for discolored teeth, which comprises blending a compound of phosphorus and calcium which produces a photoactive effect by light irradiation. (10) The method for producing a bleaching material for discolored teeth according to (9) above, wherein 4% or less of hydrogen peroxide water is mixed with a compound of phosphorus and calcium that produces a photoactive effect by light irradiation. (11) The bleaching material according to any one of (1) to (7), a means for attaching the bleaching material, an irradiation device, and / or
Or a discolored tooth bleaching system in combination with a tooth preparation material. (12) The bleaching system for discolored teeth according to (11) above, which comprises a combination of irradiation devices that emit visible-light purple light and / or ultraviolet light.

[0011]

BEST MODE FOR CARRYING OUT THE INVENTION Next, the present invention will be described in more detail. The present invention is mainly characterized by utilizing oxidation and reduction effects due to photoactivity and achieving a high bleaching effect on discolored teeth. In the present invention,
Discoloration is defined as having a broad meaning including coloring. Basically, the drug materials and devices used in the present invention are one or more of phosphorus and calcium compounds such as apatite, hydrogen peroxide solution (preferably 4% or less) phosphoric acid, and pyrophosphoric acid. , Light (irradiation equipment) is sufficient, and its safety, workability, and bleaching effect are remarkable.

The bleaching material of the present invention comprises, in one preferred embodiment, a compound of phosphorus and calcium. Here, as the compound of phosphorus and calcium, for example, amorphous apatite or calcium phosphate having a particle diameter of about 1 nm to 10 μm or a compound mainly containing it is used, but not limited thereto. As long as it is an effective compound, that is, a compound of phosphorus and calcium that produces a photoactive effect, it can be similarly used regardless of its form and properties. In this case, the one having a small particle size can be expected to have high activity, the amount to be attached can be small, and the use amount can be reduced, for example, a high bleaching effect can be obtained in a short time because the coating film can be thin, There are advantages such as
Especially desirable.

The compound consisting of phosphorus and calcium according to the present invention will be described with reference to its preferred embodiments.
However, the present invention is not limited to the following embodiments. In the present invention, the photoactivity is measured and the level of bleaching can be quantified using the measured value as an index, as will be specifically shown in Examples described later. When the photoactivity is 0.1 or more, the stains on the teeth of F1 to F2 can be decomposed, and it can be used as a bleaching material. If it is more preferably 0.2 or more, teeth of F3 or less can be bleached, and if it is more preferably 0.3 or more, most organic chemical substances can be adsorbed and decomposed.

The amount ratio of the above-mentioned components is, for example, one with a slight degree of discoloration and a degree with a high degree of discoloration, which can be appropriately changed and adjusted, whereby products suitable for each case can be prepared. The bleaching material of the present invention is usually used by blending a compound of phosphorus and calcium in water, kneading and dispersing the solution to obtain a uniform transparent solution or in the form of a paste, but not limited thereto. Those prepared in the same manner are included in the scope of the present invention. In this case, blending of the above components, kneading, means for preparing a bleaching material such as dispersion, device,
The means for attaching the bleaching material is not particularly limited, and any appropriate means can be used. As a method for attaching the bleaching material to the tooth surface, for example, a method in which the bleaching material is directly applied to the tooth surface is exemplified as a preferable method, but the method is not limited to this and an appropriate method can be used. At this time, the bleaching material of the present invention, that is, the content of the compound of phosphorus and calcium having a photoactive action, cloth, paper,
It may be impregnated with glass cloth, ceramics paper, organic gel, inorganic gel, or the like, adhered to the tooth surface, and irradiated with light. In addition, an appropriate method or means, such as a method of holding the bleaching material in a suitable carrier and mounting the bleaching material on a tooth or a dentition and adhering it, can be used.

The bleaching material of the present invention is characterized in that the above-mentioned two components are used in combination as an active ingredient. For example, it can be used in the form of a solution or paste containing these components. In addition, it is also possible to use these components in a form in which these components are separately combined as appropriate, and the form is not particularly limited. The bleaching of discolored teeth with the above bleaching agent is carried out by applying a solution or paste of a compound of phosphorus and calcium having a photoactive effect to, for example, the tooth surface, and repeating the treatment of irradiating with light several times. The number of times of coating and light irradiation may be appropriately adjusted depending on the degree of color change and the degree of color change, and is not particularly limited. In the attachment operation such as application of the solution or paste, a new solution or paste is usually attached every about 1 to 20 minutes, and the interval and frequency thereof may be appropriately set according to the tooth condition. The bleaching material of the present invention is effective for bleaching both unmyelinated teeth and myelinated teeth, and exerts a remarkable effect in bleaching those teeth safely and simply. The above bleaching agent can be used not only as a compound of phosphorus and calcium, but also as a complex with a low concentration, that is, 4% or less of hydrogen peroxide solution and / or one or more acids such as phosphoric acid and pyrophosphoric acid. .

