JP2002527403A5 - - Google Patents
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- Publication number
- JP2002527403A5 JP2002527403A5 JP2000575531A JP2000575531A JP2002527403A5 JP 2002527403 A5 JP2002527403 A5 JP 2002527403A5 JP 2000575531 A JP2000575531 A JP 2000575531A JP 2000575531 A JP2000575531 A JP 2000575531A JP 2002527403 A5 JP2002527403 A5 JP 2002527403A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- lymphotoxin
- agent
- receptor
- virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003795 chemical substances by application Substances 0.000 description 7
- 102000018170 Lymphotoxin beta Receptor Human genes 0.000 description 4
- 108010091221 Lymphotoxin beta Receptor Proteins 0.000 description 4
- 102000003959 Lymphotoxin-beta Human genes 0.000 description 3
- 108090000362 Lymphotoxin-beta Proteins 0.000 description 3
- 230000005860 defense response to virus Effects 0.000 description 2
- 108020001507 fusion proteins Proteins 0.000 description 2
- 102000037865 fusion proteins Human genes 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 241000725619 Dengue virus Species 0.000 description 1
- 241001115402 Ebolavirus Species 0.000 description 1
- 241000712902 Lassa mammarenavirus Species 0.000 description 1
- 241001115401 Marburgvirus Species 0.000 description 1
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 description 1
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002981 blocking agent Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10366298P | 1998-10-09 | 1998-10-09 | |
| US60/103,662 | 1998-10-09 | ||
| PCT/US1999/023477 WO2000021558A1 (en) | 1998-10-09 | 1999-10-08 | Reversal of viral-induced systemic shock and respiratory distress by blockade of the lymphotoxin beta pathway |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010035451A Division JP2010155852A (ja) | 1998-10-09 | 2010-02-19 | リンホトキシンβ経路の遮断によるウイルス誘導性全身性ショックおよび呼吸窮迫の逆転 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002527403A JP2002527403A (ja) | 2002-08-27 |
| JP2002527403A5 true JP2002527403A5 (https=) | 2006-11-02 |
| JP4713738B2 JP4713738B2 (ja) | 2011-06-29 |
Family
ID=22296372
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000575531A Expired - Fee Related JP4713738B2 (ja) | 1998-10-09 | 1999-10-08 | リンホトキシンβ経路の遮断によるウイルス誘導性全身性ショックおよび呼吸窮迫の逆転 |
| JP2010035451A Pending JP2010155852A (ja) | 1998-10-09 | 2010-02-19 | リンホトキシンβ経路の遮断によるウイルス誘導性全身性ショックおよび呼吸窮迫の逆転 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010035451A Pending JP2010155852A (ja) | 1998-10-09 | 2010-02-19 | リンホトキシンβ経路の遮断によるウイルス誘導性全身性ショックおよび呼吸窮迫の逆転 |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US20020001585A1 (https=) |
| EP (1) | EP1119370B1 (https=) |
| JP (2) | JP4713738B2 (https=) |
| KR (1) | KR100888832B1 (https=) |
| CN (1) | CN1200733C (https=) |
| AT (1) | ATE329618T1 (https=) |
| AU (1) | AU777492C (https=) |
| BR (1) | BR9915025A (https=) |
| CA (1) | CA2344049C (https=) |
| CY (1) | CY1105059T1 (https=) |
| CZ (1) | CZ20011272A3 (https=) |
| DE (1) | DE69931944T2 (https=) |
| DK (1) | DK1119370T3 (https=) |
| EA (1) | EA006703B1 (https=) |
| EE (1) | EE04661B1 (https=) |
| ES (1) | ES2267294T3 (https=) |
| HU (1) | HUP0103773A3 (https=) |
| IL (2) | IL142284A0 (https=) |
| IS (1) | IS2514B (https=) |
| NO (1) | NO326905B1 (https=) |
| NZ (1) | NZ510560A (https=) |
| PL (1) | PL195264B1 (https=) |
| PT (1) | PT1119370E (https=) |
| SG (1) | SG121778A1 (https=) |
| SK (1) | SK4662001A3 (https=) |
| TR (1) | TR200100974T2 (https=) |
| WO (1) | WO2000021558A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5925351A (en) * | 1995-07-21 | 1999-07-20 | Biogen, Inc. | Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease |
| US7118742B2 (en) | 1997-07-07 | 2006-10-10 | La Jolla Institute For Allergy And Immunology | Ligand for herpes simplex virus entry mediator and methods of use |
| US6998108B1 (en) | 1997-07-07 | 2006-02-14 | La Jolla Institute For Allergy And Immunology | Antibodies to p30 polypeptides and methods making and using same |
| US7060667B1 (en) | 1998-01-30 | 2006-06-13 | Biogen Idec Ma, Inc. | Treatment of follicular lymphomas using inhibitors of the LT pathway |
| CA2344049C (en) * | 1998-10-09 | 2009-12-15 | Biogen, Inc. | Reversal of viral-induced systemic shock and respiratory distress by blockade of the lymphotoxin beta pathway |
| TR200504220T2 (tr) | 1998-12-17 | 2007-04-24 | Biogen Idec Ma Inc. | Aktif limfotoksin-beta reseptör imunoglobülin şimeAktif limfotoksin-beta reseptör imunoglobülin şimerik proteinlerinin yüksek düzey ifadesi ve saflaştrik proteinlerinin yüksek düzey ifadesi ve saflaştırılması için bir yöntem.ırılması için bir yöntem. |
| WO2001079496A2 (en) * | 2000-03-13 | 2001-10-25 | La Jolla Institute For Allergy And Immunology | Ligand for herpes simplex virus entry mediator and methods of use |
| EP1674575B1 (en) * | 2000-04-12 | 2010-10-06 | La Jolla Institute For Allergy And Immunology | Ligand for herpes simplex virus entry mediator and methods of use |
| CA2529945A1 (en) * | 2003-06-27 | 2005-01-06 | Biogen Idec Ma Inc. | Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions |
| AU2005227322A1 (en) * | 2004-03-23 | 2005-10-06 | Biogen Idec Ma Inc. | Receptor coupling agents and therapeutic uses thereof |
| WO2006074399A2 (en) * | 2005-01-05 | 2006-07-13 | Biogen Idec Ma Inc. | Multispecific binding molecules comprising connecting peptides |
| US8338376B2 (en) * | 2006-10-20 | 2012-12-25 | Biogen Idec Ma Inc. | Compositions comprising variant LT-B-R-IG fusion proteins |
| JP2010506955A (ja) * | 2006-10-20 | 2010-03-04 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 可溶性リンホトキシンβレセプターによる脱髄障害の処置 |
| US20090136427A1 (en) * | 2007-09-18 | 2009-05-28 | La Jolla Institute For Allergy And Immunology | LIGHT Inhibitors For Asthma, Lung and Airway Inflammation, Respiratory, Interstitial, Pulmonary and Fibrotic Disease Treatment |
| CN106591446A (zh) * | 2016-12-07 | 2017-04-26 | 中国人民解放军军事医学科学院微生物流行病研究所 | 细胞通路调控分子在作为药物靶点及诊断ebov感染中的应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4485045A (en) * | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| DE3218121A1 (de) | 1982-05-14 | 1983-11-17 | Leskovar, Peter, Dr.-Ing., 8000 München | Arzneimittel zur tumorbehandlung |
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4544545A (en) * | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US5225538A (en) * | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| WO1992000329A1 (en) * | 1990-06-27 | 1992-01-09 | Biogen, Inc. | Surface complexed lymphotoxin |
| US5795964A (en) * | 1990-06-27 | 1998-08-18 | Biogen, Inc. | Lymphotoxin-beta and lymphotoxin-beta complexes |
| US7030080B2 (en) * | 1990-06-27 | 2006-04-18 | Biogen, Inc. | Lymphotoxin-β, lymphotoxin-β complexes, pharmaceutical preparations and therapeutic uses thereof |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| DE69334224D1 (de) | 1992-12-04 | 2008-07-17 | Biogen Idec Inc | Lymphotoxin-beta, lymphotoxin-beta komplexe, pharmazeutische zubereitungen und therapeutische verwendungen davon |
| US6312691B1 (en) * | 1996-01-26 | 2001-11-06 | Jeffrey L. Browning | Lymphotoxin-α/β complexes and anti-lympotoxin-β receptor antibodies as anti-tumor agents |
| CN1900116A (zh) | 1995-01-26 | 2007-01-24 | 拜奥根Idec马萨诸塞公司 | 抗－LT－β－R抗体、含有该抗体的药用组合物及其制药应用 |
| US5925351A (en) * | 1995-07-21 | 1999-07-20 | Biogen, Inc. | Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease |
| US6291207B1 (en) * | 1995-07-28 | 2001-09-18 | Northwestern University | Herpes virus entry receptor protein |
| SK55399A3 (en) * | 1996-10-25 | 2000-10-09 | Biogen Inc | Soluble lymphotoxin-beta receptors, anti-lymphotoxin receptor antibodies, and anti-lymphotoxin ligand antibodies as therapeutic agents for the treatment of immunological diseases |
| US7255854B1 (en) * | 1996-10-25 | 2007-08-14 | Biogen, Inc. | Use of lymphotoxin-β receptor blocking agents for the treatment of antibody mediated immunological diseases |
| GB9622660D0 (en) * | 1996-10-31 | 1997-01-08 | Biocine Spa | Immunogenic detoxified mutant toxin |
| US7060667B1 (en) * | 1998-01-30 | 2006-06-13 | Biogen Idec Ma, Inc. | Treatment of follicular lymphomas using inhibitors of the LT pathway |
| CA2344049C (en) * | 1998-10-09 | 2009-12-15 | Biogen, Inc. | Reversal of viral-induced systemic shock and respiratory distress by blockade of the lymphotoxin beta pathway |
| TR200504220T2 (tr) * | 1998-12-17 | 2007-04-24 | Biogen Idec Ma Inc. | Aktif limfotoksin-beta reseptör imunoglobülin şimeAktif limfotoksin-beta reseptör imunoglobülin şimerik proteinlerinin yüksek düzey ifadesi ve saflaştrik proteinlerinin yüksek düzey ifadesi ve saflaştırılması için bir yöntem.ırılması için bir yöntem. |
| CN1678625A (zh) * | 2002-07-01 | 2005-10-05 | 比奥根艾迪克Ma公司 | 人源化抗淋巴毒素β受体的抗体 |
-
1999
- 1999-10-08 CA CA002344049A patent/CA2344049C/en not_active Expired - Fee Related
- 1999-10-08 KR KR1020017004493A patent/KR100888832B1/ko not_active Expired - Fee Related
- 1999-10-08 TR TR2001/00974T patent/TR200100974T2/xx unknown
- 1999-10-08 SK SK466-2001A patent/SK4662001A3/sk unknown
- 1999-10-08 WO PCT/US1999/023477 patent/WO2000021558A1/en not_active Ceased
- 1999-10-08 HU HU0103773A patent/HUP0103773A3/hu unknown
- 1999-10-08 JP JP2000575531A patent/JP4713738B2/ja not_active Expired - Fee Related
- 1999-10-08 AT AT99950270T patent/ATE329618T1/de active
- 1999-10-08 AU AU62964/99A patent/AU777492C/en not_active Ceased
- 1999-10-08 CN CNB998119555A patent/CN1200733C/zh not_active Expired - Fee Related
- 1999-10-08 EP EP99950270A patent/EP1119370B1/en not_active Expired - Lifetime
- 1999-10-08 ES ES99950270T patent/ES2267294T3/es not_active Expired - Lifetime
- 1999-10-08 EA EA200100430A patent/EA006703B1/ru not_active IP Right Cessation
- 1999-10-08 NZ NZ510560A patent/NZ510560A/en not_active IP Right Cessation
- 1999-10-08 EE EEP200100211A patent/EE04661B1/xx not_active IP Right Cessation
- 1999-10-08 PL PL99347177A patent/PL195264B1/pl unknown
- 1999-10-08 SG SG200303599A patent/SG121778A1/en unknown
- 1999-10-08 DE DE69931944T patent/DE69931944T2/de not_active Expired - Lifetime
- 1999-10-08 PT PT99950270T patent/PT1119370E/pt unknown
- 1999-10-08 CZ CZ20011272A patent/CZ20011272A3/cs unknown
- 1999-10-08 IL IL14228499A patent/IL142284A0/xx unknown
- 1999-10-08 DK DK99950270T patent/DK1119370T3/da active
- 1999-10-08 BR BR9915025-5A patent/BR9915025A/pt not_active Application Discontinuation
-
2001
- 2001-03-09 IS IS5882A patent/IS2514B/is unknown
- 2001-03-27 IL IL142284A patent/IL142284A/en not_active IP Right Cessation
- 2001-04-06 NO NO20011757A patent/NO326905B1/no not_active IP Right Cessation
- 2001-04-09 US US09/829,031 patent/US20020001585A1/en not_active Abandoned
-
2004
- 2004-04-21 US US10/829,720 patent/US7452530B2/en not_active Expired - Fee Related
-
2006
- 2006-06-26 CY CY20061100872T patent/CY1105059T1/el unknown
-
2008
- 2008-10-08 US US12/247,374 patent/US20090087403A1/en not_active Abandoned
-
2010
- 2010-02-19 JP JP2010035451A patent/JP2010155852A/ja active Pending
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