The compound of phosphorus and calcium is Ca ₉ (P
It is preferable to use one or more kinds of apatite having O ₄ ) ₆ in its structure, octacalcium phosphate, tricalcium phosphate and the like. Among the apatites, hydroxyapatite and fluorapatite are excellent in biocompatibility. Moreover, it is preferable because it has a high photoactive function. Further, although these apatites usually contain calcium as a metal element,
e, Cr, Mg, Zr, Al or the like may be partially substituted. Phosphorus and calcium compounds are more compatible with tooth enamel and bleach more effectively than other materials. That is, since the powder is easily adsorbed on the enamel when applied to the tooth surface, it can be sufficiently bleached even if the photoactivity is not so large. Also, for that reason, it promotes remineralization of enamel, and when high-concentration hydrogen peroxide is used, the enamel may be decalcified and damaged, resulting in loss of surface gloss and reversion. It will be easier. The finer particle size of the compound of phosphorus and calcium is preferable because the activity is higher and the biocompatibility is also excellent. Therefore, it is preferable that the particle size of the compound of phosphorus and calcium is produced by a production method capable of obtaining a compound of phosphorus and calcium. Particularly, a compound of phosphorus and calcium produced in the simulated body fluid is preferable. The phosphorus-calcium compound produced by this method has a small particle size and a large surface area, and therefore has very good photoactivity and biocompatibility. For the production of such apatite, the one precipitated in the simulated body fluid is most preferable. Of course, other general manufacturing methods are also possible, for example, wet method, hydrothermal method, mechanochemical method, and may be collected from bones of natural coral or animals.

Simulated body fluids are NaCl, NaHCO ₃ , K
Cl, K ₂ HPO ₄ , 3H ₂ O, MgCl ₂ , 6H ₂
O, CaCl ₂ and Na ₂ SO ₄ or NaF, FeS
It is prepared by dissolving O ₄ , FeCl _{3 and the} like in water. Further, it is preferable to adjust the pH to 7 to 8, particularly 7.4 with HCl, (CH ₂ OH) 3 CNH _2, or the like.
The composition of the simulated body fluid used in the present invention is Na ⁺ 120-
1000 mM, K ⁺ 1 to 200 mM, Ca ²⁺ 0.5 to 1
00 mM, Mg ²⁺ 0.5 to 50 mM, Cl ^- 80 to 20
_{^{00mM, HCO 3- 0.5~300mM, HPO 4}} 2- 1
˜200 mM, SO ₄ ²⁻ 0.1 to 200 mM, F ^- 0.
5 mM, one or more kinds of metal ions such as Fe, Cr, Zr and Al are preferably 0.1 to 20 mM. If the concentration is lower than this, it takes time to precipitate the compound composed of phosphorus and calcium, and if the concentration is higher than this, precipitation of the compound composed of phosphorus and calcium occurs rapidly, making it difficult to control the shape and particle size. . The temperature of the simulated body fluid is preferably 30 to 100 ° C. If the temperature is lower than this, it takes time for the compound of phosphorus and calcium to precipitate, and if the temperature is higher than this, the particle size and porosity cannot be controlled due to the evaporation of the simulated body fluid. Most preferably, the temperature is 30 to 60 ° C.
The time is preferably 10 seconds to 18 days. When the time is shorter than this, precipitation of the compound composed of phosphorus and calcium is insufficient, and when the time is longer than this, it becomes too large.

The photoactivity, shape, composition and temperature of the simulated body fluid,
It can be controlled by changing the time. When the content of phosphorus or calcium is reduced, the temperature is lowered, or the time is shortened, a compound composed of phosphorus and calcium having a small particle size is produced. When the content of phosphorus or calcium is increased or the temperature is raised, the particle size of the compound composed of phosphorus and calcium increases. The compound consisting of phosphorus and calcium thus deposited is
It may be amorphous or crystalline, and may be calcium phosphate such as tricalcium phosphate, octacalcium phosphate, apatite such as hydroxyapatite, fluoroapatite, chloroapatite, and the like. It will be. Also, when actually used, it may be washed after being filtered or centrifuged,
Depending on the application, it may be used as it is or after being concentrated.

One preferable form of the calcium phosphate according to the present invention can be represented by the following general formula. A ₉ (BO ₄ ) ₆ is included in the structure, preferably A _x (BO _y ) _z X, wherein A is C
a, Co, Ni, Cu, Al, La, Cr, Fe, Mg
Represents various kinds of metal atoms, B represents atoms such as P and S, and X represents a hydroxyl group (—OH), a halogen atom (eg, F, Cl), and the like. Examples of such calcium phosphate include, but are not limited to, apatite, hydroxyapatite, fluoroapatite, chloroapatite, tricalcium phosphate, calcium hydrogen phosphate and the like. In the present invention, apatite that can be preferably used is hydroxyapatite or fluorapatite in which X in the above formula is a hydroxyl group or fluorine, and more preferably X in the above formula is a hydroxyl group, and A is Calcium (Ca)
Is apatite. Furthermore, Co, Ni, Cu, A
It may be partially substituted with 1, La, Cr, Fe, Mg or the like.

Further, the shape thereof is preferably a plate shape or a ribbon shape because it is excellent in photoactivity and adsorption function. Usually, for example, apatite has a shape like a hexagonal prism, but a plate is particularly preferable. However, since the shape is originally a hexagonal column, even if the shape is initially plate-like at the time of manufacturing, the particles grow to be hexagonal when they grow. Therefore, if the originally formed particles have a plate-like shape, the function of the compound of phosphorus and calcium having a half-finished shape or half-finished shape can be sufficiently exhibited. For example, the ratio of the thinnest portion to the longest portion may be 1.2 or more. When it is smaller than this, the photoactivity becomes small, and more preferably at least 1.5.

As described above, the finer particle size of the phosphorus and calcium compound is preferable because the activity is higher and the biocompatibility is also excellent. Therefore, the finer particle size of the compound of phosphorus and calcium is produced in the simulated body fluid. Preferably. The compound of phosphorus and calcium produced by this method has a small particle size and a large surface area, and therefore has excellent adsorbability, photoactivity and biocompatibility. The thus obtained apatite according to the present invention adsorbs proteins, amino acids, bacteria, viruses and the like and has good biocompatibility. The particle size is preferably 1 nm to 10 microns. If it is smaller than this, it is difficult to handle, and if it is larger than this, photoactivity and adsorptivity are deteriorated. The specific surface area is preferably 5 m ² / g or more, and if it is smaller than this, photoactivity and adsorptivity deteriorate. It is preferably 1 nm to 2 μm. If it is 2 μm or more, it becomes difficult to apply it to the tooth surface.

[0022]

The main action of the bleaching material of the present invention is the bleaching action by the compound of phosphorus and calcium. When a compound of phosphorus and calcium is irradiated with light, electrons and holes are generated, which react with hydrogen peroxide to generate active oxygen. This active oxygen has a much stronger oxidizing power than ozone, and can oxidatively decompose almost all organic substances to carbon dioxide gas. Furthermore, for example, when used as a solution with 4% hydrogen peroxide solution, active oxygen is easily generated by irradiation of light, and active oxygen having a strong oxidizing power is easily generated. Values such as reactivity with hydroxyl groups and hydroxyl groups surely increase, and a synergistic effect occurs by overlapping with the oxidizing action of 4% hydrogen peroxide solution itself.

By the way, the tooth coloring factors are as follows:
It is roughly divided into extrinsic and intrinsic. Exogenous coloring factor I. Food ingredients (pigments) Hard water (iron-containing, etc.) Favorite beverages (tea, coffee, cocoa, coca cola, red wine, etc.) II. Oral bacteria-produced pigment III. Tobacco IV. Metal vapor V. Drug (disinfectant)

Endogenous coloring factor I. Pulp necrosis II. Intradental hemorrhage (after trauma, demyelination, arsenous acid) III. Root canal filler components (amalgam, silver powder, iodine, etc.) IV. Tooth corrosion, rheumatic fever V. Metabolic disease (congenital) Tissue browning Alkaptonuria, congenital erythropoietic Gilfin disease, fetal erythroblastosis neonatal severe jaundice VI. Drugs (antibiotics, root canal remedies) VII. Hard water (fluorine-containing)

The above coloring factors are caused by various pigments, iron salts, tannic acid, chlorhexidine, benzalkonium chlorhexidine chloride, cyclones and the like, and these colored substances are deposited on the enamel and dentin of teeth. Since the solution of phosphorus and calcium and 4% or less hydrogen peroxide solution has excellent biocompatibility, it infiltrates between the enamel trabecula of teeth and between dentin, and the colored substance is oxidized and reduced by photoactivity. Decompose and bleach. The bleaching method of the present invention can exert a high bleaching effect on the above-mentioned intrinsic and extrinsic and discolored teeth. Examples of the light source (irradiation device) used in the present invention include incandescent lamps, fluorescent lamps, halogen lamps, xenon lamps, mercury lamps, UV lamps, etc., but in terms of safety, convenience, and bleaching effect. Therefore, particularly preferable are LEDs (light emitting diodes), semiconductor lasers, lamps (penlights), and the like.
The light to be irradiated is preferably light containing a large amount of short-wavelength light having a large energy such as ultraviolet light from the viewpoint of generation of active oxygen due to photoactivation and its oxidation, but ultraviolet light is harmful because it causes inflammation and cancer in the human body. Therefore, visible light is preferable from the viewpoint of safety, and of these, violet light having large energy is most preferable. In the present invention, the bleaching material,
A tooth bleaching system (kit) can be obtained by appropriately combining the means for applying the bleaching material (applying device or the like), irradiation device, other drug, other material for treating teeth, device and the like.

[0026]

EXAMPLES Next, the present invention will be specifically described based on examples, but the present invention is not limited to the examples. Example (1) Measurement of photoactivity Photoactivity was measured as follows. In the dye decolorization experiment, glossy paper dyed with hematoporferin was coated with apatite and irradiated with light to measure the change in color. For dyeing paper, EP for inkjet printer
Back side of SON Super Fine gloss film, using SIGMA H-5518 for hematoporferin, special grade reagent for ethanol, dipping the film in 0.1% hematoporferin ethanol solution (0.1 g / 100 ml), then 9 x It cut into 50 mm and obtained the sample. A halogen lamp light source device (manufactured by USHIO INC.) Was used for light irradiation (light source device: model JCR12V-100WC,
The wavelength is 380 to 460 nm, the power is 100 W, and the irradiation energy is 204 mW / cm ² at the above wavelength). The color difference meter used OFC-300A (made by Nippon Denshoku Industries Co., Ltd.). After applying 40 mg of apatite 0.06% aqueous solution onto paper, irradiating the tip of the optical cable of the irradiation device with light at 3 mm for 1 minute, washing the sample piece with distilled water, and then wiping off the water well It was measured with a meter. This 5
Repeated times. The L * value was 61 before the experiment. Photoactivity was defined as L * value after experiment-L * value before experiment / L * value before experiment.

(2) Preparation of bleaching material As shown in Table 1, synthesized phosphorus and calcium compounds were used.
Water and hydrogen peroxide solution were mixed, kneaded and dispersed to prepare a solution. The compounds 1 to 4 of phosphorus and calcium show 1 to 4 shown in Table 2. As a simulated body fluid, NaCl, NaH
_{CO 3, KCl, K 2 HPO} 4 · 3H 2 O, MgCl 2
・ 6H ₂ O, CaCl ₂ and Na ₂ SO ₄ or Na
Using F, FeSO ₄ , FeCl _3, etc., and distilled water, an aqueous solution having a composition shown in Table 2 and having a pH of 7.4 was prepared and allowed to stand.

(3) Preparation of tooth bleaching system The above bleaching material, an application instrument, an irradiation instrument (using a purple light of a metal halide lamp) and a pretreatment instrument are combined and housed in a container, and a tooth bleaching system (kit ) Was produced.

(4) Bleaching of discolored teeth Bleaching of discolored teeth Using the above bleaching material, the discolored teeth were bleached in the following procedure. 1) As a preliminary preparation, plaque, tartar, tar, etc. were removed with an ultrasonic scaler. 2) After cleaning the tooth surface with a rubber cup etc. by the usual method,
Dried. 3) Simple moisture protection was performed. 4) Each solution was applied to the tooth surface and irradiated with visible light. 5) One time was defined as 1 minute, and the application of the above solution and light irradiation were repeated 5 times every 1 minute.

(5) Results Table 1 shows the effect of the bleaching agent. As is clear from Table 1, those having a slight degree of color change (F1) were subjected to the above procedure about once, and those having a medium degree of color change (F2 to 3) were about 2 times.
A remarkable bleaching effect and bactericidal effect were obtained after ~ 3 times. Furthermore,
The bleaching effect was obtained after about 4 to 5 times in the case of high discoloration (F4). The bleaching effect was highly durable with no turning back. Further, since the bleaching material of the present invention can obtain a remarkable bleaching effect and a disinfecting effect due to a synergistic effect with the bleaching effect of calcium phosphate, the work as in the case of the conventional highly toxic 30-35% hydrogen peroxide solution. Without the various restrictions above,
Moreover, since it is excellent in safety, it was found that it can be used for both myelinated and unmyelinated teeth. Further, the bleaching effect of the bleaching material of the present invention is about 4 times or more shorter than that of the conventional bleaching material containing titanium dioxide or hydrogen peroxide as a main chemical material, in view of its oxidation energy. Turns out you can get it in time. Furthermore,
As can be seen from Table 1, the lower the concentration of hydrogen peroxide solution, the longer the time required.

[0031]

[Table 1]

[0032]

[Table 2]

The classification of the degree of color change was as follows. F1: Light yellow, brown, and gray with the entire crown uniformly colored, with no visible stripe pattern. F2: Darker than F1, the whole crown was uniformly colored, and no stripe pattern was seen. F3: Dark gray, bluish gray with a stripe pattern. F4: Remarkably dark purple, grayish purple and discolored throughout the crown. Moreover, the display of the effect was as follows. ++: The bleaching effect was remarkably improved to white. ++: A bleaching effect is recognized, but some coloring (discoloration) remains.

[0034]

As described in detail above, the present invention is a bleaching material for adhering to the surface of a discolored tooth and bleaching the discolored tooth on the basis of the photoactive action generated by irradiating the part with light. The present invention also relates to a bleaching material, etc., characterized in that a compound consisting of phosphorus and calcium that produces photoactivity upon irradiation with light is combined as an active ingredient. According to the present invention, (1) new bleaching for discolored teeth It is possible to provide a material, (2) it is possible to bleach both myelinated teeth and unmyelinated teeth, and (3) it is effective in removing bacteria in the oral cavity,
(4) High safety, simple workability and bleaching effect in a short period of time can be obtained, (5) Psychological burden on the examinee can be reduced, (6) Color tone level can be controlled, ( 7) Since it is possible to obtain a particular effect such that it is possible to select the improvement of the color tone desired by the examinee, the contribution of the present invention to the improvement of the aesthetics of teeth is great.

Claims (12)

[Claims] 1. A bleaching material for a discolored tooth, which is used by being applied to the surface of a tooth, which contains a compound of phosphorus and calcium. 2. A bleaching material for a discolored tooth, which is used by being applied to the surface of a tooth and which contains a compound of phosphorus and calcium, a hydrogen peroxide solution and / or an acid. 3. The bleaching material for discolored teeth according to claim 1, which contains a photoactive compound of phosphorus and calcium. 4. A bleaching material for adhering to the surface of a discolored tooth and bleaching the discolored tooth on the basis of the photoactive action generated by irradiating the portion with light, which is a phosphor which produces a photoactive action by light irradiation. A bleaching material for discolored teeth, which comprises a combination of a calcium compound and a calcium compound as an active ingredient. 5. A bleaching material for adhering to the surface of a discolored tooth and bleaching the discolored tooth on the basis of a photoactive action generated by irradiating the portion with light, which is a phosphor which produces a photoactive action by light irradiation. A bleaching material for discolored teeth, which comprises a compound of calcium, calcium and hydrogen peroxide and / or acid as active ingredients. 6. The bleaching material for discolored teeth according to claim 5, which contains a compound of phosphorus and calcium having a particle diameter of about 1 nm to 10 μm and 4% or less of hydrogen peroxide solution. 7. A compound of phosphorus and calcium, such as hydroxyapatite, fluorapatite, octacalcium phosphate,
The bleaching material for discolored teeth according to any one of claims 1 to 6, further comprising one or more kinds of calcium phosphates typified by tricalcium phosphate. 8. A compound of phosphorus and calcium is A ₉ (B
O ₄ ) ₆ X, where A is Ca, Co, Ni, Cu, A
Metal atoms represented by 1, La, Cr, Fe and Mg, B
The bleaching material for discolored teeth according to any one of claims 1 to 7, wherein P is a P atom, S atom is X, and X is one or more of a hydroxyl group and a halogen atom, and is generated in a simulated body fluid. . 9. A method for producing a bleaching material for bleaching a discolored tooth on the basis of a photoactive action which is produced by adhering the surface of the discolored tooth and irradiating the portion with light. A method for producing a bleaching material for discolored teeth, which comprises blending a compound of phosphorus and calcium which produces a photoactive effect by light irradiation. 10. The method for producing a bleaching material for discolored teeth according to claim 9, wherein 4% or less of hydrogen peroxide water is blended with a compound of phosphorus and calcium which produces a photoactive action by light irradiation. 11. A bleaching system for discolored teeth, which comprises a combination of the bleaching material according to any one of claims 1 to 7 and a means for applying the bleaching material, an irradiation device, and / or a tooth preparation material. . 12. The bleaching system for discolored teeth according to claim 11, which is combined with an irradiation device that emits visible light of purple light and / or ultraviolet light.